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Genomes and Genes
| CUL4BSummaryGene Symbol: CUL4B Description: cullin 4B Alias: MRXHF2, MRXS15, MRXSC, SFM2, CUL-4B, cullin-4B Species: human Top Publications
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Publications
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiersTianwei Li
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Arch Biochem Biophys 453:70-4. 2006..Most of the E1-like activating enzymes, E2-like conjugating enzymes and the majorities of the known target as well as some previously unreported proteins for SUMO-2, SUMO-3, and NEDD8 pathways were identified...- cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene familyE T Kipreos
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
Cell 85:829-39. 1996..cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast... - Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaksClaudia Kerzendorfer
Human DNA Damage Response Disorders Group, University of Sussex, Brighton, UK
Hum Mol Genet 19:1324-34. 2010..But, the functional distinction between CUL4A and CUL4B, if any, is unclear... - Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxiaBertrand Isidor
Service de Genetique Medicale, Centre Hospitalier Universitaire de Nantes 7, quai Moncousu, 44000 Nantes Cedex, France
Am J Med Genet A 152:175-80. 2010The CUL4B gene encodes a member of Cullin-RING ubiquitin ligase complex. Point mutations in CUL4B were identified recently in patients with syndromic X-linked mental retardation (XLMR)... - Cullins in human intra-uterine growth restriction: expressional and epigenetic alterationsG Gascoin-Lachambre
département génétique et développement, Institut Cochin, INSERM U567, CNRS UMR 8104, Faculté de Médecine Université Paris Descartes, Paris, France
Placenta 31:151-7. 2010..Our work hypothesis is that Cullins, particularly CUL4B and CUL7, are involved in placental diseases and especially in IUGR... - A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndromeM Badura-Stronka
Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland
Clin Genet 77:141-4. 2010..300354) is a recently identified syndromic form of X-linked mental retardation (XLMR) caused by mutations in the CUL4B gene. In total, nine XLMR families carrying mutations in the CUL4B gene have been described to date... - CRL4s: the CUL4-RING E3 ubiquitin ligasesSarah Jackson
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
Trends Biochem Sci 34:562-70. 2009..Many CRL4 complexes are involved in chromatin regulation and are frequently hijacked by different viruses... - Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progressionYongxin Zou
Key Laboratory of Experimental Teratology, Ministry of Education, Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, 44 Wen hua Xi Lu, Jinan, Shandong 250012, China
J Biol Chem 284:33320-32. 2009CUL4A and CUL4B, which are derived from the same ancestor, CUL4, encode scaffold proteins that organize cullin-RING ubiquitin ligase (E3) complexes... - An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligasesMichael Hans Olma
Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, 8093 Zurich, Switzerland
J Cell Sci 122:1035-44. 2009..Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with CRL4 complexes... - DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stressVan Leung-Pineda
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
Cancer Res 69:2630-7. 2009..DDB1 is part of an E3 ligase complex that includes the cullin proteins Cul4A and Cul4B. We report that Cul4A/DDB1 negatively regulates Chk1 stability in vivo... - A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumorsGustavo A Miranda-Carboni
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 22:3121-34. 2008..Instead, turnover required Cullin 4A and Cullin 4B, components of an alternative E3 ubiquitin ligase induced in response to active Wnt signaling... - AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functionsFumiaki Ohtake
Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
Biochem Pharmacol 77:474-84. 2009..has recently been shown to promote the proteolysis of ERalpha/AR through assembling a ubiquitin ligase complex, CUL4B(AhR). In the CUL4B(AhR) complex, AhR acts as a substrate-recognition subunit to recruit ERalpha/AR... - Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1Xiao Bin Lv
State Key Laboratory of Oncology in South China, Department of Experimental Research, Sun Yat sen University Cancer Center, 510060 Guangzhou, China
J Biol Chem 285:18234-40. 2010..Strikingly, the APC/C(Cdh1) substrate levels are normal in cell knockdowns of Cul4A and Cul4B, which, along with DDB1, form an E3 ligase complex... - CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationTarek Abbas
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
Mol Cell 40:9-21. 2010..These results demonstrate a central role of CRL4(Cdt2)-dependent cell-cycle regulation of Set8 for the maintenance of a stable epigenetic state essential for cell viability... - Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleusTadashi Nakagawa
Department of Biochemistry and Biophysics Lineberger Comprehensive Cancer Center Program in Molecular Biology and Biotechnology University of North Carolina at Chapel Hill Chapel Hill, NC USA
Cell Cycle 10:4197-8. 2011..Comment on: Nakagawa T, et al. Mol Cell. 2011; 43:381-91... - X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expressionTadashi Nakagawa
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Cell 43:381-91. 2011b>CUL4B, encoding a scaffold protein for the assembly of Cullin4B-Ring ubiquitin ligase (CRL4B) complexes, is frequently mutated in X-linked mental retardation (XLMR) patients... - CUL4B: trash talking at chromatinErin M Green
Department of Biology, Stanford University, Stanford, CA, USA
Mol Cell 43:321-3. 2011..Xiong (2011) reveal a mechanism targeting WDR5 for proteolysis dependent on the X-linked mental retardation gene, CUL4B. This provides a link between the stability of a chromatin factor and gene expression implicated in neurological .. - Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradationXi Li
Key Laboratory of Experimental Teratology, Ministry of Education, Institute of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong 250012, China
J Biol Chem 286:32344-54. 2011b>Cullin 4B (CUL4B) is a scaffold protein that assembles cullin-RING ubiquitin ligase (E3) complexes... - COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) bindingXicheng Mao
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 286:32355-65. 2011..These findings highlight a novel mechanism of CRL activation and suggest that CRL regulation may underlie the pleiotropic activities of COMMD1... - The cullin protein familyAntonio Sarikas
Institute of Pharmacology and Toxicology, Technische Universitat Munchen, 80802 Munich, Germany
Genome Biol 12:220. 2011..Moreover, mutations in CUL7 and CUL4B genes have been linked to hereditary human diseases. - Cross-talk of dioxin and estrogen receptor signals through the ubiquitin systemFumiaki Ohtake
Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
J Steroid Biochem Mol Biol 127:102-7. 2011..In addition to such genomic actions, AhR mediates non-genomic actions of AhR-ligands through the assembly of a CUL4B-based ubiquitin ligase complex and promotes the degradation of ER? and AR... - CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase functionClaudia Kerzendorfer
Human DNA Damage Response Disorders Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
Mech Ageing Dev 132:366-73. 2011..We discuss the unexpected association of defective CUL4B with syndromal X-linked mental retardation in humans and speculate on the biochemical consequences and clinical .. - Cul4A is essential for spermatogenesis and male fertilityDragana Kopanja
Department of Biochemistry and Molecular Genetics M C 669, University of Illinois, College of Medicine, 900 S Ashland Ave, Chicago, IL 60607, USA
Dev Biol 352:278-87. 2011The mammalian Cul4 genes, Cul4A and Cul4B, encode the scaffold components of the cullin-based E3 ubiquitin ligases. The two Cul4 genes are functionally redundant... - Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferasePriya Aggarwal
Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 18:329-40. 2010..Importantly, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity... - Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signalingSimone Kobe de Oliveira
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianopolis, Brazil
Biochem Pharmacol 77:723-33. 2009..the AHR recruits a large number of binding partners, including HSP90, p23, XAP2 and the ubiquitin ligases cullin 4B and CHIP. Furthermore, XAP2 binds the cyclic nucleotide phosphodiesterases PDE2A and PDE4A5... - PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexTarek Abbas
Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Genes Dev 22:2496-506. 2008..Finally, we show that the CRL4(Cdt2) and the SCF(Skp2) ubiquitin ligases are redundant with each other in promoting the degradation of p21 during an unperturbed S phase of the cell cycle... - The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2AJennifer Guerrero-Santoro
Department of Microbiology and Molecular Genetics, School of Medicine, Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Res 68:5014-22. 2008..Mutations in DDB2 cause a cancer prone syndrome, xeroderma pigmentosum group E (XP-E). CUL4A and its paralog, cullin 4B (CUL4B), copurify with the UV-DDB complex, but it is unclear whether CUL4B has a role in NER as a separate E3 .. - CAND1 enhances deneddylation of CUL1 by COP9 signalosomeKyoeng Woo Min
Department of Biochemistry and Protein Network Research Center, Yonsei University, Seoul 120 749, Republic of Korea
Biochem Biophys Res Commun 334:867-74. 2005..Our data suggest that enhancement of CSN-mediated deneddylation by CAND1 may contribute to its function as a positive regulator of SCFs in vivo... - Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complexDonna D Zhang
Department of Biochemistry, University of Missouri Columbia, M121 Medical Sciences Building, Columbia, MO 65212, USA
Mol Cell Biol 24:10941-53. 2004.... - Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpointLeigh Ann A Higa
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Nat Cell Biol 5:1008-15. 2003..Our study reveals an evolutionarily conserved and uncharacterized G1 checkpoint that induces CDT1 proteolysis by the CUL4-ROC1 ubiquitin E3 ligase and CSN complexes in response to DNA damage... - TIP120A associates with cullins and modulates ubiquitin ligase activityKyoeng Woo Min
Department of Biochemistry and Protein Network Research Center, Yonsei University, Seoul 120 749, Korea
J Biol Chem 278:15905-10. 2003..In a search for proteins involved in regulation of cullin-containing E3 ubiquitin ligases we immunopurified CUL4B-containing complex from HeLa cells and identified TIP120A as an associated protein by mass spectrometry... - CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complexJianyu Zheng
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, Yale University, New Haven, CT 06520, USA
Mol Cell 10:1519-26. 2002..Our data suggest that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled with the incorporation of F box proteins into the SCF complex, causing their destabilization... - CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complexDora C Dias
Derald H Ruttenberg Cancer Center and Department of Human Genetics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Proc Natl Acad Sci U S A 99:16601-6. 2002..Strikingly, CUL7 selectively interacts with Skp1.Fbx29 but not with Skp1.betaTRCP2 or Skp1.Skp2. Thus, CUL7 may define a previously uncharacterized, Fbx29-mediated, and ubiquitin-dependent proteolysis pathway... - JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotypeE A Jones
Institute of Human Genetics, School of Biochemistry and Genetics, Ground Floor, Ridley Building, University of Newcastle upon Tyne, Claremont Place, Newcastle upon Tyne NE1 7RU, UK
J Med Genet 37:658-62. 2000..We conclude that JAG1 is expressed in the structures affected in Alagille syndrome, such as the pulmonary artery, anterior chamber of the eye, and face... - Covalent modification of all members of human cullin family proteins by NEDD8T Hori
Tokyo Metropolitan Institute of Medical Science, Japan
Oncogene 18:6829-34. 1999..The enhanced expression of all Cul-family proteins except Cul-5 was observed in a variety of tumor cell lines... - ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activityT Ohta
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599, USA
Mol Cell 3:535-41. 1999..Ubiquitination of phosphorylated I kappa B alpha can be catalyzed by the ROC1 immunocomplex in vitro. Hence, combinations of ROC/APC11 and cullin proteins proteins potentially constitute a wide variety of ubiquitin ligases... - Cloning and characterization of mouse cullin4B/E3 ubiquitin ligaseRachana Tripathi
Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
J Biosci 30:329-37. 2005..Immuno staining of differentiated PCC4 cells with N-terminal Cul4B antibody showed enhanced expression of Cul4B and its translocation into the nucleus upon differentiation... - Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradationLeigh Ann Higa
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cell Cycle 5:71-7. 2006..We provide evidence that human CUL4B, a paralogue of human CUL4A, is involved in cyclin E regulation... - PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitinationTakeshi Senga
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 281:6246-52. 2006..Therefore PCNA, the matchmaker for many proteins involved in DNA and chromatin metabolism, also serves to promote the targeted degradation of associated proteins in S-phase or after DNA damage... - mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligasePapia Ghosh
Laboratory of Cancer Genomics, Division of Basic Science, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
Cell Cycle 7:373-81. 2008..Loss of CUL4B or DDB1 specifically blocks the phosphorylation of S6 kinase at threonine 389 and 4E-BP1 at serine 65 and .. - Cullin4B/E3-ubiquitin ligase negatively regulates beta-cateninRachana Tripathi
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
J Biosci 32:1133-8. 2007..Here we present the functional characterization of E3-ubiquitin ligase encoded by cul4B. RNAi-mediated knock-down of Cul4B in a mouse cell line C3H T10 (1/2) results in an increase in beta-catenin .. - Substrate-mediated regulation of cullin neddylationEng Hui Chew
Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
J Biol Chem 282:17032-40. 2007..These ligases are composed of one of six mammalian cullin homologs (Cul1, Cul2, Cul3, Cul4a, Cul4b, and Cul5), the Ring finger containing protein Roc1/Rbx1, and cullin homolog-specific adaptor and substrate .. - Dioxin receptor is a ligand-dependent E3 ubiquitin ligaseFumiaki Ohtake
ERATO, Japan Science and Technology Agency, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
Nature 446:562-6. 2007..ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR)... - Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardationYongxin Zou
Key Laboratory for Experimental Teratology of the Ministry of Education, Institute of Medical Genetics, Shandong University School of Medicine, Shandong, China
Am J Hum Genet 80:561-6. 2007..Screening of candidate genes in a 10-Mb region on Xq25 implicated CUL4B as the causative gene... - Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremorPatrick S Tarpey
Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Am J Hum Genet 80:345-52. 2007We have identified three truncating, two splice-site, and three missense variants at conserved amino acids in the CUL4B gene on Xq24 in 8 of 250 families with X-linked mental retardation (XLMR)... - Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damageHengbin Wang
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Kaul Human Genetics Building Room 402A, 720 South 20th Street, 35294, USA
Mol Cell 22:383-94. 2006..Thus, our studies uncover CUL4-DDB-ROC1 as a histone ubiquitin ligase and demonstrate that histone H3 and H4 ubiquitylation participates in the cellular response to DNA damage... - Identification of NEDD8-conjugation site in human cullin-2H Wada
Department of Internal Medicine, Institute of Molecular Medicine for the Prevention of Human Diseases, Houston, Texas 77030, USA
Biochem Biophys Res Commun 257:100-5. 1999.... - CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylationLeigh Ann Higa
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Nat Cell Biol 8:1277-83. 2006..Our studies suggest that CUL4-DDB1 ligases use WDR proteins as molecular adaptors for substrate recognition, and modulate multiple biological processes through ubiquitin-dependent proteolysis...
Research Grants
- ROLE OF CULLIN 4A IN TUMOR DEVELOPMENT.Pradip Raychaudhuri; Fiscal Year: 2005..Also, the PI will develop a transgenic mouse model that over expresses cullin-4A in keratinocytes, which would enable him to study the oncogenic function in vivo. ..
- Role of Ubp-M and H2A deubiquitination in chromatin and cellular functionHengbin Wang; Fiscal Year: 2010..However, due to the amount of work in this application and the uncertain outcome of these experiments, we did not list these experiments as a Specific Aim. ..
- Role of Ubp-M and H2A deubiquitination in chromatin and cellular functionHengbin Wang; Fiscal Year: 2009..However, due to the amount of work in this application and the uncertain outcome of these experiments, we did not list these experiments as a Specific Aim. ..