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Genomes and Genes
| BAG4SummaryGene Symbol: BAG4 Description: BCL2-associated athanogene 4 Alias: BAG-4, SODD, BAG family molecular chaperone regulator 4, BAG-family molecular chaperone regulator-4, bcl-2-associated athanogene 4, silencer of death domains Species: human Top Publications
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Publications
[Hair dysplasia in oculo-dento-digital syndrome. Apropos of a mother-daughter case]H Adamski
Service de Dermatologie, CHU Pontchaillou, Rennes
Ann Dermatol Venereol 121:694-9. 1994Oculo-dento-digital syndrome (SODD) as defined by Meyer-Schwickerath in 1957 is a rare entity (84 cases) which belongs to ectodermal dysplasias...- [Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs]Hong Fang Tao
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:501-5. 2007This study was aimed to investigate the changes of silencer of death domains (SODD), survivin, caspase 3, caspase 8 and caspase 9 in the apoptotic process of human leukemia cells induced by chemotherapeutic drugs in order to explore the .. - A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23B M Riley
Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
Am J Med Genet A 143:846-52. 2007..Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 (recessive multipoint HLOD 1.07) and BAG4 (recessive multipoint HLOD 1.31). - Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70Hirotaka Matsui
Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
Mol Cell 25:99-112. 2007..The RNA binding potential of Hsc70 is regulated by cochaperones including Bag-4 (also SODD), CHIP, Hip, and Hsp40... - Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancerZeng Quan Yang
Breast Cancer Program, University of Michigan School of Medicine, Ann Arbor, Michigan 48201, USA
Cancer Res 66:11632-43. 2006..We further showed that three of these genes (LSM1, BAG4, and C8orf4) induce transformed phenotypes when overexpressed in MCF-10A cells, and overexpression of these genes .. - ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme componentsZhigang Chen
Office of Biotechnology Activities, National Institutes of Health, 6705 Rockledge Dr, Suite 750, Bethesda, MD 20892, USA
Am J Physiol Gastrointest Liver Physiol 292:G53-65. 2007..splicing regulatory protein (KSRP), apobec-1 binding protein (ABBP)1, ABBP2, and Bcl-2-associated athanogene 4 (BAG4) were unaltered. In the human intestinal cell line Caco-2, the increase of apoB mRNA editing from approximately 1... - Natural compounds obtained through centrifugal molecular distillationVanessa Mayumi Ito
Separation Process Development Laboratory, School of Chemical Engineering, State University of Campinas, PO Box 6066, 13081 970 Campinas, Brazil
Appl Biochem Biotechnol 129:716-26. 2006Soybean oil deodorized distillate (SODD) is a byproduct from refining edible soybean oil; however, the deodorization process removes unsaponifiable materials, such as sterols and tocopherols. Tocopherols are highly added value materials... - Usefulness of the final filter of the IV infusion set in intravenous administration of drugs--contamination of injection preparations by insoluble microparticles and its causesKeiji Kuramoto
Pharmacy Section, Medical Corporation Funayama Hospital, Yonezawa City, Japan
Yakugaku Zasshi 126:289-95. 2006..These results suggest that incorporation of a final filter in the IV line is extremely necessary not only for the prevention of bacterial infections, but also for elimination of insoluble microparticles... - A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalisShuichi Wada
CREST, Japan Science Technology Agency, Kawaguchi, Saitama 333 0012 corrected Japan
Cell Stress Chaperones 11:23-33. 2006..BAG2 group is conserved between humans and protostomes but was not found in Ciona, and BAG4 and BAG5 groups seem to be specific to vertebrates... - Expression of SODD and P65 in ALL of children and its relationship with chemotherapeutic drugsHongfang Tao
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
J Huazhong Univ Sci Technolog Med Sci 27:326-9. 2007The expression of silence of death domains (SODD) and its clinical significance and relationship with phospho-NF-kappaB-p65 proteins in bone marrow cells of childhood acute lymphoblastic leukaemia (ALL) were explored, and the expression .. - BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancerChristina M Annunziata
Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Clin Cancer Res 13:6585-92. 2007..We hypothesized that elevated expression in ovarian cancer of the BAG family of prosurvival proteins and associated partners would be associated with clinical features of aggressiveness in ovarian cancer... - Transforming properties of 8p11-12 amplified genes in human breast cancerZeng Quan Yang
Breast Cancer Program and Systems and Computational Biology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 70:8487-97. 2010..We identified 21 candidate genes and provided evidence that three genes, namely, LSM-1, TC-1, and BAG4, have transforming properties when overexpressed... - Positive and negative cis-regulatory elements directing postfertilization maternal mRNA translational control in mouse embryosSanthi Potireddy
Fels Institute for Cancer Research and Molecular Biology, Information Science and Technology Center, Temple University, Philadelphia, PA 19140, USA
Am J Physiol Cell Physiol 299:C818-27. 2010..We used the Bag4 3' untranslated region (UTR) as a model... - Novel protein ligands of the annexin A7 N-terminal region suggest pro-beta helices engage one another with high specificityCarl E Creutz
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Gen Physiol Biophys 28:F7-F13. 2009..A7 N terminal region were identified by yeast two hybrid screening: the TNFalpha receptor regulatory protein SODD (Suppressor Of Death Domains) and KIAA0280, a protein of unknown function... - Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarraysElisabetta Caprini
Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico and National Centre for Rare Diseases, Istituto Superiore di Sanita, Rome, Italy
Cancer Res 69:8438-46. 2009..in aberrant chromosomal regions that included cancer-related genes such as members of the NF-kappaB pathway (BAG4, BTRC, NKIRAS2, PSMD3, and TRAF2) that might explain its constitutive activation in CTCL... - Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinomaMari Bunkholt Elstrand
Section for Gynecologic Oncology, Division of Obstetrics and Gynecology, Norwegian Radium Hospital, Oslo, Norway
Int J Gynecol Pathol 28:211-21. 2009..HSP70 expression in effusions may be a prognostic marker of poor survival, with a similar role for Bcl-2 in primary carcinomas... - Nursing interventions to reduce the risk of catheter-associated urinary tract infection: part 2: staff education, monitoring, and care techniquesMargaret Willson
Columbia Hospital, Milwaukee, Wisconsin, USA
J Wound Ostomy Continence Nurs 36:137-54. 2009.... - Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancerIsabelle Bernard-Pierrot
UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Paris, France
Cancer Res 68:7165-75. 2008..profiling data for a series of 152 ductal breast carcinomas and 21 cell lines identified five genes (LSM1, BAG4, DDHD2, PPAPDC1B, and WHSC1L1) within the amplified region as consistently overexpressed due to an increased gene .. - Natural compounds obtained through centrifugal molecular distillationVanessa Mayumi Ito
Separtaion Process Development Laboratory, School of Chemical Engineering, State University of Campinas, PO Box 6066, 13081 970 Campinas, Brazil
Appl Biochem Biotechnol 131:716-26. 2006Soybean oil deodorized distillate (SODD) is a byproduct from refining edible soybean oil; however, the deodorization process removes unsaponifiable materials, such as sterols and tocopherols. Tocopherols are highly added value materials... - A proteomics strategy for the enrichment of receptor-associated complexesMaddalena Cross
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Proteomics 5:4754-63. 2005..So far among these candidate proteins, dynein, claudin and silencer of death domains co-immunoprecipitated with the CSF-1R, suggesting association... - A comparison of three neonatal resuscitation devicesStacie Bennett
Department of Pediatrics, Division of Neonatology, UCSD Medical Center, 401 Dickenson, MPF 1 140, San Diego, CA 92103 8774, USA
Resuscitation 67:113-8. 2005.... - Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domainKiyoshi Miki
Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Mol Cell Biol 22:2536-43. 2002..It has been suggested that silencer of death domain (SODD) binds TNFR1 monomers to prevent self-aggregation... - Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains proteinK Antoku
Department of Medicine, Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute, BST E1055, 211 Lothrop Street, Pittsburgh, Pennsylvania 15213 2582, USA
Biochem Biophys Res Commun 286:1003-10. 2001..The BAG-4 protein that we cloned also corresponds to the recently isolated suppressor of death domains (SODD) protein, a molecule that binds and inhibits signaling by tumor necrosis factor receptor 1 (TNFR1)... - Samui, a novel cold-inducible gene, encoding a protein with a BAG domain similar to silencer of death domains (SODD/BAG-4), isolated from Bombyx diapause eggsY Moribe
Laboratory of Sericulture and Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Japan
Eur J Biochem 268:3432-42. 2001..Samui contained nuclear localization-signals, a ssDNA-binding motif and a BAG domain similar to that of SODD/BAG-4. Because Samui could bind to HSP70, it is a member of BAG protein family... - Enhanced expression of Silencer of death domains (SODD/BAG-4) in pancreatic cancerF Ozawa
Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, CH 3010, Switzerland
Biochem Biophys Res Commun 271:409-13. 2000Pancreatic cancers are resistant to TNF-alpha-mediated apoptosis. Silencer of death domains (SODD) binds to TNF-alpha receptor TNFR-1, and prevents spontaneous self-association of death domains and inappropriate receptor signaling... - Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikisS M Frisch
The Burnham Institute 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Curr Biol 9:1047-9. 1999..In this assay, silencer of death domains (SODD) and dominant-negative FAS-associated death domain protein (FADD) efficiently inhibited anoikis in .. - Apoptosis: Silencing the death receptorsJ Tschopp
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066, Epalinges, Switzerland
Curr Biol 9:R381-4. 1999..An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively .. - Prevention of constitutive TNF receptor 1 signaling by silencer of death domainsY Jiang
Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
Science 283:543-6. 1999..This apparent paradox may be explained by silencer of death domains (SODD), a widely expressed approximately 60-kilodalton protein that was found to be associated with the .. - An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulatorsS Takayama
The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 274:781-6. 1999..The findings suggest opportunities for specification and diversification of Hsp70/Hsc70 chaperone functions through interactions with various BAG-family proteins... - Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cellsH Eichholtz-Wirth
Institute of Radiobiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
Anticancer Res 22:235-40. 2002..Of major importance for resistance in HT-R15 cells is the silencer of death domain, SODD/BAG4... - BAG4/SODD protein contains a short BAG domainKlára Briknarová
Burnham Institute, La Jolla, CA 92037, USA
J Biol Chem 277:31172-8. 2002..We have determined the solution structure of BD from BAG4/SODD (silencer of death domains) by multidimensional nuclear magnetic resonance methods and compared it to the corresponding domain in .. - Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviourIan Todd
Institute of Infection, Immunity and Inflammation, Division of Immunology, School of Molecular Medical Sciences, University of Nottingham, UK
Immunology 113:65-79. 2004..and chaperones, and with the signal transducer TRADD, but not with the inhibitor, silencer of death domain (SODD)... - Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editingPaul P Lau
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 278:52988-96. 2003..BAG-4, a chaperone-regulating protein, also known as SODD (silencer of death domains), is a member of the BAG family of proteins... - Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domainsRobert Endres
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, D 81675 Munich, Germany
Mol Cell Biol 23:6609-17. 2003The silencer of death domains (SODD) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 (TNFR1) in the absence of ligand... - Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplantsRafia S Al-Lamki
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
Am J Pathol 163:401-11. 2003..We have extended our studies to examine the expression of Silencer of Death Domains (SODD), a protein that binds to the cytoplasmic portion of TNFR1 to inhibit signaling in the absence of .. - Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal deathSachiko Shinoda
Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA
Eur J Neurosci 17:2065-76. 2003..Seizures caused a rapid decline in the expression of the silencer of death domains protein within injured CA3... - Role of SODD in regulation of tumor necrosis factor responsesHidetoshi Takada
Advanced Medical Discovery Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
Mol Cell Biol 23:4026-33. 2003..It was suggested that the silencer of death domains (SODD) protein constitutively associates intracellularly with TNFR1 and inhibits the recruitment of .. - Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathwaysHedda Eichholtz-Wirth
GSF National Research Center for Environment and Health, Institute of Radiobiology, Ingolstaedter Landstr 1, D 85764, Neuherberg, Germany
Cancer Lett 194:81-9. 2003The involvement of SODD/BAG-4 was studied in TNFR1 signaling, using SODD/BAG-4- overexpressing HeLa cells as a cellular model... - Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26Masuko Katoh
M and M Medical BioInformatics, Narashino 275 0022, Japan
Int J Mol Med 11:579-83. 2003..Inter-chromosomal comparison revealed that the human BAG3-FGFR2-TACC2 region was paralogous to the human BAG4-FGFR1-TACC1 region... - Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeletonParvin Rahman
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
J Biol Chem 286:29758-70. 2011..In this current study, we identify a molecular co-chaperone termed silencer of death domains (SODD/BAG4) that forms a complex with several 5-ptase family members, including SKIP, SHIP1, and SHIP2...
Research Grants
- NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinomaWeibiao Cao; Fiscal Year: 2010..In addition, ROS may upregulate cyclin D1 and the silencer of the death domain (SODD). Upregulation of cyclin D1 and SODD will increase cell proliferation and decrease apoptosis in these cells...
- ANNEXIN PHOSPHORYLATION: CAUSES AND CONSEQUENCESCARL CREUTZ; Fiscal Year: 2004....
- CALCIUM DEPENDENT MEMBRANE BINDING PROTEINSCARL CREUTZ; Fiscal Year: 2002....