CAPON

Summary

Gene Symbol: CAPON
Description: nitric oxide synthase 1 (neuronal) adaptor protein
Alias: 6330408P19Rik, CAPON, C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON), C-terminal PDZ ligand of neuronal nitric oxide synthase protein, carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain, nitric oxide synthase 1 adaptor protein
Species: human

Top Publications

  1. ncbi Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate
    Barbara Kremeyer
    The Galton Laboratory, Department of Biology, University College London, London, UK
    Hum Hered 67:163-73. 2009
  2. ncbi Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON
    M Fang
    Department of Neuroscience, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Neuron 28:183-93. 2000
  3. ncbi Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
  4. ncbi Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study
    Albert Jan L H J Aarnoudse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Circulation 116:10-6. 2007
  5. ncbi Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK
    Biol Psychiatry 59:195-7. 2006
  6. ncbi Identification of a schizophrenia-associated functional noncoding variant in NOS1AP
    Naomi S Wratten
    Rutgers University Department of Genetics, 145 Bevier Road, Piscataway, NJ 08854, USA
    Am J Psychiatry 166:434-41. 2009
  7. ncbi A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 38:644-51. 2006
  8. ncbi Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hum Hered 64:214-9. 2007
  9. ncbi Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Ann Med 41:144-51. 2009
  10. ncbi Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007

Research Grants

  1. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
  2. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2007
  3. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    SOLOMON SNYDER; Fiscal Year: 2007
  4. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2009
  5. Effects of Neonatal MDMA on Brain and Behavior
    Charles Vorhees; Fiscal Year: 2007
  6. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
  7. SYNAPTIC REGULATION OF NITRIC OXIDE
    David Bredt; Fiscal Year: 2005
  8. Elucidating the Role of miRNA Dysregulation in Schizophrenia and Bipolar Disorder
    Linda Brzustowicz; Fiscal Year: 2007
  9. Genetic Components of Autism Spectrum Disorders
    Linda Brzustowicz; Fiscal Year: 2006
  10. Molecular Genetics of Schizophrenia Susceptibility
    Linda Brzustowicz; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications102 found, 100 shown here

  1. ncbi Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate
    Barbara Kremeyer
    The Galton Laboratory, Department of Biology, University College London, London, UK
    Hum Hered 67:163-73. 2009
    ....
  2. ncbi Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON
    M Fang
    Department of Neuroscience, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Neuron 28:183-93. 2000
    ..Here we identify a selective interaction of the nNOS adaptor protein CAPON with Dexras1, a brain-enriched member of the Ras family of small monomeric G proteins...
  3. ncbi Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
    ..5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias...
  4. ncbi Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study
    Albert Jan L H J Aarnoudse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Circulation 116:10-6. 2007
    ..In a recent genome-wide association study, a common variant (rs10494366) in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene was found to be associated with QT-interval variation...
  5. ncbi Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK
    Biol Psychiatry 59:195-7. 2006
    ..It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families...
  6. ncbi Identification of a schizophrenia-associated functional noncoding variant in NOS1AP
    Naomi S Wratten
    Rutgers University Department of Genetics, 145 Bevier Road, Piscataway, NJ 08854, USA
    Am J Psychiatry 166:434-41. 2009
    ..In this study the authors sought to apply novel statistical methods and conduct additional biological experiments to isolate at least one risk allele within NOS1AP...
  7. ncbi A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 38:644-51. 2006
    ..This genome-wide study identified NOS1AP (CAPON), a regulator of neuronal nitric oxide synthase, as a new target that modulates cardiac repolarization...
  8. ncbi Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish
    Wendy Post
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hum Hered 64:214-9. 2007
    ..genome-wide association study, we discovered an association of the electrocardiographic QT interval with polymorphisms in the NOS1AP (CAPON) gene. The purpose of the current study was to replicate this association in the Old Order Amish.
  9. ncbi Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Ann Med 41:144-51. 2009
    Common genetic variants in the nitric oxide synthase 1 adaptor protein gene (NOS1AP) and in the HERG potassium channel gene (KCNH2) have been associated with cardiac repolarization in middle-aged and elderly subjects.
  10. ncbi Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
    ..We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits...
  11. ncbi A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers
    Matthijs L Becker
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Br J Clin Pharmacol 67:61-7. 2009
    ..The aim was to investigate whether this polymorphism is associated with cardiovascular mortality in users of CCBs...
  12. ncbi Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center 3000, CA, Rotterdam, The Netherlands
    Hum Mol Genet 18:347-57. 2009
    ..In genome-wide association studies, a common variant (rs10494366T > G) within the nitric oxide synthase 1 adaptor protein (NOS1AP) gene was identified and consistently associated with QT-interval duration...
  13. ncbi Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 57:1108-14. 2008
    ..We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of ..
  14. ncbi Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea
    Matthijs L Becker
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenet Genomics 18:591-7. 2008
    The single nucleotide polymorphism rs10494366 in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene is associated with QTc prolongation, through an effect on the intracellular Ca levels...
  15. ncbi Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population
    Yonglan Zheng
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Biochem Biophys Res Commun 328:809-15. 2005
    ..Recently, some genetic variants within CAPON have been reported as exhibiting significant linkage disequilibrium to schizophrenia in Canadian familial-..
  16. ncbi Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    Arne Pfeufer
    Institute of Human Genetics, Helmholtz Center Munich, Germany
    Nat Genet 41:407-14. 2009
    ..These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD...
  17. ncbi Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON
    Samie R Jaffrey
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:3199-204. 2002
    ..Here, we show that the nNOS adapter protein, CAPON, interacts with synapsins I, II, and III through an N-terminal phosphotyrosine-binding domain interaction, which ..
  18. ncbi Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder
    Bin Xu
    Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS Med 2:e263. 2005
    ..between schizophrenia and markers within the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON). Prior sequencing of the ten exons of CAPON failed to reveal a coding mutation associated with illness.
  19. ncbi Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
    Martin D Tobin
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1132-41. 2008
    ..We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise...
  20. ncbi CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95
    S R Jaffrey
    The Johns Hopkins University School of Medicine, Department of Neuroscience, Pharmacology and Molecular Sciences, Baltimore, Maryland 21205, USA
    Neuron 20:115-24. 1998
    ..Here, we report the identification of a novel nNOS-associated protein, CAPON, which is highly enriched in brain and has numerous colocalizations with nNOS...
  21. ncbi Effect of caponization and exogenous androgens implantation on blood lipid and lipoprotein profile in male chickens
    K L Chen
    Department of Animal Science, National Chiayi University 600, Taiwan
    Poult Sci 89:924-30. 2010
    ..Sixteen intact caponized (capon) male chickens and 16 female chickens were assigned for trial 1, and 16 sham-operated (sham) male chickens and 64 ..
  22. ncbi Effects of caponization and different forms of exogenous androgen implantation on immunity in male chicks
    K L Chen
    Department of Animal Science, National Chiayi University, Chiayi 600, Taiwan
    Poult Sci 89:887-94. 2010
    ..Each of 27 sham-operated (sham) and caponized (capon) male chickens were used for trial 1...
  23. ncbi Siderophore production by marine-derived fungi
    Brian Holinsworth
    Department of Natural Sciences, Northeastern State University, Tahlequah, OK 74464, USA
    Biometals 22:625-32. 2009
    ..strain produced the rare catecholate siderophore pistillarin when grown under relatively high iron concentrations (Capon et al. J Nat Prod 70:1746-1752, 2007)...
  24. ncbi A novel M3 muscarinic acetylcholine receptor is expressed in chick atrium and ventricle
    A P Gadbut
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    J Biol Chem 269:25823-9. 1994
    ..G., Ashkenazi, A., Winslow, J.W., Smith, D.H., Ramachandran, J., and Capon, D.J. (1987) EMBO J. 6, 3923-3929). Tietje and Nathanson (Tietje, K.M., and Nathanson, N. M. (1991) J. Biol. Chem...
  25. ncbi CAPON expression in skeletal muscle is regulated by position, repair, NOS activity, and dystrophy
    Laurent Segalat
    CNRS UPR5534, Université Lyon 1 and Institut Cochin, INSERM U567, 75014 Paris, France
    Exp Cell Res 302:170-9. 2005
    ..In neurons, the adaptor protein, carboxy-terminal PDZ ligand of nNOS (CAPON), regulates the distribution of neuronal nitric oxide synthase (nNOS), which produces the key signaling molecule ..
  26. ncbi Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95
    H Tochio
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, Kowloon, P R China
    J Mol Biol 295:225-37. 2000
    ..The interaction of the PSD-95 PDZ2 with a carboxyl-terminal peptide derived from a cytoplasmic protein CAPON was studied by NMR titration experiments...
  27. ncbi GAPDH mediates nitrosylation of nuclear proteins
    Michael D Kornberg
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 12:1094-100. 2010
    ..5) and CAPON. As the three principal isoforms of NOS--neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS)--are ..
  28. ncbi High range resolution medical acoustic vascular imaging with frequency domain interferometry
    Hirofumi Taki
    Graduate School of Informatics, Department of Communications and Computer Engineering, Kyoto University, Japan
    Conf Proc IEEE Eng Med Biol Soc 2010:5298-301. 2010
    For high range resolution acoustic vascular imaging we apply frequency domain interferometry and Capon method to a few frames of in-phase and quadrature (IQ) data acquired by a commercial ultrasonographic device...
  29. ncbi Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 203:713-22. 2009
    ..Previous studies have suggested that there is an inverse genetic relationship between ethanol consumption (two-bottle choice, continuous access) and ethanol withdrawal (e.g., Metten et al., Behav Brain Res 95:113-122, 1998a)...
  30. ncbi Spatiotemporal expression of Dexras1 after spinal cord transection in rats
    Xin Li
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, 19 Qi xiu Road, Nantong, Jiangsu 226001, China
    Cell Mol Neurobiol 28:371-88. 2008
    ..Furthermore, colocalization of Dexras1, carboxy-terminal PSD95/DLG/ZO-1 (PDZ) ligand of nNOS (CAPON) and nNOS was observed in neurons and glial cells, supporting the existence of ternary complexes in this model...
  31. ncbi Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene
    Janice A Husted
    Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada
    Schizophr Res 121:187-92. 2010
    ..61, 11.91, respectively). The results suggest that childhood trauma is associated with expression of schizophrenia independent of measured genetic susceptibility and may be a candidate for gene-environment research using genetic variants...
  32. ncbi Changes in mRNA for post-synaptic density-95 (PSD-95) and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase following facial nerve transection
    Y H Che
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Japan
    Brain Res Mol Brain Res 76:325-35. 2000
    ..neuronal nitric oxide synthase (nNOS), which is competitively inhibited by carboxy-terminal PDZ ligand of nNOS (CAPON) and, thereby, nNOS activity is thought to be regulated by PSD-95 and CAPON...
  33. ncbi Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk
    K K Nicodemus
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 13:873-7. 2008
    ..of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1, PRODH, RGS4, TNF-alpha) interacted with serious obstetric ..
  34. ncbi In-vivo validation of fast spectral velocity estimation techniques
    K L Hansen
    Section of Ultrasound, Department of Radiology, Rigshospitalet, Blegdamsvej 9, DK 2100 Kbh Ø, Denmark
    Ultrasonics 50:52-9. 2010
    ..Two adaptive filterbank methods have been suggested to reduce the OW: Blood spectral Power Capon (BPC) and the Blood Amplitude and Phase EStimation method (BAPES)...
  35. ncbi Capon beamforming in medical ultrasound imaging with focused beams
    Francois Vignon
    Philips Research North America, Ultrasound Imaging and Therapy, Briarcliff Manor, NY, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 55:619-28. 2008
    ..It leads to images with limited resolution and contrast. This paper presents an adaptation of the Capon beamformer algorithm to ultrasound medical imaging with focused beams...
  36. ncbi Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q
    Inga Prokopenko
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Diabetes 58:1704-9. 2009
    ..We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search for variants responsible for this linkage signal...
  37. ncbi Neuronal-NOS adaptor protein expression after spreading depression: implications for NO production and ischemic tolerance
    Amanda K Wiggins
    Howard Florey Institute of Experimental Physiology and Medicine, Department of Medicine, Austin and Repatriation Medical Centre, The University of Melbourne, Victoria, Australia
    J Neurochem 87:1368-80. 2003
    ..Therefore, the present study examined the effect of CSD on the spatiotemporal expression of PIN, CAPON, PSD-95, Mn-SOD and Cu/Zn-SOD mRNA in the rat brain...
  38. ncbi The genome-wide expression profile of Nelumbinis semen on lipopolysaccharide-stimulated BV-2 microglial cells
    Sung Hwa Sohn
    Department of Physiology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Biol Pharm Bull 32:1012-20. 2009
    ..These results suggested that NS can affect the MAPK signaling pathway and mitochondrial functions in BV-2 cells activated with LPS...
  39. ncbi No evidence for excess runs of homozygosity in bipolar disorder
    Anna E Vine
    Centre for Psychiatry, University College London, UK
    Psychiatr Genet 19:165-70. 2009
    ..Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3)...
  40. ncbi Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia
    Rainald Schmidt-Kastner
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
    Schizophr Res 84:253-71. 2006
    ..The analysis showed that more than 50% of these genes, particularly AKT1, BDNF, CAPON, CCKAR, CHRNA7, CNR1, COMT, DNTBP1, GAD1, GRM3, IL10, MLC1, NOTCH4, NRG1, NR4A2/NURR1, PRODH, RELN, RGS4, RTN4/..
  41. ncbi Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene
    T Watanabe
    Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan
    J Biol Chem 265:7432-9. 1990
    ..De Caro, A. M., Adrich, Z., Fournet, B., Capon, C., Bonicel, J. J., De Caro, J. D., and Rovery, M. (1989) Biochim. Biophys...
  42. ncbi Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: a preliminary report
    Gregory Costain
    Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 122:81-4. 2010
    ..These results suggest that the changes are primarily due to genetic risk and not illness effects, and may represent an intermediate phenotype...
  43. ncbi Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls
    Richard Delorme
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 11:108. 2010
    ..Previous genetic and functional studies explored the role of NOS1AP in these psychiatric conditions, but only a limited number explored the sequence variability of NOS1AP...
  44. ncbi Norterpenoids and related peroxides from the formosan marine sponge Negombata corticata
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 73:1538-43. 2010
    ..on the basis of interpretation of spectroscopic data and by the application of the empirical rule established by Capon and MacLeod...
  45. ncbi Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules
    A Traunecker
    Basel Institute for Immunology, Switzerland
    Nature 339:68-70. 1989
    ..Similar chimaeric molecules, combining CD4 with human IgG were recently described by Capon et al., but these included the CH1 domain and did not bind Clq...
  46. ncbi Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population
    C Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, People s Republic of China
    Diabetologia 53:290-8. 2010
    ..Although this association was not replicated in additional samples of European descent, it remains unknown whether NOS1AP plays a role in Chinese individuals...
  47. ncbi Genomic landscape of positive natural selection in Northern European populations
    Tuuli Lappalainen
    Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    Eur J Hum Genet 18:471-8. 2010
    ..Altogether, this study demonstrates the potential of genome-wide data sets to discover loci that lie behind evolutionary adaptation in different human populations...
  48. ncbi NOS1AP is a genetic modifier of the long-QT syndrome
    Lia Crotti
    Department of Lung, Blood, and Heart, University of Pavia, Pavia, Italy
    Circulation 120:1657-63. 2009
    ..Recent evidence indicates that common variants in NOS1AP are associated with the QT-interval duration in the general population...
  49. ncbi Association of the rs10918594 of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphisms with the graft function after kidney transplantation
    Maciej Zukowski
    Department of Anaesthetics and Intensive Care, Pomeranian Medical University, Szczecin, Poland
    Ann Transplant 16:72-6. 2011
    The purpose of this study was to investigate the relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function (DGF) in kidney transplant recipients.
  50. ncbi NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study
    A Y Chu
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
    Diabetologia 53:510-6. 2010
    ....
  51. ncbi Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II
    Neeru M Sharma
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 92:348-57. 2011
    ..NR(1) and nNOS are normally linked, they can be disconnected by nNOS sequestering with nNOS-associated protein (CAPON)...
  52. ncbi In-vivo studies of new vector velocity and adaptive spectral estimators in medical ultrasound
    Kristoffer Lindskov Hansen
    Department of Radiology, Rigshospitalet, Blegdamsvej 9, 2200 Copenhagen, Denmark
    Dan Med Bull 57:1-23. 2010
    ..Directional Beamforming and Plane Wave Excitation) and adaptive spectral estimators (Blood spectral Power Capon and Blood Amplitude and Phase Estimation)...
  53. ncbi N-phenylglucosylamine hydrolysis: a mechanistic probe of ?-glucosidase
    Ying Na
    Department of Chemistry, Tulane University, New Orleans, LA 70118, USA
    Bioorg Chem 39:111-3. 2011
    ..The reason for this (as pointed out by Capon and Connett in 1965) is that, in contrast to the mechanism for O- or S-glycoside hydrolysis, hydrolysis of these N-..
  54. ncbi Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
    ..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
  55. ncbi Filterbank spectral estimators for the analysis of surface EMG signals during isometric contractions
    Stephen R Alty
    King s College London, Division of Engineering, WC2R 2LS, UK
    Conf Proc IEEE Eng Med Biol Soc 2010:3527-30. 2010
    ..this paper we propose the use of data-adaptive filterbank spectral analysis techniques, namely the Power Spectrum Capon (PSC) and the Amplitude Spectrum Capon (ASC) methods...
  56. ncbi Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease
    Shawn K Westaway
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Circ Cardiovasc Genet 4:397-402. 2011
    ..We conducted a systematic candidate-gene approach using haplotype-tagging single nucleotide polymorphisms (htSNPs) to identify genes associated with SCD risk in the context of CAD...
  57. ncbi Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome
    Marta Tomas
    Molecular Cardiology Laboratories, IRCCS Salvatore Maugeri Foundation, Pavia, Italy
    J Am Coll Cardiol 55:2745-52. 2010
    ..We investigated the role of nitric oxide 1 adaptor protein (NOS1AP) as a genetic modifier of long QT syndrome (LQTS)...
  58. ncbi A common variant of NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes
    J Lu
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China
    Diabet Med 27:1074-9. 2010
    ..The aim of the study was to investigate the association of polymorphisms of the nitric oxide synthase 1 adaptor protein (NOS1AP) gene with QT interval in Chinese subjects with or without Type 2 diabetes.
  59. ncbi NOS1AP associates with Scribble and regulates dendritic spine development
    Lindsay Richier
    Departments of Pharmacology, Surgery, and Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Neurosci 30:4796-805. 2010
    ..with neuronal nitric oxide synthase (nNOS) adaptor protein (NOS1AP) [also known as C-terminal PDZ ligand of nNOS (CAPON)] and is found both presynaptically and postsynaptically...
  60. ncbi Effect of caponization and exogenous androgen implantation on muscle characteristics of male chickens
    T T Chen
    Graduate Institute of Agriculture, National Chiayi University, Chiayi, Taiwan
    Poult Sci 89:558-63. 2010
    ..Sixteen intact males and caponized (capon) chickens each were assigned for trial 1...
  61. ncbi A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese
    Wen Qin
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
    Acta Pharmacol Sin 31:450-4. 2010
    ..To investigate a potential association between SNP rs10494366 in the neural nitric oxide synthase adaptor protein (NOS1AP) and efficacy of repaglinide (an insulin secretagogue) in newly diagnosed Shanghai Chinese type 2 diabetes patients...
  62. ncbi The nuclear localization of CAPON in hippocampus and cerebral cortex neurons after lipopolysaccharide stimulation
    Bai Shao
    Department of Neurosurgery, Affiliated Dongtai Hospital of Nantong University, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, PR China
    Neuroimmunomodulation 18:89-97. 2011
    ..b>CAPON, a nNOS regulator, helps regulate nNOS stability, localization and possibly expression during synapse formation as ..
  63. ncbi Spatiotemporal patterns of dexamethasone-induced Ras protein 1 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis
    Heng Gao
    The Affiliated Jiangyin Hospital of Nantong University, The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226001, People s Republic of China
    J Mol Neurosci 41:198-209. 2010
    ..neuronal nitric oxide synthase (nNOS) that could form a ternary complex with carboxy-terminal PDZ ligand of nNOS (CAPON) and nNOS, to specific targets to enhance NO signaling...
  64. ncbi Inhibition of nitric oxide-induced nuclear localization of CAPON by NMDA receptor antagonist in cultured rat primary astrocytes
    Jing Jiang
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province 226001, PR China
    Neurochem Int 56:561-8. 2010
    ..In the present study, we found that carboxy-terminal PDZ ligand of nNOS (CAPON) mainly located in the nucleus of astrocytes stimulated with NO donor sodium nitroprusside (SNP) or GSNO or N-..
  65. ncbi Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells
    Jose M Moran
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Nitric Oxide 23:51-9. 2010
    ....
  66. ncbi A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project
    Fabio Marroni
    Institute of Genetic Medicine, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany
    Circ Cardiovasc Genet 2:322-8. 2009
    ..We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations...
  67. ncbi Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hum Mol Genet 18:4213-8. 2009
    ..69, P = 0.23; joint HR = 0.60, P = 0.0018). In conclusion, this study provided additional evidence for association between genetic variation within NOS1AP and SCD. The mechanism by which this effect is exerted remains to be elucidated...
  68. ncbi Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression
    Gregers Wegener
    Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
    Int J Neuropsychopharmacol 13:461-73. 2010
    ..transcript expression of upstream regulatory proteins in the NMDA-NO signalling pathway, including NMDAR1, nNOS, CAPON, PIN and PSD95...
  69. ncbi Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli, 5, 40123 Bologna BO, Italy
    Curr Med Chem 15:2472-517. 2008
    ..The selected variants, both mutations and polymorphisms, may help in defining a next-to-come genetic assessment to be performed before drug prescription in order to improve drug safety...
  70. ncbi Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120
    J A McKeating
    Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    J Virol 67:4932-44. 1993
    ..A. Lasky, G. M. Nakamura, D. H. Smith, C. Fennie, C. Shimasaki, E. Patzer, P. Berman, T. Gregory, and D. Capon, Cell 50:975-985, 1987; and U. Olshevsky, E. Helseth, C. Furman, J. Li, W. Haseltine, and J. Sodroski, J. Virol...
  71. ncbi Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
    Eur J Hum Genet 16:1275-82. 2008
    ..to satisfactorily confirm previously reported associations between schizophrenia and the genes RGS4 and NOS1AP/CAPON. These genes flank UHMK1 and all three loci are within a 700 kb region showing linkage to schizophrenia...
  72. ncbi Involvement of CAPON and nitric oxide synthases in rat muscle regeneration after peripheral nerve injury
    Mengling Chen
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, China
    J Mol Neurosci 34:89-100. 2008
    Carboxy-terminal PDZ ligand of nNOS (CAPON) protein, as an adaptor, binds to nNOS via the PDZ domain helping regulate neuronal nitric oxide synthase (nNOS) activity at post-synaptic sites in neurons (Jaffrey et al...
  73. ncbi Expression of CAPON after spinal cord injury in rats
    Chun Cheng
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, 19 Qi xiu Road, Nantong, Jiangsu 226001, China
    J Mol Neurosci 34:109-19. 2008
    The adaptor protein, carboxy-terminal PDZ ligand of nNOS (CAPON), regulates the distribution of neuronal nitric oxide synthase (nNOS) that increased after spinal cord injury (SCI) and produces the key signaling molecule nitric oxide (NO)...
  74. ncbi Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection
    Aiguo Shen
    The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, People s Republic of China
    J Chem Neuroanat 35:85-93. 2008
    ..disc large tumor suppressor/zonula occuldens-1 protein (PDZ) ligand of neuronal nitric oxide synthase (CAPON), as an adaptor, interacts with nNOS via the PDZ domain helping regulate nNOS activity at postsynaptic sites in ..
  75. ncbi eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?
    Christopher J Carter
    Schizophr Bull 33:1343-53. 2007
    ..Both may affect common stress-related signaling pathways that dictate oligodendrocyte viability and synaptic plasticity...
  76. ncbi Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene
    Vinay Puri
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, London, UK
    Biol Psychiatry 61:873-9. 2007
    ..Based on this information, several research groups have published evidence that markers within both the RGS4 and CAPON genes, which are 700 kb apart, independently showed allelic association with schizophrenia...
  77. ncbi Multistatic adaptive microwave imaging for early breast cancer detection
    Yao Xie
    Department of Electrical and Computer Engineering, University of Florida, Gainesville 32611, USA
    IEEE Trans Biomed Eng 53:1647-57. 2006
    ..MAMI is a two-stage robust Capon beamforming (RCB) based image formation algorithm...
  78. ncbi Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22
    Linda M Brzustowicz
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Am J Hum Genet 74:1057-63. 2004
    ..fall within the genomic extent of the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON), making it a prime positional candidate for the schizophrenia-susceptibility locus on 1q22, although initial ..
  79. ncbi The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells
    T Ort
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Eur J Cell Biol 79:621-30. 2000
    ..Thus, we propose that ICA512, through beta2-syntrophin and nNOS, links secretory granules with the actin cytoskeleton and signaling pathways involving nitric oxide...
  80. ncbi Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans
    K Gieseler
    CGMC, CNRS UMR5534, Universite Lyon 1, 43 Boulevard du 11 Novembre, 69622, Villeurbanne Cedex, France
    Curr Biol 10:1092-7. 2000
    ..The nematode worm Caenorhabditis elegans has a dystrophin homologue (dys-1), but null mutations in dys-1 do not result in muscle degeneration...
  81. ncbi Common candidate gene variants are associated with QT interval duration in the general population
    A Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Intern Med 265:448-58. 2009
    ..As 30-40% of the QT-interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population-based sample...
  82. ncbi Adaptive spectral doppler estimation
    Fredrik Gran
    GN ReSound A S Algorithm R and D, Ballerup, Denmark
    IEEE Trans Ultrason Ferroelectr Freq Control 56:700-14. 2009
    ..The blood power spectral capon (BPC) method is based on a standard minimum variance technique adapted to account for both averaging over slow-..
  83. ncbi NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway
    Damien Carrel
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    J Neurosci 29:8248-58. 2009
    ..Our work explored possible roles played by nitric oxide synthase 1 adaptor protein (NOS1AP; also known as C-terminal PDZ ligand of neuronal nitric oxide synthase or CAPON) in ..
  84. ncbi Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation
    Charlotte van Noord
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Pharmacogenet Genomics 19:260-6. 2009
    ..To study whether NOS1AP single nucleotide polymorphisms (SNPs), rs10494366 T>G and rs10918594 C>G, modify the heart-rate-corrected QT (QTc) prolonging effect of calcium channel blockers...
  85. ncbi Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4333. 2009
    ..These results highlight the consistent and complex role of NOS1AP genetic variants in modulating QT interval...
  86. ncbi Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies
    Ilja M Nolte
    Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 4:e6138. 2009
    ..These data offer further mechanistic insights into genetic influence on the QT interval which may predispose to life threatening arrhythmias and sudden cardiac death...
  87. ncbi Effect of caponization and different exogenous androgen on hepatic lipid and beta-oxidase of male chickens
    K L Chen
    Department of Animal Science, National Chiayi University, Chiayi, Taiwan
    Poult Sci 88:1033-9. 2009
    ..Sixteen each male caponized (capon) and female chickens were assigned for trial 1, and 16 sham-operated (sham) and 64 capons were selected in trial 2,..
  88. ncbi Research progress on neurobiology of neuronal nitric oxide synthase
    Chun Xia Luo
    Department of Pharmacology, School of Pharmacy, Laboratory of Cerebrovascular Disease, Nanjing Medical University, Nanjing 210029, China
    Neurosci Bull 27:23-35. 2011
    ..large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and dynein light chain (LC)...
  89. ncbi Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats
    Marco Orsetti
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche DiSCAFF, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    Pharmacogenet Genomics 19:600-12. 2009
    ..The aim of this study was to investigate the molecular mechanism(s) of QTP antidepressant effect by coupling the CMS protocol with Affymetrix microarray technology to screen the entire rat genome for gene changes in the frontal cortex...
  90. ncbi An efficient method of early caponization in slow-growing meat-type chickens
    K Rikimaru
    Livestock Experiment Station, Akita Prefectural Agriculture, Forestry and Fisheries Research Center, Jin guji, Daisen 019 1701, Akita, Japan
    Poult Sci 90:1852-7. 2011
    ..shortens the caponizing time significantly and improves the decrease in the daily weight gain after caponization, thereby enabling efficient capon production from slow-growing meat-type chickens at early stages of development.
  91. ncbi Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury
    Zhiming Cui
    The Second Hospital of Nantong University, Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China
    Vet J 187:374-80. 2011
    Neuronal nitric oxide synthase (nNOS) has been implicated in peripheral nerve lesions and regeneration. The CAPON adaptor protein interacts with the PDZ domain of nNOS, helping to regulate nNOS activity at post-synaptic sites in neurones,..
  92. ncbi Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters
    Kimmo Porthan
    Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
    Heart Rhythm 7:898-903. 2010
    ....
  93. ncbi Beamspace adaptive beamforming for ultrasound imaging
    Carl Inge Colombo Nilsen
    Dept of Inf, Univ of Oslo, Oslo, Norway
    IEEE Trans Ultrason Ferroelectr Freq Control 56:2187-97. 2009
    Applying the Capon adaptive beamformer in medical ultrasound imaging results in enhanced resolution by improving the interference-suppressing capabilities of the array...
  94. ncbi Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
    M Gotthardt
    Department of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas 75390-9046, USA
    J Biol Chem 275:25616-24. 2000
    ..They form the basis for the elucidation of the molecular pathways by which cells respond to the diversity of ligands that bind to these multifunctional receptors on the cell surface...
  95. ncbi Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
    Camilla Helene Andreasen
    Steno Diabetes Center, 2820 Gentofte, Denmark
    BMC Med Genet 9:118. 2008
    ..encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal) adaptor protein (CAPON) are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak...
  96. ncbi Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
    Todd Lencz
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Proc Natl Acad Sci U S A 104:19942-7. 2007
    ..Other risk ROHs feature haplotypes that are also common in healthy individuals, possibly indicating a source of balancing selection...
  97. ncbi Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations
    W H Linda Kao
    Department of Epidemiology, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Circulation 119:940-51. 2009
    ..association study demonstrated that allelic variants (rs10494366 and rs4657139) in the nitric oxide synthase 1 adaptor protein (NOS1AP), which encodes a carboxy-terminal PDZ ligand of neuronal nitric oxide synthase, are ..
  98. ncbi CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart
    Kuan Cheng Chang
    Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:4477-82. 2008
    ..Apart from the rare disease-causing mutations, common genetic variants in CAPON, a neuronal nitric oxide synthase (NOS1) regulator, have recently been associated with QT interval variations in a ..
  99. ncbi Family-based association studies of CAPON and schizophrenia in the Chinese Han population
    C Fang
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Prog Neuropsychopharmacol Biol Psychiatry 32:1210-3. 2008
    Although there is evidence pointing to CAPON as a susceptible gene for schizophrenia, the results of independent association studies have so far been inconsistent. A recent case-control study by Zheng et al...
  100. ncbi Genetic variation in the NOS1AP gene is associated with the incidence of diabetes mellitus in users of calcium channel blockers
    M L Becker
    Diabetologia 51:2138-40. 2008

Research Grants75

  1. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..NMDA receptors by 3H-MK-801 autoradiography and receptor complex-associated immunocytochemistry for PSD95, nNOS, CAPON, Dexras1, and Synapsin I-III...
  2. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2007
    ..NMDA receptors by 3H-MK-801 autoradiography and receptor complex-associated immunocytochemistry for PSD95, nNOS, CAPON, Dexras1, and Synapsin I-III...
  3. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    SOLOMON SNYDER; Fiscal Year: 2007
    ..2) nNOS Associated Proteins-Focus on CAPON: CAPON is a nNOS associated protein we discovered, which may serve as a scaffold linking nNOS to other proteins...
  4. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2009
    ..In addition, as part of the American Recovery and Reinvestment Act, this Competitive Revision will provide job opportunities and security and stimulate the economy. ..
  5. Effects of Neonatal MDMA on Brain and Behavior
    Charles Vorhees; Fiscal Year: 2007
    ..New data show that exposed offspring have altered expression of CAPON, PSD95, nNOS, and NMDA-NR1 (all members of the NMDA receptor complex)...
  6. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ..New data show that exposed offspring have altered expression of CAPON, PSD95, nNOS, and NMDA-NR1 (all members of the NMDA receptor complex)...
  7. SYNAPTIC REGULATION OF NITRIC OXIDE
    David Bredt; Fiscal Year: 2005
    ..PDZ domain contains a conserved binding pocket that associates with the C-termini of certain proteins including CAPON and phosphofructokinase...
  8. Elucidating the Role of miRNA Dysregulation in Schizophrenia and Bipolar Disorder
    Linda Brzustowicz; Fiscal Year: 2007
    ..A better understanding of microRNA function in the normal and pathological state could provide novel insights into new therapeutic approaches for schizophrenia and bipolar disorder. ..
  9. Genetic Components of Autism Spectrum Disorders
    Linda Brzustowicz; Fiscal Year: 2006
    ..abstract_text> ..
  10. Molecular Genetics of Schizophrenia Susceptibility
    Linda Brzustowicz; Fiscal Year: 2007
    ..We anticipate that these methods will be of future use for finding additional susceptibility genes for schizophrenia and other complex disorders. ..
  11. Genetic Components of Autism Spectrum Disorders
    Linda Brzustowicz; Fiscal Year: 2007
    ..abstract_text> ..
  12. MOLECULAR GENETICS OF SCHIZOPHRENIA LOCUS ON 1Q21-22
    Linda Brzustowicz; Fiscal Year: 2003
    ..Unraveling the genetics of this complex disorder will also facilitate the investigation of the environmental triggers of disease expression, and could ultimately lead to strategies to prevent the onset of clinical symptoms. ..
  13. Elucidating the Role of miRNA Dysregulation in Schizophrenia and Bipolar Disorder
    Linda M Brzustowicz; Fiscal Year: 2010
    ..A better understanding of microRNA function in the normal and pathological state could provide novel insights into new therapeutic approaches for schizophrenia and bipolar disorder. ..
  14. Identification and Functional Assessment of Autism Susceptibility Genes
    Linda Brzustowicz; Fiscal Year: 2009
    ..These accomplishments will lead to important translational research so that better diagnoses, treatments and preventions can be developed for ASD. ..
  15. Neurocircuitry Mapping and Genotyping Core
    Robert Hitzemann; Fiscal Year: 2007
    ..The core will also provide (aim 4) tissue for gene array and proteomics analyses and a high thoughput SNP genotyping facility for all INIA-West investigators. ..
  16. Mapping the Genes for Complex Behavioral Traits
    Robert J Hitzemann; Fiscal Year: 2010
    ..With this information in hand, it should be possible to develop new therapeutic strategies and interventions. . ..
  17. Genome-Wide Screens for Autism Susceptibility Loci
    Dan Arking; Fiscal Year: 2004
    ..These techniques should prove particularly robust for susceptibility gene identification, as they are not hindered by the current limited understanding of both gene function and regulation. ..
  18. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
    ..We believe the second conference will be even more successful than the first. ..
  19. MAPPING THE GENES FOR ETHANOL AND DOPAMINE PHENOTYPES
    Robert Hitzemann; Fiscal Year: 2003
    ....
  20. Mapping the Genes for Ethanol Related Phenotypes
    Robert Hitzemann; Fiscal Year: 2007
    ..We argue that such multiple sources of evidence will exclude the possibility of a false positive result. Aim 5 will test this hypothesis ..
  21. Subclinical Vascular Disease and Metabolic Abnormalities in MACS
    Wendy Post; Fiscal Year: 2009
    ..Results can be used to target prevention strategies. (End of Abstract) ..
  22. Identifying Molecular Subtypes of Schizophrenia: A Novel Genomic Approach
    Todd Lencz; Fiscal Year: 2010
    ..Findings will create new opportunities for diagnosis and prediction of schizophrenia, and for understanding its biology. ..
  23. MESA Family Study
    Wendy Post; Fiscal Year: 2007
    ....
  24. Identifying Molecular Subtypes of Schizophrenia: A Novel Genomic Approach
    Todd Lencz; Fiscal Year: 2009
    ..Findings will create new opportunities for diagnosis and prediction of schizophrenia, and for understanding its biology. ..
  25. MESA Family Study
    Wendy Post; Fiscal Year: 2004
    ..abstract_text> ..
  26. Identifying & Characterizing Prodromal Schizophrenia
    Todd Lencz; Fiscal Year: 2007
    ..This study will provide the candidate with the knowledge and research experience necessary to apply for an R01 to expand upon this research from a neurodevelopmental perspective. ..
  27. Genetic determinants of cardiac repolarization
    Christopher Newton Cheh; Fiscal Year: 2007
    ..Through the proposed research and educational training, Dr. Newton-Cheh will acquire the skills needed to pursue independent cardiovascular research at the cutting edge of genomic science. ..
  28. Subclinical Vascular Disease and Metabolic Abnormalities in MACS
    Wendy S Post; Fiscal Year: 2010
    ..Results can be used to target prevention strategies. (End of Abstract) ..