FGFR1

Summary

Gene Symbol: FGFR1
Description: fibroblast growth factor receptor 1
Alias: BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, KAL2, N-SAM, OGD, bFGF-R-1, FGFR1/PLAG1 fusion, FMS-like tyrosine kinase 2, basic fibroblast growth factor receptor 1, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, proto-oncogene c-Fgr
Species: human

Top Publications

  1. ncbi Overexpression of fibroblast growth factor receptors FGFR1 and FGFR2 in renal cell carcinoma
    Ilya Tsimafeyeu
    Kidney Cancer Research Bureau, Moscow, Russia
    Scand J Urol Nephrol 45:190-5. 2011
  2. ncbi Cellular signaling by fibroblast growth factor receptors
    V P Eswarakumar
    Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, P O Box 208066, SHM B 295, New Haven, CT 06520, USA
    Cytokine Growth Factor Rev 16:139-49. 2005
  3. ncbi Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene
    Nelly Pitteloud
    Reproductive Endocrine Unit and National Center for Infertility Research, Bartlett Hall Extension 5, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:1317-22. 2005
  4. ncbi Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome
    Ana Paula Abreu
    Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, 05403 900 Sao Paulo, Brasil
    J Clin Endocrinol Metab 93:4113-8. 2008
  5. ncbi Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia
    Ericka Barbosa Trarbach
    Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, Av Dr Eneas de Carvalho Aguiar, 155 2o andar Bloco 6, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 91:4006-12. 2006
  6. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
  7. ncbi Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells
    Fang Zong
    Department of Laboratory Medicine, Division of Pathology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e7346. 2009
  8. ncbi Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
    Haijie Yang
    Research Laboratories, National Neuroscience Institute, Singapore 308433
    J Biol Chem 283:5287-95. 2008
  9. ncbi Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation
    J F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 152:1307-12. 2001
  10. ncbi Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and Harvard Reproductive Endocrine Science Centers, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:6281-6. 2006

Research Grants

  1. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
  2. Defective nuclear FGFR1 signaling - a new model for PD
    MICHAL STACHOWIAK; Fiscal Year: 2003
  3. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2003
  4. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2004
  5. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2010
  6. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
  7. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2007
  8. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2009
  9. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2011
  10. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2010

Detail Information

Publications206 found, 100 shown here

  1. ncbi Overexpression of fibroblast growth factor receptors FGFR1 and FGFR2 in renal cell carcinoma
    Ilya Tsimafeyeu
    Kidney Cancer Research Bureau, Moscow, Russia
    Scand J Urol Nephrol 45:190-5. 2011
    ..Membrane antigens such as FGFR expressed in RCC are attractive targets for new therapeutic and diagnostic applications. This study evaluated the expression of FGFR1 and FGFR2 in RCC.
  2. ncbi Cellular signaling by fibroblast growth factor receptors
    V P Eswarakumar
    Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, P O Box 208066, SHM B 295, New Haven, CT 06520, USA
    Cytokine Growth Factor Rev 16:139-49. 2005
    ..binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4...
  3. ncbi Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene
    Nelly Pitteloud
    Reproductive Endocrine Unit and National Center for Infertility Research, Bartlett Hall Extension 5, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:1317-22. 2005
    ..Recently, loss-of-function mutations in the fibroblast growth factor receptor 1 (FGFR1) gene have been shown to cause autosomal dominant KS...
  4. ncbi Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome
    Ana Paula Abreu
    Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, 05403 900 Sao Paulo, Brasil
    J Clin Endocrinol Metab 93:4113-8. 2008
    ..Physiological activation of the prokineticin pathway has a critical role in olfactory bulb morphogenesis and GnRH secretion in mice...
  5. ncbi Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia
    Ericka Barbosa Trarbach
    Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, Av Dr Eneas de Carvalho Aguiar, 155 2o andar Bloco 6, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 91:4006-12. 2006
    ..To date, loss-of-function mutations in the genes encoding anosmin-1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1) have been described in the X-linked and autosomal dominant forms of this syndrome, respectively.
  6. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  7. ncbi Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells
    Fang Zong
    Department of Laboratory Medicine, Division of Pathology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e7346. 2009
    ..Our study opens a new perspective in the proteoglycan field and provides more evidence of nuclear interactions of syndecan-1...
  8. ncbi Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
    Haijie Yang
    Research Laboratories, National Neuroscience Institute, Singapore 308433
    J Biol Chem 283:5287-95. 2008
    ....
  9. ncbi Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation
    J F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 152:1307-12. 2001
    ..Furthermore, we show that nuclear FGFR1 induces c-Jun and is involved in the regulation of cell proliferation...
  10. ncbi Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and Harvard Reproductive Endocrine Science Centers, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:6281-6. 2006
    Mutations in KAL1 and FGFR1 cause Kallmann syndrome (KS), whereas mutations in the GNRHR and GPR54 genes cause idiopathic hypogonadotropic hypogonadism with normal olfaction (nIHH)...
  11. ncbi Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients
    Naoko Sato
    National Research Institute for Child Health and Development, Tokyo 154 8567, Japan
    J Clin Endocrinol Metab 89:1079-88. 2004
    ..Molecular studies were performed for Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, also known as KAL2) by sequence analysis for all the coding exons, by PCR-based deletion analysis, and by ..
  12. ncbi Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC)
    Kolja Freier
    Abteilung Molekulare Genetik B060, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Oral Oncol 43:60-6. 2007
    ..Furthermore, a distinct high-level amplification of the fibroblast growth factor receptor 1 (FGFR1) locus was detected in two cases...
  13. ncbi Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, New York, NY 10016, USA
    Science 276:955-60. 1997
    ..Two compounds from this class inhibited the kinase activity of fibroblast growth factor receptor 1 (FGFR1) and showed differential specificity toward other receptor tyrosine kinases...
  14. ncbi Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells
    M Curto
    Department of Biological Sciences, Hunter College of the City University of New York, New York 10021, USA
    Biochem Biophys Res Commun 243:555-60. 1998
    In response to fibroblast growth factor (FGF), FGF receptor-1 (FGFR-1) (flg) becomes tyrosine phosphorylated and associates with phospholipase C gamma (PLC gamma) and a 90 kDa protein...
  15. ncbi Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism
    Taneli Raivio
    Reproductive Endocrine Unit, Department of Medicine, The Harvard Center for Reproductive Endocrine Sciences, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4380-90. 2009
    b>FGFR1 mutations have been identified in about 10% of patients with Kallmann syndrome. Recently cases of idiopathic hypogonadotropic hypogonadism (IHH) with a normal sense of smell (nIHH) have been reported.
  16. ncbi Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly
    Omar A Ibrahimi
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Biochemistry 43:4724-30. 2004
    ..The recent FGF2-FGFR1-heparin crystal structure provides a detailed but static view of the FGF-FGFR-heparin complex...
  17. ncbi Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and National Center for Infertility Research, Bartlett Hall Extension 5, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, United States
    Mol Cell Endocrinol 254:60-9. 2006
    ..for anosmin-1, a key protein involved in olfactory and GnRH neuronal migration through a putative interaction with FGFR1. Heterozygous mutations in the FGFR1 gene accompanied by a high frequency of cleft palate and other facial ..
  18. ncbi Exon III splicing of fibroblast growth factor receptor 1 is modulated by growth factors and cyclin D1
    Guowei Chen
    Department of General, Visceral, and Transplantation Surgery, University of Ulm, Ulm, Germany
    Pancreas 37:159-64. 2008
    Fibroblast growth factor receptor 1 (FGFR1) isoform IIIc enhances and FGFR1-IIIb inhibits pancreatic cancer cell growth. Nothing is presently known about the expression and regulation of human FGFR1-III isoforms...
  19. ncbi Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis
    Marianne Valesky
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Med 8:103-12. 2002
    ..regression, does it suffice to block expression of bFGF and/or FGFR-1 in only the melanoma cells, or is it essential to inhibit expression of bFGF and/or FGFR-1 in both the melanoma cells and the melanoma cell-interspersing vasculature?..
  20. ncbi Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1
    Lydia W T Cheung
    School of Biological Sciences, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
    Cardiovasc Res 89:419-25. 2011
    ..Rg1 can activate the glucocorticoid receptor (GR). However, the mechanism that transmits these pro-angiogenic effects is still unclear...
  21. ncbi Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry
    Anders M Hinsby
    MDS Proteomics A S, Staermosegaardsvej 6, Odense DK 5230, Denmark
    Mol Cell Proteomics 2:29-36. 2003
    ....
  22. ncbi Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome
    Catherine Dode
    Institut Cochin et Laboratoire de Biochimie et Génétique Moléculaire, Hopital Cochin, 75014 Paris, France
    Nat Genet 33:463-5. 2003
    ..We establish here that loss-of-function mutations in FGFR1 underlie KAL2 whereas a gain-of-function mutation in FGFR1 has been shown to cause a form of craniosynostosis...
  23. ncbi Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
    J Schlessinger
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 6:743-50. 2000
    ..This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling...
  24. ncbi cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1)
    E K Stachowiak
    Molecular and Structural Neurobiology and Gene Therapy Program, Department Pathology and Anatomical Sciences, State University of New York, Buffalo 14214, USA
    J Neurochem 84:1296-312. 2003
    ..We show that nuclear fibroblast growth factor receptor-1 (FGFR1) mediates cAMP-induced neuronal differentiation and regulates CREB and CREB binding protein (CBP) function in ..
  25. ncbi Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin
    David M Bryant
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia 4072
    Mol Biol Cell 16:14-23. 2005
    ..In this study, we investigated the location, trafficking, and function of FGFR1 and E-cadherin and report a novel mechanism, based on endocytic trafficking, for the coregulation of E-cadherin ..
  26. ncbi Direct FGF receptor 1 activation through an anti-idiotypic strategy mimicks the biological activity of FGF-2 and inhibits the progression of the bladder carcinoma derived from NBT-II cells
    Bernard Malavaud
    Institut de Pharmacologie et Biologie Structurale, UMR CNRS 5089, 205 route de Narbonne, Toulouse 31077, France
    Oncogene 23:6769-78. 2004
    ..Although FGFR-1 dimerization achieved by AIdF-2 injection led to highly differentiated and smaller NBT-II tumors, no sign of reduction of tumor angiogenesis was observed, thus suggesting that endothelial cells are resistant to FGF...
  27. ncbi 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling
    Yafang Hu
    Department of Pathology and Anatomical Sciences, State University of New York, Buffalo, New York 142214, USA
    J Biol Chem 279:29325-35. 2004
    Fibroblast growth factor receptor 1 (FGFR1) is a transmembrane protein capable of transducing stimulation by secreted FGFs...
  28. ncbi Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
    Hirotaka Komaba
    Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe, Japan
    Kidney Int 77:232-8. 2010
    Fibroblast growth factor 23 (FGF23) exerts its effect by binding to its cognate FGF receptor 1 (FGFR1) in the presence of its co-receptor Klotho...
  29. ncbi Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain
    Lijuan Fu
    Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Comp Neurol 462:265-73. 2003
    ..The current study suggests that HEGFR and HFGFR1 are likely to play different roles during human brain development, but that these roles will be similar to those observed in the rodent brain...
  30. ncbi Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Respir Cell Mol Biol 27:517-25. 2002
    ..007) and was inversely correlated with FEV(1) values (P < 0.007). Our results suggest an autocrine role of the FGF-FGFR-1 system in the pathogenesis of COPD-associated vascular remodeling...
  31. ncbi Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin
    Lars Lundin
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, S 751 85, Uppsala, Sweden
    Exp Cell Res 287:190-8. 2003
    ..Our data imply that tyrosine 463 is phosphorylated and able to transduce signals in response to FGF-2 treatment alone; furthermore, we suggest that FGFR-1 dimerization/kinase activation is stabilized by heparin...
  32. ncbi Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite
    Jing Jiao
    Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Arch Biochem Biophys 410:187-200. 2003
    ....
  33. ncbi Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56
    Ferdynand J Kos
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Immunol Cell Biol 80:364-9. 2002
    ..We demonstrate that ligation of FGFR1 beta on J.C2-14 Jurkat T cells by CD56 on fixed NK-92 cells costimulates TCR/CD3-triggered IL-2 production...
  34. ncbi Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin
    Katja Kirschbaum
    Department of Molecular Biology, Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Markwiesenstrasse 55, 72770 Reutlingen, Germany
    J Biol Chem 284:28533-42. 2009
    ..Here, we show a new link between FGFR1 and the cell adhesion molecule neurofascin, which is important for neurite outgrowth...
  35. ncbi Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
    David C West
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    J Biol Chem 280:13457-64. 2005
    ..Npn-1 was also found to potentiate the growth stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins...
  36. ncbi Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development
    Peetra Ulrica Magnusson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 25:944-9. 2005
    ..The purpose of this study was to clarify the role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in hematopoietic/endothelial development...
  37. ncbi Structural and functional diversity in the FGF receptor multigene family
    D E Johnson
    Howard Hughes Medical Institute, University of California, San Francisco 94143-0724
    Adv Cancer Res 60:1-41. 1993
  38. ncbi FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
    Jorge Sergio Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 12:6652-62. 2006
    ..However, little is known about the putative therapeutic targets for these tumors. The aim of this study was to characterize CLCs at the molecular genetic level and identify putative therapeutic targets...
  39. ncbi Overexpression of the fibroblast growth factor receptor-1 gene correlates with liver metastasis in colorectal cancer
    Tsutomu Sato
    Gastroenterological Center, Yokohama City University Medical Center, Kanagawa ken 232 0024, Japan
    Oncol Rep 21:211-6. 2009
    ..Our results suggested that overexpression of the FGFR-1 gene might lead to liver metastasis in colorectal cancer. Overexpression of the FGFR-1 gene may thus be a useful predictor of liver metastasis in patients with colorectal cancer...
  40. ncbi A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
    M Muenke
    Children s Hospital of Philadelphia
    Nat Genet 8:269-74. 1994
    ..Here we present evidence that mutations in the fibroblast growth factor receptor-1 (FGFR1) gene, which maps to 8p, cause one form of familial Pfeiffer syndrome...
  41. ncbi Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes
    C H Widberg
    Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Am J Physiol Endocrinol Metab 296:E121-31. 2009
    ..A combination of biochemical and genetic approaches revealed an important role for FGFR1. Knock down of FGFR1 expression by small-interfering RNA reduced FGF-1-stimulated signaling events, proliferation, ..
  42. ncbi Impaired FGF signaling contributes to cleft lip and palate
    Bridget M Riley
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 104:4512-7. 2007
    ..We sequenced the coding regions and performed association testing on 12 genes (FGFR1, FGFR2, FGFR3, FGF2, FGF3, FGF4, FGF7, FGF8, FGF9, FGF10, FGF18, and NUDT6) and used protein structure analyses to ..
  43. ncbi Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth...
  44. ncbi Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    Vigdis Sørensen
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Mol Cell Biol 28:4129-41. 2008
    ..The activity level of p38 MAPK was not found to affect endocytosis or intracellular sorting of FGF1/FGFR1. Instead, we found that p38 MAPK regulates FGF1 translocation by phosphorylation of FGFR1 at Ser777...
  45. ncbi Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
    Ellen Margrethe Haugsten
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, 0310 Oslo, Norway
    Mol Biol Cell 19:3390-403. 2008
    ..in internalization and sorting of fibroblast growth factor receptor (FGFR), we constructed several mutants of FGFR1 in which lysines, potential ubiquitination sites, were substituted for arginines...
  46. ncbi Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, 10016, USA
    Mol Cell Biol 16:977-89. 1996
    ..We have previously shown that autophosphorylated tyrosine 766 in FGFR1 serves as a binding site for one of the SH2 domains of phospholipase Cy and couples FGFR1 to phosphatidylinositol ..
  47. ncbi Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action
    M K Stachowiak
    Laboratory of Molecular Neurobiology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Brain Res Mol Brain Res 38:161-5. 1996
    Fractionation of human astrocytes revealed the presence of 103, 118, and 145 kDa forms of FGF receptor 1 (FGFR1) in isolated nuclei. Only trace amounts of FGFR1 proteins were detected in the cell membrane or cytoplasmic fractions...
  48. ncbi Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42
    B C Low
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Biol Chem 274:33123-30. 1999
    ..FGF signaling pathway, we have initiated a yeast two-hybrid screening using the cytosolic domain of FGF receptor-1 (Flg)...
  49. ncbi The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells
    Rita Rosenthal
    Augenklinik und Hochschulambulanz, Charite Universitatsmedizin, Berlin Campus Benjamin Franklin, Berlin, Germany
    Biochem Biophys Res Commun 337:241-7. 2005
    ..Our findings support the hypothesis that there are two different FGFR-1- and FGFR-2-dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD...
  50. ncbi Alteration on the expression of IL-1, PDGF, TGF-beta, EGF, and FGF receptors and c-Fos and c-Myc proteins in bone marrow mesenchymal stroma cells from advanced untreated lung and breast cancer patients
    Erica Leonor Hofer
    Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina
    Stem Cells Dev 14:587-94. 2005
    ..The alterations we describe could help to explain the deficiency regarding the proliferative and confluence capacity of BM stroma cells in cancer patients...
  51. ncbi The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
    C Popovici
    Laboratoire d Oncologie Moleculaire, U 119 INSERM, Institut de Cancérologie et d Immunologie de Marseille, France
    Blood 93:1381-9. 1999
    ..The t(8;13) translocation has recently been shown to result in a fusion between the FGFR1 gene that encodes a tyrosine kinase receptor for fibroblast growth factors and a novel gene, FIM (also called RAMP ..
  52. ncbi Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease
    Michele Rossini
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Kidney Int 68:2621-8. 2005
    ....
  53. ncbi Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer
    Darren C Tomlinson
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Cancer Res 69:4613-20. 2009
    ..normal human urothelial cells, urothelial carcinoma cell lines, and tumor samples and showed that FGFR1 expression is increased in a high proportion of cell lines and tumors independent of stage and grade...
  54. ncbi Structure of a heparin-linked biologically active dimer of fibroblast growth factor
    A D DiGabriele
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 393:812-7. 1998
    ..The dimerization of heparin-linked acidic FGF observed here is an elegant mechanism for the modulation of signalling through combinatorial homodimerization and heterodimerization of the 12 known members of the FGF family...
  55. ncbi Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome
    S H Kim
    Centre for Neuroendocrinology, Royal Free and University College Medical School, University College London, London, UK
    J Neuroendocrinol 20:141-63. 2008
    ..KAL2, identified as the fibroblast growth factor receptor 1 (FGFR1) gene, has now been recognised to be the underlying genetic defect for an autosomal dominant form of KS...
  56. ncbi Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation
    Xiaohong Fang
    Department of Pathology and Anatomical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 280:28451-62. 2005
    In integrative nuclear fibroblast growth factor receptor-1 (FGFR1) signaling a newly synthesized FGFR1 translocates to the nucleus to stimulate cell differentiation and associated gene activities...
  57. ncbi Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors
    Nadja Jastrebova
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 23 Uppsala, Sweden
    J Biol Chem 281:26884-92. 2006
    ..In all systems studied, the stability of FGF-oligosaccharide-FR complexes correlated with the overall level of saccharide O-sulfation rather than on the precise distribution of sulfate groups...
  58. ncbi Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
    Ellen Margrethe Haugsten
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, The University of Oslo, Montebello, 0310 Oslo, Norway
    J Cell Sci 118:3869-81. 2005
    ..For this purpose, we transfected HeLa cells with any one of the four tyrosine kinase FGF receptors (FGFR1-4)...
  59. ncbi Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
    H Larsson
    Department of Medical Biochemistry and Microbiology, Uppsala University Biomedical Center, Box 575, S 751 23 Uppsala, Sweden
    J Biol Chem 274:25726-34. 1999
    ..Our data indicate that Crk participates in signaling complexes downstream of FGFR-1, which propagate mitogenic signals...
  60. ncbi Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1
    E Levi
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Proc Natl Acad Sci U S A 93:7069-74. 1996
    Recent studies have demonstrated the existence of a soluble fibroblast growth factor (FGF) receptor type 1 (FGFR1) extracellular domain in the circulation and in vascular basement membranes...
  61. ncbi The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells
    Michael J Cross
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Sweden
    Mol Biol Cell 13:2881-93. 2002
    ..We conclude, that Shb binds to tyrosine 766 in the FGFR-1 and regulates FGF-mediated mitogenicity via FRS2 phosphorylation and the subsequent activation of the Ras/MEK/MAPK pathway...
  62. ncbi The structure and function of vertebrate fibroblast growth factor receptor 1
    Casper Groth
    Department of Molecular Biosciences and Special Research Centre for the Molecular Genetics of Development, Adelaide University, SA, Australia
    Int J Dev Biol 46:393-400. 2002
    The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body...
  63. ncbi Fibroblast growth factor receptor-1 regulation of Src family kinases
    E Landgren
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    Oncogene 10:2027-35. 1995
    ..Moreover, inhibition of PKC attenuated the bFGF induced decrease in autophosphorylation of Src family members. These data indicate a negative regulatory role for PKC on Src kinase activity in certain cell types...
  64. ncbi A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism
    Ning Xu
    Section of Reproductive Endocrinology, Infertility, and Genetics, Department of Obstetrics and Gynecology, The Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912 3360, USA
    J Clin Endocrinol Metab 92:1155-8. 2007
    ..Currently, the fibroblast growth factor receptor 1 (FGFR1) gene is the only known autosomal dominant cause of KS, which is also associated with synkinesia, midfacial ..
  65. ncbi Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer
    K Sahadevan
    Urology Research Group, Northern Institute for Cancer Research, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Pathol 213:82-90. 2007
    ..To identify the most relevant targets, we simultaneously investigated FGFR1-4 expression using a prostate cancer tissue microarray (TMA) and in laser capture microdissected (LCM) prostate ..
  66. ncbi 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
    G Guasch
    Laboratoire d Oncologie Moleculaire, INSERM U 119, IFR 57, Marseille, France
    Mol Cell Biol 21:8129-42. 2001
    The FOP-fibroblast growth factor receptor 1 (FGFR1) fusion protein is expressed as a consequence of a t(6;8) (q27;p12) translocation associated with a stem cell myeloproliferative disorder with lymphoma, myeloid hyperplasia and ..
  67. ncbi Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence
    O Katoh
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 53:1136-41. 1993
    ..The sam3 protein, 800 amino acids long, has high homology to mouse K-sam/bek (67%) and N-sam/flg (63%), which we also cloned as the mouse counterparts of human K-sam/bek and N-sam/flg genes, other members of this ..
  68. ncbi Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, Columbus, OH, USA
    Mol Vis 12:15-25. 2006
    The developing lens expresses at least three different FGF receptor genes (Fgfr1, Fgfr2, Fgfr3). Furthermore, FGFs have been shown to induce lens epithelial cells to differentiate into fiber cells both in vitro and in vivo...
  69. ncbi FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
    ..In this study, we show that proximal tubules express FGFR1, -3, and -4 but not FGFR2 mRNA...
  70. ncbi Fibroblast growth factor receptor-1 signaling in pancreatic islet beta-cells is modulated by the extracellular matrix
    Dawn M Kilkenny
    Cell Imaging Shared Resource, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    Mol Endocrinol 22:196-205. 2008
    ..Fibroblast growth factor receptor-1 (FGFR1) has recently been implicated as a signaling pathway that is important for normal beta-cell function...
  71. ncbi FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression
    Pei Yu Chen
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 284:15980-92. 2009
    ..Here, we show using signal transduction mutants of FGF receptor 1 (FGFR1) expressed in rat VSMC that the adaptor protein FRS2 is essential for FGFR1-mediated phenotypic modulation and ..
  72. ncbi Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis
    Xinqiang Huang
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:1481-90. 2006
    ..Of the four FGF receptor (FGFR) tyrosine kinases, only FGFR4 is expressed in mature hepatocytes. Although FGFR1 is expressed by hepatic cell progenitors and adult nonparenchymal cells, ectopic expression is commonly observed ..
  73. ncbi Integrative nuclear signaling in cell development--a role for FGF receptor-1
    Michal K Stachowiak
    Molecular and Structural Neurobiology and Gene Therapy Program, State University of New York, Buffalo, New York 14214, USA
    DNA Cell Biol 26:811-26. 2007
    ..summarizes our current understanding of a novel "Integrative Nuclear Fibroblast Growth Factor Receptor-1 (FGFR1) Signaling" (INFS) pathway, which influences differentiation of neural progenitor cells and the associated ..
  74. ncbi Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak
    B G Ciruna
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 124:2829-41. 1997
    ..In the mouse, FGF receptor-1 (FGFR1) is expressed in an appropriate spatial and temporal manner to be orchestrating these functions...
  75. ncbi Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse
    Yasushi Ohkubo
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 24:6057-69. 2004
    Fibroblast growth factor receptor 1 (Fgfr1) is expressed at high levels by progenitor cells of the ventricular zone (VZ) within the hippocampal primordium...
  76. ncbi Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor
    Yongyou Zhang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030 3303
    Mol Endocrinol 22:167-75. 2008
    ..FRS2alpha and FRS2beta, and has been shown to recruit multiple signaling molecules, including Grb2 and Shp2, to FGFR1. To better understand how FRS2 interacted with FGFR1, in vivo binding assays with coexpressed FGFR1 and FRS2 ..
  77. ncbi Regulation of fibroblast growth factor receptor-1 (FGFR1) by thyroid hormone: identification of a thyroid hormone response element in the murine Fgfr1 promoter
    Patrick J O'Shea
    Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Endocrinology 148:5966-76. 2007
    ..Nevertheless, the mechanisms of T(3) action in bone are poorly defined. Fibroblast growth factor receptor-1 (FGFR1) is also essential for bone formation...
  78. ncbi Fibroblast growth factor receptor 1 gene expression is required for cardiomyocyte proliferation and is repressed by Sp3
    Mahdie Seyed
    Department of Cell Biology and Anatomy, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    J Mol Cell Cardiol 44:510-9. 2008
    Fibroblast growth factor receptor 1 (FGFR1) is the only high-affinity FGFR in the vertebrate myocardium...
  79. ncbi Sp1 is required for transcriptional activation of the fibroblast growth factor receptor 1 gene in neonatal cardiomyocytes
    Mahdie Seyed
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Department of Cell Biology and Anatomy, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Gene 400:150-7. 2007
    Fibroblast growth factor receptor 1 (FGFR1) is the predominant FGFR in cardiac tissue and regulates proliferation, differentiation, and maintenance of normal myocardium...
  80. ncbi [The role of human fibroblast growth factor receptor 1-IIIb isoform in proliferation of pancreatic ductal cells and its effects to mitogen-activated protein kinase]
    Zhan bing LIU
    Department of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 86:2812-6. 2006
    To study the role of IIIb isoform of human fibroblast growth factor receptor 1 (FGFR1-IIIb) in proliferation of pancreatic ductal cells and its effects on mitogen-activated protein kinase (MAPK).
  81. ncbi Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A
    Kouros Motamed
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Cell Biochem 90:408-23. 2003
    ..growth factor (bFGF/FGF-2) or interfere with complex formation between FGF-2 and its high-affinity FGF receptor-1 (FGFR1), yet both native SPARC and a peptide derived from the C-terminal high-affinity Ca(2+)-binding region of protein ..
  82. ncbi Chronic activity of ectopic type 1 fibroblast growth factor receptor tyrosine kinase in prostate epithelium results in hyperplasia accompanied by intraepithelial neoplasia
    Fen Wang
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Prostate 58:1-12. 2004
    Ectopic expression of fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase in epithelial cells is associated with progression of prostate cancer...
  83. ncbi Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth
    Zhanbing Liu
    Department of General, Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
    Cancer Res 67:2712-9. 2007
    ..Nothing is presently known about possible roles of the human FGFR1-IIIb mRNA splice variant...
  84. ncbi Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis
    Xinqiang Huang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030, USA
    Mol Carcinog 48:553-62. 2009
    ..b>FGFR1 that is normally associated with activated nonparenchymal cells appears ectopically in hepatoma cells...
  85. ncbi Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healing
    Hongbing Zhang
    Five Prime Therapeutics Inc, South San Francisco, CA, USA
    Eur J Cell Biol 83:3-11. 2004
    ..A poorly characterized splice variant is FGFR1-IIIb, recently found to be a functional FGF receptor predominantly expressed in the skin...
  86. ncbi A competitive PCR-based method to measure human fibroblast growth factor receptor 1-4 (FGFR1-4) gene expression
    M Tartaglia
    Laboratorio di Metabolisma e Biochimica Patologica, Istituto Superiore di Sanita, Rome, Italy
    DNA Cell Biol 20:367-79. 2001
    ..Here, we describe a precise and reliable competitive PCR-based assay to evaluate human FGFR1-4 gene expression...
  87. ncbi Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities
    S Werner
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Mol Cell Biol 12:82-8. 1992
    We have cloned a genomic region of the murine fibroblast growth factor (FGF) receptor 1 (FGFR1) gene that includes three alternative exons for the third immunoglobulinlike domain in the extracellular region of the receptor...
  88. ncbi Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3)
    R Rosenthal
    Institut für Klinische Physiologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    FASEB J 15:970-7. 2001
    In contrast to the fibroblast growth factor receptor 1 (FGFR1), little is known about intracellular signaling of FGFR2...
  89. ncbi Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section
    Krisztina Valter
    CNS Stability and Degeneration Group, Research School of Biological Sciences, The Australian National University, Canberra City, Canberra, ACT 2601, Australia
    Invest Ophthalmol Vis Sci 46:1748-54. 2005
    ..To assess neurotrophic factor upregulation in the retina after damage to the optic nerve and relate that regulation to changes in photoreceptor stability and function...
  90. ncbi FGFR1 expression and FGFR1-FGF-2 colocalisation in rat retina: sites of FGF-2 action on rat photoreceptors
    Krisztina Valter
    NSW Retinal Dystrophy Research Centre and Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, F13, Sydney, NSW 2006 Australia
    Growth Factors 20:177-88. 2002
    To identify sites of FGF-2 action on photoreceptors of the rat retina, by localizing FGFR1 in the intact retina, and to assess the colocalisation of FGF-2 with FGFR1.
  91. ncbi Compound deficiencies in multiple fibroblast growth factor signalling components differentially impact the murine gonadotrophin-releasing hormone system
    W C J Chung
    Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0354, USA
    J Neuroendocrinol 22:944-50. 2010
    ..Some KS patients harbour mutations in the fibroblast growth factor receptor 1 (Fgfr1) and Fgf8 genes...
  92. ncbi A case of Kallmann syndrome carrying a missense mutation in alternatively spliced exon 8A encoding the immunoglobulin-like domain IIIb of fibroblast growth factor receptor 1
    Kiyonori Miura
    Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Japan
    Hum Reprod 25:1076-80. 2010
    Fibroblast growth factor receptor 1 (FGFR1) is one of the causative genes for Kallmann syndrome (KS), which is characterized by isolated hypogonadotropic hypogonadism with anosmia/hyposmia...
  93. ncbi FGFR1 and anosmin-1 underlying genetically distinct forms of Kallmann syndrome are co-expressed and interact in olfactory bulbs
    Besma Ayari
    INSERM U 616, Equipe Avenir, CHU Pitié Salpêtrière 47 Bd de l Hôpital, 75651, Paris Cedex 13, France
    Dev Genes Evol 217:169-75. 2007
    ..matrix protein that promotes axonal guidance and branch formation in vitro; and KAL-2, which encodes the known FGFR1. The implication of FGFR1 and anosmin-1 in the same developmental disease led us to test whether anosmin-1 and ..
  94. ncbi Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children
    S J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Dermatol 161:884-9. 2009
    Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined.
  95. ncbi FGFR1 mutations in Kallmann syndrome
    C Villanueva
    Avenir Team Genetics and Physiology of Pubertal Onset, INSERM U676, Robert Debre Hospital, Paris Diderot University, Paris, France
    Front Horm Res 39:51-61. 2010
    ..The second gene (KAL2) was initially unexpected, as it was known to encode the fibroblast growth receptor 1 (FGFR1)...
  96. ncbi Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells
    Maleeha Rizvi
    Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London, UK
    Exp Biol Med (Maywood) 235:886-91. 2010
    ..Twenty-four hours after gas exposure, cell injury was provoked with oxygen-glucose deprived (OGD) culture medium for three hours...
  97. ncbi Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation
    Sheng Mei Zhu
    Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hang Zhou 310003, People s Republic of China
    Anesth Analg 109:1493-9. 2009
    ..the effects of propofol on edema and assessed its neuroprotective actions in an oxygen and glucose deprivation (OGD) model of cultured rat astrocytes...
  98. ncbi Effect of feeding fermented liquid feed and fermented grain on gastrointestinal ecology and growth performance in piglets
    N Canibe
    University of Aarhus, Faculty of Agricultural Sciences, Department of Animal Health, Welfare and Nutrition, Denmark
    J Anim Sci 85:2959-71. 2007
    ..all nonheated and nonpelleted diets) were: a dry meal diet (DRY); a fermented, liquid cereal grain feed (FLG); and a fermented liquid feed (FLF)...
  99. ncbi [Protection of hepatocyte growth factor on neurons subjected to oxygen-glucose deprivation/reperfusion.]
    Fang He
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410008, China E mail
    Sheng Li Xue Bao 60:235-42. 2008
    ..the effect of hepatocyte growth factor (HGF) on cortical neurons exposed to oxygen-glucose deprivation/reperfusion (OGD/R). Primary cultured cerebral cortical neurons were prepared from Sprague-Dawley rats...
  100. ncbi The synthetic inhibitor of fibroblast growth factor receptor PD166866 controls negatively the growth of tumor cells in culture
    Gianfranco Risuleo
    Dipartimento di Genetica e Biologia Molecolare, Sapienza Universita di Roma, Italy
    J Exp Clin Cancer Res 28:151. 2009
    ..Growth Factors (FGF) in growth control is indisputable: in particular, FGF1 and its tyrosine kinase receptor (FGFR1) act through a very complex network of mechanisms and pathways...
  101. ncbi [Clinical features of the nephrotic syndrome associated with ichthyosis vulgaris and analysis of related gene mutation]
    Zhi hui Li
    Department of Nephrology, Kidney Laboratory of Hunan Pediatric Research Institute, Hunan Children s Hospital, Changsha 410007, China
    Zhonghua Er Ke Za Zhi 48:44-9. 2010
    To study clinical features of 3 children who presented with nephrotic syndrome (NS) associated with ichthyosis vulgaris (IV), and to detect relationship between NS associated with IV in patients and FLG gene or NPHS2 gene.

Research Grants67

  1. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..b>FGFR1 and FGFR2, negatively regulate growth of the bones and fibrous tissues, respectively...
  2. Defective nuclear FGFR1 signaling - a new model for PD
    MICHAL STACHOWIAK; Fiscal Year: 2003
    ..This INFS is initiated by the activation of the FGF-2 and FGF receptor-1 (FGFR1) genes followed by transfer of FGFR1 and FGF-2 proteins directly from the cytoplasm to the cell nucleus: Nuclear ..
  3. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2003
    ..that in addition to HSPG as a receptor, AAV2 also requires a co-receptor, fibroblast growth factor receptor 1 (FGFR1), for successful infection...
  4. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2004
    ..that in addition to HSPG as a receptor, AAV2 also requires a co-receptor, fibroblast growth factor receptor 1 (FGFR1), for successful infection...
  5. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2010
    ..In contrast, Fgf receptor1 (Fgfr1) is not involved in prenatal cortical development, but may increase the differentiation or survival of cortical ..
  6. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
    ..We propose to identify protein-DNA interactions and kinase cascades conferring FGFR1/FGFR2-regulated gene expression in osteoblasts, using osteocalcin (OC) and interstitial collagenase (MMP) FGF ..
  7. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2007
    ..The four known FGFRs (FGFR1-FGFR4) are receptor tyrosine kinases (RTKs) activated by binding FGFs and heparin or heparan sulfate proteoglycans ..
  8. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2009
    ..The four known FGFRs (FGFR1-FGFR4) are receptor tyrosine kinases (RTKs) activated by binding FGFs and heparin or heparan sulfate proteoglycans ..
  9. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2011
    ..Activating mutations in human FGFR1, FGFR2, and FGFRS are associated with skeletal dysplasias including craniosynostosis and dwarfing syndromes...
  10. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2010
    ..Activating mutations in human FGFR1, FGFR2, and FGFRS are associated with skeletal dysplasias including craniosynostosis and dwarfing syndromes...
  11. Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndrome
    Jing Chen; Fiscal Year: 2007
    Dysregulation of fibroblast growth factor receptor 1 (FGFR1) has been associated with pathogenesis and disease progression of a number of human malignancies...
  12. Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndrome
    Jing Chen; Fiscal Year: 2009
    Dysregulation of fibroblast growth factor receptor 1 (FGFR1) has been associated with pathogenesis and disease progression of a number of human malignancies...
  13. Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndrome
    Jing Chen; Fiscal Year: 2010
    Dysregulation of fibroblast growth factor receptor 1 (FGFR1) has been associated with pathogenesis and disease progression of a number of human malignancies...
  14. PRODUCTION OF ALTERNATIVE FGF RECEPTOR FORMS IN TUMORS
    Gilbert Cote; Fiscal Year: 2007
    ..We have focused on the fibroblast growth factor receptor 1 gene (FGFR1) because the level of a high-affinity form of FGFR1 is dramatically elevated in GBM as a result of altered ..
  15. PRODUCTION OF ALTERNATIVE FGF RECEPTOR FORMS IN TUMORS
    Gilbert J Cote; Fiscal Year: 2010
    ..We have focused on the fibroblast growth factor receptor 1 gene (FGFR1) because the level of a high-affinity form of FGFR1 is dramatically elevated in GBM as a result of altered ..
  16. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2009
    ..Mammalian FGFR genes (FGFR1-4) encode single pass transmembrane receptors composed of an extracellular ligand binding region, and a ..
  17. SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
    Michael Cunningham; Fiscal Year: 2009
    ..It has been shown that mutations in the fibroblast growth factor receptors (FGFR1-3), TWIST1, MSX2, and the EFNB1 each cause craniosynostosis syndrome in humans...
  18. SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
    Michael L Cunningham; Fiscal Year: 2010
    ..It has been shown that mutations in the fibroblast growth factor receptors (FGFR1-3), TWIST1, MSX2, and the EFNB1 each cause craniosynostosis syndrome in humans...
  19. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert Friesel; Fiscal Year: 2009
    ..Activating mutations in human FGFR1, FGFR2, and FGFRS are associated with skeletal dysplasias including craniosynostosis and dwarfing syndromes...
  20. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert Friesel; Fiscal Year: 2007
    ..Activating mutations in human FGFR1, FGFR2, and FGFRS are associated with skeletal dysplasias including craniosynostosis and dwarfing syndromes...
  21. Pathogenesis & Therapy of 8p11 Leukemia/Lymphoma
    RICHARD VAN ETTEN; Fiscal Year: 2007
    ..from EMS patients have acquired chromosomal translocations involving the fibroblast growth factor receptor-1 (FGFR1) gene on 8p11 and express fusions of different N-terminal partner proteins with the tyrosine kinase domain of ..
  22. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2004
    ..The mammalian FGF receptor (FGFR) family is composed of four genes (FGFR1-FGFR4). Each FGFR binds a unique repertoire of FGF ligands...
  23. FRS2-mediated Signals in Prostatic Tumorigenesis and Development
    Fen Wang; Fiscal Year: 2010
    ..protein linking the FGFR kinases to downstream signaling targets, which is differentially phosphorylated by the FGFR1 and FGFR2 kinases in prostate epithelial cells...
  24. FRS2-mediated Signals in Prostatic Tumorigenesis and Development
    Fen Wang; Fiscal Year: 2009
    ..protein linking the FGFR kinases to downstream signaling targets, which is differentially phosphorylated by the FGFR1 and FGFR2 kinases in prostate epithelial cells...
  25. Role of FGF Receptors in the Developing Kidney
    Carlton Bates; Fiscal Year: 2007
    ..The Specific Aims are: 1.To fully characterize the temporal and lineage specific expression patterns of fgfr1 and fgfr2 in the developing kidney. 2...
  26. Role of FGF Receptors in the Developing Kidney
    Carlton Bates; Fiscal Year: 2009
    ..The Specific Aims are: 1.To fully characterize the temporal and lineage specific expression patterns of fgfr1 and fgfr2 in the developing kidney. 2...
  27. Receptor-specific signaling of FGFR in the prostate
    Fen Wang; Fiscal Year: 2007
    ..Abnormal activation of SNT1 by ectopic FGFR1 kinase relays the mitogenic signals to downstream effectors or mediators and contributes to prostate tumor cell ..
  28. Breast cancer oncogenes on the 8p11 amplicon.
    Stephen Ethier; Fiscal Year: 2007
    ..2. FGFR1 is amplified in two of these cell lines, but is over expressed in only one of them...
  29. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2010
    ..Although mutations in KAL1, FGFR1, and GNRHR genes account for 20-30% of cases and digenic disease has been reported in a few families, the ..