BCL2L2

Summary

Gene Symbol: BCL2L2
Description: BCL2-like 2
Alias: BCL-W, BCL2-L-2, BCLW, PPP1R51, apoptosis regulator BCL-W, bcl-2-like protein 2, protein phosphatase 1, regulatory subunit 51
Species: human

Top Publications

  1. ncbi bcl-w, a novel member of the bcl-2 family, promotes cell survival
    L Gibson
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Oncogene 13:665-75. 1996
  2. ncbi Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix
    Alexei Yu Denisov
    Department of Biochemistry and Montreal Joint Center for Structural Biology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:21124-8. 2003
  3. ncbi The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
    Mark G Hinds
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    EMBO J 22:1497-507. 2003
  4. ncbi Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
  5. ncbi Tissue expression and subcellular localization of the pro-survival molecule Bcl-w
    L A O'Reilly
    The Walter and Eliza Hall Institute, Melbourne, Australia
    Cell Death Differ 8:486-94. 2001
  6. ncbi Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
    H Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O Royal Melbourne Hospital, 3050 Vic, Australia
    Science 293:1829-32. 2001
  7. ncbi Mouse keratinocytes express c98, a novel gene homologous to bcl-2, that is stimulated by insulin-like growth factor 1 and prevents dexamethasone-induced apoptosis
    Hung Yi Su
    Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, 1, Hseuh Fu, Road, Pingtung 91201, Taiwan, ROC
    Biochim Biophys Acta 1676:127-37. 2004
  8. ncbi Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice
    Jian Zhong
    Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky Medical Center, MN649 0298, Lexington, KY 40536, USA
    Biochim Biophys Acta 1762:468-77. 2006
  9. ncbi Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup
    A A Shati
    Biology Department, King Khalid University, Abha 61321, Saudi Arabia
    Neuroscience 175:66-74. 2011
  10. ncbi Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential and prevention of caspase 3 activation
    Yan Ge
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 7:29-38. 2005

Research Grants

  1. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2003
  2. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1999
  3. Enterocyte Apoptosis after Intestinal Resection
    Brad Warner; Fiscal Year: 2006
  4. Molecular determinants of epileptic brain injury
    Roger Simon; Fiscal Year: 2007
  5. Cell excitation in ischemic brain injury.
    Roger Pancoast Simon; Fiscal Year: 2010
  6. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2009
  7. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2007
  8. MOLECULAR MECHANISMS OF SEIZURE INDUCED BRAIN INJURY
    Roger Simon; Fiscal Year: 2007
  9. MOLECULAR MECHANISMS OF SEIZURE INDUCED BRAIN INJURY
    Roger Simon; Fiscal Year: 2009
  10. FUNCTION OF BCL-W IN MURINE DEVELOPMENT
    GRANT MACGREGOR; Fiscal Year: 2001

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi bcl-w, a novel member of the bcl-2 family, promotes cell survival
    L Gibson
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Oncogene 13:665-75. 1996
    ..These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene...
  2. ncbi Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix
    Alexei Yu Denisov
    Department of Biochemistry and Montreal Joint Center for Structural Biology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:21124-8. 2003
    ....
  3. ncbi The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
    Mark G Hinds
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    EMBO J 22:1497-507. 2003
    ..Moreover, Bcl-w does not act only by sequestering the BH3-only proteins. There fore, pro-survival Bcl-2-like molecules probably control the activation of downstream effectors by a mechanism that remains to be elucidated...
  4. ncbi Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
  5. ncbi Tissue expression and subcellular localization of the pro-survival molecule Bcl-w
    L A O'Reilly
    The Walter and Eliza Hall Institute, Melbourne, Australia
    Cell Death Differ 8:486-94. 2001
    ..The implications of these results are discussed in the context of the phenotype of Bcl-w-null mice and recent data that suggest that Bcl-w may play a role in colon carcinogenesis...
  6. ncbi Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
    H Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O Royal Melbourne Hospital, 3050 Vic, Australia
    Science 293:1829-32. 2001
    ..Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures...
  7. ncbi Mouse keratinocytes express c98, a novel gene homologous to bcl-2, that is stimulated by insulin-like growth factor 1 and prevents dexamethasone-induced apoptosis
    Hung Yi Su
    Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, 1, Hseuh Fu, Road, Pingtung 91201, Taiwan, ROC
    Biochim Biophys Acta 1676:127-37. 2004
    ..Taken together, our current data demonstrated that IGF-1 plays an anti-apoptotic role in the DEX-induced apoptosis in epidermal keratinocytes and this, at least in part, may be mediated through expression of c98...
  8. ncbi Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice
    Jian Zhong
    Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky Medical Center, MN649 0298, Lexington, KY 40536, USA
    Biochim Biophys Acta 1762:468-77. 2006
    ....
  9. ncbi Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup
    A A Shati
    Biology Department, King Khalid University, Abha 61321, Saudi Arabia
    Neuroscience 175:66-74. 2011
    ....
  10. ncbi Anaplasma phagocytophilum inhibits human neutrophil apoptosis via upregulation of bfl-1, maintenance of mitochondrial membrane potential and prevention of caspase 3 activation
    Yan Ge
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 7:29-38. 2005
    ..These results suggest that A. phagocytophilum inhibits human neutrophil apoptosis via transcriptional upregulation of bfl-1 and inhibition of mitochondria-mediated activation of caspase 3...
  11. ncbi Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed PC12 cells
    M P Kashyap
    Indian Institute of Toxicology Research, Lucknow, India
    Chem Res Toxicol 23:1663-72. 2010
    ..Our data demonstrates that MCP induced the apoptotic cell death in neuronal cells and identifies the possible cellular and molecular mechanisms of organophosphate pesticide-induced apoptosis in neuronal cells...
  12. ncbi Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice
    Nicole P Bernal
    Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 130:412-23. 2006
    ..We sought to test the hypothesis that epidermal growth factor receptor signaling regulates specific Bcl-2 family members (Bax and Bcl-w) to direct apoptosis and adaptation after massive small-bowel resection...
  13. ncbi BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity
    A J Ross
    Center for Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dev Biol 239:295-308. 2001
    Male mice deficient in BCLW, a death-protecting member of the BCL2 family, are sterile due to an arrest in spermatogenesis that is associated with a gradual loss of germ cells and Sertoli cells from the testis...
  14. ncbi [Changes in gene expression in the course of proliferative processes in the parathyroid gland]
    Bela Szende
    I Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Budapest, Hungary
    Magy Onkol 50:137-40. 2006
    ..CASP1,10, BFAR, BOD, BCL2L2, TRANCE were underexpressed in both hyperplasia and adenoma...
  15. ncbi ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adducts
    Michal Ugarenko
    Department of Biochemistry, La Trobe University, Victoria 3086, Australia
    Biochem Pharmacol 79:339-49. 2010
    ....
  16. ncbi Spermatogenesis in Bclw-deficient mice
    L D Russell
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    Biol Reprod 65:318-32. 2001
    b>Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice that are mutant for Bclw display progressive and nearly complete testicular degeneration...
  17. ncbi TLR ligand decreases mesenteric ischemia and reperfusion injury-induced gut damage through TNF-alpha signaling
    Lee Wei Chen
    Institute of Emergency and Critical Care Medicine, National Yang Ming University, Taipei
    Shock 30:563-70. 2008
    ....
  18. ncbi Monocrotophos induced apoptosis in PC12 cells: role of xenobiotic metabolizing cytochrome P450s
    Mahendra Pratap Kashyap
    Indian Institute of Toxicology Research, Lucknow, India
    PLoS ONE 6:e17757. 2011
    ..of caspase-3/9, Bax, Bcl(2), P(53), P(21), GSTP1-1 were significantly upregulated, whereas the levels of Bclw, Mcl1 were downregulated...
  19. ncbi Bcl-2 family gene expression during severe hyperoxia induced lung injury
    M A O'Reilly
    Department of Pediatrics, School of Medicine and Dentistry, Children s Hospital at Strong, University of Rochester, New York 14642, USA
    Lab Invest 80:1845-54. 2000
    ..These findings suggest that oxygen-induced lung injury does not depend on the relative expression of these Bcl-2 members...
  20. ncbi Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells
    Ann Zeuner
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Blood 113:1522-5. 2009
    ..Altogether, these results suggest that small-molecule inhibitors of Bcl-2/Bcl-X(L) may be used in the treatment of patients with PV with high JAK2V617F allele burden...
  21. ncbi Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737
    Kenneth W Young
    MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK
    Neuropharmacology 58:1258-67. 2010
    ..Our data suggests that caspase-dependent cleavage of Bid may be a downstream amplification event which enhances the rate of mitochondrial fragmentation...
  22. ncbi Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia
    Cyprian V Weaver
    Department of Medicine, Lillihei Heart Institute, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, USA
    Exp Toxicol Pathol 59:265-72. 2008
    ....
  23. ncbi Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis
    Anatasha C Crawford
    Lombardi Comprehensive Cancer Center and Department of Oncology, School of Medicine, Georgetown University, Washington, District of Columbia, United States of America
    PLoS ONE 5:e8604. 2010
    BCL2 family members affect cell fate decisions in breast cancer but the role of BCL-W (BCL2L2) is unknown...
  24. ncbi The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1
    Nur Khairiah Mohd-Ismail
    Collaborative Anti Viral Research Group, Institute of Molecular and Cell Biology, Singapore
    J Virol 83:9993-10006. 2009
    ..Taken together, the core protein is a novel BH3-only viral homologue that contributes to the induction of apoptosis during HCV infection...
  25. ncbi Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 101:2393-400. 2003
    ....
  26. ncbi RNA expression bcl-w, a new related protein Bcl-2 family, and caspase-3 in isolated sertoli cells from pre-pubertal rat testes
    A Giannattasio
    Department of Virology, Ascalesi Hospital, Naples, Italy
    J Endocrinol Invest 25:RC23-5. 2002
    ..Further studies are required to understand whether the expression of Bcl-W and caspases is different before and after puberty in rat testis and/or in pathological conditions, that lead to an increased cell apoptosis...
  27. ncbi Integrated profiling of basal and luminal breast cancers
    José Adélaïde
    Marseille Cancer Research Center, Department of Molecular Oncology, Institut Paoli Calmettes and UMR599 Institut National de la Santé et de la Recherche Médicale, Marseille, France
    Cancer Res 67:11565-75. 2007
    ..Rare high-level amplifications contained BCL2L2, CCNE, EGFR, FGFR2, IGF1R, NOTCH2, and PIK3CA. Potential gene breaks involved ETV6 and FLT3...
  28. ncbi Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level
    She Min Zeng
    Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA
    J Gend Specif Med 6:36-42. 2003
    ..The Bcl-2 family mediates erythropoietin-dependent survival of erythroid progenitor cells and regulates erythropoiesis. We assessed for any association between Bcl-2 family nucleotide variation and hematocrit (HCT) in healthy blood donors...
  29. ncbi Association of CD45(dim)VLA-4 (+) cells with the NKT cell lineage and their selective expression of IL-13, IP-15, and CCR3 transcripts
    Agata Matejuk
    Pathology Department, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Portland, OR 97239 3098, USA
    Arch Immunol Ther Exp (Warsz) 54:183-91. 2006
    ..Although their appearance was dependent upon an elevated hormonal level, E2 was not required for their production, as they also were induced by immunization with Mycobacterium tuberculosis as a component of complete Freund's adjuvant...
  30. ncbi Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines
    Cheppail Ramachandran
    Research Institute, Miami Children s Hospital, Miami, FL 33155, USA
    Anticancer Res 25:3293-302. 2005
    ..The up-regulated genes include HIAP1, CRAF1, TRAF6, CASP1, CASP2, CASP3, CASP4, HPRT, GADD45, MCL-1, NIP1, BCL2L2, TRAP3, GSTP1, DAXX, PIG11, UBC, PIG3, PCNA, CDC10, JNK1 and RBP2...
  31. ncbi Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells
    Guorong Li
    Department of Ophthalmology, Duke University, Durham, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:2999-3007. 2011
    ..To investigate the biological functions of miR-204 in human trabecular meshwork (HTM) cells...
  32. ncbi Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers
    S Kitamura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Br J Cancer 83:668-73. 2000
    ..These findings suggest that Met expression modulates apoptosis through bcl -w expression in colorectal tumours...
  33. ncbi Induction of Bad-mediated apoptosis by Sindbis virus infection: involvement of pro-survival members of the Bcl-2 family
    Kohji Moriishi
    Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Virology 292:258-71. 2002
    ....
  34. ncbi Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver
    Hayato Hikita
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatology 50:1217-26. 2009
    ..Mcl-1 and Bcl-xL are two major anti-apoptotic Bcl-2 family proteins expressed in the liver and cooperatively control hepatic integrity during liver development and in adult liver homeostasis in a gene dose-dependent manner...
  35. ncbi In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
    Kylie D Mason
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:17961-6. 2008
    ..Our data suggest that antagonism of Bcl-2 with small organic compounds is an attractive approach to enhance the efficacy of conventional therapy for the treatment of Myc-driven lymphomas that over-express this prosurvival molecule...
  36. ncbi An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
    Glenn Liu
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    Clin Cancer Res 15:3172-6. 2009
    ..In this multi-institution phase I/II trial, we evaluated the safety and efficacy of single-agent AT-101, in men with chemotherapy naïve, castrate-resistant prostate cancer (CRPC)...
  37. ncbi Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice
    Young Sun Lee
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Yeonsu ku, Incheon, South Korea
    J Virol 83:8004-11. 2009
    ....
  38. ncbi Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition
    Sujeong Jang
    Department of Physiology, Chonnam National University Medical School, Gwangju 501 190, Republic of Korea
    Brain Res 1313:25-33. 2010
    ....
  39. ncbi IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis
    Yanxia Ning
    Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057, USA
    Mol Cancer Ther 9:1274-85. 2010
    ..These observations support the exploration of clinical trials combining antiestrogens and compounds that can induce IRF1, such as IFNgamma, for the treatment of some ER-positive breast cancers...
  40. ncbi Tumor necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist
    Janne S Suominen
    Departments of Physiology and Pediatrics, University of Turku, Turku, Finland
    Eur J Endocrinol 151:629-40. 2004
    ..Furthermore, the effects of infliximab were studied. Infliximab is a TNF-alpha antagonist used in autoimmune disorders, such as rheumatoid arthritis and Crohn's disease...
  41. ncbi Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma
    Mahmood Manavi
    Department of Gynecology and Obstetrics, Division of Special Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Gynecol Oncol 105:418-26. 2007
    ....
  42. ncbi Small-molecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer
    Ramzi Mohammad
    Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Department of Internal Medicine, Detroit, Michigan 48201, USA
    Recent Pat Anticancer Drug Discov 3:20-30. 2008
    ..A broad-spectrum or "pan" SMI which targets multiple Bcl-2 family proteins is the goal...
  43. ncbi Ligand specificity in fragment-based drug design
    Sarah Barelier
    Laboratoire des Sciences Analytiques, UMR CNRS 5180, Universite de Lyon, Universite Claude Bernard, Lyon 1, Bat ESCPE Lyon, Domaine Scientifique de la Doua, 69100 Villeurbanne, France
    J Med Chem 53:5256-66. 2010
    ..Low specificity was observed between homologous proteins or unrelated poorly druggable proteins, while higher specificity could be achieved with highly druggable targets...
  44. ncbi Follicle-stimulating hormone affects spermatogonial survival by regulating the intrinsic apoptotic pathway in adult rats
    Saleela M Ruwanpura
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Biol Reprod 78:705-13. 2008
    ..A reduction in the level of the intrinsic pathway transcript Bcl2l2 (apoptosis suppressor gene) following FSH suppression for 4 days shows that FSH regulates some components of the ..
  45. ncbi Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway
    Silvia A Mandel
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Technion Rappaport Faculty of Medicine, P O Box 9697, Haifa, 31096, Israel
    Neurochem Res 32:1694-9. 2007
    ..It is interesting to determine whether a similar effect is seen in Parkinsonian patients after long-term treatment with rasagiline, which may have implications as a possible disease modifying agent...
  46. ncbi Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary
    C P Leo
    Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305 5317, USA
    Endocrinology 140:5469-77. 1999
    ..In conclusion, rat Mcl-1 was identified as an ovarian BAD-interacting protein and the message for the antiapoptotic Mcl-1 protein was induced after treatment with gonadotropins in granulosa and thecal cells of growing follicles...
  47. ncbi Activation of apoptotic pathways in experimental acute afterload-induced right ventricular failure
    Céline Dewachter
    Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium
    Crit Care Med 38:1405-13. 2010
    ..We hypothesized that persistent right ventricular dysfunction might be related to activation of apoptotic pathways...
  48. ncbi Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta
    M Moser
    Institute for Pathology, University of Regensburg Medical School, Germany
    Genes Dev 11:1938-48. 1997
    ..Sequence analyses of ARPKD patients and linkage analyses using intragenic polymorphic markers indicate that the AP-2beta gene is located in close proximity to but distinct from the ARPKD gene...
  49. ncbi Surface functionalisation of PLGA nanoparticles for gene silencing
    Morten Ø Andersen
    Interdisciplinary Nanoscience Center iNANO, Ny Munkegade 118, University of Aarhus, Aarhus C, Denmark
    Biomaterials 31:5671-7. 2010
    ..1 cells. This rapid method for surface modification of PLGA nanoparticles promotes its application for alternative cetylated functional derivatives as a strategy to control specific biological properties of nanoparticles...
  50. ncbi Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats
    Xiao Lei Hu
    Department of Public Health and Clinical Medicine, Medicine, Umeå Stroke Centre, Umea University Hospital, S 901 87, Sweden
    Eur J Neurosci 20:1177-88. 2004
    ..pro-apoptotic proteins could be associated with the translocation of Smac/DIABLO from the mitochondria to the cytosol and therefore closely related to cell death or survival after focal cerebral ischaemia...
  51. ncbi Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w
    Mingzhong Yao
    Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurosci 25:1149-58. 2005
    ..Complete elucidation of the mechanism of Abeta-induced apoptosis promises to accelerate development of neuroprotective interventions for the treatment of AD...
  52. ncbi Mitochondrial morphogenesis, dendrite development, and synapse formation in cerebellum require both Bcl-w and the glutamate receptor delta2
    Qiong A Liu
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    PLoS Genet 4:e1000097. 2008
    ....
  53. ncbi Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells
    N Bhatnagar
    Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, 58108, USA
    Cell Death Dis 1:e105. 2010
    ..Antiapoptotic genes BCL2L2 (encoding Bcl-w) and E2F6 are identified as the targets of miR-205 and miR-31, respectively...
  54. ncbi Upregulation of AKT attenuates amyloid-?-induced cell apoptosis
    Gang Yin
    Department of Pathophysiology, the Key Laboratory of Neurological Diseases of the Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Alzheimers Dis 25:337-45. 2011
    ..Our data suggest that upregulation of AKT could be a promising therapeutic strategy for arresting A? toxicity in AD patients...
  55. ncbi Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats
    Yutao Geng
    The Institute of Medicine, Qiqihar Medical University, Qiqihar 161006, China
    Biol Pharm Bull 33:836-43. 2010
    ..These results suggest that beta-asarone may be a potential candidate for development as a therapeutic agent to manage cognitive impairment associated with conditions such as Alzheimer's disease...
  56. ncbi A putative role for human BFK in DNA damage-induced apoptosis
    Nesrin Ozören
    Department of Molecular Biology and Genetics, Apoptosis and Cancer Immunology Laboratory AKIL, Bogazici University, Istanbul, Turkey
    Biotechnol J 4:1046-54. 2009
    ..The cleaved form of the protein is dependent on the presence of BAX or BAK for its ability to induce apoptosis, since BAX(-/-)-BAK(-/-) double-knockout MEFs are completely resistant to BFK-induced apoptosis...
  57. ncbi High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry
    Ramona F Curpan
    Computational Chemistry Group, Romanian Academy Institute of Chemistry, Timisoara, Romania
    Assay Drug Dev Technol 9:465-74. 2011
    ..We discuss some of the lessons learned about screening a chemical library provided by the National Institutes of Health Small Molecule Repository (?195,000 compounds) using high-throughput flow cytometry...
  58. ncbi Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells
    Alba Pérez-Perarnau
    Departament de Ciències Fisiològiques II, Institut d Investigacio Biomedica de Bellvitge, Universitat de Barcelona, L Hospitalet de Llobregat, Spain
    Epigenetics 6:1228-35. 2011
    ..Thus, Kendine 92 is a novel HDACi with anticancer efficacy for non-proliferating CLL cells...
  59. ncbi Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death
    Barbora Brodska
    Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Cell Biochem Funct 27:167-75. 2009
    ..We suggest that variations in c-Myc and p21(WAF1) expression decelerate the apoptosis in the early period and increase the resistance of resting PBL against SAHA...
  60. ncbi UV-radiation, apoptosis and skin
    Nives Pustisek
    Children s Hospital Klaićeva, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
    Coll Antropol 35:339-41. 2011
    ..The balance between the pro-apoptotic and anti-apoptotic proteins determines cell survival or death. We discuss recent findings in the molecular mechanisms of UV induced apoptosis...
  61. ncbi Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma
    William A Michaud
    Massachusetts General Hospital MGH Cancer Center, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Cancer Res 15:1645-54. 2009
    ....
  62. ncbi Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy
    Min H Kang
    Cancer Center and the Department of Cell Biology and Biochemistry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Clin Cancer Res 15:1126-32. 2009
    ..Here, we review the role of the Bcl-2 family in apoptotic pathways and those agents that are known and/or designed to inhibit the anti-apoptotic Bcl-2 family of proteins...
  63. ncbi Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer
    Neal Ready
    Duke University Medical Center, Durham, NC, USA
    J Thorac Oncol 6:781-5. 2011
    ..AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w. In vivo and in vitro studies have exhibited broad activity of AT-101, including synergy with docetaxel in non-small cell lung cancer tumor models...
  64. ncbi An imbalance between apoptosis and proliferation contributes to follicular persistence in polycystic ovaries in rats
    Natalia R Salvetti
    Departamento de Ciencias Morfologicas, Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Argentina
    Reprod Biol Endocrinol 7:68. 2009
    ..Thus, our objective was to evaluate apoptosis and proliferation in ovarian cystic follicles in rats in order to investigate the cause of cystic follicle formation and persistence...
  65. ncbi Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis
    Shivani Srivastava
    Department of Biology, Stanford University, Stanford, CA, USA
    Clin Immunol 136:257-68. 2010
    ..Thus, SJIA monocytes are resistant to apoptosis due to alterations in both the extrinsic and intrinsic apoptosis pathways, and circulating factors associated with active SJIA may confer this phenotype...
  66. ncbi Oncogenic functions of secreted Frizzled-related protein 2 in human renal cancer
    Soichiro Yamamura
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Mol Cancer Ther 9:1680-7. 2010
    ..This study may provide better strategies for the management of renal cancer through regulation of sFRP2 pathways...
  67. ncbi Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2
    Ju Yeon Kim
    Department of Biological Science, Gachon University of Medicine and Science, 534 2 Yeonsu dong, Yeonsu gu, Incheon 406 799, Republic of Korea
    Food Chem Toxicol 48:2259-64. 2010
    ..and control cells, and Baculoviral IAP repeat-containing protein 8 (BIRC8) and apoptosis regulator Bcl-W (Bcl2L2) were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
  68. ncbi Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
    Erinna F Lee
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Biol Chem 284:30508-17. 2009
    ..Such differences are likely to influence and be important in the quest for compounds capable of selectively antagonizing the different family members...
  69. ncbi Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats
    Urvi Telang
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, NY 14260, USA
    Mol Nutr Food Res 54:1802-6. 2010
    ....
  70. ncbi Inflammation and survival pathways: chronic lymphocytic leukemia as a model system
    Lisa S Chen
    Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Biochem Pharmacol 80:1936-45. 2010
    ..Vigorous efforts are being made to create small molecules that affect these proteins directly or indirectly. Several of these pharmacological inhibitors are in early clinical trials for patients with hematological malignancies...
  71. ncbi Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis
    Ludmila Khailova
    Department of Pediatrics and Steele Children s Research Center, University of Arizona, Tucson, Arizona 85724 5073, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1118-27. 2010
    ..bifidum to downregulate apoptosis in the rat NEC model and in IEC-6 cells by a COX-2-dependent matter and suggests a molecular mechanism by which this probiotic reduces mucosal injury and preserves intestinal integrity...
  72. ncbi High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma
    Goh Eun Chung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Oncol Rep 23:113-9. 2010
    ..These results indicate that miR-15b expression in HCC tissues may predict a low risk of HCC recurrence. In addition, the modulation of miR-15b expression may be useful as an apoptosis-sensitizing strategy for HCC treatment...
  73. ncbi BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists
    K C Goldsmith
    The Children s Hospital of Philadelphia, Philadelphia, 19104 4318, USA
    Cell Death Differ 17:872-82. 2010
    ....
  74. ncbi Cloning and characterization of the 5'UTR of the rat anti-apoptotic Bcl-w gene
    Martine Uittenbogaard
    Department of Anatomy and Regenerative Biology, George Washington University Medical Center, 2300 I Street N W, Washington, DC 20037, USA
    Biochem Biophys Res Commun 389:657-62. 2009
    ..Finally, we provide the first evidence of Bcl-w localization in the growth cones of differentiating neuronal cells, suggestive of a potential synaptic neuroprotective role...
  75. ncbi siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells
    Morten Ø Andersen
    Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, Denmark
    Mol Ther 18:2018-27. 2010
    ..The released siRNAs were capable of gene silencing BCL2L2 and TRIB2, in mesenchymal stem cells (MSCs), enhancing osteogenic and adipogenic differentiation, respectively...
  76. ncbi [The Bcl-2 family pathway in gametes and preimplantation embryos]
    I Boumela
    CNRS UMR 5086, IFR 128, Institut de Biologie et Chimie des Proteines, Universite de Lyon 1, 69367 Lyon, France
    Gynecol Obstet Fertil 37:720-32. 2009
    ..Aside from basic research, a better understanding of apoptosis-related proteins and mechanisms involved in gamete and embryo viability at the molecular level may provide new guides for diagnosis and therapeutic strategies...
  77. ncbi Sensory neuropathy attributable to loss of Bcl-w
    Stephanie L Courchesne
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Neurosci 31:1624-34. 2011
    ..Collectively, these data establish bcl-w(-/-) mice as an animal model of small fiber sensory neuropathy and provide new insight regarding the role of Bcl-w and of mitochondria in preventing axonal degeneration...
  78. ncbi MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family
    L J Beverly
    Department of Cancer Genetics and Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Oncogene 28:1274-9. 2009
    ..showed that, in addition to the well characterized BCL2 and BCLxl (BCL2L1), the other four family members -- BCLw (BCL2L2), BCLb (BCL2L10), BFL1 (BCL2A1) and MCL1 -- also cooperate with MYC to accelerate leukemogenesis...
  79. ncbi Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    Mai Nguyen
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 104:19512-7. 2007
    ..In both cases, this resistance was overcome by obatoclax. These findings support a rational clinical development opportunity for the compound in cancer indications or treatments where MCL-1 contributes to resistance to cell killing...
  80. ncbi Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo
    Tracey H Wagner
    Department of Anesthesiology, School of Medicine, Washington University in St Louis, St Louis, MO 63110, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1751-9. 2007
    ..In addition, our data suggest that the ability of bcl-2 overexpression to improve survival in sepsis in this model is related in part to prevention of sepsis-induced alterations in spleen transcriptional responses...
  81. ncbi A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma
    D Chauhan
    The Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 26:2374-80. 2007
    ....
  82. ncbi Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells
    B M Pickering
    Cancer Research UK Clinical Centre, Southampton General Hospital, Southampton, UK
    Oncogene 26:1166-77. 2007
    ..These results demonstrate that a substantial proportion of CLL are dependent on NF-kappaB for enhanced survival and suggest that inhibition of NF-kappaB may have therapeutic potential...
  83. ncbi Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: potential role of bacterial proteases in host signalling
    Sonya Urnowey
    Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, Alabama 36688 0002, USA
    BMC Microbiol 6:26. 2006
    ..Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined...
  84. ncbi Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis
    J A Dominov
    Myogenesis Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Dev Dyn 220:18-26. 2001
    ..Thus, Bcl-2 function is required for particular stages of fetal and postnatal myogenesis...
  85. ncbi The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression
    Nhan L Tran
    Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
    J Biol Chem 280:3483-92. 2005
    ..Targeted therapy against Fn14 as an adjuvant to surgery may improve management of invasive glioma cells and advance the outcome of this devastating cancer...
  86. ncbi Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands
    Catherine L Day
    Department of Biochemistry, University of Otago, Dunedin 9001, New Zealand
    J Biol Chem 280:4738-44. 2005
    ..Elucidating the selective action of certain BH3-only ligands is required for delineating their mode of action and will aid the search for effective BH3-mimetic drugs...
  87. ncbi Gene expression profiling of p53(+/-) knockout and wild-type mice following diethylstilbestrol administration
    Mohd Nazil Salleh
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang Selangor, Malaysia
    IUBMB Life 56:409-16. 2004
    ....
  88. ncbi Increased Bcl-w expression following focally evoked limbic seizures in the rat
    D C Henshall
    Robert S Dow Neurobiology Laboratories, Legacy Clinical Research and Technology Center, 1225 NE 2nd Avenue, Portland, OR, 97232, USA
    Neurosci Lett 305:153-6. 2001
    ..These data suggest Bcl-w may be involved in the modulation of seizure-induced brain injury...
  89. ncbi Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK
    Susan Ceryak
    Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 255:139-49. 2004
    ..Continued investigation into the cellular and molecular mechanisms of Cr(VI)-induced cell cycle and apoptosis control should further the understanding of Cr(VI)-associated carcinogenesis...
  90. ncbi Identification of a Bcl-XL binding region within the ATPase domain of Apaf-1
    Hirohiko Yajima
    Department of Molecular Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
    Biochem Biophys Res Commun 309:520-7. 2003
    ..Bcl-2, Bcl-w, A1/Bfl-1, and Boo/Diva failed to show the same capacity for binding to BBR as Bcl-XL. These results indicate that Bcl-XL directly binds to a specific region in Apaf-1...
  91. ncbi Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis
    J Bae
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Apoptosis 6:319-30. 2001
    ..Thus, highly conserved BAD interacts with diverse antiapoptotic Bcl-2 members to regulate apoptosis...
  92. ncbi Impacts of glutathione peroxidase-1 knockout on the protection by injected selenium against the pro-oxidant-induced liver aponecrosis and signaling in selenium-deficient mice
    Wen Hsing Cheng
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    Free Radic Biol Med 34:918-27. 2003
    ..Therefore, the low level of GPX1 activity in the Se-deficient mice can exert a potent role in defending against liver aponecrosis induced by moderate oxidative stress...
  93. ncbi Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation
    Andrea Jurisicova
    Departments of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Mol Hum Reprod 9:133-41. 2003
    ..These findings suggest that cellular fragmentation in a subset of human preimplantation embryos could be regulated by certain components of a genetic programme of cell death...
  94. ncbi The Bcl-2 apoptotic switch in cancer development and therapy
    J M Adams
    Department of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Oncogene 26:1324-37. 2007
    ..Better understanding of the Bcl-2 family is clarifying its role in cancer development, revealing how conventional therapy works and stimulating the search for "BH3 mimetics" as a novel class of anticancer drugs...
  95. ncbi Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein
    Ying Xim Tan
    Collaborative Anti Viral Research Group, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore
    J Virol 81:6346-55. 2007
    ..In addition, fractionation experiments showed that 7a colocalized with Bcl-XL at the endoplasmic reticulum as well as the mitochondria, suggesting that they may form complexes in different membranous compartments...
  96. ncbi Signaling components involved in Bcl-w-induced migration of gastric cancer cells
    In Hwa Bae
    Laboratory of Radiation Cancer Biology, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Gu, Seoul, South Korea
    Cancer Lett 277:22-8. 2009
    ..These findings significantly advance our understandings of the Bcl-w-induced signaling processes that results in the migration and invasion of cancer cells...
  97. ncbi Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors
    Kate F Whitecross
    Cancer Immunology Program, The Peter MacCallum Cancer Centre, Trescowthick Research Laboratories, East Melbourne, Australia
    Blood 113:1982-91. 2009
    ..Our studies provide important preclinical data on the binding specificity of ABT-737 and its usefulness against primary hematologic malignancies when used as a single agent and in combination with HDACi...
  98. ncbi BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis
    Leslie A Miller
    Department of Dermatology, School of Medicine, University of Colorado Denver, Aurora, Colorado 80010, USA
    J Invest Dermatol 129:964-71. 2009
    ....
  99. ncbi Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
    S Y Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical School, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 94:12401-6. 1997
    ....
  100. ncbi ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
    Scott Ackler
    Global Pharmaceutical Research and Development, Abbott Laboratories, Building AP3 105, 100 Abbott Park Road, Abbott Park, IL 60064 6074, USA
    Mol Cancer Ther 7:3265-74. 2008
    ..These data suggest that combination of ABT-263 and rapamycin or its analogues represents a promising therapeutic strategy for the treatment of lymphoma...
  101. ncbi Testicular degeneration in Bclw-deficient mice
    A J Ross
    Center for Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Genet 18:251-6. 1998
    ..Molecular analysis indicates that the gene mutated is Bclw, a death-protecting member of the Bcl2 family...

Research Grants71

  1. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2003
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  2. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1999
    ....
  3. Enterocyte Apoptosis after Intestinal Resection
    Brad Warner; Fiscal Year: 2006
    ..This information is vital for the future development of safe and effective clinical therapy designed to amplify this important compensatory response in patients suffering massive intestinal loss. ..
  4. Molecular determinants of epileptic brain injury
    Roger Simon; Fiscal Year: 2007
    ..brief, electrographically defined seizures, thereby offering novel, focused neuroprotective targets beyond anticonvulsants for treating at-risk epilepsy patients. ..
  5. Cell excitation in ischemic brain injury.
    Roger Pancoast Simon; Fiscal Year: 2010
    ..As such, understanding the endogenous mechanisms that regulate rapid ischemic tolerance may lead to the identification of novel therapeutic targets for the treatment of stroke. ..
  6. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2009
    ....
  7. Bcl-2 selective inhibitors: development and application to cancer treatment
    Chengguo Xing; Fiscal Year: 2007
    ....
  8. MOLECULAR MECHANISMS OF SEIZURE INDUCED BRAIN INJURY
    Roger Simon; Fiscal Year: 2007
    ..Finally, using continuous video-EEC monitoring, we will investigate how prevention of neuronal damage following seizures effects the development of an epileptic phenotype. ..
  9. MOLECULAR MECHANISMS OF SEIZURE INDUCED BRAIN INJURY
    Roger Simon; Fiscal Year: 2009
    ..Finally, using continuous video-EEC monitoring, we will investigate how prevention of neuronal damage following seizures effects the development of an epileptic phenotype. ..
  10. FUNCTION OF BCL-W IN MURINE DEVELOPMENT
    GRANT MACGREGOR; Fiscal Year: 2001
    ..Such information may ultimately be used to help develop molecular therapies of human disease that arise from deregulated apoptosis. ..
  11. Cell excitation in ischemic brain injury.
    Roger Simon; Fiscal Year: 2007
    ..As such, understanding the endogenous mechanisms that regulate rapid ischemic tolerance may lead to the identification of novel therapeutic targets for the treatment of stroke. ..
  12. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2004
    ....
  13. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2009
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  14. Spatial Considerations in Neuronal Survival Signals
    Rosalind Segal; Fiscal Year: 2009
    ..members that are likely to protect cells from progressive neurodegeneration, including the anti-apoptotic gene bclw and the survival-promoting factor IGF-1...
  15. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2007
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  16. Transcriptional Dynamics of Neuronal Survival
    Anne Chiaramello; Fiscal Year: 2009
    ..Ultimately, the combined differentiation and neuro-protective properties of Nex1 may have broad implications for the design of novel therapeutic approaches to treat neurodegenerative diseases and CNS injuries. ..
  17. Transcriptional Dynamics of Neuronal Survival
    Anne Chiaramello; Fiscal Year: 2009
    ..Ultimately, the combined differentiation and neuro-protective properties of Nex1 may have broad implications for the design of novel therapeutic approaches to treat neurodegenerative diseases and CNS injuries. ..
  18. Transcriptional Dynamics of Neuronal Survival
    ANNE ELIANE CHIARAMELLO; Fiscal Year: 2010
    ..Ultimately, the combined differentiation and neuro-protective properties of Nex1 may have broad implications for the design of novel therapeutic approaches to treat neurodegenerative diseases and CNS injuries. ..
  19. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2005
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in neurodegenerative diseases ..
  20. Survival Signaling After Genotoxic Insult
    Susan Ceryak; Fiscal Year: 2009
    ..Delineation of the molecular circuitry involved in AKT survival signaling may have the added benefit of identifying molecular targets for rational drug design in anti-cancer therapy. ..
  21. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O apos REILLY; Fiscal Year: 2011
    ....
  22. Mitochondrial Fission and Fusion in Alzheimer Disease
    Xiongwei Zhu; Fiscal Year: 2009
    ....
  23. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2007
    ..Therefore, understanding the normal functions of bcl-2 during nephrogenesis and the consequences of its interaction with paxillin will give us important insight into kidney morphogenesis and pathogenesis. ..
  24. Specific Targets for Pancreatic Cancer Therapy
    Ramzi Mohammad; Fiscal Year: 2007
    ..Targeting Bcl-2/Bcl-xL, NF-kB and COX-2 could be novel therapeutic treatment of pancreatic cancer. ..
  25. Survival Signaling After Genotoxic Insult
    Susan Ceryak; Fiscal Year: 2007
    ..Delineation of the molecular circuitry involved in AKT survival signaling may have the added benefit of identifying molecular targets for rational drug design in anti-cancer therapy. ..
  26. Mitochondrial Fission and Fusion in Alzheimer Disease
    Xiongwei Zhu; Fiscal Year: 2010
    ....
  27. Metal Ion is Critical in amyloid beta Induced JNK Activation
    Xiongwei Zhu; Fiscal Year: 2007
    ..Aim 3: Determine the effect of metal ion chelation on Ab-induced JNK activation. Aim 4: Determine whether H2O2 mediates metal-augmented AB-induced JNK activation. ..
  28. Metal Ion is Critical in amyloid beta Induced JNK Activation
    Xiongwei Zhu; Fiscal Year: 2009
    ..Aim 3: Determine the effect of metal ion chelation on Ab-induced JNK activation. Aim 4: Determine whether H2O2 mediates metal-augmented AB-induced JNK activation. ..