Research Topics
Genomes and Genes
| CLACSummaryGene Symbol: CLAC Description: collagen, type XXV, alpha 1 Alias: AMY, CLAC, CLAC-P, CLACP, alzheimer disease amyloid-associated protein, collagen alpha-1(XXV) chain, collagen-like Alzheimer amyloid plaque component, collagenous Alzheimer amyloid plaque component Species: human Top Publications
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Publications
Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's diseaseCharlotte Forsell
Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KASPAC, Novum, S 141 57 Huddinge, Sweden
Neurobiol Aging 31:409-15. 2010The COL25A1 gene, located in 4q25, encodes the CLAC protein, which has been implicated in Alzheimer's disease (AD) pathogenesis...- CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongationHiroyoshi Kakuyama
Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Karolinska Institutet, SE 141 57 Huddinge, Sweden
Biochemistry 44:15602-9. 2005..important for the pathogenesis, and a recently discovered plaque-associated protein is the collagenous Alzheimer amyloid plaque component (CLAC)... - Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregatesLinda Söderberg
Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center KASPAC, Neurotec, Novum, Huddinge, Sweden
FEBS J 272:2231-6. 2005Recently, a novel plaque-associated protein, collagenous Alzheimer amyloid plaque component (CLAC), was identified in brains from patients with Alzheimer's disease... - CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrilsYoshihide Osada
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo Bunkyoku Tokyo, 113 0033, Japan
J Biol Chem 280:8596-605. 2005CLAC (collagenous Alzheimer amyloid plaque component) is a proteolytic fragment derived from a novel membrane-bound collagen, CLAC-P/collagen type XXV, that deposits in senile plaques associated with amyloid beta peptides (Abeta) in the .. - Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding siteLinda Söderberg
Karolinska Institutet and Sumitomo Pharmaceuticals Alzheimer Center, Neurotec, Novum, SE 141 57 Huddinge, Sweden
J Biol Chem 280:1007-15. 2005..and one recently identified amyloid-associated protein is the collagen-like Alzheimer amyloid plaque component CLAC. It is not known how CLAC deposition affects Abeta plaque genesis and the progress of the disease... - Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid depositsHisatomo Kowa
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Bunkyo ku, Hongo, Tokyo 113 0033, Japan
Am J Pathol 165:273-81. 2004b>Collagenous Alzheimer amyloid plaque component (CLAC) is a unique non-Abeta amyloid component of senile plaques (SP) derived from a transmembrane collagen termed CLAC-precursor... - CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXVTadafumi Hashimoto
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033
EMBO J 21:1524-34. 2002..Thus, we named the 9D2 antigen as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV... - Characterization of medium-chain triacylglycerol (MCT)-enriched seed oil from Cinnamomum camphora (Lauraceae) and its oxidative stabilityJiang Ning Hu
State Key Laboratory of Food Science and Technology, Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi, China
J Agric Food Chem 59:4771-8. 2011..27%) and lauric acid (39.93%). The predominant TAG species in CCSO was LaCC/CLaC (ECN 32, 79.29%)... - Algorithms for calling gains and losses in array CGH dataPei Wang
Cancer Prevention Program, Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Methods Mol Biol 556:99-116. 2009..for calling gains and losses in array-based comparative genomic hybridization (array CGH) data, including CBS, CLAC, CGHseg, and Fused Lasso. We illustrate the performance of the methods through simulated and real data examples... - COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivoYing Tong
Department of Neurology, University of California San Francisco, 1550 Fourth Street, Rock Hall Rm548, San Francisco, CA, 94158, USA
Neurogenetics 11:41-52. 2010..These findings demonstrate that COL25A1 leads to AD-like pathology in vivo. Modulation of COL25A1 function may represent an alternative therapeutic intervention for AD... - Clinical and statistical evaluation of 1st Automatic: a pilot studyAnne Thilde Andersen
Department of Health Science and Technology, Aalborg University, DK 9220 Aalborg Ost, Denmark
Stud Health Technol Inform 150:389-93. 2009..Quantitative measurements of pH, pCO2, pO2, Na+, K+, Ca2+, cGlu, cLac and tHb were performed on 21 paired whole blood specimens collected into the standard blood gas syringes and .. - Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glandsReiko Arita
Itoh Clinic, 626 11 Minaminakano, Minuma ku, Saitama, Saitama 337 0042, Japan
Jpn J Ophthalmol 56:14-9. 2012To observe morphological changes in the meibomian glands of patients with contact lens-related allergic conjunctivitis (CLAC) and to assess the relations between the morphological changes and eyelid and tear film parameters. - Genetic variability of spermatozoon production and morphology in laboratory miceL V Osadchuk
Laboratory of Endocrinological Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
Bull Exp Biol Med 149:739-42. 2010..production of spermatozoa and incidence of atypical spermatogenesis were studied in males of 7 inbred strains: BALB/cLac, PT, CBA/Lac, DD, A/He, C57Bl/6J, and YT... - Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody productionSharon A Chung
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, United States of America
PLoS Genet 7:e1001323. 2011..Lack of strong SNP associations may suggest that other types of genetic variation or non-genetic factors such as environmental exposures have a greater impact on susceptibility to anti-dsDNA - SLE... - Cofactor-free detection of phosphatidylserine with cyclic peptides mimicking lactadherinHong Zheng
Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, United States
J Am Chem Soc 133:15280-3. 2011..Unlike annexin V or its small molecule mimics, the cLac peptides selectively target PS-presenting membranes with no need for metal cofactors... - Genome-wide association analysis of age at onset in schizophrenia in a European-American sampleKe Sheng Wang
Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, 37614 1700, USA
Am J Med Genet B Neuropsychiatr Genet 156:671-80. 2011..05). These findings provide evidence of several genetic variants influencing AAO of SCZ... - Changes in aggressive behavior, thermoregulation, and endocrine responses in BALB/cLac and C57Bl/6J mice under cold exposureM P Moshkin
Biological Institute, Siberian Branch of Russia s Academy of Sciences, Novosibirsk
Physiol Behav 53:535-8. 1993..consumption at different ambient temperatures, and calorigenic effect of noradrenaline have been studied in BALB/cLac and C57Bl/6J males. Under normal temperature conditions, there have been no significant interstrain differences... - Fluorescently labeled inhibitor for profiling cytoplasmic peptide:N-glycanaseShinya Hagihara
RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Glycobiology 17:1070-6. 2007..Interestingly, a drastically simplified chloroacetamidyl chitobiose derivative [(GlcNAc)(2)-ClAc] was also reactive to PNGase... - Influence of genetic dissimilarity of mother and fetus on progesterone concentrations in pregnant mice and adaptive features of offspringL A Gerlinskaya
Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy Science, 630091, Novosibirsk, Frunze str, 11, Russia
Reproduction 121:409-17. 2001Concentrations of progesterone in blood plasma and tissue were studied in pregnant mice of strains BALB/cLac and C57BL/6J... - Molecular identification of AMY, an Alzheimer disease amyloid-associated proteinLinda Söderberg
Department of Neurotec, Karolinska Institutet, Huddinge, Sweden
J Neuropathol Exp Neurol 62:1108-17. 2003..the chromatographic and immunological profile of AMY resembled the recently identified amyloid-associated protein CLAC, derived from a transmembrane collagen-like precursor, CLAC-P... - Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's diseaseYann Verdier
Department of Medical Chemistry, University of Szeged, and Protein Chemistry Research Group of the Hungarian Academy of Science, Szeged, Hungary
Curr Protein Pept Sci 5:19-31. 2004..integrins, the alpha7nicotinic acetylcholine receptor (alpha7nAChR), the P75 neurotrophin receptor (P75NTR) and the CLAC-P/collagen type XXV (collagen-like Alzheimer amyloid plaque component precursor/collagen XXV)... - Enantioselective affinity chromatography of a chiral drug by crystalline and carrier-bound antibody fab fragmentAntti Vuolanto
Laboratory of Bioprocess Engineering, Helsinki University of Technology, P O Box 6100, FIN 02015 HUT, Finland
Biotechnol Prog 20:771-6. 2004..Glutaraldehyde cross-linked ENA5His crystals (CLAC) packed in a column separated pure enantiomers from the racemic mixture of the drug... - A method for calling gains and losses in array CGH dataPei Wang
Department of Statistics, Stanford University, CA, 94305, USA
Biostatistics 6:45-58. 2005..In this paper, we propose a new algorithm 'Cluster along chromosomes' (CLAC) for the analysis of array CGH data... - Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Naoto Watanabe
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 280:41967-75. 2005..the N-terminal six transmembrane domains (TMDs) was swapped with those of CD4 (a type I transmembrane protein) or CLAC-P (a type II transmembrane protein)... - In vitro binding and functional studies of Ac-RYYRIK-ol and its derivatives, novel partial agonists of the nociceptin/orphanin F/Q receptorOzge Gunduz
Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
Neurosignals 15:91-101. 2006..The N-terminal modifications with various acyl groups (ClAc, pivaloyl, formyl, benzoyl, mesyl) decreased the affinity of the ligand towards the receptor and the intrinsic .. - [Base excess. Parameter with exceptional clinical significance]W Schaffartzik
Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Unfallkrankenhaus Berlin, Warener Strasse 7, 12683 Berlin, Deutschland
Anaesthesist 56:478-81. 2007..The BE and measurement of the lactate concentration (cLac) play an important role in diagnosing critically ill patients... - Preparation of activated carbon derived from cotton linter fibers by fused NaOH activation and its application for oxytetracycline (OTC) adsorptionYuanyuan Sun
Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan 250100, China
J Colloid Interface Sci 368:521-7. 2012..The cotton linter fibers activated carbon (CLAC) was characterized by N(2) adsorption/desorption isotherms, Fourier transform infrared spectroscopy (FTIR), and ..