CASP4

Summary

Gene Symbol: CASP4
Description: caspase 4, apoptosis-related cysteine peptidase
Alias: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, CASP-4, ICE(rel)-II, apoptotic cysteine protease Mih1/TX, caspase 4, apoptosis-related cysteine protease, caspase-4, protease ICH-2, protease TX
Species: human

Top Publications

  1. ncbi Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, LMRC 123, Boston, MA 02115, USA
    Biochim Biophys Acta 1762:742-54. 2006
  2. ncbi IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha
    A D Howard
    Department of Biochemical and Molecular Pathology, Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065
    J Immunol 147:2964-9. 1991
  3. ncbi Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 )
    Umayal Lakshmanan
    Cell Death and Human Diseases, Genomics and Genetics Division, Institute of Molecular and Cell Biology, Proteos, Singapore, Republic of Singapore
    J Immunol 179:8480-90. 2007
  4. ncbi Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis
    Futoshi Yukioka
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurochem Int 52:683-7. 2008
  5. ncbi Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
    N Inohara
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:14560-7. 1999
  6. ncbi Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases
    M Van de Craen
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Gent, Belgium
    FEBS Lett 445:149-54. 1999
  7. ncbi Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
    Sanjay Kumar
    Musculoskeletal Diseases, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA, 19406, USA
    Cytokine 18:61-71. 2002
  8. ncbi Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9
    R R Annand
    Mitotix Inc, One Kendall Square, Bldg 600, Cambridge MA 02139, USA
    Biochem J 342:655-65. 1999
  9. ncbi Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
    S M Srinivasula
    Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 93:14486-91. 1996
  10. ncbi A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells
    C Faucheu
    Roussel Uclaf, Romainville, France
    EMBO J 14:1914-22. 1995

Research Grants

  1. Site-specific Allosteric Inhibitors for Inflammatory Caspases
    James Wells; Fiscal Year: 2007
  2. Site-specific Allosteric Inhibitors for Inflammatory Caspases
    James A Wells; Fiscal Year: 2010
  3. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Julian Hoff; Fiscal Year: 2006
  4. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Guohua Xi; Fiscal Year: 2009
  5. Proteasome Inhibition and ER Stress
    David McConkey; Fiscal Year: 2009
  6. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2010
  7. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2011
  8. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    Lawrence H Boise; Fiscal Year: 2010
  9. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    LAWRENCE BOISE; Fiscal Year: 2009
  10. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    Lawrence H Boise; Fiscal Year: 2011

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, LMRC 123, Boston, MA 02115, USA
    Biochim Biophys Acta 1762:742-54. 2006
    ..Cop, as an inhibitor of an important apical caspase cell death axis, may provide a tool for modulating pathological cell death...
  2. ncbi IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha
    A D Howard
    Department of Biochemical and Molecular Pathology, Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065
    J Immunol 147:2964-9. 1991
    ..Substitutions at P2'-P4' and P6' had relatively little effect on cleavage activity. These results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P1'...
  3. ncbi Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 )
    Umayal Lakshmanan
    Cell Death and Human Diseases, Genomics and Genetics Division, Institute of Molecular and Cell Biology, Proteos, Singapore, Republic of Singapore
    J Immunol 179:8480-90. 2007
    ..Our data suggest that the TRAF6-caspase-4 interaction, triggered by LPS, leads to NF-kappaB-dependent transcriptional up-regulation and secretion of important cytokines and chemokines in innate immune signaling in human monocytic cells...
  4. ncbi Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis
    Futoshi Yukioka
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurochem Int 52:683-7. 2008
    ..To sum up our data, the familial AD-linked PS1 mutation accelerates the cleavage of caspase-4 under the ER stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c...
  5. ncbi Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
    N Inohara
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:14560-7. 1999
    ..Thus, Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kappaB activation pathways...
  6. ncbi Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases
    M Van de Craen
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Gent, Belgium
    FEBS Lett 445:149-54. 1999
    ..None of five missense mutations affected the sensitivity of PSI to caspase-mediated cleavage. This suggests that AD pathogenesis associated with PS1 missense mutations cannot be explained by a change in caspase-dependent processing...
  7. ncbi Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
    Sanjay Kumar
    Musculoskeletal Diseases, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA, 19406, USA
    Cytokine 18:61-71. 2002
    ..Finally, we have localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7b may be involved in immune response, inflammatory diseases and/or cancer...
  8. ncbi Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9
    R R Annand
    Mitotix Inc, One Kendall Square, Bldg 600, Cambridge MA 02139, USA
    Biochem J 342:655-65. 1999
    ..PI9 is the first example of a human serpin analogue that inhibits members of this class of cysteine proteinases...
  9. ncbi Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
    S M Srinivasula
    Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 93:14486-91. 1996
    ..On the other hand, Mch4 could be a second upstream protease that is responsible for activation of the same protease cascade in CrmA-insensitive apoptotic pathways...
  10. ncbi A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells
    C Faucheu
    Roussel Uclaf, Romainville, France
    EMBO J 14:1914-22. 1995
    ..In addition, this protein induces apoptosis in transfected COS cells. TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death...
  11. ncbi Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases
    J Kamens
    BASF Bioresearch Corporation, Worcester, Massachusetts 01605, USA
    J Biol Chem 270:15250-6. 1995
    ..A comparison of the inhibitor profiles and substrate cleavage by ICH-2 and ICE shows that the enzymes share catalytic properties but may differ in substrate specificities, suggesting that the two enzymes have different functions in vivo...
  12. ncbi Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
    Y Hu
    Departments of Pathology and Comprehensive Cancer Center, 1500 East Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 95:4386-91. 1998
    ..These experiments demonstrate that Bcl-XL associates with caspase-9 and Apaf-1, and show that Bcl-XL inhibits the maturation of caspase-9 mediated by Apaf-1, a process that is evolutionarily conserved from nematodes to humans...
  13. ncbi Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire
    Leopold Eckhart
    Department of Dermatology, Medical University of Vienna, Vienna, Austria
    Mol Biol Evol 25:831-41. 2008
    ..We conclude that gene inactivations have occurred in each of the 3 caspase clades and that gene loss has been as critical as gene duplication in the evolution of the human repertoire of caspases...
  14. ncbi Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
    Jung Yeon Yi
    School of Veterinary Medicine, Kangwon National University, Gangwon, Republic of Korea
    Arch Toxicol 83:795-803. 2009
    ..In conclusion, caspase-4 and -12 can be activated by benzene treatment without inducing cell apoptosis in mouse bone marrow, which are partly under the regulation of the p53 gene...
  15. ncbi Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma
    X Y Lin
    Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Biol Chem 275:39920-6. 2000
    ..Interferon-gamma strongly induced CASP1 and CASP5 but not CASP4 or CASP13 gene expression in HT-29 colon carcinoma cells...
  16. ncbi Mutational analysis of caspase 1, 4, and 5 genes in common human cancers
    Young Hwa Soung
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 137 701, South Korea
    Hum Pathol 39:895-900. 2008
    ..In addition, the data indicate that caspase-5 gene is commonly mutated in the MSI-positive cancers, and suggest that inactivation of caspase-5 may play a role in the tumorigenesis of MSI-positive cancers...
  17. ncbi Inflammatory stimuli regulate caspase substrate profiles
    Nicholas J Agard
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:880-93. 2010
    ..Finally, our data suggest that inducers of inflammation may subtly alter caspase-1 substrate profiles...
  18. ncbi [Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
    Hui Li
    Department of Otorhinolaryngology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 39:324-7. 2004
    ..To examine the expression of apoptosis-related genes c-IAP2 and caspase-4 in sinonasal squamous carcinoma. To investigate the role and mechanism of the two apoptosis-related genes in nasal cavity and sinus squamons carcinoma...
  19. ncbi Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung ep
    Seon Hee Oh
    Research Center for Resistant Cells, College of Medicine, Chosun University, Dong Gu, Gwangu 501 759, Korea
    J Pharmacol Exp Ther 329:112-22. 2009
    ..Our results indicate that the differential responses of capsaicin and DHC for cell protection are caused by the extent of the UPR and autophagy that are both regulated by the level of JNK and ERK activation...
  20. ncbi Inflammasomes and inflammatory caspases in skin inflammation
    Lars Iversen
    Department of Dermatology, Aarhus University Hospital, PP Orumsgade 11, DK 8000 Aarhus C, Denmark
    Expert Rev Mol Diagn 8:697-705. 2008
    ..This article will review some of the most recent findings, identifying inflammasomes and inflammatory caspases as potential inducers and regulators of skin inflammation in contact hypersensitivity and psoriasis...
  21. ncbi Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis
    Cheol Hee Choi
    Research Center for Resistant Cells, College of Medicine, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, Korea
    Mol Pharmacol 78:114-25. 2010
    ....
  22. ncbi OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells
    Margaret A Park
    Department of Biochemistry, 401 College Street, Massey Cancer Center, Room 280a, Box 980035, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 73:1168-84. 2008
    ..OSU enhanced the expression of Beclin 1 and ATG5 and cleavage of pro-caspase 4 in a PERK-dependent fashion and promoted the Beclin 1- and ATG5-dependent formation of vacuoles containing LC3, ..
  23. ncbi Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia
    Wei Ching Huang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    J Pharmacol Exp Ther 329:524-31. 2009
    ..Taken together, we show that GSK-3beta exhibits a mechanism of ER stress-induced lysosomal apoptosis in leukemia involving caspase-2-induced LMP and cathepsin B relocation, which result in caspase-8 and -3 activation...
  24. ncbi Monitoring caspase activity in living cells using fluorescent proteins and flow cytometry
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculosketal and Skin Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 164:1901-13. 2004
    ..caspase inhibitors indicated the probe was highly sensitive to cleavage by caspase 6 and 8, less sensitive to caspase 4, and resistant to other caspases...
  25. ncbi MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells
    Jose L R Brito
    Institute for Cancer Research, Section of Haemato oncology, London, UK
    Haematologica 94:78-86. 2009
    ..The involvement of MMSET in the pathogenesis of t(4;14) multiple myeloma and the mechanism or genes deregulated by MMSET upregulation are still unclear...
  26. ncbi A bicistronic expression system for bacterial production of authentic human interleukin-18
    Robert B Kirkpatrick
    Department of Gene Expression, Protein Biochemistry, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Rd, King of Prussia, PA 19406, USA
    Protein Expr Purif 27:279-92. 2003
    ....
  27. ncbi Reaction Pathways of 2-Iodoacetic Acid on Cu(100): Coverage-Dependent Competition between C-I Bond Scission and COOH Deprotonation and Identification of Surface Intermediates
    Yi Shiue Lin
    Department of Chemistry, National Cheng Kung University 1, Ta Hsueh Road, Tainan, Taiwan, ROC
    Langmuir 26:8218-25. 2010
    ....
  28. ncbi Active caspase-1-mediated secretion of retinoic acid inducible gene-I
    Min Jung Kim
    Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
    J Immunol 181:7324-31. 2008
    ..Our data suggest a novel mechanism that negatively regulates RIG-I-mediated signaling activity via caspase-1-dependent secretion of RIG-I protein...
  29. ncbi Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer
    Takahiro Yaguchi
    Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
    Digestion 81:62-7. 2010
    ..In the Western blot analysis, caspase-4 activation was identified in gastric biopsy samples...
  30. ncbi Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad
    Stanley D W Miller
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Hepatology 46:496-503. 2007
    ..CONCLUSION: These data show that caspase-4 is not essential for ZAAT-induced apoptosis in HEK293 cells and implicates P-I-3-kinase and Bad as potential therapeutic targets for the liver disease associated with ZAAT deficiency...
  31. ncbi Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells
    Zong Mei Bian
    Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan 48105, USA
    Invest Ophthalmol Vis Sci 50:6006-14. 2009
    ..To investigate the functional involvement of caspase-4 in human retinal pigment epithelial (hRPE) cells...
  32. ncbi Molecular pathways involved in loss of kidney graft function with tubular atrophy and interstitial fibrosis
    Daniel G Maluf
    Department of Surgery, Division of Transplant, Virginia Commonwealth University, Richmond, Virginia 23298 0057, United States of America
    Mol Med 14:276-85. 2008
    ..Genes involved in apoptosis (for example, CASP4 and CASP5) were importantly overexpressed in IF/TA...
  33. ncbi Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Anticancer Res 25:3293-302. 2005
    ..The up-regulated genes include HIAP1, CRAF1, TRAF6, CASP1, CASP2, CASP3, CASP4, HPRT, GADD45, MCL-1, NIP1, BCL2L2, TRAP3, GSTP1, DAXX, PIG11, UBC, PIG3, PCNA, CDC10, JNK1 and RBP2...
  34. ncbi HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
    Peter Pyrko
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer Res 67:10920-8. 2007
    ..Because ER stress has also been reported as the mechanism for insulin resistance and diabetes, our ER stress model of PI function may also explain why these drugs may induce insulin resistance as one of their most common side effects...
  35. ncbi Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis
    Chen Chen Jiang
    Immunology and Oncology Unit, Newcastle Misericordiae Hospital, Newcastle, New South Wales, Australia
    Cancer Res 67:9750-61. 2007
    ..Taken together, these results seem to have important implications for new treatment strategies in melanoma by combinations of agents that induce ER stress and inhibitors of the MEK/ERK pathway...
  36. ncbi Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells
    Teresa Nieto-Miguel
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    Cancer Res 67:10368-78. 2007
    ..Our data also indicate that mitochondria are indispensable for this edelfosine-induced cell death initiated by ER stress...
  37. ncbi Involvement of IRE1? signaling in the hippocampus in patients with mesial temporal lobe epilepsy
    Gonglu Liu
    Department of Neurology, Shanghai Jiaotong University Affiliated First People s Hospital, Hongkou District, PR China
    Brain Res Bull 84:94-102. 2011
    ..Our data suggest that chronic epilepsy is associated with ER stress, as well as induction of both IRE1?-mediated pro- and anti-apoptotic signaling pathways...
  38. ncbi Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes
    Chuan Ging Wu
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 4255, USA
    Mol Med 12:47-53. 2006
    ....
  39. ncbi Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Cancer 110:1083-95. 2007
    ..Garlic-derived organosulfur compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) provide significant protection against carcinogenesis...
  40. ncbi Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein
    Li Hua Chen
    Immunology and Oncology Unit, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Cancer Res 68:834-42. 2008
    ..Whereas the MEK/ERK signaling pathway plays an important role in inhibiting ER stress-induced caspase-4 activation, ARC seems to be critical in blocking activation of caspase-8 in melanoma cells subjected to ER stress...
  41. ncbi Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model
    Sandra E Juul
    Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
    Dev Neurosci 30:231-42. 2008
    ..01). The interleukin-10 expression was higher in the rEpo-treated animals. Apoptotic and proinflammatory gene expression persisted for 168 h. There was no increase in angiogenic gene expression at the time points studied...
  42. ncbi Microarray analysis identifies differentially expressed genes induced by human papillomavirus type 18 E6 silencing RNA
    Wei Min
    Institute of Molecular Biology, Southern Medical University, Guangzhou, People s Republic of China
    Int J Gynecol Cancer 19:547-63. 2009
    ..and cellular pathways in detail, including cell cycle-related genes, CCNG1 and p21; apoptosis-related genes, CASP4, CASP6, IGFBP3, and DFFA; ubiquitin proteolysis pathway-related genes, UBE3A and UBE2C; keratinocyte ..
  43. ncbi Induction of apoptosis by combined treatment with differentiation-inducing agents and interferon-alpha in human lung cancer cells
    Yuri Yamamoto-Yamaguchi
    Saitama Cancer Center Research Institute, 818 Komuro, Ina, Saitama 362 0806, Japan
    Anticancer Res 23:2537-47. 2003
    ..We show here that combined treatment-induced cell death is caused by apoptosis...
  44. ncbi Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss
    Ai xia Liu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, China
    J Clin Endocrinol Metab 96:E493-7. 2011
    ..It has been suggested that elevated reactive oxygen species trigger endoplasmic reticulum (ER) stress by influencing ER function. However, it is unclear whether ER stress is associated with EPL...
  45. ncbi Caspase activity inhibition delays programmed spermatogenic cell death in vitro
    Laura L Tres
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Arch Histol Cytol 67:315-24. 2004
    ....
  46. ncbi New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs
    Daniela Arduino
    Centro de Neurociencias e Biologia Celular, Universidade de Coimbra, 3030 Coimbra, Portugal
    Front Biosci 13:6763-74. 2008
    ..A, B and C were more effective than DFP (a 3,4-HP iron-chelating agent in clinical use) in MPP+ induced cell death. Therefore, these results evidenced a neuroprotective and antiapoptotic role for the compounds studied...
  47. ncbi Establishment of cholinergic neuron-like cell lines with differential vulnerability to nitrosative stress
    David A Personett
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 4:75-88. 2007
    ..We have identified two cholinergic cell lines useful for molecular studies of cholinergic vulnerability. We hypothesize that, in cholinergic neurons, control of ER stress signaling may be a major factor in differential vulnerability...
  48. ncbi Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress
    Girija Dasmahapatra
    Department of Medicine, Massey Cancer Center, Virginia Commonwealth University Health Systems, Richmond, VA 23298, USA
    Cancer Biol Ther 8:808-19. 2009
    ..They also raise the possibility that such a strategy may be effective in different DLBCL sub-types (e.g., GC- or ABC), and in bortezomib-resistant disease...
  49. ncbi Oxidative stress involvement in Physalis angulata-induced apoptosis in human oral cancer cells
    H Z Lee
    School of Pharmacy, China Medical University, 91, Hsueh Shih Road, Taichung 40402, Taiwan
    Food Chem Toxicol 47:561-70. 2009
    ..angulata-induced cell death through inhibition of the proteins expression of HO-1, Cu/Zn SOD and HSP70...
  50. ncbi Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress
    Kanako Akamatsu
    Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Anticancer Res 29:2195-204. 2009
    ..Ion channel modulators have been previously associated with cell proliferation and cell death in human cancer cell lines...
  51. ncbi Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells
    Maiko Suzuki
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Cancer Chemother Pharmacol 64:1115-22. 2009
    ..We investigated the role of endoplasmic reticulum (ER) stress in the enhancing effect of SAHA on CDDP, compared with the ER stressor thapsigargin...
  52. ncbi Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells
    Justine S Fitzgerald
    Department of Obstetrics, Friedrich Schiller University Jena, Bachstrasse 18, 07740 Jena, Germany
    Int J Biochem Cell Biol 37:2284-96. 2005
    ....
  53. ncbi Butyric acid induces apoptosis via oxidative stress in Jurkat T-cells
    T Kurita-Ochiai
    Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271 8587, Japan
    J Dent Res 89:689-94. 2010
    ..These results suggest that butyric acid is involved in mitochondrial-dysfunction- and endoplasmic reticulum stress-mediated apoptosis in human Jurkat T-cells via a ROS-dependent mechanism...
  54. ncbi Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation
    Hee Jung Um
    Department of Immunology, School of Medicine, Keimyung University, Taegu 700 712, South Korea
    Int J Oncol 36:1007-13. 2010
    ..Taken together, the stronger antitumor activity of HS-1793 originates, at least in part, from its ability for Akt inactivation...
  55. ncbi Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells
    Min Jung Choi
    Department of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo Gu, Daegu 704 701, South Korea
    Toxicol In Vitro 25:692-8. 2011
    ..Taken together, the present study provides strong evidence supporting an important role of the ER stress response in mediating withaferin A-induced apoptosis...
  56. ncbi Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53
    Kristine Mann
    Department of Biological Sciences and Biomedical Program, University of Alaska, 3211 Providence Drive, Anchorage, AK 99508, USA
    Oncogene 24:3964-75. 2005
    ..These studies show that WR1065 specifically modulates a subset of p53 target genes in a colon carcinoma cell line, consistent with the observation that this agent elicits essentially p53-dependent, cell cycle arrest responses...
  57. ncbi Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors
    Sylvain L'espérance
    Department of Medicine, Faculty of Medicine, Laval University, Quebec G1K 7P4, Canada
    Int J Oncol 29:5-24. 2006
    ..and cell cycle control (NGFRAP1, TPD52L1, TAX1BP1) and tumor suppression and apoptosis (SMOC2, TIMP3, AXIN1, CASP4, P53SCV)...
  58. ncbi Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells
    D Mu
    Department of Respiratory Disease, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Methods Find Exp Clin Pharmacol 29:33-8. 2007
    ..These results demonstrated that DHA can induce apoptosis of lung cancer cell line SPC-A-1 cells and that calcium and survivin participated in the apoptotic signalling pathways...
  59. ncbi FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
    Yuji Kajiwara
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, USA
    PLoS ONE 4:e5071. 2009
    ..We screened stable cell lines with a macroarray focusing on AD-related genes and identified CASP4, encoding caspase-4, as a target of this silencing complex...
  60. ncbi Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis
    Wei Chung Hsieh
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC
    Mol Cells 30:311-8. 2010
    ..In conclusion, overexpression of ODC suppresses TG-induced apoptosis by blocking caspase-4 activation and PERK phosphorylation, attenuating CHOP expression and inhibiting the mitochondria-mediated apoptotic pathway...
  61. ncbi Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms
    Francesca Nicolau-Galmés
    Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain
    Apoptosis 16:1253-67. 2011
    ..These findings demonstrate the great potential of terfenadine to kill melanoma cells through different cellular signaling pathways and could contribute to define new therapeutic strategies in melanoma...
  62. ncbi Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress
    Tadanobu Yoshikawa
    Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, Japan
    Curr Eye Res 36:1153-63. 2011
    ..To investigate the effects of endoplasmic reticulum (ER) stress on the tight junctions of the retinal pigment epithelial (RPE) cells in vitro...
  63. ncbi Methylanthraquinone from Hedyotis diffusa WILLD induces Ca(2+)-mediated apoptosis in human breast cancer cells
    Zheng Liu
    School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, China
    Toxicol In Vitro 24:142-7. 2010
    ..These results suggested that methylanthraquinone from Hedyotis diffusa WILLD induced MCF-7 cells apoptosis via Ca(2+)/calpain/caspase-4 pathway...
  64. ncbi Non-canonical inflammasome activation targets caspase-11
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
    Nature 479:117-21. 2011
    ..These data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections...
  65. ncbi Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants
    Jean Ann Maguire
    Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4539, United States
    Int J Biochem Cell Biol 44:101-12. 2012
    ..However, inhibition of either caspase 4 or c-jun kinase (JNK) each blocked caspase 3 mediated cell death...
  66. ncbi Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress
    Shinsuke Matsuzaki
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Neurochem Int 56:352-6. 2010
    ..These results suggest that the disturbance of Ca(2+) homeostasis induced by ER stress should cause the activation of caspase-4 resulting in the neural cell death...
  67. ncbi Mutational analysis of caspase genes in prostate carcinomas
    Min Sung Kim
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    APMIS 118:308-12. 2010
    ..The data suggest that apoptosis evasion in prostate carcinoma may be dependent on other mechanisms besides genetic alteration of caspase-encoding genes...
  68. ncbi Anti-inflammatory activity of PYNOD and its mechanism in humans and mice
    Ryu Imamura
    Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Immunol 184:5874-84. 2010
    ..Furthermore, PYNOD-transgenic mice were resistant to lethal endotoxic shock. Thus, PYNOD is the first example of an NLR that possesses an anti-inflammatory function in vivo...
  69. ncbi Sigma-1Rs are upregulated via PERK/eIF2?/ATF4 pathway and execute protective function in ER stress
    Teruhiko Mitsuda
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 415:519-25. 2011
    ..These results indicate that Sig-1Rs are transcriptionally upregulated via the PERK/eIF2?/ATF4 pathway and ameliolate cell death signaling. This study is the first report identifying the transcription factor regulating Sig-1Rs expression...
  70. ncbi Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway
    Olga Burmistrova
    Departamento de Bioquimica, Unidad Asociada al Consejo Superior de Investigaciones Cientificas, Universidad de Las Palmas de Gran Canaria, Instituto Canario de Investigación del Cáncer, Plaza Dr Pasteur s n, Las Palmas de Gran Canaria, Spain
    Cancer Lett 309:71-7. 2011
    ....
  71. ncbi Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways
    Chin Chung Lin
    Department of Chinese Medicine, Fong Yuan Hospital, Executive Yuan, Taichung 420, Taiwan, ROC
    Int J Oncol 39:217-24. 2011
    ..The potent in vitro antitumor activities suggest that wogonin could be developed for the treatment of human osteosarcoma in the future...
  72. ncbi Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways
    Mi Ja Lee
    Department of Pathology, College of Medicine, Chosun University, Dong Gu, Gwangju, Republic of Korea
    Toxicology 264:205-14. 2009
    ..Thus, both ER stress- and mitochondria-mediated death pathways are involved in capsaicin-induced apoptosis...
  73. ncbi Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils
    François Binet
    Laboratoire de recherche en inflammation et physiologie des granulocytes, Universite du Quebec, INRS Institut Armand Frappier, Laval, QC, Canada
    Biochem Biophys Res Commun 391:18-23. 2010
    ..Our results demonstrate for the first time that the ER stress-mediated apoptotic pathway operates in human neutrophils...
  74. ncbi White matter hyperintensity volume is increased in small vessel stroke subtypes
    N S Rost
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
    Neurology 75:1670-7. 2010
    ..Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant...
  75. ncbi Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heart
    Youn Jin Kim
    Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Seoul, Korea
    Korean J Anesthesiol 58:153-61. 2010
    ..The aim of this study was to examine the cardiac function and transcriptional response of the heart to propofol after ischemia-reperfusion...
  76. ncbi Reduced estimated glomerular filtration rate is associated with stroke outcome after intravenous rt-PA: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry
    Masaki Naganuma
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Cerebrovasc Dis 31:123-9. 2011
    ..The aim of this study was to determine whether renal dysfunction affects the outcome of stroke patients treated with recombinant tissue plasminogen activator (rt-PA)...
  77. ncbi Screening for beneficial effects of oral intake of sweet corn by DNA microarray analysis
    Yoshihiko Tokuji
    Dept of Agriculture and Life Science, Obihiro Univ of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Food Sci 74:H197-203. 2009
    ..Dietary corn upregulated expression levels of genes that regulate apoptosis positively (for example, BOK, BID, CASP4). These results suggested that sweet corn is a valuable food for suppressing cancer...
  78. ncbi Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29209, USA
    Cancer 116:164-76. 2010
    ....
  79. ncbi Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies
    Caroline E Lovelock
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU
    Stroke 41:1222-8. 2010
    ..Insights could be gained by pooling data on MB frequency stratified by antithrombotic use in cohorts with ICH and ischemic stroke (IS)/transient ischemic attack (TIA)...
  80. ncbi Apoptotic gene expression in potentially fertile and subfertile men
    M C O Cavalcanti
    Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf Buchheim Str 7, Giessen D 35385, Germany
    Mol Hum Reprod 17:415-20. 2011
    ..DNA fragmentation and apoptosis, we investigated whether the DNA fragmentation factor 40 (DFF40) ratio or caspase (Casp4, Casp6) and tumor necrosis factor superfamily member 10 (TNFSF10) ratio together with the P1/P2 ratio represents a ..
  81. ncbi Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum
    Kana Takemoto
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Neurochem Int 58:880-7. 2011
    ..Thus, the present study revealed that mitochondria could be a potential regulator of the UPR in the ER through mitochondrial TRAP1...
  82. ncbi Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis
    Ling Fei Wu
    Department of Gastroenterology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, PR China
    Oncol Rep 26:73-9. 2011
    ..However, JNK protein expression was not altered. These results show that ERS is involved in the adenosine-induced HepG2 cell apoptosis...
  83. ncbi Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress
    Frank W King
    Bionovo Inc, Emeryville, California, United States of America
    PLoS ONE 4:e7283. 2009
    ..second, induction of endoplasmic reticulum stress culminating in phosphorylation of eIF2alpha and activation of caspase 4. These pro-apoptotic pathways are activated by TAIII selectively in tumor cells but not in normal cells...
  84. ncbi Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation
    Denis Selimovic
    INSERM U977, and Department of Operative Dentistry and Endodontics, Dental Faculty, University of Strasbourg, Strasbourg, France
    Carcinogenesis 32:1268-78. 2011
    ..In conclusion, our data provide insight into the molecular mechanism of APR-2-induced apoptosis and suggest APR-2 gene transfer as an alternative approach for the treatment of chemoresistance melanoma metastasis...
  85. ncbi Structure and chromosome localization of the human CASP8 gene
    J Grenet
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis TN 38101, USA
    Gene 226:225-32. 1999
    ..Thus, it appears that CASP8 and CASP10 have evolved by tandem gene duplication, much like the CASP1, CASP4 and CASP5 gene cluster on human chromosome 11q22.2-22.3.
  86. ncbi Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis
    Esther A Obeng
    Department of Microbiology and Immunology, The University of Miami School of Medicine, Florida 33101, USA
    J Biol Chem 280:29578-87. 2005
    ..These data suggest that caspase-12 and caspase-4 are not required for the induction of ER stress-induced apoptosis and that caspase-4-like activity is not always associated with an initiating event...
  87. ncbi Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model
    Travis Young
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1031, USA
    Oncogene 24:6174-84. 2005
    ..Cellular caspase 4 activity is, however, suppressed in the T29H cells, suggesting that the maturation process of caspase 4 is ..
  88. ncbi Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B
    E A Atkinson
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 273:21261-6. 1998
    ....
  89. ncbi Apoptosis in polycystic kidney disease: involvement of caspases
    S M Ali
    Departments of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Am J Physiol Regul Integr Comp Physiol 278:R763-9. 2000
    ..use of various substrates in enzyme activity assays, we have demonstrated a greater than sevenfold increase in caspase 4 activity and a sixfold increase in caspase 3 activity...
  90. ncbi Discrimination of native protein structures using atom-atom contact scoring
    Brendan J McConkey
    Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 100:3215-20. 2003
    ..and validated by using established protein decoy sets, including the "Rosetta" decoys and data from the CASP4 structure predictions...
  91. ncbi Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information
    Igor Tsigelny
    Department of Chemistry and Biochemistry 0654, University of California San Diego, La Jolla, CA 92093, USA
    Protein Eng 15:347-52. 2002
    ..We tested our program against all of the protein targets proposed in the CASP4 competition...
  92. ncbi Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracorporeal membrane oxygenation
    D Gazzolo
    Department of Neonatology, G Gaslini Children s University Hospital, Genoa, Italy
    Acta Paediatr 91:218-21. 2002
    ..24) (p < 0.05). CONCLUSION: This study suggests that blood S100B measurement could be a promising tool for the identification of infants at risk of ICH when imaging assessment and clinical symptoms of haemorrhage might still be silent...
  93. ncbi The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 157:115-24. 2002
    ....
  94. ncbi Application of PROSPECT in CASP4: characterizing protein structures with new folds
    D Xu
    Computational Biology Section, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830 6480, USA
    Proteins . 2001
    In the Fourth Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP4), we predicted all 43 targets using our threading application PROSPECT...
  95. ncbi CASP2 knowledge-based approach to distant homology recognition and fold prediction in CASP4
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, United Kingdom
    Proteins . 2001
    ..Four years later, in CASP4, we have applied essentially the same knowledge-based approach to distant homology recognition, concentrating our ..
  96. ncbi Assessment of the CASP4 fold recognition category
    M J Sippl
    Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, Austria
    Proteins . 2001
    We present the assessment of the CASP4 fold recognition category...
  97. ncbi Comparative modeling of CASP4 target proteins: combining results of sequence search with three-dimensional structure assessment
    C Venclovas
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Proteins . 2001
    ..proteins were submitted during the fourth round of "blind" protein structure prediction experiment (CASP4; http://PredictionCenter.llnl.gov/casp4)...
  98. ncbi Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL
    Sung Jo Kim
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1826-34. 2006
    ..Our results provide insight into at least one of the molecular mechanisms of apoptosis in INCL and may allow the identification of potential targets for therapeutic intervention...
  99. ncbi Inflammatory caspases and inflammasomes: master switches of inflammation
    F Martinon
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland
    Cell Death Differ 14:10-22. 2007
    ....
  100. ncbi Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors
    Katsue Miyoshi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Alzheimers Dis 16:551-64. 2009
    ..Our present data suggest that these PS1 mutants accelerate the activation of initiator caspases and promote apoptosis, which may be associated, at least in part, with amyloid-beta production...
  101. ncbi Control of ER stress by a chemical chaperone counteracts apoptotic signals in IFN-gamma-treated murine hepatocytes
    Keita Kanki
    Department of Pharmaceutical Sciences, Musashino University, 1 1 20 Shinmachi, Nishitokyo, Tokyo, Japan
    Apoptosis 14:309-19. 2009
    ..These results suggest that ER stress plays a crucial role in mediating apoptosis of hepatocytes induced by IFN-gamma, and a chemical chaperone is an effective inhibitor of the ER stress...

Research Grants62

  1. Site-specific Allosteric Inhibitors for Inflammatory Caspases
    James Wells; Fiscal Year: 2007
    ..These drugs would be anticipated to have more selectivity and less side effects than existing drugs. ..
  2. Site-specific Allosteric Inhibitors for Inflammatory Caspases
    James A Wells; Fiscal Year: 2010
    ..These drugs would be anticipated to have more selectivity and less side effects than existing drugs. ..
  3. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Julian Hoff; Fiscal Year: 2006
    ..The purpose of our project is to investigate the mechanisms involved in thrombin-induced brain edema. If our hypotheses are correct, these experiments may lead to novel methods of treating ICH. ..
  4. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Guohua Xi; Fiscal Year: 2009
    ..The purpose of our project is to investigate the mechanisms involved in thrombin-induced brain edema. If our hypotheses are correct, these experiments may lead to novel methods of treating ICH. ..
  5. Proteasome Inhibition and ER Stress
    David McConkey; Fiscal Year: 2009
    ....
  6. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2010
    ....
  7. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2011
    ....
  8. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    Lawrence H Boise; Fiscal Year: 2010
    ....
  9. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    LAWRENCE BOISE; Fiscal Year: 2009
    ....
  10. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    Lawrence H Boise; Fiscal Year: 2011
    ....
  11. MECHANISMS OF SECONDARY INJURY IN CEREBRAL HEMORRHAGE
    ALLYSON ZAZULIA; Fiscal Year: 2007
    ..These hypotheses will be tested using sequential PET or MRI studies in 60 patients with acute ICH. ..
  12. Role of Prostaglandin Receptors in Stroke
    SYLVAIN DORE; Fiscal Year: 2010
    ..Such information is required to develop and test receptor agonist/antagonist interventions for potential use in clinical trials for hemorrhagic stroke. ..
  13. Delayed Neurodegeneration After Intracerebral Hemorrhage
    Guohua Xi; Fiscal Year: 2007
    ..The long-term goal of our studies is to limit hemorrhagic brain injury. If our hypotheses are correct, these experiments may lead to novel therapies for ICH by either limiting iron overload or attenuating oxidative brain injury. ..
  14. INTERNAL BONDING IN PROTEINS
    HAROLD SCHERAGA; Fiscal Year: 2005
    ..With the additional correlation terms, we achieved partial success in CASP4. With improvements in the UNRES and all-atom force fields, and in global optimization methods, proposed here in ..
  15. ABCA3: Biosynthesis, Trafficking, and Cellular Responses in Health and Disease
    Surafel Mulugeta; Fiscal Year: 2010
    ..We believe the knowledge gained from this project will have a broad application not only toward a better understanding of lung pathogenesis but will offer insights for targeted therapeutic intervention. ..
  16. ABCA3: Biosynthesis, Trafficking, and Cellular Responses in Health and Disease
    Surafel Mulugeta; Fiscal Year: 2009
    ..We believe the knowledge gained from this project will have a broad application not only toward a better understanding of lung pathogenesis but will offer insights for targeted therapeutic intervention. ..
  17. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra E Juul; Fiscal Year: 2010
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  18. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  19. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  20. HEMIDESMOSOMAL PROTEIN LINKAGE MAP BY TWO-HYBRID SYSTEM
    Sirpa Aho; Fiscal Year: 2002
    ..abstract_text> ..
  21. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  22. BIOREGULATION OF THE SPERMATOGONIAL STEM CELL LINEAGE
    LAURA TRES; Fiscal Year: 2003
    ..2. In the long range, the discovery of ways to prevent and modulate spermatogonial cell death may have significant therapeutic and anticonceptive potentials in humans. ..
  23. Combined Methods for Protein-Structure Prediction
    Kevin Karplus; Fiscal Year: 2007
    ....
  24. Targeting Hexokinase II in Chemotherapy
    JOHN PASTORINO; Fiscal Year: 2009
    ....