AURKA

Summary

Gene Symbol: AURKA
Description: aurora kinase A
Alias: AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, ARK-1, IPL1-related kinase, aurora 2, aurora-related kinase 1, aurora/IPL1-like kinase, aurora/IPL1-related kinase 1, breast tumor-amplified kinase, breast-tumor-amplified kinase, hARK1, protein phosphatase 1, regulatory subunit 47, serine/threonine kinase 6, serine/threonine protein kinase 15, serine/threonine-protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase aurora-A
Species: human

Top Publications

  1. ncbi Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
    Patrick Meraldi
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    EMBO J 21:483-92. 2002
  2. ncbi Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    H Zhou
    Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 20:189-93. 1998
  3. ncbi Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:991-7. 2003
  4. ncbi Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma
    Rudolf Reiter
    Department of Otolaryngology Head and Neck Surgery, Universitatsklinikum Ulm, Ulm, Germany
    Clin Cancer Res 12:5136-41. 2006
  5. ncbi Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215
    Qiyuan Liu
    Departments of Pathology and Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 279:52175-82. 2004
  6. ncbi A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
    S Sen
    Division of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    Oncogene 14:2195-200. 1997
  7. ncbi Aurora-A interacts with Cyclin B1 and enhances its stability
    Lili Qin
    State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Cancer Lett 275:77-85. 2009
  8. ncbi 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile
    Daniele Fancelli
    Nerviano Medical Sciences S r l viale Pasteur 10, 20014 Nerviano, Milan, Italy
    J Med Chem 49:7247-51. 2006
  9. ncbi MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy
    Kara Hoar
    Department of Molecular and Cellular Oncology, Millenium Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Mol Cell Biol 27:4513-25. 2007
  10. ncbi Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions
    Altaf A Dar
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer 112:1688-98. 2008

Research Grants

  1. Aurora-A/BTAK/STK15 Oncoprotein in Mitotic Spindle Assembly and Checkpoint Respon
    Subrata Sen; Fiscal Year: 2010
  2. BRCA1 function in G2-M checkpoint and mitosis
    Toru Ouchi; Fiscal Year: 2007
  3. BRCA1 function in G2-M checkpoint and mitosis
    Toru Ouchi; Fiscal Year: 2006
  4. Regulation of Chromosome Segregation
    SUSAN BIGGINS; Fiscal Year: 2006
  5. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2010
  6. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
  7. Circle of Willis variability and migraine
    Brett Cucchiara; Fiscal Year: 2007
  8. Assembly and Function of Mammalian Centrosomes
    Ryoko Kuriyama; Fiscal Year: 2007
  9. TOGAVIRUS REPLICATION OF STRATEGIES AND EVOLUTION
    James Strauss; Fiscal Year: 1999
  10. Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer
    Bogdan A Czerniak; Fiscal Year: 2010

Detail Information

Publications257 found, 100 shown here

  1. ncbi Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
    Patrick Meraldi
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    EMBO J 21:483-92. 2002
    ..We propose that errors during cell division, combined with the inability to detect the resulting hyperploidy, constitute a major cause for numerical centrosome aberrations in tumors...
  2. ncbi Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    H Zhou
    Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 20:189-93. 1998
    ..Here, we report that STK15 (also known as BTAK and aurora2), encoding a centrosome-associated kinase, is amplified and overexpressed in multiple human tumour cell types, ..
  3. ncbi Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:991-7. 2003
    ..Overexpression of the STK15/BTAK/Aurora A gene located on chromosome 20q13, which encodes a centrosome-associated serine/threonine kinase, has ..
  4. ncbi Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma
    Rudolf Reiter
    Department of Otolaryngology Head and Neck Surgery, Universitatsklinikum Ulm, Ulm, Germany
    Clin Cancer Res 12:5136-41. 2006
    Aurora kinase A (AURKA/STK15/BTAK) encodes a serine/threonine kinase associated with chromosomal distribution and its up-regulation induces chromosomal instability, thereby leading to aneuploidy and cell transformation in several types ..
  5. ncbi Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215
    Qiyuan Liu
    Departments of Pathology and Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 279:52175-82. 2004
    ..B., Czerniak, B. A., and Sen, S. (2004) Nat. Genet. 36, 55-62). Our data indicate that phosphorylation of p53 at Ser-215 by Aurora-A is a major mechanism to inactivate p53 and can provide a molecular insight for Aurora-A function...
  6. ncbi A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
    S Sen
    Division of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    Oncogene 14:2195-200. 1997
    ..We describe in this paper isolation of a novel gene named BTAK, encoding a putative member of protein serine/threonine kinase family localized on chromosome 20q13 that is ..
  7. ncbi Aurora-A interacts with Cyclin B1 and enhances its stability
    Lili Qin
    State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Cancer Lett 275:77-85. 2009
    ..These results provide new insight into the mechanism of how deregulated Aurora-A contributes to genomic instability and carcinogenesis...
  8. ncbi 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile
    Daniele Fancelli
    Nerviano Medical Sciences S r l viale Pasteur 10, 20014 Nerviano, Milan, Italy
    J Med Chem 49:7247-51. 2006
    ....
  9. ncbi MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy
    Kara Hoar
    Department of Molecular and Cellular Oncology, Millenium Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Mol Cell Biol 27:4513-25. 2007
    ..Taken together, these results suggest that Aurora A inhibition kills tumor cells through the development of deleterious aneuploidy...
  10. ncbi Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions
    Altaf A Dar
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer 112:1688-98. 2008
    ..In this study, the authors investigated the prevalence and biological significance of Aurora Kinase A (AURKA) overexpression in upper gastrointestinal adenocarcinomas.
  11. ncbi Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    Hiroshi Katayama
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 36:55-62. 2004
    Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers...
  12. ncbi Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival
    Jin E Yao
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou, PR China
    Mol Cancer 8:95. 2009
    ..As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which Aurora-A enhances cancer cell survival remain to be elucidated...
  13. ncbi Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration
    Chao Chin Li
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, 155 Li Nong Street, Section 2, Peitou, Taipei 112, Taiwan
    Mol Cancer Res 7:678-88. 2009
    ..This transgenic mouse model provides a useful system that allows the study of the physiologic effects of Aurora-A on liver regeneration and the genetic pathways of Aurora-A-mediated tumorigenesis in liver...
  14. ncbi Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases
    Reiko Ban
    Department of Biochemistry, Shimane University School of Medicine, Izumo 693 8501, Japan
    J Biol Chem 284:28367-81. 2009
    ..Our results provide new insight into a regulatory mechanism of +TIPs in cell cycle transition...
  15. ncbi Mitotic kinases as regulators of cell division and its checkpoints
    E A Nigg
    Max Planck Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Rev Mol Cell Biol 2:21-32. 2001
    ..Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission...
  16. ncbi The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis
    Masami Yamada
    Department of Genetic Disease Research, Osaka City University Graduate School of Medicine, Abeno, Osaka, Japan
    Cell Adh Migr 4:180-4. 2010
    ....
  17. ncbi Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
    Xiang Bo Wan
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou 510060, China
    Carcinogenesis 29:1930-7. 2008
    ..Small chemical inhibitor VX-680 may offer as a promising molecular targeting agent in human NPC...
  18. ncbi Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma
    Shang Bin Yang
    Laboratory of Cell and Molecular Biology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021 Beijing, PR China
    Oncol Rep 17:1083-8. 2007
    Aurora-A/BTAK/STK15 gene which encodes a centrosome-associated kinase is located on chromosome 20q13.2, a highly amplified region in various human tumors...
  19. ncbi Aurora-A overexpression as an early marker of reflux-related columnar mucosa and Barrett's oesophagus
    V Agnese
    Section of Medical Oncology, Department of Surgery and Oncology, Universita di Palermo, Italy
    Ann Oncol 18:vi110-5. 2007
    ..Aurora-A overexpression leads to centrosome amplification, chromosomal instability and aneuploidy in mammalian cells...
  20. ncbi Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
    Toru Hirota
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Japan
    Cell 114:585-98. 2003
    ..Depletion of Ajuba prevented activation of Aurora-A at centrosomes in late G2 phase and inhibited mitotic entry. Overall, our data suggest that Ajuba is an essential activator of Aurora-A in mitotic commitment...
  21. ncbi Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
    Richard Bayliss
    Structural and Computational Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Mol Cell 12:851-62. 2003
    ..The recognition between Aurora-A and TPX2 resembles that between the cAPK catalytic core and its flanking regions, suggesting this molecular mechanism may be a recurring theme in kinase regulation...
  22. ncbi Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly
    Ming Ying Tsai
    Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, Maryland 21218, USA
    Curr Biol 15:2156-63. 2005
    The roles of the kinase Aurora A (AurA) in centrosome function and spindle assembly have been established in Drosophila, C. elegans, and Xenopus egg extracts ...
  23. ncbi Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells
    Hua Yang
    Department of Pathology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, 33612, USA
    Int J Cancer 119:2304-12. 2006
    ....
  24. ncbi AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    Shubha Anand
    CR UK Department of Oncology and the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cancer Cell 3:51-62. 2003
    ..Consistent with this conclusion, elevated Aurora-A expression causes resistance to apoptosis induced by Taxol in a human cancer cell line...
  25. ncbi Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer
    Tatiana M Gritsko
    Department of Pathology and Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    Clin Cancer Res 9:1420-6. 2003
    Previous studies have demonstrated amplification of the centrosome serine/threonine kinase BTAK/Aurora-A in 10-25% of ovarian cancers...
  26. ncbi The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas
    Wilfried Reichardt
    Institute of Human Genetics, Saarland University, Saarland University Hospital, Homburg Saar, Germany
    Oncol Rep 10:1275-9. 2003
    ..correlation between the recurrence and progression of astrocytic low grade gliomas and the amplification of the STK15 gene located in the chromosomal region 20q13...
  27. ncbi Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma
    Christine G Hammerschmied
    Department of Urology, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 17:3-7. 2007
    ..b>STK15 is an important protein in control of the integrity of the mitotic spindle apparatus and genomic stability...
  28. ncbi The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
    A O Walter
    DNAX Research Institute, Palo Alto, California 94304, USA
    Oncogene 19:4906-16. 2000
    b>Aurora2 is a cell cycle regulated serine/threonine protein kinase which is overexpressed in many tumor cell lines. We demonstrate that Aurora2 is regulated by phosphorylation in a cell cycle dependent manner...
  29. ncbi Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation
    Nadia Trieselmann
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada, M5S 1A8
    J Cell Sci 116:4791-8. 2003
    ..Therefore, by regulating a subset of TPX2 and Kid activities, Ran modulates at least two processes involved in spindle assembly...
  30. ncbi TACC1-chTOG-Aurora A protein complex in breast cancer
    Nathalie Conte
    Department of Molecular Oncology, U119 INSERM, Institut Paoli Calmettes, IFR57, Marseille, France
    Oncogene 22:8102-16. 2003
    ....
  31. ncbi STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis
    Melanie E Royce
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:12-9. 2004
    ..b>STK15 maps to this amplicon...
  32. ncbi Functional interaction of Aurora-A and PP2A during mitosis
    Virginie Horn
    Institut Albert Bonniot, Centre de Recherche Institut National de la Santé et de la Recherche Médicale, Université Joseph Fourier U 823, Equipe DySAD, Universite Joseph Fourier Site Sante, BP 170, F38042, Grenoble Cedex 09, France
    Mol Biol Cell 18:1233-41. 2007
    ....
  33. ncbi The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1
    Jian Du
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Nucleic Acids Res 30:5465-75. 2002
    Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation...
  34. ncbi Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases
    Claudia Crosio
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Strasbourg, France
    Mol Cell Biol 22:874-85. 2002
    ..Here we show that the expression of Aurora-A and Aurora-B, two kinases of the Aurora/AIK family, is tightly coordinated with H3 phosphorylation during the G(2)/M transition...
  35. ncbi Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
    Brenda Lauffart
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Biochem J 363:195-200. 2002
    ..This suggests that the TACC proteins can form multiple complexes, dysregulation of which may be an important step during tumorigenesis...
  36. ncbi Expression of STK15 mRNA in hepatocellular carcinoma and its prognostic significance
    Rui Wang
    Department of Medical Oncology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing, PR China
    Clin Biochem 42:641-7. 2009
    To investigate whether the STK15 mRNA expression correlates with clinicopathologic features and the prognosis of HCC patients.
  37. ncbi Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy
    Silke Lassmann
    Institute of Pathology, University Hospital, Albert Ludwigs University Freiburg, Freiburg, Germany
    Clin Cancer Res 13:4083-91. 2007
    To investigate the expression and regulation of the centrosomal kinase Aurora-A/STK15 (AURKA) in epithelial ovarian cancers and to determine the prognostic and predictive value of this marker for patients with late stage epithelial ..
  38. ncbi Human TPX2 is required for targeting Aurora-A kinase to the spindle
    Thomas A Kufer
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Cell Biol 158:617-23. 2002
    ..We propose that human TPX2 is required for targeting Aurora-A kinase to the spindle apparatus. In turn, Aurora-A might regulate the function of TPX2 during spindle assembly...
  39. ncbi Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function
    Shih Shun Chen
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    EMBO J 21:4491-9. 2002
    Using a transactivation-defective p53 derivative as bait, STK15, a centrosome-associated oncogenic serine/threonine kinase, was isolated as a p53 partner...
  40. ncbi Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation
    R Rong
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 26:7700-8. 2007
    ..In view of our results, we propose that Aurora-A-mediated phosphorylation of RASSF1A is a novel mechanism that regulates the ability of this tumor suppressor to interact with microtubules and modulate M-phase cell cycle progression...
  41. ncbi Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers
    Silke Lassmann
    Institute of Pathology, University Medical Center, Albert Ludwigs University, Breisacherstrasse 115a, Freiburg, Germany
    Mod Pathol 22:1385-97. 2009
    ..Thus, sporadic colorectal cancers exhibit different mechanisms of aurora A regulation and this may impact the efficacy of aurora-targeted therapies...
  42. ncbi Essential roles of mTOR/Akt pathway in Aurora-A cell transformation
    Makoto Taga
    ENH, Department of Medicine, Northwestern University, Evanston, IL 60201, USA
    Int J Biol Sci 5:444-50. 2009
    ..These results strongly suggest that commitment of cell transformation by Aurora-A is determined by at least co-activation of Akt/mTOR pathway...
  43. ncbi HEF1-dependent Aurora A activation induces disassembly of the primary cilium
    Elena N Pugacheva
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Cell 129:1351-63. 2007
    ..show that interactions between the prometastatic scaffolding protein HEF1/Cas-L/NEDD9 and the oncogenic Aurora A (AurA) kinase at the basal body of cilia causes phosphorylation and activation of HDAC6, a tubulin deacetylase, promoting ..
  44. ncbi BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition
    Mutsuko Ouchi
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 279:19643-8. 2004
    Aurora-A/BTAK/STK15 localizes to the centrosome in the G(2)-M phase, and its kinase activity regulates the G(2) to M transition of the cell cycle...
  45. ncbi Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis
    Masaaki Tatsuka
    Department of Regulatory Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima 734 8553, Japan
    Oncogene 24:1122-7. 2005
    ....
  46. ncbi Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1
    M Kimura
    Department of Molecular Pathobiochemistry, Gifu University School of Medicine, Tsukasamachi 40, Gifu 500, Japan
    J Biol Chem 272:13766-71. 1997
    ..which shares high amino acid identities with the Aurora/Ipl1 protein kinase family; hence the cDNA is designated as aik (aurora/IPL1-related kinase)...
  47. ncbi Mitotic activation of the kinase Aurora-A requires its binding partner Bora
    Andrea Hutterer
    Institute of Molecular Biotechnology IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Dev Cell 11:147-57. 2006
    ..We propose a model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A...
  48. ncbi Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types
    Amanda Ewart-Toland
    UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Carcinogenesis 26:1368-73. 2005
    b>STK15 (Aurora-A) is a serine/threonine kinase involved in mitotic chromosomal segregation...
  49. ncbi Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A
    Chang Tze Ricky Yu
    Division of Molecular and Genomic Medicine, National Health Research Institutes, No 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China
    Mol Cell Biol 25:5789-800. 2005
    ..While this combined approach was simply an initial attempt to answer a range of complex biological questions, our findings do suggest that HURP is a potential oncogenic target of Aurora-A...
  50. ncbi Inhibition of Aurora A in response to DNA damage
    A Krystyniak
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Oncogene 25:338-48. 2006
    ..Here, we provide evidence that Aurora A (AurA) was inhibited upon generation of double-strand breaks in DNA...
  51. ncbi Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain
    Jim Wong
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Mol Biol Cell 19:2083-91. 2008
    ..We concluded that phosphorylation of HURP by Aurora A provides a regulatory mechanism for the control of spindle assembly and function...
  52. ncbi Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms
    E Comperat
    Service Central d Anatomie et Cytologie Pathologiques et d Urologie, hôpital La Pitié Salpêtrière, 83, Bd de l Hopital, 75013, Paris, France
    Virchows Arch 450:419-24. 2007
    ..03 in the NILGC group. Aurora-A is a more sensitive marker than MIB-1 to predict relapse in pTa bladder neoplasias. The combination of both markers seems to have a very powerful predictive value of recurrence (p<0.001)...
  53. ncbi Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells
    Yoshikazu Ando
    Department of Pharmacology and Horizontal Medical Research Organization, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Mol Biol Cell 18:3752-63. 2007
    ..These results suggest that Rho GTPases function in G2/M transition of mammalian cells by mediating multiple signaling pathways converging to centrosomal activation of Aurora-A...
  54. ncbi NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment
    Daisuke Mori
    Osaka City University Graduate School of Medicine, Genetic Disease Research, Asahi machi 1 4 3 Abeno, Osaka 545 8586, Japan
    Mol Cell Biol 27:352-67. 2007
    ..Our findings suggest that Aurora-A-mediated phosphorylation of NDEL1 is essential for centrosomal separation and centrosomal maturation and for mitotic entry...
  55. ncbi Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein
    David L Satinover
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 101:8625-30. 2004
    ..These results suggest that both I-2 and TPX2 function as allosteric activators of Aurora-A. This implies that I-2 is a bifunctional signaling protein with separate domains to inhibit PP1 and directly stimulate Aurora-A kinase...
  56. ncbi Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition
    Stéphanie Dutertre
    Groupe Cycle Cellulaire CNRS UMR6061 IFR97, Génomique Fonctionnelle et Santé, Universite de Rennes I, 35043 Rennes, France
    J Cell Sci 117:2523-31. 2004
    ..This phosphorylation might locally participate in the control of the onset of mitosis. These findings re-emphasise the role of the centrosome as a functional integrator of the pathways contributing to the triggering of mitosis...
  57. ncbi Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma
    Xiaoping Miao
    Department of Etiology and Carcinogenesis and Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Cancer Res 64:2680-3. 2004
    b>STK15/BTAK/Aurora-A involved in regulating centrosomes and chromosome segregation is amplified and overexpressed in human cancers...
  58. ncbi STK15 polymorphism and breast cancer risk in a population-based study
    Kathleen M Egan
    Vanderbilt University Medical Center, Suite 6000, MCE, Nashville, TN 37232 8300, USA
    Carcinogenesis 25:2149-53. 2004
    b>STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis...
  59. ncbi Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma
    Tong Sun
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 25:2225-30. 2004
    Aurora-A/BTAK/STK15, involved in regulating centrosomes and chromosome segregation, is overexpressed in human breast carcinoma and other cancers...
  60. ncbi IKKalpha regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation
    Shashi Prajapati
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Cell Cycle 5:2371-80. 2006
    ..Taken together, these data provide the evidence that IKKalpha regulates the M phase of the cell cycle by modulating Aurora A phosphorylation and activation leading to the regulation of the M phase of the cell cycle...
  61. ncbi The aurora kinase A regulates GSK-3beta in gastric cancer cells
    A A Dar
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Oncogene 28:866-75. 2009
    Aurora kinase A (AURKA) is located at 20q13, a region that is frequently amplified in gastric cancer...
  62. ncbi Overexpression and amplification of Aurora-A in hepatocellular carcinoma
    Yung Ming Jeng
    Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    Clin Cancer Res 10:2065-71. 2004
    Aurora-A/STK15/BTAK, a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation...
  63. ncbi STK15 polymorphisms and association with risk of invasive ovarian cancer
    Richard A Dicioccio
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1589-94. 2004
    b>STK15 is a putative oncogene that codes for a centrosome-associated, serine/threonine kinase, the normal function of which is to ensure accurate segregation of chromosomes during mitosis...
  64. ncbi A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
    J R Bischoff
    SUGEN, Inc, Redwood City, California 94063, USA
    EMBO J 17:3052-65. 1998
    ..We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell-cycle-regulated serine/threonine kinases...
  65. ncbi Intravenous magnesium sulfate rapidly alleviates headaches of various types
    A Mauskop
    Department of Neurology, State University of New York, Health Science Center at Brooklyn 11203, USA
    Headache 36:154-60. 1996
    ..2 +/- 7.3 years] and 29 women [37.8 +/- 10.2 years]), 16 patients had migraines without aura, 9 patients had cluster headaches, 4 patients had chronic tension-type headaches, and 11 had chronic migrainous ..
  66. ncbi AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma
    Fan Yang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 24:836-45. 2011
    Aurora kinase A (AURKA), a serine/threonine kinase, has been shown to regulate the cell cycle checkpoint and maintain genomic integrity. AURKA is overexpressed in various carcinomas...
  67. ncbi Decreased serum interleukin-2 level in patients with chronic headache
    T Shimomura
    Division of Neurology, Tottori University Faculty of Medicine, Yonago, Japan
    Headache 31:310-3. 1991
    ..Thirteen subjects suffering from migraine without aura (5 males and 8 females, mean age: 32.8 years) and 46 subjects (20 males and 26 females, mean age: 39...
  68. ncbi Dracula's teeth syndrome
    D E Jacome
    Department of Medicine, Franklin Medical Center, Greenfield, Massachusetts, USA
    Headache 41:892-4. 2001
    ..RESULTS: A 52-year-old woman with history of migraine without aura for 40 years exhibited focal right facial involuntary tonic contracture accompanying chronic severe pain over the ..
  69. ncbi Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines
    V Covelli
    II Faculty of Medicine, University of Naples, Italy
    Immunopharmacol Immunotoxicol 20:199-209. 1998
    ..This review will place emphasis on some clinical conditions, such as phobia and migraine without aura (MWA), characterized by anxiety disorders...
  70. ncbi Comparison of intravenous valproate versus intramuscular dihydroergotamine and metoclopramide for acute treatment of migraine headache
    K R Edwards
    Western New England Pain and Headache Center, Southwestern Vermont Medical Center, Bennington, VT 05201, USA
    Headache 41:976-80. 2001
    ..and tolerability of intravenous valproate for the acute treatment of migraine headache with or without aura (International Headache Society diagnostic criteria 1.1 and 1...
  71. ncbi Oral almotriptan in the treatment of migraine: safety and tolerability
    D W Dodick
    Department of Neurology, Mayo Clinic Scottsdale, Ariz
    Headache 41:449-55. 2001
    ..CONCLUSIONS: Almotriptan was safe and well tolerated in nearly all adult patients with migraine, with and without aura, enrolled in these studies...
  72. ncbi Prognostic significance of Aurora-A expression in human bladder cancer
    Yu Lei
    Tianjin Unode Laboratory of Basic Medical Urology, Tianjin Institute of Urology, Department of Urology, The Second Hospital of Tianjin Medical University, PR China
    Acta Histochem 113:514-8. 2011
    ..Our study suggests that overexpression of Aurora-A gene may play an important role in the progression of bladder cancer and that Aurora-A expression is an independent factor for predicting the prognosis of bladder cancer in patients...
  73. ncbi Spontaneous oscillations in cerebral blood flow velocity give evidence of different autonomic dysfunctions in various types of headache
    U Sliwka
    Department of Neurology, Friedrich-Schiller University, Philosophenweg 3, D-07740 Jena, Germany
    Headache 41:157-63. 2001
    ..monitoring of the middle cerebral artery B waves and Mayer waves were studied in 30 patients with migraine without aura, 28 subjects with tension-type headache, and 30 normal controls...
  74. ncbi Antiepileptic drugs: how they work in headache
    F M Cutrer
    Department of Neurology, Harvard Medical School, and Headache Center, Massachusetts General/Brigham and Women's Hospitals, Boston, MA 02114, USA
    Headache 41:S3-10. 2001
    ..AEDs may be useful in migraine prevention through such mechanisms as modulating the biochemical phenomena of aura or acting directly on the nociceptive system...
  75. ncbi Assessing the relative incidence of mitochondrial DNA A3243G in migraine without aura with maternal inheritance
    G Di Gennaro
    IRCCS Neuromed, Pozzilli, Italy
    Headache 40:568-71. 2000
    OBJECTIVE: To determine whether patients with migraine without aura with maternal "inheritance" are affected by a monosymptomatic form of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes) or ..
  76. ncbi Shared mechanisms and comorbidities in neurologic and psychiatric disorders
    S D Silberstein
    Department of Neurology, Jefferson Medical College and Jefferson Headache Clinic, Philadelphia, PA 19107, USA
    Headache 41:S11-7. 2001
    ..migraine and stroke, particularly among women of childbearing age and individuals who experience migraine with aura. Lastly, a bidirectional association between migraine and essential tremor also exists...
  77. ncbi Platelet antibodies in patients with migraine
    M Schabet
    , , Germany
    Headache 38:472-4. 1998
    ..We therefore, examined sera from 42 migraineurs without aura, 26 migraineurs with aura, and 107 headache-free blood donors for platelet-reactive antibodies using the platelet ..
  78. ncbi Migraine with aura: a vicious cycle perpetuated by potassium-induced vasoconstriction
    D B Young
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Headache 32:24-34. 1992
    Two hypotheses have dominated attempts to understand the etiology of migraine with aura or classic migraine; the vascular spasm model proposed by Wolff and colleagues, and the spreading cortical depression hypothesis...
  79. ncbi Migraine complicated by brachial plexopathy as displayed by MRI and MRA: aberrant subclavian artery and cervical ribs
    E H Saxton
    Department of Neurology, UCLA School of Medicine, USA
    J Natl Med Assoc 91:333-41. 1999
    This article describes migraine without aura since childhood in a patient with bilateral cervical ribs...
  80. ncbi beta-endorphin in plasma and monocytes in juvenile headache
    P A Battistella
    Department of Pediatrics, University of Padua, Padova, Italy
    Headache 36:91-4. 1996
    ..cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/..
  81. ncbi Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness?
    K M Welch
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160-7300, USA
    Headache 41:629-37. 2001
    ..R2' is a measure of non-heme iron in tissues. METHODS: Seventeen patients diagnosed with EM with and without aura, 17 patients diagnosed with CDH and medication overuse, and 17 normal adults (N) were imaged with a 3...
  82. ncbi Genetic and environmental factors associated with migraine in schoolchildren
    A Bener
    Department of Community Medicine, Faculty of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates
    Headache 40:152-7. 2000
    ..9 +/- 2.5 years). Of the children who had migraine, 20 (12.6%) had migraine without aura, and 13 (8.2%) had migraine with aura...
  83. ncbi [Migrainous aura subtypes in hospitalized children]
    Agnieszka Biedrón
    Katedra Neurologii Dzieci i Młodziezy, Uniwersytet Jagielloński Collegium Medicum, Krakow
    Przegl Lek 66:952-7. 2009
    Migraine with aura is characterized by reversible focal neurological symptoms preceding or accompanying headache...
  84. ncbi Botulinum toxin type A as a migraine preventive treatment. For the BOTOX Migraine Clinical Research Group
    S Silberstein
    Thomas Jefferson University School of Medicine, Philadelphia, PA, USA
    Headache 40:445-50. 2000
    ..study of 123 subjects with a history of two to eight moderate-to-severe migraine attacks per month, with or without aura. Participants were randomized to receive single administrations of vehicle or botulinum toxin type A, 25 U or 75 U, ..
  85. ncbi Prevalence of migraine in Croatia: a population-based survey
    R Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Italy
    Headache 41:805-12. 2001
    ..1%). Among 636 active migraineurs, 399 (62.7%) were women and 237 (37.3%) were men; 55.8% had migraine without aura, 35.2% migraine with aura, and 6.9% migraine both with and without aura...
  86. ncbi Neck mobility in different headache disorders
    J A Zwart
    Department of Neurology, Regionsykehuset i Trondheim, Norway
    Headache 37:6-11. 1997
    ..and 90 headache patients were investigated, where of 28 patients suffered from common migraine (migraine without aura), 34 from tension-type headache (9 episodic and 25 chronic), and 28 patients from cervicogenic headache...
  87. ncbi Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group
    R A Ophoff
    MGC-Department of Human Genetics, Sylvius Laboratory, Leiden (The Netherlands) University, The Netherlands
    Headache 37:479-85. 1997
    A gene for familial hemiplegic migraine, a subtype of migraine with aura, was assigned to chromosome 19p13...
  88. ncbi Migraine symptoms: results of a survey of self-reported migraineurs
    S D Silberstein
    Temple University School of Medicine, Philadelphia, PA, USA
    Headache 35:387-96. 1995
    ..Many migraine patients suffer needlessly because their nausea and vomiting are both unreported to, and unrecognized by physicians. The presence of these symptoms is crucial to diagnose migraine not accompanied by aura.
  89. ncbi Continuous intravenous dihydroergotamine in the treatment of intractable headache
    R G Ford
    Ford Headache Clinic, Birmingham, AL 35213, USA
    Headache 37:129-36. 1997
    ..Seventy-one (42%) had drug rebound headache. One hundred thirty-eight (81%) had refractory migraine without aura, and 28 (16%) had migraine with aura. Treatment consisted of either continuous i.v...
  90. ncbi MMPI changes associated with therapeutic intervention: a migraine control study
    A Y Fan
    Department of Acute and Intractable Diseases, Chinese Medicine Institute, Nanjing University of Traditional Chinese Medicine and Pharmacy, Peoples Republic of China
    Headache 39:581-5. 1999
    ..Twenty-three Chinese patients (5 men, 18 women) with migraine (2 with aura, 21 without aura) were given the Chinese edition of the MMPI, before and after treatment, and were compared with 30 ..
  91. ncbi Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine
    F G Freitag
    Diamond Headache Clinic, Chicago, Ill 60614-1726, USA
    Headache 41:391-8. 2001
    ..with acetaminophen to sumatriptan succinate for the treatment of mild-to-moderate migraine, with or without aura, when taken at the first sign of an attack...
  92. ncbi Dosing and administration of ergotamine tartrate and dihydroergotamine
    N T Mathew
    Houston Headache Clinic, TX 77004, USA
    Headache 37:S26-32. 1997
    ..Dihydroergotamine can be administered at any time during a migraine attack, including the aura. Intravenous administration provides rapid peak plasma levels and is the most effective form when a rapid effect is ..
  93. ncbi A community-based prevalence study on headache in Malaysia
    E E Alders
    University of Amsterdam, The Netherlands
    Headache 36:379-84. 1996
    ..0%. Migraine with aura accounted for only 10.6% of the migrainous population. The last-year prevalence of tension headache was 26.5% (94...
  94. ncbi Prevalence of migraine in patients with systemic lupus erythematosus
    B I Glanz
    Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Headache 41:285-9. 2001
    ..Of the patients with migraine, 56% met criteria for migraine without aura and 44% met criteria for migraine with aura...
  95. ncbi Prevalence of frequent headache in a population sample
    A I Scher
    Department of Epidemiology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Headache 38:497-506. 1998
    ..of male frequent headache sufferers met International Headache Society (IHS) criteria for migraine (with or without aura)...
  96. ncbi Transformed migraine is a cause of chronic daily headaches
    S Konno
    Cerebral Blood Flow Laboratory, Veterans Administration Medical Center, Houston, Texas, USA
    Headache 39:95-100. 1999
    ..pain occurring daily; more than 15 days each month; often associated with a history of migraine, with or without aura; or with a history of tension-type headaches occurring alone or both occurring together...
  97. ncbi Recurrent classic migraine attacks following transdermal scopolamine intoxication
    C R Gordon
    Motion Sickness and Human Performance Laboratory, Israeli Naval Hyperbaric Institute, Haifa
    Headache 31:172-4. 1991
    ..The migraine attacks comprised a prodrome of apathy, bad mood and loss of appetite lasting several hours. An aura of scintillating spots, left arm numbness and paresthesias lasting several minutes was followed by a severe ..
  98. ncbi [Clinical study on epileptic aura in children with temporal lobe epilepsy]
    M Ohtsu
    Department of Pediatrics, Tokyo Women's Medical University, School of Medicine, Tokyo
    No To Hattatsu 33:409-15. 2001
    We studied the clinical characteristics of epileptic aura with temporal lobe epilepsy (TLE) in children, by retrospectively reviewing medical records of 33 patients whose first seizures developed under 15 years of age...
  99. ncbi The diagnosis of headache in primary care: factors in the agreement of clinical and standardized diagnoses
    P E Stang
    Department of Applied Healthcare Research, Glaxo Inc. Research Institute, Research Triangle Park, North Carolina 27709
    Headache 34:138-42. 1994
    ..Among patients with algorithm-diagnosed migraine, female gender, increased disability, and the presence of aura increased the likelihood that the clinician would also diagnose migraine...
  100. ncbi Reversible cognitive decline accompanies migraine and cluster headaches
    J S Meyer
    Cerebrovascular Research, Baylor College of Medicine, Houston, TX, USA
    Headache 40:638-46. 2000
    ..One hundred thirty-three patients had migraine without aura, 39 migraine with aura, 11 periodic cluster (by IHS criteria), and 13 had migrainous transformation into chronic ..

Research Grants81

  1. Aurora-A/BTAK/STK15 Oncoprotein in Mitotic Spindle Assembly and Checkpoint Respon
    Subrata Sen; Fiscal Year: 2010
    Aurora-A/BTAK/STK15 is a critical regulator of mitotic chromosome segregation and a putative oncoprotein capable of inducing chromosomal instability and oncogenic transformation when ectopically over expressed in mammalian cells in ..
  2. BRCA1 function in G2-M checkpoint and mitosis
    Toru Ouchi; Fiscal Year: 2007
    ..We plan to utilize BRCA1(-/-) mouse embryo fibroblasts (MEFs) for the proposed experiments. These studies are all aimed at a deeper understanding of both processes of oncogenic transformation and novel approaches to cancer therapy. ..
  3. BRCA1 function in G2-M checkpoint and mitosis
    Toru Ouchi; Fiscal Year: 2006
    ..We plan to utilize BRCA1(-/-) mouse embryo fibroblasts (MEFs) for the proposed experiments. These studies are all aimed at a deeper understanding of both processes of oncogenic transformation and novel approaches to cancer therapy. ..
  4. Regulation of Chromosome Segregation
    SUSAN BIGGINS; Fiscal Year: 2006
    ..A key regulator of kinetochore function is the conserved Ip11/aurora2 protein kinase...
  5. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2010
    ..e., nausea, vomiting, photophobia or phonophobia with or without aura)...
  6. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..Patients with migraine with and without aura and matched controls will be enrolled in a 1:1:1 ratio, with 75 patients in each group...
  7. Circle of Willis variability and migraine
    Brett Cucchiara; Fiscal Year: 2007
    ..Patients with migraine with and without aura and matched controls will be enrolled in a 1:1:1 ratio, with 75 patients in each group...
  8. Assembly and Function of Mammalian Centrosomes
    Ryoko Kuriyama; Fiscal Year: 2007
    ..As centrosome abnormalities are implicated in the origin of chromosome instability and cancer pathogenesis, the study will be useful in establishing strategies for prevention, diagnosis, and treatment of human cancers. ..
  9. TOGAVIRUS REPLICATION OF STRATEGIES AND EVOLUTION
    James Strauss; Fiscal Year: 1999
    ..We propose a series of experiments to define the encapsidation signals of Aura and Ross River viruses. 2) The cellular receptors used by alphaviruses to enter cells will be further characterized...
  10. Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer
    Bogdan A Czerniak; Fiscal Year: 2010
    ..The clinical use of such a test will represent a novel standard of practice facilitating early treatment of bladder cancer and positively affecting the survival rates of the patients with bladder cancer. ..
  11. NEUROENDOCRINE BASES OF REPRODUCTIVE BEHAVIOR
    ANNE ETGEN; Fiscal Year: 2001
    ..be used to determine the effects of E on: 1) mRNA and protein levels of b-adrenergic receptor kinase 1 and 2 (b-ARK1, and b-ARK2) and 2) the mRNA and protein levels of b-arrestin1 and b-arrestin2...
  12. Novel human oncogene STK15/BTAK/Aurora 2
    Subrata Sen; Fiscal Year: 2004
    ..4. Determine the expression profiles of STK15 kinase and its interacting proteins in colon cancer specimens of different histological grades and stages with or ..
  13. Systems Architecture And Dynamical Behaviors of the Kinases That Drive M-Phase
    JOSEPH RICHARD POMERENING; Fiscal Year: 2010
    ..This work will yield insights into how the actions of protein networks guide cells to make proper decisions as they proliferate, and may provide significant clues into how cells work to avoid making errors during this process. ..
  14. Novel Druggable Exosites in Protein Kinases
    Ruben Abagyan; Fiscal Year: 2009
    ..The nature of the project is multi-disciplinary and we believe that the goals are within reach due to our combined expertise in computational, molecular and structural biology. ..
  15. Novel Druggable Exosites in Protein Kinases
    Ruben Abagyan; Fiscal Year: 2007
    ..The nature of the project is multi-disciplinary and we believe that the goals are within reach due to our combined expertise in computational, molecular and structural biology. ..
  16. DEVELOPMENT OF LOW FREQUENCY MEG HARDWARE AND SOFTWARE
    Norman Tepley; Fiscal Year: 2002
    ..During the next grant period the physiological differences and similarities between migraine with aura and migraine without aura (classic and common migraine) will be studied using MEG signals essentially identical to ..
  17. Mitotic Checkpoint Regulators: Roles in Development and Cancer
    Terry van Dyke; Fiscal Year: 2009
    ....
  18. Mitotic Checkpoint Regulators: Roles in Development and Cancer
    Terry van Dyke; Fiscal Year: 2007
    ....
  19. Mitotic Checkpoint Regulators: Roles in Development and Cancer
    William F Marzluff; Fiscal Year: 2010
    ....
  20. Cortical Inhibition During Visual Perception in Migraine
    Yue Cao; Fiscal Year: 2002
    ..Visual aura can occur prior to the onset of migraine pain...
  21. Migraine Prophylaxis with Precision Spectral Filters
    Jie Huang; Fiscal Year: 2007
    ..recent study supports the hypothesis that high susceptibility to perceptual illusions in migraineurs with visual aura is associated with hyper activation in visual cortex in response to "strong" stimuli...
  22. Migraine Pathophysiology and Treatment Mechanisms
    Michael Moskowitz; Fiscal Year: 2007
    ..Aiming to achieve a greater understanding of the neural substrate of migraine aura and headache, our program comprises 3 multidisciplinary Projects, plus a Scientific and an Administrative Core...
  23. Craniosacral Therapy in Migraine Feasibility Study
    John Mann; Fiscal Year: 2007
    ..Patients with migraine, with or without aura, under care of a neurologist will be studied...
  24. HEF1 Coordination of Cell Cycle, Migration, and Invasion in Cancer
    Erica A Golemis; Fiscal Year: 2010
    ..will assess the factors regulating HEF1 movement from focal adhesions to centrosomes, allowing HEF1 activation of AurA at mitotic entry. We will determine whether Src and FAK contribute directly to this process...