cyclin E

Summary

Gene Symbol: cyclin E
Description: cyclin E1
Alias: CCNE, G1/S-specific cyclin-E1, cyclin Es, cyclin Et
Species: human

Top Publications

  1. ncbi Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
    Roshan Agarwal
    The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
    Clin Cancer Res 15:3654-62. 2009
  2. ncbi HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter
    Longwen Deng
    Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, D C 20037, USA
    J Biol Chem 277:33922-9. 2002
  3. ncbi HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin
    M Kundu
    Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 273:8130-6. 1998
  4. ncbi Post-translational modification and stability of low molecular weight cyclin E
    B B Mull
    Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 28:3167-76. 2009
  5. ncbi Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    D M Koepp
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA
    Science 294:173-7. 2001
  6. ncbi cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis
    Hege Ugland
    Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, N 0317 Oslo, Norway
    Mol Biol Cell 19:5082-92. 2008
  7. ncbi Cyclin E-induced S phase without activation of the pRb/E2F pathway
    J Lukas
    Danish Cancer Society, Division of Cancer Biology, Copenhagen
    Genes Dev 11:1479-92. 1997
  8. ncbi Tat protein induces self-perpetuating permissivity for productive HIV-1 infection
    C J Li
    Division of Cell Growth and Regulation, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA cjli mbcrr harvard edu
    Proc Natl Acad Sci U S A 94:8116-20. 1997
  9. ncbi NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry
    A Boudrez
    Afdeling Biochemie and Center for Human Genetics VIB, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 275:25411-7. 2000
  10. ncbi Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases
    I Blomberg
    Forschungsschwerpunkt Angewandte Tumorvirologie F0400, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Mol Cell Biol 19:6183-94. 1999

Research Grants

  1. Emory-GA Tech Nanotechnology Center for Personalized an*
    Shuming Nie; Fiscal Year: 2007
  2. Nanomaterials for Cancer Diagnostics and Therapeutics
    Chad Mirkin; Fiscal Year: 2007
  3. Carolina Center of Cancer Nanotechnology Excellence
    Rudolph Juliano; Fiscal Year: 2007
  4. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen L Goode; Fiscal Year: 2010
  5. THE S. CEREVISIAE S PHASE CHECKPOINT
    Steven Reed; Fiscal Year: 2003
  6. CKS PROTEINS IN CELL CYCLE CONTROL AND TUMOROGENESIS
    Steven Reed; Fiscal Year: 2001
  7. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2007
  8. CKS PROTEINS IN CELL CYCLE CONTROL AND TUMOROGENESIS
    Steven I Reed; Fiscal Year: 2010
  9. Cellular and molecular mechanism of retinoids in podocytes
    John C He; Fiscal Year: 2010
  10. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA apos AYAN; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications163 found, 100 shown here

  1. ncbi Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
    Roshan Agarwal
    The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
    Clin Cancer Res 15:3654-62. 2009
    ..We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling...
  2. ncbi HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter
    Longwen Deng
    Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, D C 20037, USA
    J Biol Chem 277:33922-9. 2002
    ..Recombinant CDK2/cyclin E stimulated Tat-dependent HIV-1 transcription in reconstituted transcription assay...
  3. ncbi HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin
    M Kundu
    Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 273:8130-6. 1998
    ..Consistent with this observation, lower levels of cyclin E-Cdk2 kinase activity and phosphorylated Rb were detected in the Tat-treated cells compared with the control cells...
  4. ncbi Post-translational modification and stability of low molecular weight cyclin E
    B B Mull
    Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 28:3167-76. 2009
    Our laboratory has previously described the presence of five tumor-specific low molecular weight isoforms of cyclin E in both tumor cell lines and breast cancer patient biopsies...
  5. ncbi Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    D M Koepp
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA
    Science 294:173-7. 2001
    b>Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of the cell cycle...
  6. ncbi cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis
    Hege Ugland
    Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, N 0317 Oslo, Norway
    Mol Biol Cell 19:5082-92. 2008
    ..Concomitantly, however, the level of cyclin E markedly increases upon cAMP induction, indicating that cyclin E may have cdk2-independent functions in these ..
  7. ncbi Cyclin E-induced S phase without activation of the pRb/E2F pathway
    J Lukas
    Danish Cancer Society, Division of Cancer Biology, Copenhagen
    Genes Dev 11:1479-92. 1997
    In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly, cyclin E-dependent Cdk2 positively regulate the G1- to S-phase transition, by phosphorylating the retinoblastoma protein (pRb), thereby releasing E2F ..
  8. ncbi Tat protein induces self-perpetuating permissivity for productive HIV-1 infection
    C J Li
    Division of Cell Growth and Regulation, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA cjli mbcrr harvard edu
    Proc Natl Acad Sci U S A 94:8116-20. 1997
    ..Accordingly, these primary T cells progressed from G0 to the late G1 phase of the cell cycle...
  9. ncbi NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry
    A Boudrez
    Afdeling Biochemie and Center for Human Genetics VIB, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 275:25411-7. 2000
    ..The binding of the FHA domain of NIPP1 to CDC5L was dependent on the phosphorylation of CDC5L, e.g. by cyclin E-Cdk2...
  10. ncbi Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases
    I Blomberg
    Forschungsschwerpunkt Angewandte Tumorvirologie F0400, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Mol Cell Biol 19:6183-94. 1999
    ..We further demonstrate that Cdc25A is activated at the same time as cyclin E- and cyclin A-dependent kinases...
  11. ncbi Deregulated cyclin E induces chromosome instability
    C H Spruck
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 401:297-300. 1999
    b>Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (Cdk2), is an important regulator of entry into S phase in the mammalian cell cycle...
  12. ncbi Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer
    Naomi Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Cancer 116:2621-34. 2010
    ..This study examined the clinical significance of CCNE1 (Cyclin E1) amplification and assessed whether CCNE1 is a potential therapeutic target in ovarian cancer...
  13. ncbi Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
    K H Moberg
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Nature 413:311-6. 2001
    ..embryogenesis, exit from the cell cycle is contingent on tightly controlled downregulation of the activity of Cyclin E-Cdk2 complexes that normally promote the transition from G1 to S phase...
  14. ncbi Ras activity regulates cyclin E degradation by the Fbw7 pathway
    Alex C Minella
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:9649-54. 2005
    The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis...
  15. ncbi Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    Markus Welcker
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 12:381-92. 2003
    Autophosphorylation-triggered ubiquitination has been proposed to be the major pathway regulating cyclin E protein abundance: phosphorylation of cyclin E on T380 by its associated CDK allows binding to the receptor subunit, Fbw7, of the ..
  16. ncbi Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
    A Koff
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 66:1217-28. 1991
    A new human cyclin, named cyclin E, was isolated by complementation of a triple cln deletion in S. cerevisiae...
  17. ncbi Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
    Stephen Orlicky
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Cell 112:243-56. 2003
    ..A 2.7 A X-ray crystal structure of a Skp1-Cdc4 complex bound to a high-affinity CPD phosphopeptide from human cyclin E reveals a core CPD motif, Leu-Leu-pThr-Pro, bound to an eight-bladed WD40 propeller domain in Cdc4...
  18. ncbi Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
    M Ohtsubo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 15:2612-24. 1995
    b>Cyclin E was first identified by screening human cDNA libraries for genes that would complement G1 cyclin mutations in Saccharomyces cerevisiae and has subsequently been found to have specific biochemical and physiological properties that ..
  19. ncbi Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
    ..traced to a defect in the execution of metaphase and subsequent transmission of chromosomes, and is dependent on cyclin E--a protein that is regulated by hCDC4 (refs 2-4)...
  20. ncbi Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
    N Dyson
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    J Virol 67:7641-7. 1993
    ..p107-associated proteins included cyclin A, cyclin E, and cdk2...
  21. ncbi A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy
    S Mazumder
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation NB40, Cleveland, OH 44195, USA
    Curr Cancer Drug Targets 4:65-75. 2004
    b>Cyclin E is essential for progression through the G1-phase of the cell cycle and initiation of DNA replication by interacting with and activating its catalytic partner, the cyclin dependent kinase 2 (Cdk2)...
  22. ncbi Cyclin E deregulation alters the biologic properties of ovarian cancer cells
    Isabelle Bedrosian
    Department of Surgical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Oncogene 23:2648-57. 2004
    We have previously shown that the low molecular weight (LMW) forms (trunk 1 and trunk 2) of cyclin E are biochemically hyperactive and induce G1/S progression in normal epithelial cells...
  23. ncbi Deregulation of cyclin E in human cells interferes with prereplication complex assembly
    Susanna Ekholm-Reed
    Dept of Molecular Biology, MB 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Cell Biol 165:789-800. 2004
    Deregulation of cyclin E expression has been associated with a broad spectrum of human malignancies...
  24. ncbi Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
    Mark Jackman
    Wellcome Cancer Research U K London Institute and Department of Zoology, University of Cambridge, Cambridge, United Kingdom CB2 1QR
    Mol Biol Cell 13:1030-45. 2002
    ..However, recently, both cyclin A and cyclin E have been implicated as regulators of centrosome replication, and it is unclear when and where these cyclin-Cdks ..
  25. ncbi Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases
    Y Takano
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Am J Pathol 156:585-94. 2000
    ..We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse ..
  26. ncbi Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma
    Raul Cassia
    Laboratory of Breast and Gynaecological Cancer, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Pathol 201:589-95. 2003
    b>Cyclin E overexpression occurs in a subset of endometrial carcinomas (ECs), but the molecular mechanisms underlying this alteration remain to be established...
  27. ncbi Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
    M J Dealy
    Department of Biology, University of California, San Diego, California 92093 0366, USA
    Nat Genet 23:245-8. 1999
    ..We show that Cul1 is required for early mouse development and that Cul1 mutants fail to regulate the abundance of the G1 cyclin, cyclin E (encoded by Ccne), during embryogenesis.
  28. ncbi Identification of differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, Oncorhynchus kisutch
    John A Luckenbach
    School of Aquatic and Fishery Sciences, University of Washington, Seattle, Washington 98195, USA
    Reprod Biol Endocrinol 6:2. 2008
    ..The aim of this study was to identify differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, a semelparous teleost that exhibits synchronous follicle development...
  29. ncbi Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin
    Yulia A Nevzorova
    Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Gastroenterology 137:691-703, 703.e1-6. 2009
    ..We investigated the relevance of E-cyclins in directing resting hepatocytes into the cell cycle after partial hepatectomy using CcnE1 and CcnE2 knockout mice...
  30. ncbi Sporadic invasive breast carcinomas with medullary features display a basal-like phenotype: an immunohistochemical and gene amplification study
    Socorro Maria Rodriguez Pinilla
    Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Surg Pathol 31:501-8. 2007
    ..In addition, we analyzed EGFR, C-MYC, and CCNE gene amplification by fluorescence in situ hybridization, because the expression of these genes is known to be ..
  31. ncbi Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: a case control study
    Demetrios A Arvanitis
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Oncol Rep 20:751-60. 2008
    ..The ability of this array of markers to identify disease status suggests that it could be used for diagnostic purposes...
  32. ncbi Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: a multiplex ligation-dependent probe amplification study
    Cathy B Moelans
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Anal Cell Pathol (Amst) 33:165-73. 2010
    ..These high-grade DCIS specific genes may be potential targets for treatment and/or predict progression...
  33. ncbi Effect of prostaglandin on luteinizing hormone-stimulated proliferation of theca externa cells from chicken prehierarchical follicles
    Yudong Jia
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou 310029, China
    Prostaglandins Other Lipid Mediat 92:77-84. 2010
    ..These results suggest that PG may promote development of chicken prehierarchical follicles and is related to dominant follicle selection in laying hens...
  34. ncbi Potentially functional polymorphisms in cell cycle genes and the survival of non-small cell lung cancer in a Chinese population
    Hongxia Ma
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Lung Cancer 73:32-7. 2011
    ..Further large and functional studies are needed to confirm our findings...
  35. ncbi Community-based nursing education and nursing accreditation by the Commission on Collegiate Nursing Education
    S Van Ort
    College of Nursing, University of Arizona, Tucson, AZ, USA
    J Prof Nurs 16:330-5. 2000
    ..is to describe the application of accreditation standards of the Commission on Collegiate Nursing Education (CCNE) in community-based nursing education...
  36. ncbi Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes
    Cathy B Moelans
    Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mod Pathol 23:1029-39. 2010
    ....
  37. ncbi Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia
    Andrea Caporali
    Regenerative Medicine, School of Clinical Medicine, University of Bristol, Bristol, England, UK
    Circulation 123:282-91. 2011
    ..microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region...
  38. ncbi Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 75:342-51. 2006
    ..Metformin treatment (10 mM, 24 h) also reduced cell proliferation and the levels of CCND2 and CCNE proteins without affecting cell viability, both in the basal state and in response to FSH...
  39. ncbi Oligonucleotide microarray analysis of apoptosis induced by 15-methoxypinusolidic acid in microglial BV2 cells
    Y Choi
    College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151 742, Korea
    Br J Pharmacol 157:1053-64. 2009
    ....
  40. ncbi Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression
    James Adjaye
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Physiol Genomics 31:315-27. 2007
    ....
  41. ncbi Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    Tiziana Parisi
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    EMBO J 22:4794-803. 2003
    In mammalian cells, cyclin E-CDK2 complexes are activated in the late G1 phase of the cell cycle and are believed to have an essential role in promoting S-phase entry...
  42. ncbi Gene networks involved in apoptosis induced by hyperthermia in human lymphoma U937 cells
    Yukihiro Furusawa
    Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Cell Biol Int 33:1253-62. 2009
    ..These findings will provide a basis for understanding the detailed molecular mechanisms of apoptosis induced by hyperthermia at 42 degrees C in cells...
  43. ncbi Down-regulation of the cyclin E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cells
    Fu Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, P R China
    BMB Rep 42:725-30. 2009
    ..Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy...
  44. ncbi Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer
    Dariush Etemadmoghadam
    Cancer Genomics Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
    PLoS ONE 5:e15498. 2010
    ..Co-amplification at 19q12 and 20q11 implies the presence of a cooperative mutational network. These observations have implications for the application of targeted therapies in CCNE1 dependent ovarian cancers...
  45. ncbi Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
    Klaus Golka
    Leibniz Research Centre for Working Environment and Human Factors, Ardeystrasse 67, 44139, Dortmund, Germany
    Arch Toxicol 85:539-54. 2011
    ..In future, besides identifying novel disease-associated rare variants by deep sequencing, it will also be important to understand how the already identified variants interact...
  46. ncbi Frequent amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC in early breast cancers: a potential role in G1/S escape
    L B Jensen
    Endocrine Cancer Group, Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK
    Cancer Biomark 5:41-9. 2009
    ..Both markers were amplified in 14% and deleted in 5% of the cases. This is the first report of genomic deletions of MYC in breast cancer...
  47. ncbi Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women
    Andrea L Niklaus
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Reprod 22:1778-88. 2007
    ....
  48. ncbi The FBXW7 beta-form is suppressed in human glioma cells
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Biochem Biophys Res Commun 354:992-8. 2007
    ..Our present results imply that FBXW7 plays a pivotal role in many tissues by controlling the amount of cell cycle promoter proteins and that dysfunction of this protein is one of the essential steps in carcinogenesis in multiple organs...
  49. ncbi Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study
    Andreas Gast
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Genes Chromosomes Cancer 49:733-45. 2010
    ....
  50. ncbi Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas
    Dariush Etemadmoghadam
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Clin Cancer Res 15:1417-27. 2009
    ..We analyzed somatic DNA copy number variation and gene expression data to identify key mechanisms associated with primary resistance in advanced-stage serous cancers...
  51. ncbi MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1369-74. 2003
    ..This is the first report on comprehensive characterization of the amplicon around the PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12...
  52. ncbi Identification of a three-gene expression signature of poor-prognosis breast carcinoma
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Mol Cancer 3:37. 2004
    ..The use of gene expression profiles could result in more accurate and objective prognostication...
  53. ncbi DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification
    M E Nowee
    Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 213:46-55. 2007
    ..Dedicated MLPA sets constitute potentially important tools for differential diagnosis and may provide footholds for tailored therapy...
  54. ncbi A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells
    Ying Wang
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, 14195, Berlin, Germany
    Stem Cell Rev 7:331-41. 2011
    ..In addition, 8-Br-cAMP and VPA have a synergistic effect on cellular reprogramming, which may be in part due to the transient down-regulation of the p53 signaling pathway during the early stages of reprogramming...
  55. ncbi Breast cancer relapse prediction based on multi-gene RT-PCR algorithm
    Elzbieta Pluciennik
    Department of Molecular Cancerogenesis, Medical University of Lodz, Mazowiecka 6 8 Str, 92 215 Lodz, Poland
    Med Sci Monit 16:CR132-136. 2010
    ..Only this kind of approach can improve cancer treatment through individualisation of disease cases with different molecular backgrounds...
  56. ncbi Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1
    Chutian Ge
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, People s Republic of China
    Biol Reprod 80:528-36. 2009
    ..These observations suggest that EGF signaling is important in regulating germ cell proliferation in the chicken embryonic gonad...
  57. ncbi Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferation
    Yalin Liao
    Department of Nutrition, University of California Davis, Davis, California, United States of America
    PLoS ONE 5:e12976. 2010
    ..Taken together, our data suggest that in mouse intestinal crypt cells, miR-103 is part of the G1/S transition regulatory network, which targets CCNE1, CDK2, and CREB1 during IGF-1 stimulated proliferation...
  58. ncbi The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins
    Minli Yu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou, People s Republic of China
    Amino Acids 40:933-41. 2011
    ..These results indicate that RA, as a bioactive metabolite of vitamin A, may promote PGC proliferation and increase intercellular aggregation of PGCs via E-cadherin and ?/?-catenins expression through the PKC signaling pathway...
  59. ncbi Analysis of breast cancer related gene expression using natural splines and the Cox proportional hazard model to identify prognostic associations
    Bas Kreike
    Division of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Breast Cancer Res Treat 122:711-20. 2010
    ....
  60. ncbi HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals
    Lindy A M Santegoets
    Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 121:759-66. 2007
    ..observed differences, we found that VIN appears to be a highly proliferative disease; many cyclins (CCNA, CCNB and CCNE) and almost all prereplication complex proteins are upregulated...
  61. ncbi Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center CNIO, Madrid, E 28029, Spain
    Breast Cancer Res 11:R86. 2009
    ..These genomic aberrations may drive carcinogenesis through the upregulation of proto-oncogenes. We have characterized DNA amplification at the human chromosomal region 13q34 in breast cancer...
  62. ncbi Genomic profiling of malignant melanoma using tiling-resolution arrayCGH
    G Jonsson
    Department of Oncology, University Hospital, Lund, Sweden
    Oncogene 26:4738-48. 2007
    ..2-q26.3 gain and 20 gain. Moreover, alterations of the various melanoma genes were associated with distinct chromosomal imbalances suggestive of specific genomic programs in melanoma development...
  63. ncbi BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets
    Eric S Calhoun
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Am J Pathol 163:1255-60. 2003
    ..This study investigated the mutational status of the serine/threonine kinase BRAF and the cyclin E regulator FBXW7 (CDC4, FBW7, AGO, SEL10) related to two distinct pancreatic carcinoma subsets: the medullary ..
  64. ncbi The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
    Matthieu Lacroix
    Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier 34293, France
    EMBO Rep 9:452-8. 2008
    ..Moreover, both COPR5 depletion and overexpression affect CCNE1 promoter expression. We propose that COPR5 is an important chromatin adaptor for PRMT5 to function on a subset of its target genes...
  65. ncbi [Accreditation processes for nurses: a historical briefing]
    Rosana Chami Gentil
    Grupo de Estudos e Pesquisas em Administração e Gerenciamento em Saúde e Enfermagem, Departamento de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, SP
    Rev Bras Enferm 62:125-31. 2009
    ..In the USA, the CCNE and NLNAC focus on evaluating Nursing courses and educational institutions, whilst generalist nurses are evaluated ..
  66. ncbi Rescue of cyclin D1 deficiency by knockin cyclin E
    Y Geng
    Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 97:767-77. 1999
    D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins...
  67. ncbi Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression
    Shugaku Takeda
    Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 20:2397-409. 2006
    ..Taspase1 deficiency incurs down-regulation of Cyclin Es, As, and Bs and up-regulation of p16(Ink4a) ...
  68. ncbi A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  69. ncbi miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes
    Qin Liu
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People s Republic of China
    Nucleic Acids Res 36:5391-404. 2008
    ..Taken together, our data suggests that miR-16 family triggers an accumulation of cells in G0/G1 by silencing multiple cell cycle genes simultaneously, rather than the individual target...
  70. ncbi Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function
    Takashi Yoshihara
    Department of Biological Sciences, Fordham University, 441 E Fordham Road, Larkin Hall, Bronx, NY 10458, USA
    Biochem Biophys Res Commun 358:1076-9. 2007
    ..Our results indicate that the down-regulation of CCND1 is an essential step for DBC2's growth suppression of cancer cells. We believe that this discovery contributes to a better understanding of DBC2's tumor suppressor function...
  71. ncbi Curricular practices in baccalaureate nursing education: results of a national survey
    Sharon L Chappy
    University of Wisconsin Oshkosh, Oshkosh, WI, USA
    J Prof Nurs 20:369-73. 2004
    ..was mailed to deans of nursing programs currently accredited by the Commission on Collegiate Nursing Education (CCNE). Results indicated current practice in curricula was diverse...
  72. ncbi MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells
    Hongping Xia
    Integrative Chemical Biology Laboratory, Institute of Molecular Technology, Department of Chemistry, 8 F, Kadoorie Biological Science Building, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Biochem Biophys Res Commun 380:205-10. 2009
    ..We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules...
  73. ncbi Association of over-expressed TFDP1 with progression of hepatocellular carcinomas
    Kohichiroh Yasui
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Hum Genet 48:609-13. 2003
    ..In conclusion, overexpression of TFDP1 may contribute to progression of some HCCs by promoting growth of the tumor cells...
  74. ncbi CDKN1B/p27 expression in peripheral T cell lymphoma not otherwise specified
    Anna Gazzola
    Department of Haematology and Oncological Sciences L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Clin Pathol 64:83-7. 2011
    ..CDKN1B/p27, a critical regulator of cell cycle and proliferation, has been suggested to be involved in T cell lymphomagenesis. This study aimed to evaluate the possible occurrence of CDKN1B/p27 aberrations in PTCL/NOS...
  75. ncbi Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis
    Suparna Mazumder
    Department of Cancer Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell Biol 27:3511-20. 2007
    The cyclin E/Cdk2 complex plays an essential role in the G(1)/S cell cycle transition and DNA replication...
  76. ncbi Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells
    Daniel Abate-Daga
    Programa Gens i Malaltia, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1803:1175-85. 2010
    ..Moreover it points out, for the first time at Chk1 activation as a key factor to mediate TK/GCV cytotoxicity...
  77. ncbi p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc
    Ji Hak Jeong
    Research Institute of Biomedical Engineering and Department of Pathology, Catholic University of Daegu School of Medicine, Nam Gu, Daegu 705 718, Korea
    Mol Cancer Ther 9:2102-13. 2010
    ..Ascofuranone-induced p21(WAF1/CIP1) associates with CDK2 and prevents CDK2-cyclin E complex formation, leading to the inactivation of E2F transcriptional activity...
  78. ncbi Amplicon profiles in ovarian serous carcinomas
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Cancer 120:2613-7. 2007
    ..Taken together, our results provide the first comprehensive analysis of DNA copy number changes in highly pure ovarian serous carcinoma. These findings may have important biological and clinical implications...
  79. ncbi [Expression and significance of the cyclin E in laryngeal carcinomas]
    Haiyan Gao
    Department of Otorhinolaryngology, the First Hospital of Inner Mongolia Medical College, Huhehaote, 010050, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:254-5. 2009
    To investigate the clinicopathological significance of the cyclin E expression in laryngeal squamous cell carcinomas (LSCCs).
  80. ncbi Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
    K A Won
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 15:4182-93. 1996
    A yeast screen was developed to identify mutations in human cyclin E that lead to stabilization of the protein in order to identify determinants important for cyclin E turnover...
  81. ncbi Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases
    Bing Hao
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 26:131-43. 2007
    The ubiquitin-mediated proteolysis of cyclin E plays a central role in cell-cycle progression, and cyclin E accumulation is a common event in cancer...
  82. ncbi Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E
    Elena Sotillo
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:14126-35. 2009
    We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin E to activate CDK2 and bypass quiescence in normal human fibroblasts (NHF)...
  83. ncbi NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    J Zhao
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:2283-97. 2000
    ..Here we show that NPAT, a substrate of the cyclin E-Cdk2 complex, is associated with human replication-dependent histone gene clusters on both chromosomes 1 and 6 in ..
  84. ncbi Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E
    Haiyong Wang
    Department of Oncology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    J Biol Chem 284:18236-43. 2009
    ..with UV or aphidicolin, and that this delayed recovery process coincides with a prolonged stabilization of cyclin E and down-regulation of Cdk2 kinase activity...
  85. ncbi Integrated profiling of basal and luminal breast cancers
    José Adélaïde
    Marseille Cancer Research Center, Department of Molecular Oncology, Institut Paoli Calmettes and UMR599 Institut National de la Santé et de la Recherche Médicale, Marseille, France
    Cancer Res 67:11565-75. 2007
    ..Rare high-level amplifications contained BCL2L2, CCNE, EGFR, FGFR2, IGF1R, NOTCH2, and PIK3CA. Potential gene breaks involved ETV6 and FLT3...
  86. ncbi [Cyclin E overexpression and centrosome amplification in squamous cell carcinoma of oral cavity]
    Yang Cai
    Department of Stomatology, Guiyang Medical College, Guiyang 550004, China
    Zhonghua Bing Li Xue Za Zhi 36:375-8. 2007
    To study the correlation between cyclin E protein overexpression and centrosome amplification in oral squamous cell carcinoma (OSCC).
  87. ncbi The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1825-35. 2007
    ..abrogate the binding of FBW7 not only to NOTCH1 but also to the two other characterized targets, c-Myc and cyclin E. The majority of the FBW7 mutations were present during relapse, and they were associated with NOTCH1 HD ..
  88. ncbi [Ethical and juridical context of the facial allotransplant]
    J P Meningaud
    Service de Chirurgie Plastique, reconstructrice et esthetique, CHU Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Ann Chir Plast Esthet 52:513-8. 2007
    ..The French national ethics advisory committee for life sciences and health (CCNE) has the duty to give advices on the ethical problems raised by the progress of knowledge in the fields of biology, ..
  89. ncbi Cyclin E-dependent localization of MCM5 regulates centrosome duplication
    Rebecca L Ferguson
    Howard Hughes Medical Institute and Program in Molecular Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Cell Sci 121:3224-32. 2008
    ..b>Cyclin E-Cdk2 has been implicated in regulating centrosome duplication both in Xenopus embryos and extracts and in ..
  90. ncbi Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
    Matthias Grimmler
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell 128:269-80. 2007
    ....
  91. ncbi Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores
    Alexandar Tzankov
    Institute of Pathology, University of Basel, Basel, Switzerland
    Leuk Lymphoma 51:199-212. 2010
    ..collective of 240 primary DLBCL using the common prognostic biomarkers Bcl-2, Bcl-6, CD10, FOXP1, MUM1, and Cyclin E. Comparison of the results relative to disease-specific survival unequivocally showed the superior discriminatory ..
  92. ncbi The Carolina Center of Cancer Nanotechnology Excellence: past accomplishments and future perspectives
    Rudy L Juliano
    University of North Carolina, Chapel Hill, NC 27599, USA
    Nanomedicine (Lond) 6:19-24. 2011
    The Carolina Center of Cancer Nanotechnology Excellence (C-CCNE) is funded by the National Cancer Institute and is based at the University of North Carolina...
  93. ncbi Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
    D J Lew
    Department of Molecular Biology, MB7 Scripps Research Institute, La Jolla, California 92037
    Cell 66:1197-206. 1991
    ..Cyclin C and E mRNAs accumulate periodically through the cell cycle, peaking at different times in G1...
  94. ncbi TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas
    Kohichiroh Yasui
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Hepatology 35:1476-84. 2002
    ..Expression of cyclin E gene (CCNE1) correlated closely with that of TFDP1 in not only cell lines, but also primary tumors...
  95. ncbi Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest
    Navdeep K Dhillon
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, CA 95616, USA
    Oncogene 21:4626-34. 2002
    ..In MCF7 cells, arrest is mediated through the CDK inhibitors p21 and p27 and through a decrease in cyclin E/CDK2 kinase activity...
  96. ncbi [Prognostic importance of altered expression of cell cycle regulators in lung cancer]
    Hirotoshi Akita
    Department of Medical Oncology, Hokkaido University Graduate School of Medicine
    Nippon Rinsho 60:267-71. 2002
  97. ncbi Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas
    Takahide Taguchi
    Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Oncol Rep 11:421-6. 2004
    ..Expression of p53, p21, p27, cyclin D1, cyclin E, and Bax in 17 such cell lines were analyzed by Western blot analysis...
  98. ncbi Standards of holistic nursing practice as guidelines for quality undergraduate nursing curricula
    Noreen Cavan Frisch
    School of Nursing RT915, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44114, USA
    J Prof Nurs 19:382-6. 2003
    The accreditation criteria of the Commission for Collegiate Nursing Education (CCNE) direct faculty to select nationally developed standards for professional practice to guide curricula and to articulate curriculum outcomes...
  99. ncbi Cyclin E1 is amplified and overexpressed in osteosarcoma
    William W Lockwood
    British Columbia Cancer Research Center, Vancouver, British Columbia, Canada
    J Mol Diagn 13:289-96. 2011
    ..Fluorescence in situ hybridization and immunohistochemical analysis confirmed the findings. Overexpression of cyclin E1 has potential prognostic and therapeutic implications that are discussed herein...
  100. ncbi Cyclins and cyclin-dependent kinases: comparative study of hepatocellular carcinoma versus cirrhosis
    Tsutomu Masaki
    Third Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan
    Hepatology 37:534-43. 2003
    ..Protein levels and kinase activities of cyclin D1, Cdk4, cyclin E, cyclin A, and Wee1 were significantly elevated in HCC compared with surrounding cirrhotic tissues...
  101. ncbi PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells
    Marat Shtutman
    Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University, Beer Sheva 84105, Israel
    Exp Cell Res 286:22-9. 2003
    ..Here we report that PKCeta associates with the cyclin E/Cdk2 complex...

Research Grants70

  1. Emory-GA Tech Nanotechnology Center for Personalized an*
    Shuming Nie; Fiscal Year: 2007
    This application proposes a cross-disciplinary Center of Cancer Nanotechnology Excellence (CCNE) at Emory University and Georgia Tech that will integrate nanotechnology with cancer biomolecular signatures (biomarkers) for personalized and ..
  2. Nanomaterials for Cancer Diagnostics and Therapeutics
    Chad Mirkin; Fiscal Year: 2007
    ..of a Nanomaterials for Cancer Diagnostics and Therapeutics Center for Cancer Nanotechnology Excellence (CCNE). To be led by the Principal Investigator, Chad A...
  3. Carolina Center of Cancer Nanotechnology Excellence
    Rudolph Juliano; Fiscal Year: 2007
    DESCRIPTION (provided by the applicant): The Carolina Center of Cancer Nanotechnology Excellence (C-CCNE) will bring together recent pioneering breakthroughs at UNC in nano-particle engineering with the world class excellence in the ..
  4. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen L Goode; Fiscal Year: 2010
    ....
  5. THE S. CEREVISIAE S PHASE CHECKPOINT
    Steven Reed; Fiscal Year: 2003
    ....
  6. CKS PROTEINS IN CELL CYCLE CONTROL AND TUMOROGENESIS
    Steven Reed; Fiscal Year: 2001
    ....
  7. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2007
    ..To understand how cyclin E-Cdk2, a key CDK required for the G1-to-S phase transition, executes its function in vivo, we developed a strategy ..
  8. CKS PROTEINS IN CELL CYCLE CONTROL AND TUMOROGENESIS
    Steven I Reed; Fiscal Year: 2010
    ..In part, this is because many mechanistic questions concerning the basic biology of cancer remain unanswered. This proposal seeks to address some of these unanswered questions. ..
  9. Cellular and molecular mechanism of retinoids in podocytes
    John C He; Fiscal Year: 2010
    ..Our study may lead to discover new targets of intervention for glomerular diseases and identify new therapy regimes of retinoids by enhancing its beneficial effects and reducing its side effects in patients with kidney diseases. ..
  10. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA apos AYAN; Fiscal Year: 2010
    ....
  11. CONTROL OF CELL DIVISION IN YEAST
    Steven Reed; Fiscal Year: 2007
    ..Ultimately, such information will be important for the diagnosis and treatment of human diseases such as cancer. ..