cdk6

Summary

Gene Symbol: cdk6
Description: cyclin-dependent kinase 6
Alias: PLSTIRE, cell division protein kinase 6, serine/threonine-protein kinase PLSTIRE
Species: human

Top Publications

  1. ncbi Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes
    Karen K Ericson
    Department of Biology, Connecticut College, New London, CT 06320, USA
    Mol Cancer Res 1:654-64. 2003
  2. ncbi Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
  3. ncbi Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
    Karine Michaud
    Department of Neurological Surgery, Helen Diller Comprehensive Cancer Center, University of California San Francisco, California 94143 0520, USA
    Cancer Res 70:3228-38. 2010
  4. ncbi Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly
    W A Braden
    Department of Cancer Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 27:7083-93. 2008
  5. ncbi Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    J Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 20:2000-9. 2001
  6. ncbi Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein
    Kerstin Haller
    Institut fur Klinische und Molekulare Virologie, D 91054 Erlangen, Germany
    Mol Cell Biol 22:3327-38. 2002
  7. ncbi Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4
    Thomas Farkas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100, Denmark
    J Biol Chem 277:26741-52. 2002
  8. ncbi Identification of ten loci associated with height highlights new biological pathways in human growth
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:584-91. 2008
  9. ncbi Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction
    T Fujimoto
    EMBL Mouse Biology Unit, Monterotondo, Italy
    EMBO J 26:2361-70. 2007
  10. ncbi Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    B A Schmidt
    Department of Urology, Heinrich Heine University of Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Cancer Res 61:4214-21. 2001

Research Grants

  1. PROLIFERATIVE EFFECTS OF CDK4 AND CDK6 DYSREGULATION
    Philip Hinds; Fiscal Year: 2006
  2. Cell Cycle Genes and Female Reproductive Function
    Hiroaki Kiyokawa; Fiscal Year: 2007
  3. Genetic Basis of Lung Tumor Progression in Mice
    Ming You; Fiscal Year: 2006
  4. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
  5. Immunotoxicology of Cigarette Smoke
    Brian Freed; Fiscal Year: 2007
  6. CDK control of myeloma pathogenesis
    SELINA Y CHEN KIANG; Fiscal Year: 2010
  7. CDK control of myeloma pathogenesis
    Selina Chen Kiang; Fiscal Year: 2009
  8. CDK control of myeloma pathogenesis
    Selina Chen Kiang; Fiscal Year: 2009
  9. P16 AND CELL SENESCENCE AND ONCOGENESIS
    Manuel Diaz; Fiscal Year: 2001
  10. Transcriptional & cell cycle control by dietary indoles
    GARY FIRESTONE; Fiscal Year: 2007

Detail Information

Publications172 found, 100 shown here

  1. ncbi Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes
    Karen K Ericson
    Department of Biology, Connecticut College, New London, CT 06320, USA
    Mol Cancer Res 1:654-64. 2003
    ..The D-cyclin-associated kinases, cyclin-dependent kinase (cdk) 4 and cdk6, are important regulators of the G(1)-S phase transition and are elevated in several types of cancers, including ..
  2. ncbi Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..0035 replication, P = 1.1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4...
  3. ncbi Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
    Karine Michaud
    Department of Neurological Surgery, Helen Diller Comprehensive Cancer Center, University of California San Francisco, California 94143 0520, USA
    Cancer Res 70:3228-38. 2010
    ..In total, our results support clinical trial evaluation of PD-0332991 against newly diagnosed as well as recurrent GBM, and indicate that Rb status is the primary determinant of potential benefit from this therapy...
  4. ncbi Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly
    W A Braden
    Department of Cancer Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 27:7083-93. 2008
    ..Combined, these studies indicate that CDK4/6 activity is important in regulating the expression of these critical mediators of DNA replication...
  5. ncbi Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    J Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 20:2000-9. 2001
    ..yet many mesenchymal cells express three seemingly redundant D cyclins and similarly, seemingly redundant Cdk4 and Cdk6 as their kinase partners...
  6. ncbi Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein
    Kerstin Haller
    Institut fur Klinische und Molekulare Virologie, D 91054 Erlangen, Germany
    Mol Cell Biol 22:3327-38. 2002
    ..Tax stimulates the cell cycle in the G(1) phase by activating the cyclin-dependent kinase (CDK) CDK4 and CDK6 holoenzyme complexes. Here we show that Tax directly interacts with CDK4...
  7. ncbi Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4
    Thomas Farkas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100, Denmark
    J Biol Chem 277:26741-52. 2002
    ..These results further elucidate the complex regulation of p130 and provide a molecular mechanism to explain the differential control of p107 and p130 by cyclin-dependent kinases...
  8. ncbi Identification of ten loci associated with height highlights new biological pathways in human growth
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:584-91. 2008
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait...
  9. ncbi Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction
    T Fujimoto
    EMBL Mouse Biology Unit, Monterotondo, Italy
    EMBO J 26:2361-70. 2007
    ..We here show that cyclin-dependent kinase 6 (Cdk6) is specifically expressed in proliferating hematopoietic progenitor cells, and that Cdk6 inhibits transcriptional ..
  10. ncbi Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    B A Schmidt
    Department of Urology, Heinrich Heine University of Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Cancer Res 61:4214-21. 2001
    ..Therefore, testicular GCTs were analyzed as to the expression of CDK2, CDK4, CDK6, and the expression of their catalytic partners cyclins D1, D2 and E by semiquantitative reverse transcription-PCR...
  11. ncbi Identification of G1 kinase activity for cdk6, a novel cyclin D partner
    M Meyerson
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    Mol Cell Biol 14:2077-86. 1994
    ..Here, we show that the human PLSTIRE gene product is a novel cyclin-dependent kinase, cdk6...
  12. ncbi Early increase in cyclin-D1 expression and accelerated entry of mouse hepatocytes into S phase after administration of the mitogen 1, 4-Bis[2-(3,5-Dichloropyridyloxy)] benzene
    G M Ledda-Columbano
    Department of Toxicology, Oncology and Molecular Pathology Unit, University of Cagliari, Cagliari, Italy
    Am J Pathol 156:91-7. 2000
    ..the expression of cyclin D1, cyclin D3, cyclin E, and cyclin A and of the cyclin-dependent kinases CDK2, CDK4, and CDK6. The involvement of the cyclin-dependent kinase inhibitors p21 and p27 and of the oncosuppressor gene p53 was also ..
  13. ncbi Linking cyclins to transcriptional control
    Olivier Coqueret
    INSERM U564, 4 rue Larrey, CHU Angers, 49033 Angers Cedex, France
    Gene 299:35-55. 2002
    ..D-type cyclins bind to and activate the cyclin-dependent kinases Cdk4 and Cdk6, which in turn phosphorylate their downstream target, the retinoblastoma protein Rb...
  14. ncbi Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia
    D Wolowiec
    Department of Hematology, Medical University, ul Pasteura 4, PL 50 367 Wroclaw, Poland
    Haematologica 86:1296-304. 2001
    ..A particular role in the regulation of these phenomena is played by proteins involved in early G1 phase regulation: pRb kinases: cyclin-dependent kinases (cdk): cdk4 and cdk6 activated by cyclins D, and universal cdk inhibitor p27(Kip1).
  15. ncbi BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases
    H Wang
    Department of Human Genetics, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    Oncogene 15:143-57. 1997
    ..indicated association with cdc2, cdk2, cdk4, cyclin B, cyclin D, cyclin A and E2F-4 but not with cdk3, cdk5, cdk6, E2F-1, E2F-2, E2F-3, E2F-5 and cyclin E...
  16. ncbi Developmental expression of cell cycle regulators in the baboon fetal adrenal gland
    Adina Dumitrescu
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Endocrinol 192:237-47. 2007
    ..of the cell cycle regulators, cyclin D1 and cyclin E, and their cyclin-dependent kinases, Cdk2, Cdk4, and Cdk6, and Ki67 a marker of cell proliferation within the baboon fetal adrenal cortex during advancing stages of ..
  17. ncbi [Molecular mechanisms controlling the cell cycle: fundamental aspects and implications for oncology]
    J F Viallard
    Service de Medecine Interne et Maladies Infectieuses, Centre François Magendie, Hopital du Haut leveque, 5, Avenue Magellan, 33604 Pessac, France
    Cancer Radiother 5:109-29. 2001
    ..While members of the INK4 family (p16INK4A, p15INK4B, p18INK4C, p19INK4D) interact specifically with CDK4 and CDK6, the CIP/KIP inhibitors p21CIP1/WAF1, p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK...
  18. ncbi Differential phosphorylation of T-47D human breast cancer cell substrates by D1-, D3-, E-, and A-type cyclin-CDK complexes
    B Sarcevic
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, New South Wales 2010, Australia
    J Biol Chem 272:33327-37. 1997
    ..substrates of the G1 and S phase cyclin-CDK complexes, including cyclin D1-CDK4, cyclin D3-CDK4, cyclin D3-CDK6, cyclin E-CDK2, and cyclin A-CDK2, which are largely undefined, we phosphorylated T-47D breast cancer cell nuclear ..
  19. ncbi Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6
    U Schulze-Gahmen
    Department of Chemistry, Earnest Orlando Berkeley National Laboratory, University of California, Berkeley, California, 94720 USA
    Structure 7:245-54. 1999
    ..A virus-encoded cyclin (v-cyclin) from herpesvirus saimiri has been shown to exhibit highest sequence homology to type D cyclins and specifically activates CDK6 of host cells to a very high degree.
  20. ncbi Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    L Meijer
    CNRS, Station Biologique, Roscoff, France
    Eur J Biochem 243:527-36. 1997
    ..65, 0.7, 0.7 and 0.2 microM, respectively). cdk4/cyclin D1 and cdk6/cyclin D2 are very poorly inhibited by roscovitine (IC50 > 100 microM)...
  21. ncbi Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells
    Rukiyah Van Dross
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City 66160, USA
    J Natl Cancer Inst 97:656-66. 2005
    ..K-cyclin/cdk phosphorylates a subset of substrates normally targeted by cyclins D, E, and A. We used cells naturally infected with KSHV to further characterize the biochemical features of K-cyclin...
  22. ncbi Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators
    S R Cerda
    Department of Medicine, Division of Gastroenterology, University of Chicago, Chicago, IL 60637, USA
    Oncogene 25:3123-38. 2006
    ..to EV control cells, PKC-delta upregulation decreased cyclin D1 and cyclin E proteins co-immunoprecipitating with cdk6 and cdk2, respectively...
  23. ncbi Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a
    R Baumgartner
    Max Planck Institute for Biochemistry D 82152, Martinsried, Federal Republic of Germany
    Structure 6:1279-90. 1998
    ..p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d)) inhibit the closely related cyclin-dependent kinases CDK4 and CDK6 as part of the regulation of the G1-->S transition in the cell-division cycle...
  24. ncbi Catalytic activities of G1 cyclin-dependent kinases and phosphorylation of retinoblastoma protein in mobilized peripheral blood CD34+ hematopoietic progenitor cells
    Kurt Leibundgut
    Department of Pediatrics, University of Bern Inselspital, CH 3010, Bern, Switzerland
    Stem Cells 23:1002-11. 2005
    ..in CD34+ cell extracts that there was high catalytic activity of G(1) cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) but low activity of CDK2...
  25. ncbi c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1
    Meryem Güller
    Institut National de la Sante et de la Recherche Medicale U773, Hopital Saint Louis, and Université Paris 7 Denis Diderot, Centre de Recherche Bichat Beaujon CRB3, BP 416, Paris F 75018, France
    World J Gastroenterol 14:6339-46. 2008
    ..To investigate the effect of stable c-Fos overexpression on immortalized human hepatocyte (IHH) proliferation...
  26. ncbi Melanoma cell autonomous growth: the Rb/E2F pathway
    R Halaban
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    Cancer Metastasis Rev 18:333-43. 1999
    ..are not well defined, but are likely to include sustained activity of cyclin-dependent kinases (CDK2, CDK4 and CDK6) as a result of loss of CDK inhibitors (such as p16INK4a and possibly p27KIP1), and persistent upregulation of ..
  27. ncbi Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes
    A Szepesi
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Blood 84:3413-21. 1994
    ..Both normal and transformed T cells contained PCNA in association with cdk2, cdk4, cdk5, and cdk6, with the amount of PCNA associated with these molecules increasing in the order listed...
  28. ncbi Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
    F K Chan
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Mol Cell Biol 15:2682-8. 1995
    ..The G1/S checkpoint is mainly dictated by the kinase activities of the cyclin D-CDK4 and/or cyclin D-CDK6 complex and the cyclin E-CDK2 complex...
  29. ncbi Expression of G1 cell cycle regulators in rat liver upon repeated exposure to thioacetamide
    Kyoung Tae Kim
    Department of Internal Medicine, Dong A University College of Medicine, Pusan, Korea
    Korean J Hepatol 13:81-90. 2007
    ..We investigated alterations of expression of cell cycle regulators in the rat liver, involved in G1 entry and progression during TA administration...
  30. ncbi Differential regulation of cyclins D1 and D3 in hepatocyte proliferation
    David G Rickheim
    Department of Medicine, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, USA
    Hepatology 36:30-8. 2002
    ..Cyclin D3 bound to both cdk4 and cdk6. Cyclin D3/cdk6 activity was readily detectable in quiescent liver and changed little after PH, and this complex ..
  31. ncbi Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity
    Eun Ryeong Hahm
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Cancer Ther 6:2686-95. 2007
    ..cell cycle arrest was associated with a decrease in protein levels of cyclin D1, cyclin-dependent kinase 4 (Cdk4), Cdk6, and/or cyclin E and suppression of complex formation between cyclin D1 and Cdk4 as revealed by immunoprecipitation ..
  32. ncbi Regulators of G1 cyclin-dependent kinases and cancers
    Mong Hong Lee
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Metastasis Rev 22:435-49. 2003
    ..CDK2, CDK4, CDK6 and their associated cyclins control the G1 to S phase transition...
  33. ncbi Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases
    Sunga Choi
    Department of Life Science, Hallym University, Gangwon Do, Korea
    Pharm Res 26:2280-8. 2009
    ..Present study was undertaken to gain insights into the mechanism of cell cycle arrest by ginseng saponin ginsenoside Rh2 (Rh2) using MCF-7 and MDA-MB-231 breast cancer cells...
  34. ncbi Proteomic co-expression of cyclin-dependent kinases 1 and 4 in human cancer cells
    Laurence Seabra
    Apoptosis Research Group, Life Sciences, Keele University, Keele, Staffordshire, UK
    Eur J Cancer 43:1483-92. 2007
    The roles of the cyclin-dependent kinases Cdk2, Cdk4 and Cdk6 and their complementary cyclin partners in moving cells from a quiescent state into active DNA synthesis are presently undergoing re-evaluation...
  35. ncbi Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex
    M Park
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 5, Room B1 04, Bethesda, Maryland 20892 0510, USA
    Development 126:4849-60. 1999
    ..of G(1)-specific cyclins (cyclin D and cyclin E) and their associated cyclin-dependent kinases (CDK2, CDK4, CDK6)...
  36. ncbi PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest
    Nabanita S Datta
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Bone Miner Res 20:1051-64. 2005
    ..Cyclin D1 was a critical mediator as a downstream effector of cAMP, PKC, and MAPK signaling, and the process was PKA-independent. The involvement of JunB has been found critical for PTHrP effects...
  37. ncbi Expression of cyclins and cdks throughout murine carcinogenesis
    V Yerly-Motta
    Cellular Immunology and Immunomolecular Therapeutic Laboratories, ETS Franche Comté, Besancon, France
    Cell Mol Biol (Noisy-le-grand) 45:1217-28. 1999
    ..91, 0.94, 0.85, 0.90 and 0.96 for cyclin D1, cyclin E, cdk2, cdk4 and cdk6, respectively) and the G2M cyclins cdks (r = 0.96, 0.97 and 0.93 for cyclins A, B and cdkl respectively)...
  38. ncbi Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells
    K J Sweeney
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Oncogene 14:1329-40. 1997
    ..inhibited by Cdk2-specific inhibitors and could phosphorylate histone H1, a substrate for Cdk2 but not for Cdk4 and Cdk6. Therefore, cyclin D2 preferentially activated Cdk2 in breast epithelial cells...
  39. ncbi Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury
    Nick D Tsihlis
    Division of Vascular Surgery and Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Ill, USA
    J Vasc Surg 51:1248-59. 2010
    ..The aims of this study are to determine the effect of IPA/NO on endothelial and vascular smooth muscle cells (VSMC) in vitro and to determine if IPA/NO inhibits neointimal hyperplasia in vivo...
  40. ncbi Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27
    T Decker
    Third Department of Medicine, Technical University of Munich, Munich, Germany
    Leukemia 16:327-34. 2002
    ..Both cyclins were associated with cdk4 but not with cdk6, which is the catalytic partner of D-type cyclins in normal B cells...
  41. ncbi Growth inhibition in antimycin A treated-lung cancer Calu-6 cells via inducing a G1 phase arrest and apoptosis
    Yong Hwan Han
    Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, JeonJu 561 180, Republic of Korea
    Lung Cancer 65:150-60. 2009
    ..AMA increased a cyclin-dependent kinase inhibitor (CDKI), p27 and decreased CDK2, CDK4, and CDK6, as well as cyclin D1 and cyclin E in Calu-6 cells. AMA also induced apoptosis in Calu-6 cells...
  42. ncbi Cyclin E-induced S phase without activation of the pRb/E2F pathway
    J Lukas
    Danish Cancer Society, Division of Cancer Biology, Copenhagen
    Genes Dev 11:1479-92. 1997
    In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly, cyclin E-dependent Cdk2 positively regulate the G1- to S-phase transition, by phosphorylating the retinoblastoma protein (pRb), thereby releasing E2F ..
  43. ncbi Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte
    Kyung Won Lee
    Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Hoegi dong, Seoul 130 701, Korea
    Carcinogenesis 28:1928-36. 2007
    ..Among the G1 phase cell cycle-related proteins, the levels of cyclin-dependent protein kinase (CDK)2, CDK6, cyclin D1, cyclin D2, cyclin D3 and cyclin E were reduced by acteoside, whereas the steady-state level of CDK4 was ..
  44. ncbi The Pezcoller lecture: cancer cell cycles revisited
    C J Sherr
    Howard Hughes Medical Institute and Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 60:3689-95. 2000
    ..Mitogen-dependent, cyclin D-dependent kinases (cdk4 and cdk6) phosphorylate the retinoblastoma (Rb) tumor suppressor protein, helping to cancel its growth-inhibitory effects ..
  45. ncbi Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    H Hirai
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:2672-81. 1995
    ..members of the mouse INK4 gene family, p19 and p18, that specifically inhibit the kinase activities of CDK4 and CDK6, but do not affect those of cyclin E-CDK2, cyclin A-CDK2, or cyclin B-CDC2, were isolated...
  46. ncbi [Dual regulation of cell cycles by Shuanghuang Shengbai Granule in Lewis-bearing mice with chemotherapy-induced myelosuppression and its mechanism]
    Li Fang Wang
    Cancer Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, and Division of Cancer Research, Shanghai Chest Hospital, Shanghai 200032, China
    Zhong Xi Yi Jie He Xue Bao 7:453-7. 2009
    ..To explore the dual regulatory effects of Shuanghuang Shengbai Granule, a compound traditional Chinese herbal medicine, on cell cycle in Lewis-bearing mice with chemotherapy-induced myelosuppression...
  47. ncbi Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
    H Serizawa
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    J Biol Chem 273:5427-30. 1998
    ..D-type CDKs, CDK4, and CDK6, phosphorylate retinoblastoma protein and are believed to regulate through the G1 phase of the cell cycle...
  48. ncbi Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease
    Malgorzata Zatyka
    Section of Medical and Molecular Genetics, Department of Pediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, United Kingdom
    Cancer Res 62:3803-11. 2002
    ..In addition, six novel targets were detected: cyclin D1 (CCND1), cell division protein kinase 6, collagen VIII alpha 1 subunit, CD59 glycoprotein precursor, integrin beta8, and interleukin 6 ..
  49. ncbi Glomerular expression of p27Kip1 in diabetic db/db mouse: role of hyperglycemia
    G Wolf
    Department of Medicine, University of Hamburg, Germany
    Kidney Int 53:869-79. 1998
    ..Immunoprecipitation experiments revealed that p27Kip1 protein associates with Cdk2 and Cdk4, but not with Cdk6. To test for the influence of hyperglycemia on cell cycle arrest and p27Kip1 expression, mesangial cells were ..
  50. ncbi [FRIL maintains quiescence of hematopoietic stem cells through regulation of cell cycle related factors]
    Jin Li
    Department of Stem Cell Biology, Institute of Transfusion Medicine, Beijing 100850, China
    Zhonghua Xue Ye Xue Za Zhi 28:37-40. 2007
    ..To explore the mechanism of Flt3 receptor-interacting lectin (FRIL) maintains quiescence of hematopoietic stem cells (HSCs) in vitro...
  51. ncbi Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 68:2599-609. 2008
    Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor...
  52. ncbi p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor
    Raya Saab
    Children s Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
    Cancer Res 69:440-8. 2009
    ..Cyclin D1, which in association with cyclin-dependent kinase (Cdk) 4 and Cdk6 phosphorylates and inactivates the RB protein, is expressed in 40% of sporadic medulloblastoma, a PNET of the ..
  53. ncbi p16 gene expression in basal cell carcinoma
    Sima Ataollahi Eshkoor
    Department of Biomedicine, Faculty of Medicine and Health Sciences Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Arch Med Res 39:668-73. 2008
    ..In this pathway, p16INK4a, an inhibitor of Rb pathway, binds to CDK4 and CDK6 competitively with cyclin D1 to prevent phosphorylation of tumor suppressor pRB gene...
  54. ncbi A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
    Marc Jung
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e10709. 2010
    ..in NCCIT cells resulted in an enrichment and up-regulation of genes associated with the cell cycle (CDKN1B, CDKN1C, CDK6 and MAPK4) and developmental processes (BMP4, HAND1, EOMES, ID2, GATA4, GATA5, ISL1 and MSX1)...
  55. ncbi Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression
    Etsu Tashiro
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223 8522, Japan
    Cancer Sci 98:629-35. 2007
    Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase...
  56. ncbi Antileukemic effect of a synthetic vitamin D3 analog, HY-11, with low potential to cause hypercalcemia
    Jin Sun Yoon
    Cancer Research Institute, Seoul National University College of Medicine, University Hospital, 28 Yon Gon Dong, Chong No Ku, Seoul, Korea
    Int J Oncol 32:387-96. 2008
    ..that HY-11 induced the G1 arrest in a dose-dependent manner, which was mediated via inactivation of CDK4 and CDK6 in association with up-regulation of CDKI (cyclin-dependent kinase inhibitor), p27 and Rb protein...
  57. ncbi Molecular mechanism of cell proliferation in rodent uterus during the estrous cycle
    Noemí Baranda-Avila
    Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico
    J Steroid Biochem Mol Biol 113:259-68. 2009
    ..Cell proliferation, ERalpha, c-fos, cyclin D1 and D3, cdk4, and cdk6 proteins were assessed in these animals by immunohistochemistry...
  58. ncbi Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)
    F Haller
    Department of Pathology, Georg August University, Gottingen, Germany
    J Pathol 215:253-62. 2008
    ..for 9p loss by comparative genomic hybridization were analysed for mRNA expression of p16INK4A, p15INK4B, CDK4, CDK6, cyclin D, p21CIP1p27KIP1, CDK2, cyclin E, cyclin B, RB and E2F1, using quantitative RT-PCR...
  59. ncbi Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: a case control study
    Demetrios A Arvanitis
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Oncol Rep 20:751-60. 2008
    ..Five genes were found to be upregulated only in tumours, RBL2, E2F2, CDK6, CCNE1 and MYC; eight in tumours and HSILs, E2F1, E2F3, E2F5, CCND1, CDK2, CDKN1B, PCNA and POLA, and five in ..
  60. ncbi Antimycin A as a mitochondria damage agent induces an S phase arrest of the cell cycle in HeLa cells
    Yong Hwan Han
    Department of Physiology, Medical School, Institute for Medical Sciences, Centers for Healthcare Technology Development, Chonbuk National University, Jeonju, Republic of Korea
    Life Sci 83:346-55. 2008
    ..The expression of CDK6, cyclin D1, cyclin E, cyclin A, and cyclin B proteins was increased by 0...
  61. ncbi Identification and location of label retaining cells in mouse liver
    Fusheng Li
    Institute of Biochemistry, College of Life Sciences, Zhejiang Sci Tech University, 310018 Hangzhou, People s Republic of China
    J Gastroenterol 45:113-21. 2010
    ..Label retaining cell (LRC) assay remains the well-known method to identify possible somatic stem/progenitor cells and their location both in situ and in vivo...
  62. ncbi Restoration of p16INK4A protein induces myogenic differentiation in RD rhabdomyosarcoma cells
    M Urashima
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Br J Cancer 79:1032-6. 1999
    p16INK4A (p16) tumour suppressor induces growth arrest by inhibiting function of cyclin-dependent kinase (CDK)4 and CDK6. Homozygous p16 gene deletion is frequent in primary rhabdomyosarcoma (RMS) cells as well as derived cell lines...
  63. ncbi The low molecular weight S-nitrosothiol, S-nitroso-N-acetylpenicillamine, promotes cell cycle progression in rabbit aortic endothelial cells
    Carlos Jorge R Oliveira
    Department of Biochemistry Molecular Biology CINTERGEN, Federal University of Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Nitric Oxide 18:241-55. 2008
    ..Synthesis of Cyclin D1 and stimulation of the cyclin-dependent kinases cdk4 and cdk6 resulted in the phosphorylation of the nuclear protein Rb and its dissociation from the E2F family of transcription ..
  64. ncbi Effect of prostaglandin on luteinizing hormone-stimulated proliferation of theca externa cells from chicken prehierarchical follicles
    Yudong Jia
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou 310029, China
    Prostaglandins Other Lipid Mediat 92:77-84. 2010
    ..H(89), SC19220 and indomethacin abolished the PGE(1)-stimulated increase in the expression of CREB1, CCND1/CDK6 and CCNE1/CDK2 mRNAs, indicating that cAMP/PKA/CREB1 signaling cascade was involved in PGE(1)-stimulated DNA ..
  65. ncbi High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma
    Alain Bernheim
    Département de biologie et de pathologie médicales, Institut de Cancerologie Gustave Roussy, Villejuif, France
    Lab Invest 88:464-73. 2008
    ..no straightforward tumor suppressor gene, but the MIRN124A2 microRNA gene, whose product regulates MMP2 and CDK6. Among unique CNAs, gains harbored CCND1, KIT/PDGFRA/KDR, MDM2, and JAK2...
  66. ncbi Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice
    Feixue Li
    Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Biol Reprod 78:127-33. 2008
    ..We also found that IL11 robustly stimulates the expression of cyclin D3 in cell culture. CDK4 and CDK6, known partners of cyclin D3, are not affected...
  67. ncbi The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Prev Res (Phila) 4:2051-61. 2011
    ..Of the downstream genes, chromatin immunoprecipitation showed that CDK6 (cyclin-dependent kinase 6), essential in G(1)-S transition, was directly regulated by JMJD2B, via demethylation of ..
  68. ncbi Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma
    Xiaoyan Chen
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 52:1193-9. 2011
    ..The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. In this study, they investigated the role of miR-137 in the pathogenesis of uveal melanoma...
  69. ncbi Immunohistochemical expression of retinoblastoma protein and p16 in renal cell carcinoma
    M Maruschke
    Department of Urology, University of Rostock, Rostock, Germany
    Urol Int 86:60-7. 2011
    ..In this study, the immunohistochemical expression of pRb and p16 in renal cell carcinoma (RCC) were examined...
  70. ncbi Alteration in the expression of cdk4 and cdk6 proteins in oral cancer and premalignant lesions
    Sopee Poomsawat
    Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
    J Oral Pathol Med 39:793-9. 2010
    Cdk4 and cdk6, key players in G1 phase, have been shown to play an important role in the development of oral squamous cell carcinoma (OSCC)...
  71. ncbi Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis
    Xian Wang
    Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina, USA
    Am J Pathol 178:345-54. 2011
    ..To study the role of CDK6 in epithelial growth and tumorigenesis, we generated transgenic mice carrying the CDK6 gene under the keratin 5 ..
  72. ncbi Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase
    Xia Xiao
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, People s Republic of China
    Int J Cancer 121:2095-104. 2007
    ..in all 3 cell lines, which was associated with an upregulation of p21 and/or p27, and downregulation of CDK4, CDK6 and CDK2. ZD6474 treatment also induced apoptosis in CNE-1 and CNE-2 cells...
  73. ncbi Functional characterization of human PFTK1 as a cyclin-dependent kinase
    Fang Shu
    Shanghai Genomics Inc, Chinese National Human Genome Center, Shanghai, Zhangjiang Hi Tech Park, Shanghai 201203, China
    Proc Natl Acad Sci U S A 104:9248-53. 2007
    ..Taken together, our data strongly suggest that PFTK1 acts as a CDK that regulates cell cycle progression and cell proliferation...
  74. ncbi Mice lacking cyclin-dependent kinase inhibitor p19Ink4d show strain-specific effects on male reproduction
    Gregory M Buchold
    Curriculum in Genetics and Molecular Biology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Reprod Dev 74:1008-20. 2007
    ..kinase inhibitors, which are important negative regulators of the G1-phase cyclin-dependent kinases CDK4 and CDK6. On a mixed C57BL/6 x 129P2/OlaHsd background, mice deficient for p19(Ink4d) exhibited defects in male reproductive ..
  75. ncbi Association study of 3 rheumatoid arthritis risk loci in systemic sclerosis in European Caucasian population
    Baptiste Coustet
    Inserm U1016, Universite Paris Descartes, Hopital Cochin, Paris, France
    Clin Exp Rheumatol 29:S6-9. 2011
    ..Systemic sclerosis (SSc) belongs to connective tissue disorders and recent data have highlighted strong associations with some autoimmunity genes shared with other autoimmune diseases...
  76. ncbi The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
    Dalibor Blazek
    Department of Medicine, Microbiology, and Immunology, Rosalind Russell Medical Research Center, University of California at San Francisco UCSF, USA
    Genes Dev 25:2158-72. 2011
    ..The essential role of CycK for organisms in vivo is further supported by the result that genetic inactivation of CycK in mice causes early embryonic lethality...
  77. ncbi Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment
    Tracy C Kuo
    University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720, USA
    Mol Cell Biol 31:2566-76. 2011
    ..We found that forced expression of Cdk6 promotes continued cell division and decreased apoptosis of leukemic cells...
  78. ncbi Recognition of Cdk2 by Cdk7
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proteins 67:1048-59. 2007
    ..Cdk7 is itself phosphorylated on the activation segment. Cdk7 phosphorylates Cdk1, Cdk2, Cdk4, and Cdk6, but only Cdk1 and Cdk2 can phosphorylate Cdk7 and none of them is able to auto-phosphorylate...
  79. ncbi Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer
    Gottfried E Konecny
    Division of Hematology Oncology, Department of Biomathematics and Biostatistics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 17:1591-602. 2011
    ..PD-0332991 is a selective inhibitor of the CDK4/6 kinases with the ability to block retinoblastoma (Rb) phosphorylation in the low nanomolar range. Here we investigate the role of CDK4/6 inhibition in human ovarian cancer...
  80. ncbi Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon
    Maria Emanuela Cuomo
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, SW3 6JB London, United Kingdom
    J Biol Chem 280:35844-58. 2005
    ..cyclin-dependent kinases (CDK) 4 and 6, generating enzymes with a substrate selectivity deviant from CDK4 and CDK6 activated by D-type cyclins, suggesting different biochemical and biological functions...
  81. ncbi Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:617-24. 2009
    ..Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes...
  82. ncbi Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCdelta
    Emad Afrasiabi
    Department of Biology, Abo Akademi University, BioCity, Artillerigatan 6, 20520 Turku, Finland
    Mol Cell Endocrinol 292:26-35. 2008
    ..The levels of cyclin D3 and the cyclin-dependent kinases cdk4 and cdk6 decreased, as did the phosphorylation of the Rb-protein. PMA did not induce apoptosis...
  83. ncbi The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity
    Simak Ali
    Department of Oncology and Chemistry, Imperial College London, London, United Kingdom
    Cancer Res 69:6208-15. 2009
    ..progression through the cell cycle requires the sequential action of cyclin-dependent kinases CDK1, CDK2, CDK4, and CDK6. Direct or indirect deregulation of CDK activity is a feature of almost all cancers and has led to the development ..
  84. ncbi Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma
    Giuseppe Altavilla
    Department of Medical Diagnostic Sciences and Special Therapies, Section of Otolaryngology, University of Padua, Via Gabelli 61, Padua, Italy
    Acta Otolaryngol 129:1242-9. 2009
    ..Human papilloma virus (HPV) was associated with sinonasal inverted papilloma (SIP) in 14/20 (70%) patients with a prevalence of HPV 6/11; alterations of the cell cycle proteins were statistically significant...
  85. ncbi microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Blood 115:2630-9. 2010
    ..Furthermore, we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region...
  86. ncbi The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells
    Te Chun Hsia
    Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
    Anticancer Res 29:309-18. 2009
    ..Rhein induced G0/G1 arrest through inhibition of cyclin D3, Cdk4 and Cdk6. The efficacious induction of apoptosis was observed at 50 microM for 12 h and up to 72 h as examined by a flow ..
  87. ncbi Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E
    Maria R Gumina
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Cell Cycle 9:820-8. 2010
    ..Whereas cell cycle distribution was not affected following individual depletion of cdk4, cdk6 or cdk2, the combined knockdown of cdk4 and cdk6 led to accumulation of LY18 cells in G(1)-phase of the cell cycle ..
  88. ncbi Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families
    Femke A De Snoo
    Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 16:1135-41. 2008
    ..The strongest evidence for an atypical nevus susceptibility gene was mapped to chromosome band 7q21.3 (two-point LOD score=2.751), a region containing candidate gene CDK6.
  89. ncbi Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..implicate genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes...
  90. ncbi [Effect of Oviductus Ranae on Cyclin D1, CDK6 and P15 expressions in the liver tissue of aged male rats]
    Hui Yao
    College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1044-6. 2010
    OBJECTIV: To investigate the effect of Oviductus Ranae (OR) on the expressions of CyclinD1, CDK6 and P15 in the liver of aged male rats.
  91. ncbi TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
    Youhna M Ayala
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Proc Natl Acad Sci U S A 105:3785-9. 2008
    ..Removal of TDP-43 in human cells significantly increases cyclin-dependent kinase 6 (Cdk6) protein and transcript levels...
  92. ncbi Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor
    Rebecca Kirk
    Structural Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 283:22325-35. 2008
    ..protein (HURP) and the inhibitor of apoptosis (IAP) protein but also functions as an activator of cyclin D-Cdk6 complexes. We identify PI31 as an Fbxo7...
  93. ncbi Functional regulation of D-type cyclins by insulin-like growth factor-I and serum in multiple myeloma cells
    Janet Glassford
    Department of Haematology, University College London, London, UK
    Br J Haematol 139:243-54. 2007
    ..Cyclin D1, cyclin D2, cyclin dependent kinase (CDK) 4, CDK6, p27(Kip1) p18(INK4C) and retinoblastoma protein (pRb) were absent in normal PCs, heterogeneously expressed in ..
  94. ncbi Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis
    Shu Fen Liou
    Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    Toxicology 256:13-24. 2009
    ..Cell cycle blockade was associated with reduced amounts of cyclin D1/2, cyclin E, Cdk2, Cdk4, and Cdk6 and increased levels of the Cdk inhibitory proteins (Cip1/p21 and Kip1/p27)...
  95. ncbi p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis
    Yasunobu Matsuda
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata, 951 8510, Japan
    Med Mol Morphol 39:169-75. 2006
    ..p16 is a G1-specific cell-cycle inhibitor that prevents the association of cyclin-dependent kinase (CDK) 4 and CDK6 with cyclin D(1)...
  96. ncbi Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors
    S Linardopoulos
    Cancer Research Campaign Beatson Laboratories, University of Glasgow, Department of Medical Oncology, United Kingdom
    Cancer Res 55:5168-72. 1995
    ..p15INK4b are cell cycle regulators that specifically bind to and inhibit the cyclin D-dependent kinases, cdk4 and cdk6. Because these genes undergo frequent deletions and/or mutations in various human cancers, we examined the status ..
  97. ncbi Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6
    P M Ojala
    Cell Cycle Laboratory, Haartman Institute, University of Helsinki, Finland
    Cancer Res 59:4984-9. 1999
    ..v-Cyclin is a KSHV-encoded homologue to D-type cyclins that associates with cellular cyclin-dependent kinase 6 (CDK6)...
  98. ncbi Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors
    P D Jeffrey
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 14:3115-25. 2000
    ..Here we present the 2.9-A crystal structure of the inactive ternary complex between Cdk6, the INK4 inhibitor p18(INK4c), and a D-type viral cyclin...
  99. ncbi Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function
    Mark Morris
    Cancer Research Campaign Laboratories, Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Oncogene 21:4277-88. 2002
    ..effects of HPVE7 frequently used in such studies, here we have employed retroviral vectors over-expressing CDK4 or CDK6 as a more representative model of naturally-occurring mutations targeting the Rb pathway...
  100. ncbi Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
    Cdk4 and Cdk6 are thought to be essential for initiation of the cell cycle in response to mitogenic stimuli...
  101. ncbi Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes
    Guiming Li
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 173:2383-91. 2004
    ..Activation through the TCR results in rapid transport of cytoplasmic cyclin-dependent kinase 6 (cdk6) to nuclei, where it associates with cyclin D and p57(Kip2) in active enzyme complexes...

Research Grants73

  1. PROLIFERATIVE EFFECTS OF CDK4 AND CDK6 DYSREGULATION
    Philip Hinds; Fiscal Year: 2006
    ....
  2. Cell Cycle Genes and Female Reproductive Function
    Hiroaki Kiyokawa; Fiscal Year: 2007
    ..These data suggest that cyclin D2 may activate other Cdk(s), possibly Cdk6, in granulosa cells upon FSH and estrogen stimuli...
  3. Genetic Basis of Lung Tumor Progression in Mice
    Ming You; Fiscal Year: 2006
    ..cellular transit through the G1 phase of the cell cycle by inhibiting the D-type cyclin-dependent kinases (CDK4 and CDK6)...
  4. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..These include the cyclin D-Cdk4 and cyclin D-Cdk6 complexes acting early in G1 and the cyclin E-Cdk2 complex acting at the G1 to S-phase boundary...
  5. Immunotoxicology of Cigarette Smoke
    Brian Freed; Fiscal Year: 2007
    ..Analysis of cell cycle proteins (Myc, Cdk4, Cdk6, cyclins, E2F4, p130) will be performed by flow cytometry, immunoprecipitation and western blot techniques...
  6. CDK control of myeloma pathogenesis
    SELINA Y CHEN KIANG; Fiscal Year: 2010
    ..We have demonstrated previously that inhibition of Cdk6 by p18INK4c, one of its physiologic inhibitors, is required for G1 cell cycle arrest during normal plasma cell ..
  7. CDK control of myeloma pathogenesis
    Selina Chen Kiang; Fiscal Year: 2009
    ..We have demonstrated previously that inhibition of Cdk6 by p18INK4c, one of its physiologic inhibitors, is required for G1 cell cycle arrest during normal plasma cell ..
  8. CDK control of myeloma pathogenesis
    Selina Chen Kiang; Fiscal Year: 2009
    ..We have demonstrated previously that inhibition of Cdk6 by p18INK4c, one of its physiologic inhibitors, is required for G1 cell cycle arrest during normal plasma cell ..
  9. P16 AND CELL SENESCENCE AND ONCOGENESIS
    Manuel Diaz; Fiscal Year: 2001
    ..suppressor gene INK4A (MTS1, CDK41, CDKN2) codes for p16, an inhibitor of the G1 cyclin-dependent kinases CDK4 and CDK6. Deletion or inactivation of this gene is a frequent event in the oncogenic process...
  10. Transcriptional & cell cycle control by dietary indoles
    GARY FIRESTONE; Fiscal Year: 2007
    ..I3C, but not DIM, down-regulates cyclin dependent kinase-6 (CDK6) expression and promoter activity, whereas, DIM selectively and rapidly stimulates expression and promoter activity ..
  11. ARF MDM2 P53 TUMOR SUPPRESSION PATHWAY
    Yanping Zhang; Fiscal Year: 2004
    ..Functionally, p16INK4a inhibits the activity of cyclin D-dependent kinases (CDK4 and CDK6), thereby maintaining the retinoblastoma protein (Rb) in its growth suppressive state...
  12. CRYSTALLOGRAPHIC STUDIES OF VIRAL CYCLINS AND CDK6
    Ursula Schulze Gahmen; Fiscal Year: 2002
    ..They associate with CDK4 and CDK6, resulting in strong kinase activity toward retinoblastoma protein and histone H1...
  13. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..include (a) bromodeoxyuridine labeling for DNA synthesis, (b) cyclins D1, E and A, and (c) cdk2, cdk4 and cdk6. Aim 2 is to determine the effect of selenium treatment on the expression of apoptotic biomarkers: (a) TUNEL assay ..
  14. IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATION
    Stephen Rosenthal; Fiscal Year: 2002
    ..and subsequently stimulates myogenin gene transcription, and we will evaluate the potential role of the cdk4/cdk6 inhibitor p19 in mediating the switch in IGF-I response from proliferation to differentiation...