CLSTN1

Summary

Gene Symbol: CLSTN1
Description: calsyntenin 1
Alias: ALC-ALPHA, CDHR12, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2, alcadein alpha 1, alcadein-alpha, alzheimer-related cadherin-like protein, cadherin-related family member 12, calsyntenin-1, non-classical cadherin XB31alpha, non-classical cadherin XB31alpha1
Species: human

Top Publications

  1. ncbi Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain
    L Vogt
    Institute of Biochemistry, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Mol Cell Neurosci 17:151-66. 2001
  2. ncbi PTEN-deficient cancers depend on PIK3CB
    Susan Wee
    Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13057-62. 2008
  3. ncbi Regulation of p110delta PI 3-kinase gene expression
    Klaartje Kok
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    PLoS ONE 4:e5145. 2009
  4. ncbi Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases
    Guo Nan Yin
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Joong Gu, Daegu, South Korea
    Brain Res 1265:158-70. 2009
  5. ncbi RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
    Holly Edwards
    Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Blood 114:2744-52. 2009
  6. ncbi Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction
    Saori Hata
    Department of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Biol Chem 284:36024-33. 2009
  7. ncbi Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 70:2389-96. 2010
  8. ncbi Expression of prion gene and presence of prion protein during development of mouse molar tooth germ
    Qalb E Saleem Khan
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Eur J Oral Sci 118:559-65. 2010
  9. ncbi Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1
    Alessio Vagnoni
    MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, PO Box 37, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    J Cell Sci 124:1032-42. 2011
  10. ncbi Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling
    Woonbok Chung
    Department of Leukemia, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e2079. 2008

Research Grants

  1. Cloning/Gene/Posterior Polymorphous corneal dystrophy
    ANTHONY ALDAVE; Fiscal Year: 2007

Scientific Experts

  • Anthony J Aldave
  • Gerold Schmitt-Ulms
  • Susanne Fransson
  • Bernard Kwabi Addo
  • S Koutros
  • Yoichi Araki
  • Toshiharu Suzuki
  • Woonbok Chung
  • Bernard Kwabi-Addo
  • Tohru Yamamoto
  • Alessio Vagnoni
  • Hans Jörg Warnatz
  • Qalb E Saleem Khan
  • Guo Nan Yin
  • Holly Edwards
  • Klaartje Kok
  • Saori Hata
  • Susan Wee
  • Jean-Pierre J Issa
  • Jaroslav Jelinek
  • Lanlan Shen
  • Jean Pierre J Issa
  • Michael Ittmann
  • H Caren
  • Naoko Kato
  • Masaki Nishimura
  • Kazuo Yamamoto
  • Anetta Konecna
  • Sachiyo Wada
  • Masahiro Mizoguchi
  • Naomi Miyagi
  • L Vogt
  • Martin Vingron
  • Marc Sultan
  • Thomas Manke
  • Lilia Rodriguez
  • Hans Lehrach
  • Alexey Soldatov
  • Ilaria Piccini
  • Dominic Schmidt
  • Tatiana Borodina
  • Kurt J De Vos
  • Wasco Wruck
  • Catherine Manser
  • Marie Laure Yaspo
  • Daniela Balzereit
  • Christopher C J Miller
  • Maria A Landin
  • Charles McL Press
  • Steinar Risnes
  • Amer Sehic
  • Harald Osmundsen
  • Tadashi Nakaya
  • Falk Fahrenholz
  • Je Yoel Cho
  • Paul Saftig
  • Masahiko Araseki
  • Maikel P Peppelenbosch
  • Alan A Dombkowski
  • Chengzhi Xie
  • Jeffrey W Taub
  • Gemma E Nock
  • Sayaka Fujishige
  • Miyako Taniguchi
  • Ralph N Martins
  • Kyoungho Suk
  • Dieter Hartmann
  • Masahiro Maeda
  • Katsuya Urakami
  • Daan W Hommes
  • Steven A Buck
  • Elizabeth A G Verrall
  • Hiroyasu Akatsu
  • Michael P Mitchell
  • Katherine M LaFiura
  • Larry H Matherly
  • Sam Gandy
  • Bart Vanhaesebroeck
  • Ho Won Lee
  • Julie L Boerner
  • Yubin Ge
  • Christoph Lengauer
  • Rosalie DeBeaumont
  • Sauveur Michel Maira
  • Sauveur-Michel Maira
  • Yung Mae Yao
  • Alice Loo
  • Frank Stegmeier
  • Christine Miller
  • Yung-mae Yao

Detail Information

Publications21

  1. ncbi Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain
    L Vogt
    Institute of Biochemistry, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Mol Cell Neurosci 17:151-66. 2001
    ..Thus, calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca2+ signaling...
  2. ncbi PTEN-deficient cancers depend on PIK3CB
    Susan Wee
    Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13057-62. 2008
    ..lentiviral inducible shRNA system to selectively inactivate the three Class IA PI3Ks, PIK3CA, PIK3CB, and PIK3CD, to determine which PI3K isoforms are responsible for driving the abnormal proliferation of PTEN-deficient cancers...
  3. ncbi Regulation of p110delta PI 3-kinase gene expression
    Klaartje Kok
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    PLoS ONE 4:e5145. 2009
    ..This also applies to the leukocyte-enriched p110delta catalytic subunit of PI3K, an enzyme that has attracted widespread interest because of its role in immunity and allergy...
  4. ncbi Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases
    Guo Nan Yin
    Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Joong Gu, Daegu, South Korea
    Brain Res 1265:158-70. 2009
    ..secreted protein acidic and rich in cysteine-like protein 1 precursor (SPARCL1), isoform 2 of calsyntenin 1 (CLSTN1), and neuronal pentraxin receptor (NPR) showed significant changes in AD or PD CSF compared with ..
  5. ncbi RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
    Holly Edwards
    Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Blood 114:2744-52. 2009
    ..significantly increased sensitivity to cytosine arabinoside, accompanied by significantly decreased expression of PIK3CD, which encodes the delta catalytic subunit of the survival kinase, phosphoinositide 3 (PI3)-kinase...
  6. ncbi Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction
    Saori Hata
    Department of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Biol Chem 284:36024-33. 2009
    ....
  7. ncbi Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 70:2389-96. 2010
    ..Cancer Cohort Consortium were examined for associations between 89 SNPs in PI3K genes (PIK3C2B, PIK3AP1, PIK3C2A, PIK3CD, and PIK3R3) and prostate cancer risk in 8,309 cases and 9,286 controls...
  8. ncbi Expression of prion gene and presence of prion protein during development of mouse molar tooth germ
    Qalb E Saleem Khan
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Eur J Oral Sci 118:559-65. 2010
    ..g. enamel matrix proteins (Amelx, Ambn, Enam), Aplp1, Clstn1, and Clu]...
  9. ncbi Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1
    Alessio Vagnoni
    MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, PO Box 37, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    J Cell Sci 124:1032-42. 2011
    ..Thus, phosphorylation of KLC1ser460 represents a mechanism for selectively regulating the binding and trafficking of calsyntenin-1...
  10. ncbi Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling
    Woonbok Chung
    Department of Leukemia, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e2079. 2008
    ..Based on methylation in primary tumors compared to normal adjacent tissues, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS and NSE1 are candidate biomarkers for prostate cancer (methylation range 50%-85%)...
  11. ncbi Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours
    H Caren
    Department of Clinical Genetics, Institute of Biomedicine, Goteborg University, Sahlgrenska University Hospital, Göteborg SE 41345, Sweden
    Br J Cancer 97:1416-24. 2007
    ..deacetylase inhibitor trichostatin A led to increased gene transcription of four of the 30 genes, ERRFI1 (MIG-6), PIK3CD, RBP7 (CRBPIV) and CASZ1, indicating that these genes could be affected by epigenetic downregulation in NBs...
  12. ncbi Age-related DNA methylation changes in normal human prostate tissues
    Bernard Kwabi-Addo
    Department of Pathology, Baylor College of Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 13:3796-802. 2007
    ..We examined the extent of gene methylation in pathologically normal human prostate as a function of age...
  13. ncbi Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 278:49448-58. 2003
    ..Deficiencies in the X11L-mediated interaction between Alc and APP and/or CTFbeta enhanced the production of Abeta, which may be related to the development or progression of AD...
  14. ncbi Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 279:24343-54. 2004
    ..Any imbalance in the metabolism of Alcs and APP may influence the FE65-dependent gene transactivation, which together with increased secretion of amyloid beta-protein may contribute to neural disorders...
  15. ncbi Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
    Gerold Schmitt-Ulms
    Institute for Neurodegenerative Disease, San Francisco, California 94143, USA
    Nat Biotechnol 22:724-31. 2004
    ..Many of these proteins have been implicated in cell adhesion/neuritic outgrowth, and harbor immunoglobulin C2 and fibronectin type III-like motifs...
  16. ncbi Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas
    Masahiro Mizoguchi
    Molecular Neuro oncology Laboratory, Department of Pathology and Neurosurgical Service, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Brain Pathol 14:372-7. 2004
    ..We studied a series of glioblastomas with FISH to assess copy number of catalytic subunits (PIK3CA and PIK3CD) and with PCR-SSCP to screen for somatic mutations of conserved regions of both catalytic and regulatory subunits...
  17. ncbi Analysis of fifteen positional candidate genes for Schnyder crystalline corneal dystrophy
    Anthony J Aldave
    Cornea Service, Jules Stein Eye Institute, University of California, Los Angeles, CA, USA
    Mol Vis 11:713-6. 2005
    ..To identify the genetic basis of Schnyder crystalline corneal dystrophy (SCCD) through screening of positional candidate genes in affected patients...
  18. ncbi Calsyntenin-1 docks vesicular cargo to kinesin-1
    Anetta Konecna
    Department of Biochemistry and Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    Mol Biol Cell 17:3651-63. 2006
    ..In summary, our results indicate that calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor...
  19. ncbi Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2
    Susanne Fransson
    Department of Clinical Genetics, University of Gothenburg, Sahlgrenska University Hospital East, S 416 85 Gothenburg, Sweden
    Genes Chromosomes Cancer 46:45-52. 2007
    ..Here we report on a significant decrease in gene expression of the genes RERE, PIK3CD, LZIC, PGD, and PEX14 and an increase of SLC2A5 when comparing tumors of favorable biology to Stage 4 ..
  20. ncbi The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    EMBO J 26:1475-86. 2007
    ..Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease...
  21. ncbi The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle
    Hans Jörg Warnatz
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    J Biol Chem 286:23521-32. 2011
    ..pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, and MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, and vault RNA)...

Research Grants2

  1. Cloning/Gene/Posterior Polymorphous corneal dystrophy
    ANTHONY ALDAVE; Fiscal Year: 2007
    ....