cyclin D2

Summary

Gene Symbol: cyclin D2
Description: cyclin D2
Alias: KIAK0002, G1/S-specific cyclin D2, G1/S-specific cyclin-D2
Species: human

Top Publications

  1. ncbi Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad
    Youngkyu Park
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 280:9135-48. 2005
  2. ncbi IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1
    Michelle M Fung
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4614, USA
    Oncogene 24:4624-33. 2005
  3. ncbi Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    H Hirai
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:2672-81. 1995
  4. ncbi Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation
    E Evron
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 61:2782-7. 2001
  5. ncbi The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner
    Junan Li
    Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 43:4394-9. 2004
  6. ncbi The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells
    Kylene Kehn
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Retrovirology 1:6. 2004
  7. ncbi Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute, Porto, Rua Dr Antonio Bernardino de Almeida, Porto, 4200 072, Portugal
    J Mol Med (Berl) 84:911-8. 2006
  8. ncbi Functional analysis of the human cyclin D2 and cyclin D3 promoters
    A R Brooks
    CV Therapeutics, Palo Alto, California 94304, USA
    J Biol Chem 271:9090-9. 1996
  9. ncbi NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity
    I Sansal
    Unité de Génétique Oncologique, CNRS UMR 1599, Institut Gustave Roussy, PR 1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Oncogene 19:5000-9. 2000
  10. ncbi Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets
    D A Tanguay
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Immunol 166:4273-7. 2001

Research Grants

  1. Mechanism of EVI1-induced Leukemogenesis
    Archibald S Perkins; Fiscal Year: 2010
  2. Mechanism of EVI1-induced Leukemogenesis
    Archibald Perkins; Fiscal Year: 2007
  3. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen Goode; Fiscal Year: 2007
  4. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2007
  5. BIOMARKERS FOR ANAL CANCER
    Stephen Hawes; Fiscal Year: 2006
  6. EPIDEMIOLOGY OF ORAL HIV 1 & 2 INFECTION IN HIGH RISK WO
    Stephen Hawes; Fiscal Year: 2003
  7. BRAIN TISSUE RESOURCE FOR NEUROPSYCHIATRIC RESEARCH
    Francine Benes; Fiscal Year: 2002
  8. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine Benes; Fiscal Year: 2009
  9. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen L Goode; Fiscal Year: 2010
  10. CORTICOLIMBIC ABNORMALITIES IN SCHIZOPHRENIC BRAIN
    Francine Benes; Fiscal Year: 2001

Scientific Experts

Detail Information

Publications154 found, 100 shown here

  1. ncbi Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad
    Youngkyu Park
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 280:9135-48. 2005
    ..In the presence of FSH plus activin, GCs exhibit enhanced expression of cyclin D2 as well as inhibin-alpha, aromatase, steroidogenic factor-1 (SF-1), cholesterol side chain (SCC), and epiregulin...
  2. ncbi IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1
    Michelle M Fung
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4614, USA
    Oncogene 24:4624-33. 2005
    ....
  3. ncbi Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    H Hirai
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:2672-81. 1995
    ..However, introduction of a vector encoding p19 into mouse NIH 3T3 cells leads to constitutive p19 synthesis, inhibits cyclin D1-CDK4 activity in vivo, and induces G1 phase arrest...
  4. ncbi Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation
    E Evron
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 61:2782-7. 2001
    b>Cyclin D2 is a member of the D-type cyclins, implicated in cell cycle regulation, differentiation, and malignant transformation...
  5. ncbi The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner
    Junan Li
    Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 43:4394-9. 2004
    ..In the presence of p16, a quaternary complex is formed between p34(SEI-1), CDK4, cyclin D2, and p16...
  6. ncbi The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells
    Kylene Kehn
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Retrovirology 1:6. 2004
    ..We have previously shown that Tax upregulates the cell cycle checkpoint proteins p21/waf1 and cyclin D2. Here we describe the consequences of upregulating these G1/S checkpoint regulators in HTLV-1 infected cells.
  7. ncbi Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute, Porto, Rua Dr Antonio Bernardino de Almeida, Porto, 4200 072, Portugal
    J Mol Med (Berl) 84:911-8. 2006
    ..To assess Cyclin D2 promoter methylation status and expression levels in prostate tissues, quantitative methylation-specific PCR and ..
  8. ncbi Functional analysis of the human cyclin D2 and cyclin D3 promoters
    A R Brooks
    CV Therapeutics, Palo Alto, California 94304, USA
    J Biol Chem 271:9090-9. 1996
    ..We determined the nucleotide sequence of the 5'-flanking region of the human cyclin D2 and cyclin D3 genes and identified the transcription start sites...
  9. ncbi NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity
    I Sansal
    Unité de Génétique Oncologique, CNRS UMR 1599, Institut Gustave Roussy, PR 1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Oncogene 19:5000-9. 2000
    ..This interaction reduces the binding of E2F-1 to DNA and its transcriptional activity. Taken together, the data suggest that NPDC-1 could influence cell cycle progression and neural differentiation through its association with E2F-1...
  10. ncbi Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets
    D A Tanguay
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Immunol 166:4273-7. 2001
    ..PMA alone promotes proliferation in B-1 cells, but not in splenic B-2 cells. Although cyclin D2-cyclin-dependent kinase 4 (cdk4) complexes mediate early retinoblastoma gene product (pRb) phosphorylation in B-..
  11. ncbi DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
    Mary Jo Fackler
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Int J Cancer 107:970-5. 2003
    ..The promoter methylation status of 5 cancer-related genes (RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist) was evaluated in 2 types of lobular cancers, in situ (LCIS) and invasive lobular carcinomas (ILC) (n =..
  12. ncbi Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases
    Y Takano
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Am J Pathol 156:585-94. 2000
    ..We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of ..
  13. ncbi Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 106:4315-21. 2005
    ..The tumor cells also failed to express cyclin D1 protein, but instead expressed either cyclin D2 (2 cases) or cyclin D3 (4 cases)...
  14. ncbi Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045 Japan
    Cancer Biol Ther 6:832-9. 2007
    ..SNP typing and custom-made microarray analyses on genes encoding stem cell signaling molecules could be utilized for the personalized medicine...
  15. ncbi Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia
    David Kerns
    J J Peters VA Medical Center, 130 West Kingsbridge Ave, Bronx, New York, NY 10468, USA
    Schizophr Res 120:150-8. 2010
    ..These data are consistent with the hypothesis that Ol and myelin deficits in SZ involve a failure of Ol precursors to appropriately exit the cell cycle in order to differentiate and mature into myelinating Ols...
  16. ncbi Profiling of cell cycle genes of breast cells exposed to etodolac
    D Roy
    Department of Natural Sciences, The City University of New York, Hostos College Campus, Bronx, NY 10451, USA
    Oncol Rep 23:1383-91. 2010
    ..This finding indicated that etodolac could play a critical role on cancer cells by inducing cell death...
  17. ncbi Stem cell regulatory gene expression in human adult dental pulp and periodontal ligament cells undergoing odontogenic/osteogenic differentiation
    Lu Liu
    Department of Operative Dentistry, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Endod 35:1368-76. 2009
    ..During development and regeneration, odontogenesis and osteogenesis are initiated by a cascade of signals driven by several master regulatory genes...
  18. ncbi Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma
    Miguel Alaminos
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    J Natl Cancer Inst 96:1208-19. 2004
    ..Transcriptional silencing of tumor suppressor genes mediated by hypermethylation of promoter CpG islands is a hallmark of human tumors. We addressed the clinical relevance of promoter hypermethylation in neuroblastoma...
  19. ncbi Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: implications for erectile dysfunction
    Jintetsu Soh
    Department of Urology, Kyoto Prefectural University Graduate School of Medical Science, Kyoto, Japan
    Urology 70:1019-23. 2007
    ..To elucidate the possible elements involved in ED in diabetes mellitus, we performed broad-scale gene expression profiling using cDNA array in the penis of streptozotocin-induced diabetic rats...
  20. ncbi MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells
    Jose L R Brito
    Institute for Cancer Research, Section of Haemato oncology, London, UK
    Haematologica 94:78-86. 2009
    ..The involvement of MMSET in the pathogenesis of t(4;14) multiple myeloma and the mechanism or genes deregulated by MMSET upregulation are still unclear...
  21. ncbi Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
    Stefan Joos
    German Cancer Research Center, H0700, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Int J Cancer 103:489-95. 2003
    ....
  22. ncbi Molecular cytogenetic anomalies and phenotype alterations in a newly established cell line from Wilms tumor with diffuse anaplasia
    Marine Faussillon
    National Institute of Health and Medical Research INSERM U507, Necker Hospital, 161, rue de Sevres, 75015 Paris, France
    Cancer Genet Cytogenet 184:22-30. 2008
    ..1 and 4p15.3, as well as an elevated copy number of cyclin D2 (CCND2) and cyclin D associated kinase (CDK4) genes on chromosome 12 (confirmed by fluorescence in situ ..
  23. ncbi Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer
    Mariana Brait
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II, 5M, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 17:2786-94. 2008
    ..The aims of our study were to elucidate the role of methylation of a large panel of genes during multistage pathogenesis of bladder cancer and to correlate our findings with patient age and other clinicopathologic features...
  24. ncbi Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma
    Brock C Christensen
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:1555-9. 2008
    ..These data suggest a novel tumorigenic mechanism of action of asbestos and may contribute to the understanding of precisely how asbestos exposure influences the etiology and clinical course of malignant mesothelioma...
  25. ncbi Methoxychlor inhibits growth of antral follicles by altering cell cycle regulators
    Rupesh K Gupta
    Division of Toxicology, Department of Veterinary Biosciences, University of Illinois, 2001 South Lincoln Avenue, 3223 VMBSB, Urbana Champaign, IL 61802, USA
    Toxicol Appl Pharmacol 240:1-7. 2009
    ..Levels of cyclin D2 (Ccnd2) and cyclin dependent kinase 4 (Cdk4) were measured using in vivo and in vitro samples...
  26. ncbi Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines
    Jens Bunt
    Department of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    Mol Cancer Res 8:1344-57. 2010
    ..Our data indicate that OTX2 directly induces a series of cell cycle genes but requires cooperating genes for an oncogenic acceleration of the cell cycle...
  27. ncbi Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors
    Eiji Sunami
    Department of Molecular Oncology, The John Wayne Cancer Institute, Saint John s Health Center, Santa Monica Blvd, Santa Monica, California 90404, USA
    Breast Cancer Res 10:R46. 2008
    ....
  28. ncbi Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women
    Wenyi Qin
    Department of Surgery, University of Missouri School of Medicine Columbia, One Hospital Drive, Columbia, MO 65212, USA
    Nutr Cancer 61:238-44. 2009
    ..Isoflavones induced dose-specific changes in RARbeta2 and CCND2 gene methylation, which correlated with genistein levels. This work provides novel insights into estrogenic and methylation effects of dietary isoflavones...
  29. ncbi Brain expressed microRNAs implicated in schizophrenia etiology
    Thomas Hansen
    Research Institute of Biological Psychiatry, Sct Hans Hospital, Roskilde, Denmark
    PLoS ONE 2:e873. 2007
    ....
  30. ncbi Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA
    Mitsutaka Kadota
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 69:7357-65. 2009
    ..Our gene amplification and somatic mutation analysis of breast primary tumors provides a coherent picture of genetic events, both corroborating and novel, offering insight into the genetic underpinnings of breast cancer progression...
  31. ncbi Extracellular tumor-related mRNA in plasma of lymphoma patients and survival implications
    Vanesa Garcia
    Department of Medical Oncology, Puerta de Hierro University Hospital, Madrid, Spain
    PLoS ONE 4:e8173. 2009
    ..These markers were also analyzed in lymphoma tissues to test possible associations with their presence in plasma...
  32. ncbi Evidence for a role of the Simian Virus 40 in human breast carcinomas
    M Hachana
    Department of Pathology, Farhat Hached Hospital, 4000 Sousse, Tunisia
    Breast Cancer Res Treat 113:43-58. 2009
    ..The aim of this study was to investigate whether the Simian Virus 40 (SV40) is implicated in human breast carcinomas (BC)...
  33. ncbi The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas
    Yasodha Natkunam
    Department of Pathology, Stanford University School of Medicine, CA, USA, and Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    Blood 109:1636-42. 2007
    ..Our results warrant inclusion of LMO2 in multivariate analyses to construct a clinically applicable immunohistologic algorithm for predicting survival in patients with DLBCL...
  34. ncbi Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma
    David Gisselsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 33:133-40. 2002
    ..These findings indicate that gain of sequences from the short arm of chromosome 12 could be a possible genetic pathway in the development of aggressive osteosarcoma...
  35. ncbi The ability of the aryl hydrocarbon receptor to regulate ovarian follicle growth and estradiol biosynthesis in mice depends on stage of sexual maturity
    Isabel Hernández-Ochoa
    Department of Comparative Biosciences, University of Illinois, Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 83:698-706. 2010
    ..AhrKO antral follicles from prepubertal mice had slower growth, produced lower estradiol levels, and had reduced cyclin D2 (Ccnd2) expression compared to WT follicles...
  36. ncbi Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma
    Shuang Wang
    Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Int J Cancer 128:753-62. 2011
    ..034). Our results suggest that DNK-NPC can be classified into 2 subtypes based on gene expression patterns, which can be used in determining prognosis and treatment of the tumor...
  37. ncbi Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 75:342-51. 2006
    ....
  38. ncbi Cellular senescence and longevity of osteophyte-derived mesenchymal stem cells compared to patient-matched bone marrow stromal cells
    Sanjleena Singh
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia
    J Cell Biochem 108:839-50. 2009
    ..Our results indicate that oMSCs retain a level of telomerase activity in vitro, which may account for the relatively greater longevity of these cells, compared with bMSCs, by preventing replicative senescence...
  39. ncbi Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
    N C Gutierrez
    Servicio de Hematologia, Hospital Universitario, Centro de Investigación del Cáncer IBMCC USAL CSIC, Salamanca, Spain
    Leukemia 24:629-37. 2010
    ....
  40. ncbi Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells
    Carla Pelusi
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Biol Reprod 79:1074-83. 2008
    ..of ovarian follicles, as well as decreased gonadotropin-induced ovarian expression of aromatase (Cyp19a1) and cyclin D2 (Ccnd2)...
  41. ncbi Genetic alterations after carbon ion irradiation in human lung adenocarcinoma cells
    Emmanouil Fokas
    Department of Radiotherapy and Radiation Oncology, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Int J Oncol 38:161-8. 2011
    ..05). Our findings provide information on the genetic signature of carbon ions in human lung adenocarcinoma cells and add to the understanding of the complicated molecular response to carbon ion irradiation...
  42. ncbi Proteomic analysis by two-dimensional electrophoresis to identify the normal human chondrocyte proteome stimulated by tumor necrosis factor alpha and interleukin-1beta
    Berta Cillero-Pastor
    INIBIC, Complejo Hospitalario Universitario A Coruña, A Coruna, Spain
    Arthritis Rheum 62:802-14. 2010
    ....
  43. ncbi TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma
    Fabricio de Carvalho
    Discipline of Hematology and Hemotherapy, Universidade Federal de Sao Paulo, UNIFESP EPM, Sao Paulo, Brazil
    Int J Cancer 125:1985-91. 2009
    ..This study represents the first quantitative evaluation of promoter methylation in MM and our data provide evidence that TGFbetaR2 hypermethylation, besides ISS, may be useful as prognostic indicator in this disease...
  44. ncbi Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells
    Lili Milani
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Nucleic Acids Res 35:e34. 2007
    ..The screening process allowed us to zoom in from 160 candidate genes to eight genes that may contain functional rSNPs in their promoter regions...
  45. ncbi The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2
    Z Hanna
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    Oncogene 8:1661-6. 1993
    ..The sequence of the Vin-1 gene is identical to that of the recently identified G1-phase cyclin D2 gene. The human homolog of the Vin-1/cyclin D2 gene (CCND2) was mapped to chromosome 12, band p13...
  46. ncbi Germinal center B cell-like (GCB) and activated B cell-like (ABC) type of diffuse large B cell lymphoma (DLBCL): analysis of molecular predictors, signatures, cell cycle state and patient survival
    S Blenk
    Department of Bioinformatics, University of Wurzburg, Biozentrum, Am Hubland Universität Würzburg, Germany
    Cancer Inform 3:399-420. 2007
    ..It predicts and supports the aggressive behaviour of the ABC subgroup. These results help to understand target interactions, improve subgroup diagnosis, risk prognosis as well as therapy in the ABC and GCB DLBCL subgroups...
  47. ncbi Transcription factor GATA-3 is essential for lens development
    Atsuko Maeda
    Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Dev Dyn 238:2280-91. 2009
    ..as well as with diminished levels of the cell-cycle inhibitors Cdkn1b/p27 and Cdkn1c/p57 and increased Ccnd2/cyclin D2 abundance...
  48. ncbi Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma
    Masahito Tsutsui
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Clin Chim Acta 411:516-20. 2010
    ..We examined preoperatively the methylated CCND2 gene levels present in the serum following release from HCC cells as a prognosis predictor in patients undergoing curative hepatectomy...
  49. ncbi Transcriptional regulation of cyclin D2 by the PKA pathway and inducible cAMP early repressor in granulosa cells
    Luis C Muniz
    Department of Biochemistry and Molecular Biology and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, New Jersey 07103, USA
    Biol Reprod 75:279-88. 2006
    b>Cyclin D2 (Ccnd2) is an essential gene for folliculogenesis, as null mutation in mice impairs granulosa cell proliferation in response to FSH. Ccnd2 mRNA is induced during the estrus cycle by FSH and is rapidly inhibited by LH...
  50. ncbi CCND2 polymorphisms associated with clearance of HBV infection
    Tae Joon Park
    Department of Life Science, Sogang University, Shinsu dong, Mapo gu, Seoul, Korea
    J Hum Genet 55:416-20. 2010
    ..They interact and construct complexes with cyclin-dependent kinase (CDK)4 or 6. The cyclin D2/CDK4 or CDK6 complexes have key roles in controlling the progression of cell cycle from the Gap 1 (G1) phase to ..
  51. ncbi MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
    Qingchuan Dong
    Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    PLoS ONE 5:e10147. 2010
    ..Let-7a may also be novel therapeutic candidate for prostate cancer given its ability to induce cell-cycle arrest and inhibit cell growth, especially in hormone-refractory prostate cancer...
  52. ncbi DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98109, USA
    Exp Mol Pathol 88:287-92. 2010
    ..Our data support the hypothesis that HCC resulting from different viral etiologies is associated with different epigenetic changes...
  53. ncbi Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Tokyo 104 0045, Japan
    Int J Mol Med 18:1019-23. 2006
    ..Small-molecule inhibitors for SMO or STK36 are suitable to be used for treatment of Hedgehog-dependent cancer...
  54. ncbi Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 33:881-6. 2008
    ....
  55. ncbi High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute Porto, Portugal
    Clin Cancer Res 13:6122-9. 2007
    ....
  56. ncbi Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation
    Y Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Curr Mol Med 9:873-86. 2009
    ..Hedgehog signaling inhibitors should be used in combination with RTK inhibitors, GPCR modulators, and/or irradiation for cancer therapy...
  57. ncbi TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency
    Kerstin Krause
    Department of Internal Medicine, Universitat Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 93:1390-3. 2008
    ..In this paper, we re-evaluate the diagnostic potential of 10 proposed candidate genes in benign and malignant thyroid pathologies in a region with borderline iodine deficiency...
  58. ncbi Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer
    K P M Suijkerbuijk
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Ann Oncol 19:1870-4. 2008
    ..We investigated whether BRCA1-associated breast tumors show cancer-predictive methylation patterns similar to those found in sporadic tumors...
  59. ncbi Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma
    Toyoki Moribe
    Research Group, Molecular Diagnostics R and D Department, Roche Diagnostics K K, Minato ku, Tokyo, Japan
    Int J Cancer 125:388-97. 2009
    ..These results indicate that the combination of these 3 genes may aid in the accurate diagnosis of early HCC...
  60. ncbi Does the 3-gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?
    Daniel Shibru
    Department of Surgery, University of California at San Francisco, San Francisco, California 94143 1674, USA
    Cancer 113:930-5. 2008
    ..The aim of the current study was to determine the diagnostic accuracy of the 3-gene assay in thyroid tissue and in FNA biopsy for distinguishing benign from malignant thyroid neoplasms...
  61. ncbi Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation
    Fang Ting Kuo
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics Gynecology, Cedars Sinai Medical Center, 8635 West Third Street, Los Angeles, California 90048, USA
    Endocrinology 152:3917-29. 2011
    ..repressor of the steroidogenic acute regulatory (StAR), P450SCC (CYP11A), P450aromatase (CYP19), and cyclin D2 (CCND2) genes, markers of ovarian follicle proliferation and differentiation...
  62. ncbi Identification of Hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system
    Anette Szczepny
    Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3168, Australia
    Biol Reprod 80:258-63. 2009
    ..Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli ..
  63. ncbi Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets
    Wenzhang Wang
    The State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, People s Republic of China
    Int J Cancer 129:1624-34. 2011
    ..Overall, this study used a large-scale data analysis to identify a qualified list of miRNAs that are consistently changed in tumors, which could lead to a better understanding of human tumor etiology...
  64. ncbi Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy
    Patricia C Sanchez-Diaz
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center at San Antonio, TX, USA
    BMC Cancer 8:280. 2008
    ..High levels of Msi1 have been reported in several malignancies including brain tumors thereby associating Msi1 and cancer...
  65. ncbi Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax
    R Iwanaga
    Laboratory of Microbiology and Immunology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Oncogene 27:5635-42. 2008
    ..protein Tax of HTLV-I can promote cell-cycle progression in resting T cells along with induction of cyclin D2 and cyclin-dependent kinase (cdk6) gene expression...
  66. ncbi Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung
    Alexander Salskov
    Division of Nuclear Medicine, Department of Radiology, Box 357115, School of Medicine, University of Washington, Seattle, WA 98195 7115, USA
    J Oncol 2011:950140. 2011
    ..Hypermethylation of CCND2 may reflect a smoking-induced precancerous change in the lung...
  67. ncbi DNA methylation profile during multistage progression of pulmonary adenocarcinomas
    Jin Haeng Chung
    Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi Do, South Korea
    Virchows Arch 459:201-11. 2011
    ....
  68. ncbi Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic ?-cells through glycolysis and calcium channels
    Seth J Salpeter
    Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Endocrinology 152:2589-98. 2011
    ..Genetic studies have demonstrated an important role for cyclin D2 in ?-cell proliferation and mass homeostasis, but its specific function in ?-cell division and mechanism of ..
  69. ncbi Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells
    Klaus A Becker
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 222:456-64. 2010
    ..We show that cyclin D2 is prominently expressed in pluripotent hES cells, but cyclin D1 eclipses cyclin D2 during differentiation...
  70. ncbi The complex landscape of genetic alterations in mantle cell lymphoma
    Cristina Royo
    Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Hematopathology Section, Hospital Clinic, 08036 Barcelona, Spain
    Semin Cancer Biol 21:322-34. 2011
    ..The better understanding of genetic alterations of MCL may offer new approaches for more patient-tailored, risk-adapted treatment options...
  71. ncbi Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR
    Leticia Quintanilla-Martinez
    Institute of Pathology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Haematologica 94:1595-8. 2009
    ..In contrast, positive immunostaining for cycD2 was found in most B-cell non-Hodgkin's lymphomas, and therefore, it is not specific for a diagnosis of cycD2(+)mantle cell lymphoma...
  72. ncbi Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology
    Laila Karra
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel
    Fertil Steril 93:2646-51. 2010
    ..To identify changes in the expression and phosphorylation of phosphatidylinositol 3-kinase (PI3K)/Akt protein kinases controlling survival and/or apoptosis of in vitro cell cultures of uterine leiomyomas...
  73. ncbi Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:935-44. 2009
    ..These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls...
  74. ncbi The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance
    Fiona M Ross
    LRF UKMF Cytogenetic Database, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury, Wilts, UK
    Haematologica 95:1221-5. 2010
    ..None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma...
  75. ncbi Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma
    Rajesh R Singh
    Department of Hematopathology and School of Health Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 69:2550-8. 2009
    ..There is a positive synergistic effect between the SHH/GLI1 and PI3K/AKT pathways that contributes to the lymphomagenic effect of NPM-ALK...
  76. ncbi Gene expression patterns induced by HPV-16 L1 virus-like particles in leukocytes from vaccine recipients
    Alfonso J Garcia-Pineres
    HPV Immunology Laboratory, Science Applications International Corporation Frederick National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 182:1706-29. 2009
    ..The strongest correlations with neutralizing Ab titers were found for cyclin D2 (CCND2) and galectin (LGALS2)...
  77. ncbi Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma
    Chun Feng Lee
    Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan, China
    World J Gastroenterol 15:356-65. 2009
    ..To identify the genes related to lymph node metastasis in human hepatocellular carcinoma (HCC), 32 HCC patients with or without lymph node metastasis were investigated by high-throughput microarray comprising 886 genes...
  78. ncbi Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts
    P Muglia
    Genetics Division, Drug Discovery, GlaxoSmithKline R and D, Verona, Italy
    Mol Psychiatry 15:589-601. 2010
    ..Meta-analysis of larger datasets is warranted to identify SNPs with smaller effects or with rarer allele frequencies that contribute to the risk of MDD...
  79. ncbi Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial
    Gary P Wang
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076, USA
    Blood 115:4356-66. 2010
    ..The approaches to sequencing and bioinformatics analysis reported here should be widely useful in assessing the outcome of gene therapy trials...
  80. ncbi Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 35:187-92. 2009
    ..Together these facts indicate that Hedgehog, TGFbeta, and RTK signals positively regulate GLI1, and that Notch, and GsPCR signals negatively regulate the GLI1...
  81. ncbi Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
    Pedro J Real
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Nat Med 15:50-8. 2009
    ..In contrast, glucocorticoid treatment induced transcriptional upregulation of cyclin D2 (Ccnd2) and protected mice from developing the intestinal goblet cell metaplasia typically induced by inhibition ..
  82. ncbi High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions
    Ana Teresa Martins
    Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute, Porto, Portugal
    Breast Cancer Res Treat 129:1-9. 2011
    ..Thus, epigenetic biomarkers provide valuable tools for breast cancer patient management...
  83. ncbi The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 107:40-55. 2009
    ....
  84. ncbi miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression
    Nan Sook Lee
    Division of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Biochem Biophys Res Commun 377:434-40. 2008
    ..regulates expression of the pluripotent stem cell marker Oct4, and it directly regulates expression of Cyclin D2 protein, a developmental regulator during gastrulation...
  85. ncbi Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach
    John R B Perry
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Diabetes 58:1463-7. 2009
    ..In a complementary approach to these single-marker studies, we attempted to identify biological pathways associated with type 2 diabetes. This approach could allow us to identify additional risk loci...
  86. ncbi Smad3 is required for normal follicular follicle-stimulating hormone responsiveness in the mouse
    Xiaoyan Gong
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, USA
    Biol Reprod 81:730-8. 2009
    ..cells from Smad3-deficient animals had lower basal expression of FSH receptor (Fshr), aromatase (Cyp19a1), and cyclin D2 (Ccnd2) mRNA compared with WT mice...
  87. ncbi A polypyrimidine tract-binding protein-dependent pathway of mRNA stability initiates with CpG activation of primary B cells
    Joseph F Porter
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
    J Immunol 181:3336-45. 2008
    ..Overall these data strongly support a novel pathway of mRNA turnover that is expressed both in T cells and B cells and depends on the formation of a PTB-containing stability complex in response to cellular activation...
  88. ncbi Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity
    Rodger E Tiedemann
    Mayo Clinic, Comprehensive Cancer Center, Division of Hematology and Oncology, Scottsdale, Arizona, USA
    J Clin Invest 118:1750-64. 2008
    ..We demonstrate here that RNAi of genes encoding cyclin D1 and cyclin D2 (CCND1 and CCND2, respectively) inhibits proliferation and is progressively cytotoxic in human myeloma cells...
  89. ncbi Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    P Sicinski
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 384:470-4. 1996
    ..investigate why mammalian cells need three distinct D-type cyclins, we have generated mice bearing a disrupted cyclin D2 gene by using gene targeting in embryonic stem cells...
  90. ncbi Comparative genomics on mammalian Fgf6-Fgf23 locus
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 16:355-8. 2005
    ..This is the first report on comparative genomics analyses on human FGF6-FGF23 gene cluster and rodents Fgf6-Fgf23 gene cluster...
  91. ncbi Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis
    K A L Tan
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom
    Biol Reprod 72:1151-60. 2005
    ..We assessed if cyclin D2 could play a role...
  92. ncbi Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis
    Christian Scholz
    Department of Hematology and Oncology, Universitatsmedizin Berlin, Charite Campus Virchow Klinikum, Berlin, Germany
    Ann Hematol 84:236-44. 2005
    ..Hereby, samples from precursor B-cell acute lymphoblastic leukemia (ALL) could be distinguished from cases of acute myeloid leukemia by virtue of N33, EGR4, CDC2, CCND2, or MOS hypermethylation in ALL...
  93. ncbi Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
    Jose M Polo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Med 10:1329-35. 2004
    ..In BCL6-positive lymphoma cells, peptide blockade caused apoptosis and cell cycle arrest. BTB domain peptide inhibitors may constitute a novel therapeutic agent for B-cell lymphomas...
  94. ncbi FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism
    Silvia Fernandez De Mattos
    Cancer Research UK Laboratories, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Mol Cell Biol 24:10058-71. 2004
    ..the BCR-ABL-expressing cell line BV173 as a model system to investigate the mechanisms whereby FoxO3a regulates cyclin D2 expression...
  95. ncbi The critical role of cyclin D2 in adult neurogenesis
    Anna Kowalczyk
    Department of Molecular and Cellular Neurobiology, Nencki Institute, 02 093 Warsaw, Poland
    J Cell Biol 167:209-13. 2004
    ..We describe herein that adult mice mutated in the cell cycle regulatory gene Ccnd2, encoding cyclin D2, lack newly born neurons in both of these brain structures...
  96. ncbi Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 13:565-74. 1992
    ..The human cyclin D1 gene (approved gene symbol, CCND1) was assigned to chromosome band 11q13, cyclin D2 (CCND2) to chromosome band 12p13, and cyclin D3 (CCND3) to chromosome band 6p21...
  97. ncbi Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1
    S Rodriguez
    Molecular Cytogenetics, Institute of Cancer Research, Sutton, Surrey, UK
    Oncogene 22:1880-91. 2003
    ..Genes such as CCND2, GLU3, LRP6 and HPH1 at 12p13 were also overexpressed. The overexpressed sequences identified, particularly those in the region amplified, represent candidate genes for involvement in TGCT development...
  98. ncbi Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour
    Dominique Baudry
    INSERM U383, Hopital Necker Enfants Malades, Universite Rene Descartes, 75743 Paris Cedex 15, France
    Oncogene 21:5566-73. 2002
    ..Moreover, our results suggest that the VEGF expression level may be of prognosis relevance for relapsed patients...
  99. ncbi New insights into testicular germ cell tumorigenesis from gene expression profiling
    Rolf I Skotheim
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Cancer Res 62:2359-64. 2002
    ....
  100. ncbi Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia
    D Wolowiec
    Department of Hematology, Medical University, ul Pasteura 4, PL 50 367 Wroclaw, Poland
    Haematologica 86:1296-304. 2001
    ..A particular role in the regulation of these phenomena is played by proteins involved in early G1 phase regulation: pRb kinases: cyclin-dependent kinases (cdk): cdk4 and cdk6 activated by cyclins D, and universal cdk inhibitor p27(Kip1)...
  101. ncbi In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3
    I Maeda
    Department of Surgery, St Marianna University School of Medicine, 2 16 1 Sugao, Niyamae ku, Kawasaki 216 8511, Japan
    FEBS Lett 494:181-5. 2001
    ..The results suggest the involvement of ROC1-cullin ligases in cyclin D1 ubiquitination and a potential mechanism whereby the cullin subunit is ubiquitinated itself while ubiquitinating a substrate...

Research Grants39

  1. Mechanism of EVI1-induced Leukemogenesis
    Archibald S Perkins; Fiscal Year: 2010
    ..To address this hypothesis, we propose three specific aims. ..
  2. Mechanism of EVI1-induced Leukemogenesis
    Archibald Perkins; Fiscal Year: 2007
    ..To address this hypothesis, we propose three specific aims. ..
  3. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen Goode; Fiscal Year: 2007
    ....
  4. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2007
    ..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..
  5. BIOMARKERS FOR ANAL CANCER
    Stephen Hawes; Fiscal Year: 2006
    ....
  6. EPIDEMIOLOGY OF ORAL HIV 1 & 2 INFECTION IN HIGH RISK WO
    Stephen Hawes; Fiscal Year: 2003
    ....
  7. BRAIN TISSUE RESOURCE FOR NEUROPSYCHIATRIC RESEARCH
    Francine Benes; Fiscal Year: 2002
    ..Over the next five years, all of these changes will enhance the "brain bank" in its role as a vital national resource. ..
  8. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine Benes; Fiscal Year: 2009
    ....
  9. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen L Goode; Fiscal Year: 2010
    ....
  10. CORTICOLIMBIC ABNORMALITIES IN SCHIZOPHRENIC BRAIN
    Francine Benes; Fiscal Year: 2001
    ....
  11. CORTICOLIMBIC SYSTEM IN SCHIZOPHRENIC BRAIN--ANALYSIS
    Francine Benes; Fiscal Year: 1993
    ....
  12. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2010
    ....