biglycan

Summary

Gene Symbol: biglycan
Description: biglycan
Alias: DSPG1, PG-S1, PGI, SLRR1A, biglycan proteoglycan, bone/cartilage proteoglycan I, bone/cartilage proteoglycan-I, dermatan sulphate proteoglycan I, small leucine-rich protein 1A
Species: human

Top Publications

  1. ncbi Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
    T Xu
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:78-82. 1998
  2. ncbi Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1
    Betty Reinboth
    Department of Pathology, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 277:3950-7. 2002
  3. ncbi The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
    Cells Tissues Organs 189:153-7. 2009
  4. ncbi The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins
    R V Iozzo
    Department of Pathology, Anatomy, and Cell Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:18843-6. 1999
  5. ncbi Interaction of biglycan with type I collagen
    E Schonherr
    Institute of Physiological Chemistry and Pathobiochemistry University of Münster, Federal Republic of Germany
    J Biol Chem 270:2776-83. 1995
  6. ncbi WISP-1 binds to decorin and biglycan
    L Desnoyers
    Department of Protein Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    J Biol Chem 276:47599-607. 2001
  7. ncbi Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species
    L W Fisher
    Bone Research Branch, National Institute of Dental Research, Bethesda, Maryland 20892
    J Biol Chem 264:4571-6. 1989
  8. ncbi Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori: a 1-year follow-up study
    J P Gisbert
    Department of Gastroenterology, Ramon y Cajal Hospital, University of Alcala de Henares, Madrid, Spain
    Eur J Gastroenterol Hepatol 11:189-200. 1999
  9. ncbi Endothelium modulates vasoconstrictor response to prostaglandin I2 in rat mesenteric resistance arteries: interaction between EP1 and TP receptors
    F E Xavier
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
    Br J Pharmacol 158:1787-95. 2009
  10. ncbi Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection
    P Sipponen
    Dept of Pathology, Helsinki University District Central Hospital, Jorvi Hospital, Espoo, Finland
    Scand J Gastroenterol 38:1209-16. 2003

Research Grants

  1. SPORE IN LUNG CANCER
    Paul Bunn; Fiscal Year: 2007
  2. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
  3. Characterizaton of Motility Factor Receptor
    Avraham Raz; Fiscal Year: 2010
  4. Social Networking and Personal Genomics: Emerging Issues for Health Research
    Sandra Soo Jin Lee; Fiscal Year: 2010
  5. MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERS
    Gregory Petsko; Fiscal Year: 2002
  6. ASPIRIN/FOLATE PREVENTION OF LARGE BOWEL POLYPS
    JOHN ANTHONY BARON; Fiscal Year: 2010
  7. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
  8. PGI & TXA SYNTHASES-MEMBRANE ANCHOR STRUCTURE/FUNCTION
    Ke He Ruan; Fiscal Year: 2003
  9. Perioperative Pelvic Floor Rehab: A Randomized Trial
    Holly Richter; Fiscal Year: 2007
  10. ORGANIZATION OF MALE REPRODUCTIVE NEURAL CIRCUITS
    Anne Murphy; Fiscal Year: 2002

Detail Information

Publications161 found, 100 shown here

  1. ncbi Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
    T Xu
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:78-82. 1998
    ..b>Biglycan (encoded by the gene Bgn) is an ECM proteoglycan that is enriched in bone and other non-skeletal connective ..
  2. ncbi Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1
    Betty Reinboth
    Department of Pathology, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 277:3950-7. 2002
    The interactions of the dermatan sulfate proteoglycans biglycan and decorin have been investigated with the elastic fiber components, tropoelastin, fibrillin-containing microfibrils, and microfibril-associated glycoproteins (MAGP) 1 and 2...
  3. ncbi The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells
    Colette A Inkson
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Bethesda, MD 20892 4320, USA
    Cells Tissues Organs 189:153-7. 2009
    b>Biglycan (BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN...
  4. ncbi The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins
    R V Iozzo
    Department of Pathology, Anatomy, and Cell Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:18843-6. 1999
  5. ncbi Interaction of biglycan with type I collagen
    E Schonherr
    Institute of Physiological Chemistry and Pathobiochemistry University of Münster, Federal Republic of Germany
    J Biol Chem 270:2776-83. 1995
    ..The structurally related proteoglycan biglycan has been proposed not to bind to fibrillar collagens...
  6. ncbi WISP-1 binds to decorin and biglycan
    L Desnoyers
    Department of Protein Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    J Biol Chem 276:47599-607. 2001
    ..Mass spectrometric analysis identified the isolated binding factors as decorin and biglycan. Decorin and biglycan interacted directly with WISP-1 and inhibited its binding to components in the conditioned ..
  7. ncbi Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species
    L W Fisher
    Bone Research Branch, National Institute of Dental Research, Bethesda, Maryland 20892
    J Biol Chem 264:4571-6. 1989
    ..For this reason, we suggest that PG I be called biglycan. The biglycan protein sequence contains 368 residues (Mr = 42,510 for the complete sequence and Mr = 37,983 for ..
  8. ncbi Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori: a 1-year follow-up study
    J P Gisbert
    Department of Gastroenterology, Ramon y Cajal Hospital, University of Alcala de Henares, Madrid, Spain
    Eur J Gastroenterol Hepatol 11:189-200. 1999
    ..Finally, an evaluation was made of the variables influencing gastrin and PG concentration, with particular attention to H. pylori infection and histological lesions of gastric mucosa...
  9. ncbi Endothelium modulates vasoconstrictor response to prostaglandin I2 in rat mesenteric resistance arteries: interaction between EP1 and TP receptors
    F E Xavier
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
    Br J Pharmacol 158:1787-95. 2009
    Prostacyclin (PGI(2)) is usually described as an endothelium-derived vasodilator, but it can also induce vasoconstriction...
  10. ncbi Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection
    P Sipponen
    Dept of Pathology, Helsinki University District Central Hospital, Jorvi Hospital, Espoo, Finland
    Scand J Gastroenterol 38:1209-16. 2003
    ..We examined how common an undiagnosed vitamin B12 deficiency is among elderly men in the general population and, in particular, how often this deficiency is related to atrophic corpus gastritis...
  11. ncbi Prostacyclin among prostanoids
    Ryszard J Gryglewski
    Jagiellonian Medical Research Centre, Krakow, Sławkowska 17, PL 31 016 Kraków, Poland
    Pharmacol Rep 60:3-11. 2008
    ..e. PG endoperoxides (PGG(2), PGH(2)), thromboxane A(2) (TXA(2)) and prostacyclin (PGI(2)). A "Rabbit aorta Contracting Substance" (RCS) played important role in discovering of labile PGs...
  12. ncbi Phytosterols decrease prostaglandin release in cultured P388D1/MAB macrophages
    Atif B Awad
    Department of Exercise and Nutrition Sciences, University of Buffalo, 15 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Prostaglandins Leukot Essent Fatty Acids 70:511-20. 2004
    ..The purpose of this study was to examine the effect of phytosterols on the release of PGE(2) and PGI(2) from lipopolysaccharide (LPS)-stimulated P388D(1)/MAB macrophage cells...
  13. ncbi Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features
    Craig H Mallinckrodt
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    BMC Psychiatry 5:1. 2005
    ..Pooled data from double-blind, placebo-controlled studies were utilized to compare the efficacy of duloxetine in depressed patients with and without melancholic features...
  14. ncbi Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension
    Hui Cao
    Department of Surgery, Renji Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
    Hepatobiliary Pancreat Dis Int 5:564-9. 2006
    ..in the pathogenesis of portal hypertension (PHT) has been extensively studied, but whether or not prostacyclin (PGI(2)) plays a role in formation and development of hyperdynamic circutatory state in PHT has not been verified...
  15. ncbi Characterization of the dermatan sulfate proteoglycans, DS-PGI and DS-PGII, from bovine articular cartilage and skin isolated by octyl-sepharose chromatography
    H U Choi
    Orthopedic Research Laboratories, Montefiore Medical Center, Bronx, New York 10467
    J Biol Chem 264:2876-84. 1989
    Two forms of dermatan sulfate proteoglycans, called DS-PGI and DS-PGII, have been isolated from both bovine fetal skin and calf articular cartilage and characterized...
  16. ncbi Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study
    P Sipponen
    Dept of Pathology, Helsinki District University Central Hospital, Espoo, Finland
    Scand J Gastroenterol 37:785-91. 2002
    ..pylori gastritis only. We investigated whether atrophic gastritis can be diagnosed and typed non-endoscopically if the serum levels of pepsinogen I (S-PGI) and gastrin-17 (S-G-17) are assayed in connection with H. pylori testing.
  17. ncbi Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer
    Paul Eduard Neagoe
    Research Center, Montreal Heart Institute, Department of Pharmacology, Universite de Montreal, 5000 Belanger St, Montreal, Quebec H1T 1C8, Canada
    J Biol Chem 280:9904-12. 2005
    ..addition, VEGF-A(165) promotes the release of other endothelial mediators including nitric oxide and prostacyclin (PGI(2))...
  18. ncbi Role of PGI2 in the formation and maintenance of hyperdynamic circulatory state of portal hypertensive rats
    Zhi Yong Wu
    Department of General Surgery, Renji Hospital, 1630 Dongfang Road, Shanghai 200127, China
    World J Gastroenterol 11:752-5. 2005
    To investigate the role of prostacyclin (PGI(2)) and nitric oxide (NO) in the development and maintenance of hyperdynamic circulatory state of chronic portal hypertensive rats.
  19. ncbi Specificity of a Vibrio vulnificus aminopeptidase toward kinins and other peptidyl substrates
    Gary P Richards
    USDA, ARS, Microbial Food Safety Research Unit, Delaware State University, 1200 N DuPont Hwy, James W W Baker Center, Dover, DE 19901, USA
    J Bacteriol 188:2056-62. 2006
    Recently, phosphoglucose isomerase with a lysyl aminopeptidase (PGI-LysAP) activity was identified in Vibrio vulnificus. In this paper, we demonstrate the proteolytic cleavage of human-derived peptides by PGI-LysAP of V...
  20. ncbi Effects of extract F of red-rooted Salvia on mucosal lesions of gastric corpus and antrum induced by hemorrhagic shock-reperfusion in rats
    L H Zhang
    Department of Anesthesiology, Second Clinical College, China Medical University, Liaoning Province, China
    World J Gastroenterol 7:672-7. 2001
    ..To compare the effects of extract F of red-rooted Salvia (EFRRS) on mucosal lesions of gastric corpus and antrum induced by hemorrhagic shock and reperfusion in rats...
  21. ncbi Phosphoglucose isomerases of hagfish, zebrafish, gray mullet, toad, and snake, with reference to the evolution of the genes in vertebrates
    Hsiao Wei Kao
    Institute of Zoology, Academia Sinica, Taipei, Taiwan 115, ROC
    Mol Biol Evol 19:367-74. 2002
    Phosphoglucose isomerase (PGI) is a protein with multiple functions...
  22. ncbi Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:271-8. 1992
    ..3. The third PGE effect and the stimulant PGI effect are blocked by morphine, indicating enteric neurones and/or sensory nerve terminals as sites of action...
  23. ncbi Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial
    Michael J Detke
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eur Neuropsychopharmacol 14:457-70. 2004
    ..This placebo-controlled study assesses the safety and efficacy of duloxetine (80 or 120 mg/day) and paroxetine (20 mg QD) during an initial 8-week acute phase and subsequent 6-month continuation phase treatment of MDD...
  24. ncbi Efficacy of venlafaxine in patients with major depressive disorder who have unsustained or no response to selective serotonin reuptake inhibitors: an open-label, uncontrolled study
    Eric Michael Kaplan
    University of South Florida, Tampa, USA
    Clin Ther 24:1194-200. 2002
    ..Approximately half of patients who are prescribed selective serotonin re-uptake inhibitors (SSRIs) either do not respond to treatment or do not experience a sustained response...
  25. ncbi Metabolic phenotype of phosphoglucose isomerase mutants of Corynebacterium glutamicum
    Achim Marx
    Degussa AG, Feed Additives, R and D Biotechnology, Kantstr 2, D 33790 Halle, Westf, Germany
    J Biotechnol 104:185-97. 2003
    ..Elsewhere, the construction of a phosphoglucose isomerase (Pgi) null mutant of the C...
  26. ncbi Novel type of glucose-6-phosphate isomerase in the hyperthermophilic archaeon Pyrococcus furiosus
    T Hansen
    Institut fur Allgemeine Mikrobiologie, Christian Albrechts Universitat Kiel, Am Botanischen Garten 1 9, D 24118 Kiel, Germany
    J Bacteriol 183:3428-35. 2001
    Glucose-6-phosphate isomerase (phosphoglucose isomerase [PGI]) (EC 5.3.1.9) from the hyperthermophilic archaeon Pyrococcus furiosus was purified 500-fold to homogeneity...
  27. ncbi Modeling and experimental design for metabolic flux analysis of lysine-producing Corynebacteria by mass spectrometry
    C Wittmann
    Biochemical Engineering Institute, Saarland University, 66123 Saarbruecken, Germany
    Metab Eng 3:173-91. 2001
    ..Phi(DH)), (iii) at the pyruvate node (Phi(PC)), and reversibilities of (iv) glucose 6-phosphate isomerase (zeta(PGI)), (v) at the pyruvate node (zeta(PC/PEPCK)), and (vi) of transaldolase and transketolases in the PPP...
  28. ncbi The polygalacturonases of Aspergillus niger are encoded by a family of diverged genes
    H J Bussink
    Department of Genetics, Wageningen Agricultural University, The Netherlands
    Eur J Biochem 208:83-90. 1992
    ..One of the two previously characterized genes coding for the abundant polygalacturonases I and II (PGI and PGII) found in a commercial pectinase preparation was used as a probe to isolate five more genes by screening a ..
  29. ncbi Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI
    Jun feng Feng
    Department of Neurological Surgery, University of California at Davis, One Shields Ave, Davis, CA 95616, USA
    Brain Res 1395:62-73. 2011
    ..Extracellular NAAG is hydrolyzed to N-acetylaspartate and glutamate by peptidase activity. In the present study PGI-02776, a newly designed di-ester prodrug of the urea-based NAAG peptidase inhibitor ZJ-43, was tested for ..
  30. ncbi Isoenzyme electrophoretic patterns in discus fish (Symphysodon aequifasciatus Pellegrin, 1904 and Symphysodon discus Heckel, 1840) from the Central Amazon
    C A Silva
    Instituto Nacional de Pesquisas da Amazonia, Coordenação de Pesquisas em Biologia Aquática, Manaus, AM, Brasil
    Genet Mol Res 7:791-805. 2008
    ..1.1.27), malate dehydrogenase (Mdh - EC 1.1.1.37), phosphoglucomutase (Pgm - EC 5.4.2.2), phosphoglucose isomerase (Pgi - EC 5.3.1.9), and super oxide dismutase (Sod - EC 1.15.1...
  31. ncbi Effects of temperature on physiology and reproductive success of a montane leaf beetle: implications for persistence of native populations enduring climate change
    Elizabeth P Dahlhoff
    Department of Biology, Santa Clara University, Santa Clara, California 95053, USA
    Physiol Biochem Zool 81:718-32. 2008
    ..The glycolytic enzyme phosphoglucose isomerase (PGI) is a marker of temperature adaptation in C. aeneicollis...
  32. ncbi Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusing
    G Barnert
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988
    ..enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI. Nine enzymes (IDH, G6P, LDH, HEX, PGM, EST, ALP, ACP, and PGI) showed distinct and reproducible banding patterns, ..
  33. ncbi Phosphoglucose isomerase genotype affects running speed and heat shock protein expression after exposure to extreme temperatures in a montane willow beetle
    Nathan E Rank
    Department of Biology, Sonoma State University, Rohnert Park, CA 94928, USA
    J Exp Biol 210:750-64. 2007
    ..Allele frequencies at the enzyme locus phosphoglucose isomerase (PGI) vary across a climatic latitudinal gradient in these populations, with PGI allele 1 being most common in cooler ..
  34. ncbi [Clinical utility of serum pepsinogen levels as a screening test of atrophic gastritis]
    Hyojin Chae
    Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Korean J Lab Med 28:201-6. 2008
    ..We evaluated the clinical utility of serum pepsinogens (PG) as a biomarker for screening of atrophic gastritis...
  35. ncbi Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts
    Yanming Bi
    Craniofacial and Skeletal Diseases Branch, Building 30 Room 225, National Institute of Dental and Craniofacial Research, National Institutes of Health, MSC 4320, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Bone 38:778-86. 2006
    ..We have previously shown that the extracellular matrix protein, biglycan (Bgn), plays an important role in the differentiation of osteoblast precursors...
  36. ncbi Duloxetine in the long-term treatment of major depressive disorder
    Joel Raskin
    Lilly Research Laboratories, Eli Lilly Canada, 3650 Danforth Avenue, Scarborough, Ontario, Canada M1N 2E8
    J Clin Psychiatry 64:1237-44. 2003
    ..This clinical trial evaluated the long-term (1 year) safety and efficacy of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, in patients with DSM-IV major depressive disorder...
  37. ncbi Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta
    Aina Martorell
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Cardiovasc Res 84:300-8. 2009
    ....
  38. ncbi Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice
    Sunil Wadhwa
    Division of Orthodontics, School of Dental Medicine, Department of Craniofacial Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 40:861-6. 2007
    b>Biglycan (Bgn) and decorin (Dcn) are highly expressed in numerous tissues in the craniofacial complex. However, their expression and function in the cranial sutures are unknown...
  39. ncbi Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI function
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Cancer Res 64:2516-22. 2004
    Autocrine motility factor/phosphoglucose isomerase (AMF/PGI) was identified as a binding partner for insulin-like growth factor binding protein-3 (IGFBP-3) in solubilized T47D and MCF-7 human breast cancer cell membranes...
  40. ncbi Ralstonia solanacearum ?PGI-1 strain KZR-5 is affected in growth, response to cold stress and invasion of tomato
    Patricia Stevens
    Department of Microbial Ecology, Centre for Ecological and Evolutionary Studies CEES, University of Groningen, P O Box 14, 9759 AA, Haren, The Netherlands
    Microb Ecol 61:101-12. 2011
    ..6 kb genomic island PGI-1, with that of environmental strain KZR-1 and potato-derived strains 1609 and 715...
  41. ncbi Bifunctional phosphoglucose/phosphomannose isomerases from the Archaea Aeropyrum pernix and Thermoplasma acidophilum constitute a novel enzyme family within the phosphoglucose isomerase superfamily
    Thomas Hansen
    Institut fur Allgemeine Mikrobiologie, Christian Albrechts Universitat Kiel, Am Botanischen Garten 1 9, D 24118 Kiel, Germany
    J Biol Chem 279:2262-72. 2004
    The hyperthermophilic crenarchaeon Aeropyrum pernix contains phosphoglucose isomerase (PGI) activity. However, obvious homologs with significant identity to known PGIs could not be identified in the sequenced genome of this organism...
  42. ncbi Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma
    Zeina Jaffar
    Center for Environmental Health Sciences, Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
    J Immunol 179:6193-203. 2007
    b>PGI(2) plays a key role in limiting Th2-mediated airway inflammation...
  43. ncbi Combined quantum mechanics/molecular mechanics study on the reversible isomerization of glucose and fructose catalyzed by Pyrococcus furiosus phosphoglucose isomerase
    Ruibo Wu
    Department of Chemistry and State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, China
    J Am Chem Soc 130:7022-31. 2008
    Phosphoglucose isomerase (PGI), which catalyzes the reversible interconversion of glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), is represented by two evolutionarily distinct protein families...
  44. ncbi Structural and functional analyses of phosphoglucose isomerase from Vibrio vulnificus and its lysyl aminopeptidase activity
    Gary P Richards
    US Department of Agriculture, Agricultural Research Service, Delaware State University, 1200 N DuPont Hwy, James WW Baker Center, Dover, DE 19901, USA
    Biochim Biophys Acta 1702:89-102. 2004
    Phosphoglucose isomerase (PGI) with a novel lysyl aminopeptidase (LysAP) activity was recently isolated and partially characterized from the human pathogen, Vibrio vulnificus. This PGI is a heterodimer consisting of 60.8- and 23...
  45. ncbi Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method
    M Mizugaki
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
    Prostaglandins Other Lipid Mediat 58:253-62. 1999
    ..in patients with retinal vascular occlusion (RVO) to elucidate the change of the thromboxane A2/prostacyclin (TX/PGI) ratio with this disease and the effect of low-dose-aspirin therapy...
  46. ncbi Acid-induced conformational changes in phosphoglucose isomerase result in its increased cell surface association and deposition on fibronectin fibrils
    Mohammad Amraei
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 278:38935-41. 2003
    Phosphoglucose isomerase (PGI) is a glycolytic enzyme that exhibits extracellular cytokine activity as autocrine motility factor, neuroleukin, and maturation factor and that has been recently implicated as an autoantigen in rheumatoid ..
  47. ncbi Rap1 mediates protective effects of iloprost against ventilator-induced lung injury
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Appl Physiol 107:1900-10. 2009
    Prostaglandin I(2) (PGI(2)) has been shown to attenuate vascular constriction, hyperpermeability, inflammation, and acute lung injury...
  48. ncbi Characterization of a lysyl aminopeptidase activity associated with phosphoglucose isomerase of Vibrio vulnificus
    Gary P Richards
    Agricultural Research Service, US Department of Agriculture, Delaware State University, James W W Baker Center, Dover, DE 19901, USA
    Biochim Biophys Acta 1700:219-29. 2004
    Phosphoglucose isomerase (PGI) is a multifunctional enzyme involved in glycolysis and gluconeogenesis and, in mammalian cells, functions as neuroleukin, autocrine motility factor (AMF), and differentiation and maturation factor (MF)...
  49. ncbi Renal prostacyclin biosynthesis in a baboon model of Shiga toxin mediated hemolytic uremic syndrome
    Richard L Siegler
    Department of Pediatrics, Division of Nephrology and Hypertension, 30 N 1900 E, 28422, Salt Lake City, UT 84132 2204, USA
    Nephron 92:363-8. 2002
    ..Prostacyclin (PGI(2)) is a potent renal vasodilator and inhibitor of platelet aggregation and adhesion...
  50. ncbi Proteoglycans in predentin: the last 15 micrometers before mineralization
    M Goldberg
    Faculte de Chirurgie Dentaire, Universite Paris V, Montrouge, France
    Connect Tissue Res 44:184-8. 2003
    ..In order to investigate the distribution and potential functions of decorin, biglycan (BGN), and fibromodulin (3 SLRPs, potentially related to dentinogenesis), we performed light and electron ..
  51. ncbi Characterization of an exopolygalacturonase from Aspergillus niger
    Afaf S Fahmy
    Molecular Biology Department, National Research Centre, Cairo, Egypt
    Appl Biochem Biotechnol 149:205-17. 2008
    Polygalacturonase (PGI) from Aspergillus niger NRRL3 was purified about 12.0-fold from the cell-free broth using diethylaminoethyl-Sepharose and Sephacryl S-200 columns...
  52. ncbi Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies
    Qin Cao
    Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China
    J Dig Dis 8:15-22. 2007
    ..The aim of this study was to evaluate the use of serum tests: serum pepsinogen I (PGI pepsinogen I/II ratio (PGR), gastrin-17 (G-17) and H...
  53. ncbi Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release
    Sylvia M Wilson
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Mol Pharmacol 79:586-95. 2011
    Herein we provide evidence for the coexpression of two distinct prostacyclin (PGI(2)) receptors (IP) on BEAS-2B human airway epithelial cells...
  54. ncbi Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study
    C Trenkwalder
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neurology 62:1391-7. 2004
    ..To evaluate the short- and long-term safety and efficacy of pergolide therapy for restless legs syndrome (RLS) in a double-blind, placebo-controlled, randomized trial (Pergolide European Australian RLS [PEARLS] study)...
  55. ncbi Regulation of the expression of cyclooxygenases and production of prostaglandin I? and E? in human coronary artery endothelial cells by curcumin
    X Tan
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    J Physiol Pharmacol 62:21-8. 2011
    Curcumin regulates prostaglandin (PG) synthesis in a variety of cells. PGE? and PGI? are generated from arachidonic acid (AA) by cyclooxygenases 1 and 2 (COX-1 and COX-2) and the synthase (PGES and PGI?S) pathways...
  56. ncbi Cloning, characterization, and nucleotide sequence analysis of a Zymomonas mobilis phosphoglucose isomerase gene that is subject to carbon source-dependent regulation
    T L Hesman
    School of Biological Sciences, University of Nebraska, Lincoln 68588 0118
    J Bacteriol 173:3215-23. 1991
    The Zymomonas mobilis gene encoding phosphoglucose isomerase (pgi) was cloned by genetic complementation of an Escherichia coli pgi mutant...
  57. ncbi Iloprost, a prostacyclin analogue, stimulates meiotic maturation and early embryonic development in pigs
    Ji Su Kim
    Development and Differentiation Research Center, Korea Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong, Daejeon 305 806, Korea
    Reprod Fertil Dev 22:437-47. 2010
    ..In hatched embryos, prostacyclin (PGI(2)) improves implantation, but its role during oocyte maturation and early embryo development remains contentious...
  58. ncbi Endothelin-1 attenuates increases in hydraulic conductivity due to platelet-activating factor via prostacyclin release
    Elizabeth L Cureton
    University of California, San Francisco East Bay, Dept of Surgery, 1411 East 31st St, Oakland, CA 94602, USA
    J Appl Physiol 110:717-23. 2011
    We previously showed that endothelin-1 (ET-1) and prostacyclin (PGI(2)) similarly attenuate increases in microvascular permeability induced by platelet-activating factor (PAF)...
  59. ncbi Prostaglandin I(2) analogues enhance growth-related oncogene-alpha expression in human monocyte-derived dendritic cells
    Chang Hung Kuo
    Department of Pediatrics, Kaohsiung Municipal Ta Tung Hospital, Kaohsiung, Taiwan, Republic of China
    Inflammation 33:334-43. 2010
    ..Prostaglandin I(2) (PGI(2)) analogues were regarded as potential treatments for asthma...
  60. ncbi Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation
    Takashi Yanagawa
    Tumor Progression and Metastasis Program, Karmanos Cancer Institute, 110 E Warren Ave, Detroit, Michigan 48201, USA
    J Biol Chem 280:10419-26. 2005
    Phosphoglucose isomerase (PGI; EC 5.3.1.9) is a cytosolic housekeeping enzyme of the sugar metabolism pathways that plays a key role in both glycolysis and gluconeogenesis...
  61. ncbi Endothelium-derived prostaglandin I(2) controls the migration of eosinophils
    Viktoria Konya
    Institute of Experimental and Clinical Pharmacology, Medical University Graz, A 8010 Graz, Austria
    J Allergy Clin Immunol 125:1105-13. 2010
    ..Prostaglandin (PG) I(2) is the major prostanoid released by endothelial cells. Mice deficient in PGI(2) receptors (IPs) show exaggerated eosinophilic inflammation in response to allergen.
  62. ncbi Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects
    George B Kudolo
    Department of Clinical Laboratory Sciences, MSC 6246, School of Allied Health Sciences, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229 3900, USA
    Thromb Res 108:151-60. 2002
    ..platelet aggregation was studied in PRP and urinary metabolites of thromboxane B(2) (TXB(2)) and prostacyclin (PGI(2)) were measured. In healthy volunteers (age, 42+/-11 years; BMI, 28.4+/-4.8 kg/m(2); n=28), the ingestion of G...
  63. ncbi Polyaspartoyl.L-arginine enhances prostacyclin synthesis in rat aortic endothelial cells
    Zhiyu Tang
    Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Eur J Pharmacol 601:124-8. 2008
    Nitric oxide (NO) and prostacyclin (PGI(2)) are two of the most important vasodilators produced by endothelial cells, the regulation of NO on PGI(2) production has not been fully clear yet. Polyaspartoyl...
  64. ncbi Down-regulation of phosphoglucose isomerase/autocrine motility factor results in mesenchymal-to-epithelial transition of human lung fibrosarcoma cells
    Tatsuyoshi Funasaka
    Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 67:4236-43. 2007
    Phosphoglucose isomerase (PGI) is one of the glycolytic enzymes and is a multifunctional enzyme that functions in glucose metabolism inside the cell while acting as a cytokine outside the cell, with properties that include autocrine ..
  65. ncbi Simultaneous inhibition of TXA(2) and PGI(2) synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats
    Fabiano E Xavier
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife 50670 420, Brazil
    Clin Sci (Lond) 119:283-92. 2010
    ..TP receptor [TXA2 (thromboxane A(2)) receptor] antagonist SQ 29548, the TXA(2) synthesis inhibitor furegrelate, the PGI(2) (prostaglandin I(2)) synthesis inhibitor TCP (tranylcypromine) or TCP+furegrelate were only determined in ..
  66. ncbi Transfusion requirements and clinical outcome in intensive care patients receiving continuous renal replacement therapy: comparison of prostacyclin vs. heparin prefilter administration
    Nis A Windeløv
    Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark
    Blood Coagul Fibrinolysis 21:414-9. 2010
    Prostacyclin (PGI(2)) analogous are potent antithrombotics recommended as prefilter infusion during renal replacement therapy (RRT) when heparin is contraindicated...
  67. ncbi Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats
    Miho Kawai
    Department of Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Transl Res 155:294-304. 2010
    Neutrophil elastase (NE) decreases the endothelial production of prostacyclin (PGI(2)) through the inhibition of endothelial nitric oxide synthase (NOS) activation and thereby contributes to the development of ischemia/reperfusion (I/R)-..
  68. ncbi Increased bone mass in adult prostacyclin-deficient mice
    Chalida Nakalekha
    Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
    J Endocrinol 204:125-33. 2010
    ..Prostaglandin E(2) (PGE(2)) regulates bone resorption and bone formation. Prostacyclin (PGI(2)) is one of the major products derived from arachidonic acid by the action of cyclooxygenase and PGI(2) synthase (..
  69. ncbi Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition
    Tillmann Cyrus
    Department of Cardiology, Washington University, St Louis, MO, United States
    Atherosclerosis 208:376-81. 2010
    Prostaglandins, such as thromboxane A(2) (TxA(2)) and prostacyclin (PGI(2)), are bioactive lipid mediators that are implicated in the pathogenesis of atherosclerosis...
  70. ncbi Inbred strain-specific effects of exercise in wild type and biglycan deficient mice
    Joseph M Wallace
    Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109 1078, USA
    Ann Biomed Eng 38:1607-17. 2010
    b>Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone...
  71. ncbi Alpha2-adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice
    James T Pearson
    Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Suita Shi, Osaka 565 8565, Japan
    Pflugers Arch 454:29-39. 2007
    ..Prostacyclin (PGI(2)) release is known to potentiate alpha(2)-adrenoreceptor (alpha(2)-AR) mediated inhibition of sympathoactivation ..
  72. ncbi Effect of H. pylori infection on the expression of cyclooxygenase-2 in human gastric mucosa
    A A Shah
    Royal College of Surgeons in Ireland, Ireland
    Prostaglandins Leukot Essent Fatty Acids 68:1-8. 2003
    Cyclooxygenase-1 is the primary isoform responsible for the production of cytoprotective prostaglandins (PGE(2) and PGI(2)) in the stomach. In contrast COX-2 is induced at the sites of inflammation...
  73. ncbi Prostacyclin analogues: prevention of cardiovascular diseases
    Tomohiro Nakayama
    Division of Molecular Diagnostics, Advanced Medical Research Center, Nihon University School of Medicine, Ooyaguchi Kamimachi, 30 1 Itabashi ku, Tokyo 173 8610, Japan
    Cardiovasc Hematol Agents Med Chem 4:351-9. 2006
    Prostacyclin (PGI(2)) inhibits platelet aggregation and vasoconstriction...
  74. ncbi Lymphocytes from patients with early stage of B-cell chronic lymphocytic leukaemia and long survival synthesize decorin
    Salvatore Campo
    Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy
    Biochimie 88:1933-9. 2006
    mRNA/cDNA gene expression of both small leucine-rich proteoglycans decorin and biglycan was evaluated by PCR real time in lymphocytes collected from patients with chronic lymphocytic leukaemia (CLL) at different stages of disease and from ..
  75. ncbi Development and validation of a LC/MS/MS method for 6-keto PGF1?, a metabolite of prostacyclin (PGI?)
    Derek L Chappell
    Clinical Development Laboratory, Merck Research Laboratories, Rahway, NJ 07065, United States
    J Pharm Biomed Anal 56:600-3. 2011
    ..Prostacyclin (PGI(2)) is a locally acting prostanoid, which mediates vasorelaxation and inhibition of platelet aggregation...
  76. ncbi Structural analogues of reactive intermediates as inhibitors of glucosamine-6-phosphate synthase and phosphoglucose isomerase
    Sławomir Milewski
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 11 12 Narutowicza St, 80 952 Gdansk, Poland
    Arch Biochem Biophys 450:39-49. 2006
    The active centers of phosphoglucose isomerase (PGI) and the hexose phosphate isomerase domain (HPI) of glucosamine-6-P (GlcN-6-P) synthase demonstrate apparent similarity in spatial arrangement of critical amino acid residues, except ..
  77. ncbi Twelve years' experience with the Patient Generated Index (PGI) of quality of life: a graded structured review
    Faith Martin
    WeD 3 East, University of Bath, Bath, BA2 7AY, UK
    Qual Life Res 16:705-15. 2007
    The Patient Generated Index (PGI) is an individualised quality of life (QoL) measure that has been in use since 1994. Various adaptations have been made to suit a variety of client groups...
  78. ncbi Eosinophilic esophagitis: perspectives of adult and pediatric gastroenterologists
    Jeremy King
    Division of Pediatric Gastroenterology, Kapiolani Medical Center for Women and Children, Honolulu, HI, USA
    Dig Dis Sci 55:973-82. 2010
    To survey pediatric (PGI) and adult gastroenterologists (AGI) regarding their perceptions about the etiology, diagnosis, and management of eosinophilic esophagitis (EoE), and to assess whether differences in the clinical approach to EoE ..
  79. ncbi Clinical use of proton-pump inhibitors but not H2-blockers or antacid/alginates raises the serum levels of amidated gastrin-17, pepsinogen I and pepsinogen II in a random adult population
    Lars Agreus
    Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 44:564-70. 2009
    ..The purpose of this study was to examine the effect of these compounds on serum levels of amidated gastrin-17 (G-17) and pepsinogens (PGI & PGII) in a large, random, adult Swedish population sample with uninfected stomach mucosa.
  80. ncbi Role of glycosaminoglycans of biglycan in BMP-2 signaling
    P A Miguez
    Department of Periodontology, University of North Carolina at Chapel Hill, CB 7450, Chapel Hill, NC 27599, USA
    Biochem Biophys Res Commun 405:262-6. 2011
    Recently we have reported that biglycan (BGN) promotes osteoblast differentiation and that this function is due in part to its ability to positively modulate bone morphogenetic protein (BMP) functions...
  81. ncbi Crocidolite induces prostaglandin I(2) release mediated by vitronectin receptor and cyclooxygenase-2 in lung cells
    Francisco J Leyva
    Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824, USA
    Lung 188:133-41. 2010
    ..had a decrease in viability and an increase in the release of lactate dehydrogenase (LDH) and 6-keto PGF(1alpha), a PGI(2) metabolite. PGI(2) release was mediated by cyclooxygenase-2 (COX-2) and vitronectin receptor (VNR)...
  82. ncbi Serum pepsinogen I, pepsinogen II, and gastrin 17 in relatives of gastric cancer patients: comparative study with type and severity of gastritis
    Arghavan Haj-Sheykholeslami
    Department of Gastroenterology, Digestive Disease Research Center, Shariati Hospital, Tehran, Iran
    Clin Gastroenterol Hepatol 6:174-9. 2008
    ..The aim of this study was to investigate the potential of biomarkers pepsinogen I (PGI), pepsinogen II (PGII), their ratio (PG I:II), as well as gastrin 17 for screening of precancerous conditions and ..
  83. ncbi Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor
    D Kolte
    Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS, USA CVMED Exploratory, Pfizer Global Research and Development, Groton, CT, USA
    Br J Pharmacol 162:1639-49. 2011
    ..of B(2) receptors leads to the formation of tissue plasminogen activator, nitric oxide (NO) and prostacyclin (PGI(2) ). An elevated kallikrein-dependent pathway has been linked to cardiovascular disease risk...
  84. ncbi 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug
    Keiichi Kuwano
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    J Pharmacol Exp Ther 322:1181-8. 2007
    Prostacyclin (PGI(2)) and its analogs are useful for the treatment of various vascular disorders, but their half-lives are too short for widespread clinical application...
  85. ncbi Serum pepsinogens and risk of esophageal squamous dysplasia
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Int J Cancer 124:456-60. 2009
    ..Low serum pepsinogen I (PGI) and low serum pepsinogen I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy, and have ..
  86. ncbi A putative genomic island, PGI-1, in Ralstonia solanacearum biovar 2 revealed by subtractive hybridization
    Patricia Stevens
    Department of Microbial Ecology, Centre for Ecological and Evolutionary Studies CEES, University of Groningen, 9759 AA Haren, The Netherlands
    Antonie Van Leeuwenhoek 98:359-77. 2010
    ..We found a deletion of a 17.6-Kb region, denoted as a putative genomic island PGI-1, in environmental strain KZR-5...
  87. ncbi Tubuloglomerular feedback is decreased in COX-1 knockout mice after chronic angiotensin II infusion
    Magali Araujo
    Division of Nephrology and Hypertension, Department of Medicine, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA
    Am J Physiol Renal Physiol 298:F1059-63. 2010
    ..Thromboxane (TxA(2)), PGE(2), and prostacyclin (PGI(2)) are the major PGs in the renal cortex of mice...
  88. ncbi The function of vascular smooth muscle phosphodiesterase III is preserved in healthy human aging
    Rachel L Elvebak
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Transl Sci 3:239-42. 2010
    ..The endothelial NO component of prostacyclin (PGI(2))-mediated vasodilation is reduced in aging...
  89. ncbi Endothelial progenitor cells stimulate cerebrovascular production of prostacyclin by paracrine activation of cyclooxygenase-2
    Anantha Vijay R Santhanam
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Circ Res 100:1379-88. 2007
    ..EPCs, basilar arteries were isolated and expression of vasoregulatory proteins, production of prostacyclin (PGI(2)), and cAMP were determined...
  90. ncbi Inbred strain-specific response to biglycan deficiency in the cortical bone of C57BL6/129 and C3H/He mice
    Joseph M Wallace
    Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Bone Miner Res 24:1002-12. 2009
    ..b>Biglycan (bgn) deficiency impacts bone through negative regulation of osteoblasts, resulting in extracellular matrix ..
  91. ncbi Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function
    Keith Morrison
    Drug Discovery Department, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
    J Pharmacol Exp Ther 335:249-55. 2010
    ..is an orally available prostacyclin (PGI(2)) receptor (IP receptor) agonist that is chemically distinct from PGI(2) and is in clinical development for the ..
  92. ncbi Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2
    Habib Derbali
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste Foy Québec, Quebec, Canada, G1V 4G5
    Am J Pathol 176:2638-45. 2010
    ..The microarray results indicated that only biglycan (BGN) and phospholipid transfer protein (PLTP) were overexpressed in the AS valves...
  93. ncbi Inhibitory effect of prostaglandin I2 on bone marrow kinetics of eosinophils in the guinea pig
    Eva M Sturm
    Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    J Leukoc Biol 90:285-91. 2011
    ..We have shown previously that PGI(2) markedly attenuates the locomotion of human eosinophils in vitro...
  94. ncbi Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice
    D Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 98:3358-63. 2001
    The cyclooxygenase (COX) product, prostacyclin (PGI(2)), inhibits platelet activation and vascular smooth-muscle cell migration and proliferation...
  95. ncbi Biglycan-deficient mice have delayed osteogenesis after marrow ablation
    X D Chen
    Craniofacial and Skeletal Disease Branch, NIDCR, Bethesda, MD, USA
    Calcif Tissue Int 72:577-82. 2003
    b>Biglycan (bgn) is a small proteoglycan in skeletal tissue that binds and regulates collagen and TGF-beta activities...
  96. ncbi Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling
    Hendrik Ungefroren
    Research Unit Molecular Oncology, Clinic for General Surgery and Thoracic Surgery, Christian Albrechts University, 24105 Kiel, Germany
    J Biol Chem 278:11041-9. 2003
    ..We have shown recently that induction of biglycan (BGN) expression by TGF-beta1 depended on a functional Smad pathway (Chen, W.-B., Lenschow, W., Tiede, K...
  97. ncbi Allele frequency shifts in response to climate change and physiological consequences of allozyme variation in a montane insect
    Nathan E Rank
    Department of Biology, Sonoma State University, 1801 E Cotati Avenue, Rohnert Park, California 9492, USA
    Evolution 56:2278-89. 2002
    ..frequency between 1988 and 1996 at three allozyme loci (isocitrate dehydrogenase, Idh; phosphoglucose isomerase, Pgi; and phosphoglucomutase, Pgm) for the leaf beetle Chrysomela aeneicollis in the Bishop Creek region of the Sierra ..
  98. ncbi The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle
    M A Bowe
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Cell Biol 148:801-10. 2000
    ..microsequencing to be the Torpedo ortholog of the small leucine-rich repeat chondroitin sulfate proteoglycan biglycan. Biglycan binding to alpha-dystroglycan was confirmed by coimmunoprecipitation with both native and recombinant ..
  99. ncbi Cyclic mechanical stretch augments prostacyclin production in cultured human uterine myometrial cells from pregnant women: possible involvement of up-regulation of prostacyclin synthase expression
    Daizo Korita
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 545 Shogoin Kawahara cho, Sakyo ku, 606 8507 Kyoto, Japan
    J Clin Endocrinol Metab 87:5209-19. 2002
    Prostacyclin (PGI(2)), a potent smooth muscle relaxant, is a major prostaglandin secreted from human myometrium...
  100. ncbi A novel pathway of prostacyclin signaling-hanging out with nuclear receptors
    Hyunjung Lim
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:3207-10. 2002
    Prostacylin (PGI(2)), one of the major prostaglandins, is derived from arachidonic acid by the action of the cyclooxygenase (COX) system coupled to PGI(2) synthase (PGIS)...

Research Grants66

  1. SPORE IN LUNG CANCER
    Paul Bunn; Fiscal Year: 2007
    ..Human tissues are used to define the frequency and prognostic relevance of abnormalities of PLA2, COX2, PGE-2, PGI-2, PGIR, PPAR's and others...
  2. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..is a continuing project aimed at characterization of the transcriptional regulation of endothelial COX-1 and PGI synthase genes. Project 2, Induction of NOS-3 and COX-2 by Vasoprotective agents, is an extension of project 1...
  3. Characterizaton of Motility Factor Receptor
    Avraham Raz; Fiscal Year: 2010
    ..Phosphoglucose isomerase (PGI) is a ubiquitous housekeeping cytosolic enzyme that plays a key role in both glycolysis and gluconeogenesis ..
  4. Social Networking and Personal Genomics: Emerging Issues for Health Research
    Sandra Soo Jin Lee; Fiscal Year: 2010
    ..how companies create online tools and forge strategic collaborations to facilitate sharing and networking around PGI. The specific aims of this research are to: 1...
  5. MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERS
    Gregory Petsko; Fiscal Year: 2002
    ..For proton transfer catalysis: phosphoglucose isomerase (PGI), which first catalyzes proton transfer to oxygen (ring-opening) and then uses acid/base catalyzed proton transfer ..
  6. ASPIRIN/FOLATE PREVENTION OF LARGE BOWEL POLYPS
    JOHN ANTHONY BARON; Fiscal Year: 2010
    ..urinary PGE-M (the main metabolite of PGE2, strongly associated with carcinogenesis in the large bowel) and urinary PGI-M (the main metabolite of prostacyclin, a likely anti-carcinogenic prostaglandin)...
  7. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
    ..abstract_text> ..
  8. PGI & TXA SYNTHASES-MEMBRANE ANCHOR STRUCTURE/FUNCTION
    Ke He Ruan; Fiscal Year: 2003
    ....
  9. Perioperative Pelvic Floor Rehab: A Randomized Trial
    Holly Richter; Fiscal Year: 2007
    ..organ prolapse/urinary incontinence sexual function questionnaire (PISQ), patient global impression of severity (PGI-S) and SF-36. Subjects will also complete a 7-day bladder diary to assess frequency of storage symptoms...
  10. ORGANIZATION OF MALE REPRODUCTIVE NEURAL CIRCUITS
    Anne Murphy; Fiscal Year: 2002
    ..This circuit comprises the MPO-->PGi-->spinal cord...
  11. MOTILITY FACTOR RECEPTOR
    Avraham Raz; Fiscal Year: 2007
    ..We found AMF to be a phosphoglucose isomerase (PGI); a glycolytic enzyme that functions as an extracellular cytokine (AMF/neuroleukin/maturation factor)...