DCUN1D1

Summary

Gene Symbol: DCUN1D1
Description: DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Alias: DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3, DCN1-like protein 1, DCUN1 domain-containing protein 1, RP42 homolog, defective in cullin neddylation protein 1-like protein 1, squamous cell carcinoma-related oncogene
Species: human

Top Publications

  1. ncbi The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
    Thimo Kurz
    Institute of Biochemistry, ETH Honggerberg, 8093 Zurich, Switzerland
    Nature 435:1257-61. 2005
  2. ncbi Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16
    C Mas
    Neurogénétique, INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, Paris, 75019, France
    Genomics 65:70-4. 2000
  3. ncbi SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
    Alexander Y Kim
    Department of Surgery, Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 283:33211-20. 2008
  4. ncbi SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2
    Pornchai O-Charoenrat
    The Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 14:6780-9. 2008
  5. ncbi DCUN1D1 is a risk factor for frontotemporal lobar degeneration
    C Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Neurol 16:870-3. 2009
  6. ncbi Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa
    James S Friedman
    Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Am J Hum Genet 84:792-800. 2009
  7. ncbi [Sequencing and analysis of the complete genome of encephalomyocarditis virus strain GXLC isolated from swine]
    Kai Chuang Shi
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    Bing Du Xue Bao 26:134-42. 2010
  8. ncbi SCCRO promotes glioma formation and malignant progression in mice
    Stephen R Broderick
    Thoracic Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Neoplasia 12:476-84. 2010
  9. ncbi SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex
    Guochang Huang
    Department of Surgery, Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 286:10297-304. 2011
  10. ncbi Metal-free inorganic ligands for colloidal nanocrystals: S2-, HS-, Se2-, HSe-, Te2-, HTe-, TeS3(2-), OH-, and NH2- as surface ligands
    Angshuman Nag
    Department of Chemistry and James Frank Institute, University of Chicago, Illinois 60637, USA
    J Am Chem Soc 133:10612-20. 2011

Scientific Experts

  • Y Ramanathan
  • Caroline Jacques
  • Cord Drogemuller
  • S Welkos
  • E Kusumaningtyas
  • Ichiro Akagi
  • Kai Chuang Shi
  • Yuquan Wen
  • Bhuvanesh Singh
  • Simon G Talbot
  • Pornchai O-Charoenrat
  • Inderpal S Sarkaria
  • Ivan Ngai
  • Guochang Huang
  • Andrew Kaufman
  • Yoshihiro Yonekawa
  • Inderpal Sarkaria
  • Lisa M Seymour
  • Angshuman Nag
  • Kenneth Wu
  • Stephen R Broderick
  • C Villa
  • James S Friedman
  • Bernard M Dickens
  • Alexander Y Kim
  • DuyKhanh Pham
  • Patricia Zettler
  • Pabbathi Reddy
  • Su Dao
  • Ronald Ghossein
  • Thimo Kurz
  • Pabbathi G Reddy
  • Ronald A Ghossein
  • Valerie W Rusch
  • Maria E Dudas
  • Mark G Kris
  • Richard J Wong
  • Cherry L Estilo
  • Matthew P Padula
  • Jessica L Tacchi
  • Graeme J Eamens
  • Lauren K Woolley
  • Benjamin B A Raymond
  • Daniel R Bogema
  • Cheryl Jenkins
  • Nicholas E Dixon
  • Mark J Walker
  • Ania T Deutscher
  • Steven P Djordjevic
  • Wenyong Liu
  • Hua Yan
  • Boris Spokoyny
  • Andrew J Kaufman
  • Dmitri V Talapin
  • CATHIE PFLEGER
  • Zhen Qiang Pan
  • Xinjiang Wang
  • Lei Fang
  • Xuejun Jiang
  • Maksym V Kovalenko
  • Jong Soo Lee
  • Lan Huang
  • S Zaffran
  • Laryssa A Huryn
  • Christopher W Towe
  • Dolores Hambardzumyan
  • Diane Carlson
  • C Mas
  • Benjamin J Golas
  • Sarina Bains
  • Goncalo R Abecasis
  • Debra Breuer
  • Anand Swaroop
  • C Fenoglio
  • Magnus Abrahamson
  • S Cappa
  • Vesna Ponjavic
  • E Scarpini
  • F Clerici
  • Shomi S Bhattacharya
  • Kari E Branham
  • David G Birch
  • L Benussi
  • Matthew J Brooks
  • Noor M Ghiasvand
  • E Venturelli
  • M T Giordana
  • Andrew R Webster
  • M Serpente
  • Naushin Waseem

Detail Information

Publications26

  1. ncbi The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
    Thimo Kurz
    Institute of Biochemistry, ETH Honggerberg, 8093 Zurich, Switzerland
    Nature 435:1257-61. 2005
    ..Both in vivo and in vitro experiments indicate that Dcn1p does not inhibit deneddylation of Cdc53p by the COP9 signalosome, but greatly increases the kinetics of the neddylation reaction...
  2. ncbi Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16
    C Mas
    Neurogénétique, INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, Paris, 75019, France
    Genomics 65:70-4. 2000
    We isolated a novel mouse gene, RP42, in a systematic search for genes expressed in proliferating neuroblasts whose human orthologs map to susceptibility loci for autism...
  3. ncbi SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
    Alexander Y Kim
    Department of Surgery, Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 283:33211-20. 2008
    ..We show that SCCRO (also known as DCUN1D1) binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and augments but is not ..
  4. ncbi SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2
    Pornchai O-Charoenrat
    The Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 14:6780-9. 2008
    Ectopic expression of squamous cell carcinoma-related oncogene (SCCRO or DCUN1D1) in NIH-3T3 cells induces invasion in vitro and produces highly invasive xenografts in nude mice with a propensity for regional lymphatical metastasis...
  5. ncbi DCUN1D1 is a risk factor for frontotemporal lobar degeneration
    C Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Neurol 16:870-3. 2009
    ..Frontotemporal lobar degeneration (FTLD) is considered as a proteinopathy; therefore, it is conceivable that genes encoding for factors involved in protein misfolding and/or degradation could play a role in its pathogenesis...
  6. ncbi Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa
    James S Friedman
    Neurobiology Neurodegeneration and Repair Laboratory N NRL, National Eye Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Am J Hum Genet 84:792-800. 2009
    ..So far, 18 genes have been identified for autosomal-dominant (ad) RP. Here, we describe an adRP locus (RP42) at chromosome 7p15 through linkage analysis in a six-generation Scandinavian family and identify a disease-causing ..
  7. ncbi [Sequencing and analysis of the complete genome of encephalomyocarditis virus strain GXLC isolated from swine]
    Kai Chuang Shi
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    Bing Du Xue Bao 26:134-42. 2010
    ..from swine belonged to subgroup Ia or Ib, and the strains from mice belonged to subgroup Ia, while the strains from Sus scro fa belonged to group II. Strain GXLC, together with other EMCV isolates from China, belonged to subgroup Ia.
  8. ncbi SCCRO promotes glioma formation and malignant progression in mice
    Stephen R Broderick
    Thoracic Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    Neoplasia 12:476-84. 2010
    ..cell carcinomas, several lines of evidence now suggest that squamous cell carcinoma-related oncogene (SCCRO; aka DCUN1D1) may play a role in the pathogenesis of a wide range of human cancers including gliomas...
  9. ncbi SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex
    Guochang Huang
    Department of Surgery, Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 286:10297-304. 2011
    SCCRO/DCUN1D1/DCN1 (squamous cell carcinoma-related oncogene/defective in cullin neddylation 1 domain containing 1/defective in cullin neddylation) serves as an accessory E3 in neddylation by binding to cullin and Ubc12 to allow ..
  10. ncbi Metal-free inorganic ligands for colloidal nanocrystals: S2-, HS-, Se2-, HSe-, Te2-, HTe-, TeS3(2-), OH-, and NH2- as surface ligands
    Angshuman Nag
    Department of Chemistry and James Frank Institute, University of Chicago, Illinois 60637, USA
    J Am Chem Soc 133:10612-20. 2011
    ....
  11. ncbi Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1
    Kenneth Wu
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 286:34060-70. 2011
    ....
  12. ncbi Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface
    Lisa M Seymour
    School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
    Cell Microbiol 14:81-94. 2012
    ..Recombinant proteins constructed to mimic P60 (rP60) and P42 (rP42) also bound plasminogen at physiologically significant levels. M...
  13. ncbi SnoN overexpression is predictive of poor survival in patients with esophageal squamous cell carcinoma
    Ichiro Akagi
    Departments of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Ann Surg Oncol 15:2965-75. 2008
    ..phosphatidylinositol (PI) 3-kinase, a telomerase RNA component (TERC), a squamous cell carcinoma-related oncogene (SCCRO), ecotropic viral integration site-1 (EVI-1), and a Ski-related novel oncogene (SnoN)...
  14. ncbi International Society for Stem Cell Research (ISSCR) Guidelines for the Conduct of Human Embryonic Stem Cell Research (December 2006)
    Bernard M Dickens
    Faculty of Law and Joint Centre for Bioethics, University of Toronto, Toronto, Canada
    Med Law 27:179-90. 2008
    ..They categorize research that on ethical grounds requires special stem cell research oversight (SCRO), and indicate how that should be undertaken...
  15. ncbi Establishing procedures for institutional oversight of stem cell research
    Patricia Zettler
    Stanford Law School, Stanford, CA, USA
    Acad Med 82:6-10. 2007
    ..of the science and ethics of stem cell protocols, AHCs need to address many practical procedural issues, such as SCRO membership, quorum, conflicts of interest, and procedures for protocol review...
  16. ncbi The NK-2 homeobox gene scarecrow (scro) is expressed in pharynx, ventral nerve cord and brain of Drosophila embryos
    S Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 94:237-41. 2000
    ..Here we describe the sequence and expression of a novel Drosophila NK-2 homeobox gene, named scarecrow (scro), which shows considerable homology to vertebrate Nkx-2.1...
  17. ncbi The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores
    S Welkos
    Divisions of Bacteriology and Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Microbiology 147:1677-85. 2001
    ..role of anti-PA ABS: Rabbit anti-PA Abs promoted the uptake of spores of the PA-producing strains Sterne, Ames and RP42, a mutant of Sterne producing only PA, but not of the pX01-Sterne-1 strain, Ames strain, or RP4, a mutant of Sterne ..
  18. ncbi The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue
    Cherry L Estilo
    Dental Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 9:2300-6. 2003
    ..Two novel oncogenes, namely squamous cell carcinoma (SCC)-related oncogene (SCCRO) and PIK3CA (gene encoding phosphatidylinositol-3 kinase catalytic alpha-polypeptide), have been identified as ..
  19. ncbi Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A
    Simon G Talbot
    Laboratory of Epithelial Cancer, Biology, and Head and Neck Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 11:530-4. 2004
    b>Squamous cell carcinoma related oncogene expression (SCCRO) correlates with vascular endothelial growth factor-A expression...
  20. ncbi SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma
    Inderpal S Sarkaria
    Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Thorac Surg 78:1734-41. 2004
    Overexpression of squamous cell carcinoma-related oncogene (SCCRO) is associated with invasive progression and poor outcomes in non-small cell lung cancer...
  21. ncbi Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors
    Caroline Jacques
    Institut National de la Sante et de la Recherche Medicale, E0018, Laboratoire de Biochimie et Biologie Moleculaire, Centre Hospitalier Universitaire d Angers, 4 rue Larrey, F 49033 Angers, France
    J Clin Endocrinol Metab 90:2314-20. 2005
    ..Seven of the 18 nuclear-encoded genes are involved in protein metabolism: DKFZP434I116, B3GTL, SNX19, RP42, SENP1, UBE2D3, and the CTSB gene, which is known to be particularly deregulated in most thyroid tumors...
  22. ncbi Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas
    Inderpal S Sarkaria
    Laboratory of Epithelial Cancer Biology, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Surgery 136:1122-8. 2004
    Our previous work has demonstrated squamous cell carcinoma-related oncogene (SCCRO) expression in adult murine adrenocortical tissue...
  23. ncbi Fine mapping of the polled locus to a 1-Mb region on bovine chromosome 1q12
    Cord Drogemuller
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17 p, 30559, Hannover, Germany
    Mamm Genome 16:613-20. 2005
    ..us to narrow the critical region for the bovine polled locus to a 1-Mb segment with a centromeric boundary at RP42-218J17_MS1 and a telomeric boundary at BM6438...
  24. ncbi Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas
    Inderpal Sarkaria
    Laboratory of Epithelial Cancer Biology, Thoracic Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 66:9437-44. 2006
    ..We identified and characterized a novel oncogene, SCC-related oncogene (SCCRO), which is amplified along the 3q26.3 region in human SCC...
  25. ncbi Reduction of aflatoxin B1 in chicken feed by using Saccharomyces cerevisiae, Rhizopus oligosporus and their combination
    E Kusumaningtyas
    Department of Mycology, Research Institute for Veterinary Science, Jl RE Martadinata 30, Bogor, 16114, Indonesia
    Mycopathologia 162:307-11. 2006
    ..Aspergillus flavus was cultured together with Sc, Ro and their combination (ScRo) in chicken feed. The aflatoxin B1 content was observed at day 0, 5, 10 and 15...
  26. ncbi Phenotypic Characterization of 3 Families With Autosomal Dominant Retinitis Pigmentosa Due to Mutations in KLHL7
    Yuquan Wen
    Retina Foundation of the Southwest, 9900 N Central Expressway, Ste 400, Dallas, TX 75231
    Arch Ophthalmol 129:1475-82. 2011
    To characterize the visual phenotype caused by mutations in the BTB-Kelch protein, KLHL7, responsible for the RP42 form of autosomal dominant retinitis pigmentosa (RP).