APBB3

Summary

Gene Symbol: APBB3
Description: amyloid beta (A4) precursor protein-binding, family B, member 3
Alias: FE65L2, SRA, FE65-like protein 2, amyloid beta A4 precursor protein-binding family B member 3, amyloid precursor interacting protein, protein Fe65-like 2
Species: human

Top Publications

  1. ncbi Natural history of eukaryotic DNA methylation systems
    Lakshminarayan M Iyer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Prog Mol Biol Transl Sci 101:25-104. 2011
  2. ncbi Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A
    Koji Kuronuma
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 279:21421-30. 2004
  3. ncbi Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer
    Michiya Kobayashi
    Department of Human Health and Medical Sciences, Kochi Medical School, Nankoku, Japan
    J Laparoendosc Adv Surg Tech A 17:461-6. 2007
  4. ncbi Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
  5. ncbi Fluconazole and voriconazole multidisk testing of Candida species for disk test calibration and MIC estimation
    G Kronvall
    Department of Microbiology and Tumor Biology MTC, Clinical Microbiology, Karolinska Institute, Karolinska Hospital, Stockholm SE 17176, Sweden
    J Clin Microbiol 39:1422-8. 2001
  6. ncbi Evaluation of surface water quality using an ecotoxicological approach: a case study of the Alqueva Reservoir (Portugal)
    Patricia Palma
    Departamento de Ciências do Ambiente, Escola Superior Agrária de Beja, Rua Pedro Soares, Apartado 6158, Beja, 7801 908, Portugal
    Environ Sci Pollut Res Int 17:703-16. 2010
  7. ncbi Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor
    Rudo Kieft
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 107:16137-41. 2010
  8. ncbi Fine root morphological adaptations in Scots pine, Norway spruce and silver birch along a latitudinal gradient in boreal forests
    Ivika Ostonen
    Institute of Geography, University of Tartu, Vanemuise 46, Estonia
    Tree Physiol 27:1627-34. 2007
  9. ncbi Comparative detection of trypanosomal DNA by loop-mediated isothermal amplification and PCR from flinders technology associates cards spotted with patient blood
    Enock Matovu
    Department of Veterinary Parasitology and Microbiology, Faculty of Veterinary Medicine, Makerere University, P O Box 7062, Kampala, Uganda
    J Clin Microbiol 48:2087-90. 2010
  10. ncbi C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009

Research Grants

  1. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2010
  2. Origin of Virulence Factors in African Trypanosomes
    ANDREW MCARTHUR; Fiscal Year: 2004
  3. Trypanosome Lysis by Human Haptoglobin Related Protein
    STEPHEN HAJDUK; Fiscal Year: 2007
  4. RNA Modification Enzymes: Methyltransferase/psi-synthase
    Robert M Stroud; Fiscal Year: 2010
  5. Role of FKBP52 in androgen signaling and hypospadias
    Weinian Shou; Fiscal Year: 2007
  6. DNA SEQUENCES IMPACT ESTROGEN AND ANTIESTROGEN ACTIVITY
    CAROLYN KLINGE; Fiscal Year: 2006
  7. Role of FKBP52 in androgen signaling and hypospadias
    Weinian Shou; Fiscal Year: 2009
  8. OSTEOGENIC REGULATION OF VASCULAR CALCIFICATION
    Dwight A Towler; Fiscal Year: 2010
  9. OSTEOGENIC REGULATION OF VASCULAR CALCIFICATION
    Dwight Towler; Fiscal Year: 2009
  10. Scavenger receptors and inhaled particles
    Lester Kobzik; Fiscal Year: 2005

Detail Information

Publications124 found, 100 shown here

  1. ncbi Natural history of eukaryotic DNA methylation systems
    Lakshminarayan M Iyer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Prog Mol Biol Transl Sci 101:25-104. 2011
    ..Eukaryotes appear to have recruited three major types of DNA-binding domains (SRA/SAD, TAM/MBD, and CXXC) in discriminating DNA with methylated or unmethylated cytosines...
  2. ncbi Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A
    Koji Kuronuma
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 279:21421-30. 2004
    ..by alveolar macrophages derived from scavenger receptor A (SR-A)-deficient mice, demonstrating that SP-A augments SRA-mediated phagocytosis...
  3. ncbi Laparoscopic D3 lymph node dissection with preservation of the superior rectal artery for the treatment of proximal sigmoid and descending colon cancer
    Michiya Kobayashi
    Department of Human Health and Medical Sciences, Kochi Medical School, Nankoku, Japan
    J Laparoendosc Adv Surg Tech A 17:461-6. 2007
    ..dissection for descending and proximal sigmoid colon cancer with the preservation of the superior rectal artery (SRA) to maintain the blood supply to the distal sigmoid colon...
  4. ncbi Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
    ..b. rhodesiense has been identified. This protein, named SRA for Serum Resistance-Associated, is a truncated version of the major and variable surface antigen of the parasite, ..
  5. ncbi Fluconazole and voriconazole multidisk testing of Candida species for disk test calibration and MIC estimation
    G Kronvall
    Department of Microbiology and Tumor Biology MTC, Clinical Microbiology, Karolinska Institute, Karolinska Hospital, Stockholm SE 17176, Sweden
    J Clin Microbiol 39:1422-8. 2001
    ..glabrata and C. krusei, the latter being fully fluconazole resistant. Single-strain regression analysis (SRA) was applied to 54 strains, including American Type Culture Collection reference strains...
  6. ncbi Evaluation of surface water quality using an ecotoxicological approach: a case study of the Alqueva Reservoir (Portugal)
    Patricia Palma
    Departamento de Ciências do Ambiente, Escola Superior Agrária de Beja, Rua Pedro Soares, Apartado 6158, Beja, 7801 908, Portugal
    Environ Sci Pollut Res Int 17:703-16. 2010
    ..The surface water toxicity was assessed using acute and chronic bioassays. The results are to be used for developing a monitoring program, including biological methods...
  7. ncbi Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor
    Rudo Kieft
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 107:16137-41. 2010
    ..causes human African sleeping sickness because it has evolved an inhibitor of TLF-1, serum resistance-associated (SRA) protein. Trypanosoma brucei gambiense lacks the SRA gene, yet it infects humans. As transfection of T. b...
  8. ncbi Fine root morphological adaptations in Scots pine, Norway spruce and silver birch along a latitudinal gradient in boreal forests
    Ivika Ostonen
    Institute of Geography, University of Tartu, Vanemuise 46, Estonia
    Tree Physiol 27:1627-34. 2007
    ..7% of the total variability. The range of variation in mean specific root area (SRA) was 51-74, 60-70 and 84-124 m(2) kg(-1) for Norway spruce, Scots pine and silver birch, respectively, and the ..
  9. ncbi Comparative detection of trypanosomal DNA by loop-mediated isothermal amplification and PCR from flinders technology associates cards spotted with patient blood
    Enock Matovu
    Department of Veterinary Parasitology and Microbiology, Faculty of Veterinary Medicine, Makerere University, P O Box 7062, Kampala, Uganda
    J Clin Microbiol 48:2087-90. 2010
    ..the Trypanozoon conserved random inserted mobile element (RIME-LAMP) and that for the serum resistance-associated (SRA) gene (SRA-LAMP) were performed...
  10. ncbi C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009
    ..In the case of T. b. rhodesiense, resistance to lysis involves interaction of the Serum Resistance-Associated (SRA) protein with the C-terminal helix of apoL1...
  11. ncbi African trypanosomiasis: sensitive and rapid detection of the sub-genus Trypanozoon by loop-mediated isothermal amplification (LAMP) of parasite DNA
    Z K Njiru
    School of Nursing Peel Campus, Murdoch University, Carleton Place, 15 17 Mandurah, WA 6210, Australia
    Int J Parasitol 38:589-99. 2008
    ..9%. The SRA gene PCR detected 21 out of 40 Trypanosoma brucei rhodesiense isolates while Trypanosoma gambiense-specific ..
  12. ncbi [Study of kini-kallikrein and renin--angiotensin systems in patients with primary open angle glaucoma]
    Djina Borovic
    Universitatea de Stat de Medicină şi Farmacie Nicolae Testemiţanu, Chisinau, Republica Moldova
    Oftalmologia 53:61-8. 2009
    To evaluate the activity of Renin-Angiotensin (SRA) and Kinin-Kalikrein (SKK) systems in patients with primary open-angle glaucoma (POAG) in tears, blood and aqueous flow.
  13. ncbi Prevalence of heparin-induced antibodies in patients with chronic renal failure undergoing hemodialysis
    Ivan Palomo
    Department of Clinical Biochemistry and Immunohematology, Faculty of Health Science, Universidad de Talca, Talca, Chile
    J Clin Lab Anal 19:189-95. 2005
    ..Additionally, in some positive cases for the previous test, a 14C- serotonin release assay (14C-SRA) was performed...
  14. ncbi Recent developments in human African trypanosomiasis
    Susan C Welburn
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland, UK
    Curr Opin Infect Dis 15:477-84. 2002
    ..Recently, Rhodesian sleeping sickness has also posed a health risk to travellers visiting game parks in East Africa...
  15. ncbi Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
    C J Carter
    Neurochem Int 50:12-38. 2007
    ..a substrate of SOAT1 and HSD11B1, binds to APOE and is tethered to LRP1 via APPB1, APBB2 and APBB3 at the cytoplasmic domain and via LRPAP1 at the extracellular domain...
  16. ncbi Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor
    Toya Nath Baral
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Nat Med 12:580-4. 2006
    ..T. b. rhodesiense expresses the apoL-I-neutralizing serum resistance-associated (SRA) protein, endowing this parasite with the ability to infect humans and cause HAT...
  17. ncbi Microinjection of exogenous somatostatin in the dorsal vagal complex inhibits pancreatic secretion via somatostatin receptor-2 in rats
    Zhuan Liao
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Am J Physiol Gastrointest Liver Physiol 292:G746-52. 2007
    ..To investigate the somatostatin inhibitory action site, a somatostatin receptor antagonist [SRA; cyclo(7-aminoheptanoyl-Phe-d-Trp-Lys-Thr)] was microinjected into the DVC before intravenous infusion of ..
  18. ncbi Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression
    C M R Turner
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Parasitology 129:445-54. 2004
    ..The sra gene has been shown previously to determine human serum resistance in T...
  19. ncbi Characterisation of the Trypanosoma brucei rhodesiense isolates from Tanzania using serum resistance associated gene as molecular marker
    S N Kibona
    National Institute for Medical Research, P O Box 482, Tabora, Tanzania
    Tanzan Health Res Bull 9:25-31. 2007
    Serum resistance associated (SRA) gene has been found to confer resistance to the innate trypanolytic factor (TLF) found in normal human serum; thus allowing Trypanosoma brucei brucei to survive exposure to normal human serum...
  20. ncbi Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
    ..The somatostatin-induced PPI deficit was partially reversed by administration of SRA-880, a selective somatostatin 1 (sst(1)) receptor antagonist...
  21. ncbi The signal recognition particle receptor alpha subunit of the hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-hydrolyzing activity
    R Moll
    Institut fur Biochemie, Medizinische Universitat zu Lubeck
    Biochim Biophys Acta 1335:218-30. 1997
    ..The 1.6 kb genomic nucleotide sequence under investigation consists of the 1.12 kb SRa gene encoding the putative signal recognition particle receptor alpha subunit (SR alpha, 42...
  22. ncbi Conjugated linoleic acids regulate triacylglycerol and cholesterol concentrations in macrophages/foam cells by the modulation of CD36 expression
    Ewa Stachowska
    Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland
    Acta Biochim Pol 57:379-84. 2010
    ..circulating LDL are taken up by macrophages through two major scavenger receptors: CD36 and scavenger receptor A (SRA). Fatty acids that are common in food, e.g...
  23. ncbi A new cochlear implant electrode design for preservation of residual hearing: a temporal bone study
    Henryk Skarzynski
    Institute of Physiology and Pathology of Hearing, Warsaw, Poland
    Acta Otolaryngol 130:435-42. 2010
    ..Technological developments play a key role in minimizing trauma to the cochlea during placement of electrodes...
  24. ncbi A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa
    S Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    J Biol Chem 269:8439-44. 1994
    ..Recently, we described a low frequency platelet alloantigen on human platelet membrane glycoprotein (GP) IIIa, termed Sra, that was involved in neonatal alloimmune thrombocytopenia...
  25. ncbi The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Neurodegener 4:28. 2009
    ..abstract:..
  26. ncbi Anti-PF4-heparin immunoglobulin G is the major class of heparin-induced thrombocytopenia antibody: findings of an enzyme-linked immunofiltration assay using membrane-bound hPF4-heparin
    C M Vun
    Haematology Department, SEALS Campus Centre, Prince of Wales Hospital, Sydney, Australia
    Br J Haematol 112:69-75. 2001
    ..Of 75 sera with a positive serotonin-release assay (SRA), anti-PF4-heparin of the immunoglobulin (Ig)G class was detected in 72 (96%) sera...
  27. ncbi African trypanosomes: intracellular trafficking of host defense molecules
    April M Shiflett
    Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    J Eukaryot Microbiol 54:18-21. 2007
    ..b. rhodesiense correlates with the evolution of a human serum resistance associated protein (SRA) that is able to ablate TLF killing. When T. b...
  28. ncbi Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
    J Alzheimers Dis 16:301-7. 2009
    ..tyrosine phosphorylation of AbetaPP also inhibits interaction of the two other Fe65 family members, Fe65L1 and Fe65L2. Likewise, docking of Fe65, Fe65L1 and Fe65L2 to APLP1 and APLP2, the two other members of the AbetaPP-gene family,..
  29. ncbi Uptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptors
    Lynda M Pierini
    Department of Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Microbiol 8:1361-70. 2006
    ..on a heat-sensitive serum component and is mediated in part by types I and II class A scavenger receptors (SRA), demonstrating for the first time that SRA can act as a receptor for opsonized pathogens...
  30. ncbi Topical therapy in anosmia: relevance of steroid-responsiveness
    M Stenner
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
    Laryngoscope 118:1681-6. 2008
    ....
  31. ncbi Physiological changes in membrane-expressed platelet factor 4: implications in heparin-induced thrombocytopenia
    M Margaret Prechel
    Department of Pathology, Loyola University Medical Center, 2160 S First Avenue, Maywood, IL 60153, USA
    Thromb Res 125:e143-8. 2010
    Many heparin-induced thrombocytopenia (HIT) antibodies cause platelet activation in the serotonin release assay (SRA) in the absence of heparin...
  32. ncbi In vivo analysis of atlantoaxial motion in individuals immobilized with the halo thoracic vest or Philadelphia collar
    Heiko Koller
    Department for Traumatology and Sports Medicine, Paracelsus Medical University, Mullner Hauptstrasse 48, Salzburg, Austria
    Spine (Phila Pa 1976) 34:670-9. 2009
    ..In vivo biomechanical comparison of the halo thoracic vest (HTV) and the Philadelphia collar (PC)...
  33. ncbi Analytical study of pulse amplification in silicon Raman amplifiers
    Ivan D Rukhlenko
    Advanced Computing and Simulation Laboratory AXL, Department of Electrical and Computer Systems Engineering, Monash University, Clayton, VIC 3800, Australia
    Opt Express 18:18324-38. 2010
    ..numerical approach is generally employed, even though it provides little insight into the contribution of different SRA parameters to the signal amplification process...
  34. ncbi Calibration of the disk diffusion test for trovafloxacin susceptibility testing of four anaerobic species
    G Kronvall
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden
    Clin Microbiol Infect 6:195-201. 2000
    ..bacterial species using minimum inhibitory concentrations (MIC) determinations, E test assays and disk diffusion test results and to calibrate the disk diffusion method for these species using single strain regression analysis (SRA).
  35. ncbi Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene
    S C Welburn
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, Edinburgh, UK
    Lancet 358:2017-9. 2001
    ..We investigated the use of a simple genetic marker to characterise parasites collected from cattle in villages within the new sleeping sickness focus in Soroti District, Uganda...
  36. ncbi The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa
    Wendy Gibson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Infect Genet Evol 1:207-14. 2002
    The human serum resistance associated (SRA) gene isolated from a Ugandan strain of Trypanosoma brucei rhodesiense has been shown to be capable by itself of conferring the trait of human infectivity on T.b. brucei by transfection...
  37. ncbi cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein
    P Malherbe
    Pharma Division PRPN, Bldg 69 333, Preclinical CNS Research, F Hoffmann La Roche, Basel, Switzerland
    Brain Res Mol Brain Res 71:159-70. 1999
    ..To investigate the interaction between Abeta and RAGE and another scavenger receptor, SRA, under physiological conditions, they were co-expressed with human betaAPP(695)-SFAD in a human cell and the level ..
  38. ncbi CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation
    Yoji Kawano
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Mol Cell Biol 25:9920-35. 2005
    ..Neurosci. 4:781-782, 2001). Here, we found that CRMP-2 interacted with the specifically Rac1-associated protein 1 (Sra-1)/WASP family verprolin-homologous protein 1 (WAVE1) complex, which is a regulator of actin cytoskeleton...
  39. ncbi MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis
    Dawn M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    PLoS Pathog 5:e1000474. 2009
    ..MARCO was used preferentially over the highly homologous scavenger receptor class A (SRA), which required TLR2 and TLR4, as well as their respective accessory molecules, in order for a slight increase in ..
  40. ncbi Expression and activity of matrix metalloproteinases in the uterus of bitches after spontaneous and induced abortion
    H Kanca
    Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, University of Ankara, Ankara, Turkey
    Reprod Domest Anim 46:197-204. 2011
    ..Five further bitches were introduced with beginning abortion (group SRA = spontaneous resorption/abortion). Seven healthy bitches between day 25 and 45 of gestation served as controls...
  41. ncbi Preserving the superior rectal artery in laparoscopic sigmoid resection for complete rectal prolapse
    Roberto Bergamaschi
    National Center for Advanced Laparoscopic Surgery, Saint Olav University Hospital, Trondheim, Norway
    Surg Laparosc Endosc Percutan Tech 13:374-6. 2003
    ..practice of dividing the mesorectum by prospectively evaluating the impact of sparing the superior rectal artery (SRA) on leak rates after laparoscopic sigmoid resection (LSR) for CRP...
  42. ncbi Hip resurfacing data from national joint registries: what do they tell us? What do they not tell us?
    Kristoff Corten
    London Health Sciences Centre, University Campus, 339 Windermere Road, London, ON, N6A 5A5, Canada
    Clin Orthop Relat Res 468:351-7. 2010
    ..We therefore reviewed SRA survivorship from national registry data and compared with that reported from individual centers...
  43. ncbi Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides
    Charlton Cooper
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E0W3, Canada
    Nucleic Acids Res 37:4518-31. 2009
    ..the unusual property to modulate the activity of steroid receptors and other transcription factors both at the RNA (SRA) and the protein (SRAP) level...
  44. ncbi Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer
    Etienne Leygue
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
    Nucl Recept Signal 5:e006. 2007
    The steroid receptor RNA activator (SRA) is a unique modulator of steroid receptor transcriptional activity, as it is able to mediate its coregulatory effects as a RNA molecule...
  45. ncbi In-flight spraying in aircrafts: determination of the exposure scenario
    Edith Berger-Preiss
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Int J Hyg Environ Health 207:419-30. 2004
    ..The aerosol product SRA spray (Standard Reference Aerosol Spray) was used for spraying...
  46. ncbi In vivo binding of [68Ga]-DOTATOC to somatostatin receptors in neuroendocrine tumours--impact of peptide mass
    Irina Velikyan
    Department of Biochemistry and Organic Chemistry, BMC, Uppsala University, Uppsala, Sweden
    Nucl Med Biol 37:265-75. 2010
    ..peptide mass on binding of [(68)Ga]-DOTATOC to neuroendocrine tumour somatostatin receptors in vivo using a tracer of variable specific radioactivity (SRA) and to show the logistic feasibility of sequential PET scans in the same patient.
  47. ncbi Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice
    Y Takakura
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Pharm Res 16:503-8. 1999
    ..This study was designed to further characterize the pDNA uptake by macrophages in order to elucidate the mechanism...
  48. ncbi Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL
    Sangeeta R Kashyap
    Department of Endocrinology, Diabetes and Metabolism, Endocrinology Institute, Lerner Research Institute Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Obesity (Silver Spring) 17:2142-8. 2009
    ..insulin resistance, endothelial dysfunction, and monocyte capacity to form foam cells through scavenger receptor A (SRA) and CD36. Ten healthy subjects underwent 24-h infusion of Intralipid/heparin and saline (0...
  49. ncbi Structural changes to ribonuclease A and their effects on biological activity
    J Soucek
    Department of Cell Physiology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 123:103-11. 1999
    ..Five previously prepared hybrid enzymes (SRA 1-5), synthesized by introducing 16 amino acid residues from RNase A into BS RNase, exerted the same ..
  50. ncbi Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins
    Michael J Duryee
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, Omaha, NE 68105, USA
    Mol Pharmacol 68:1423-30. 2005
    ..Reverse transcription-polymerase chain reaction (RT-PCR) analysis and scavenger receptor Type A (SRA) knock-out mice were used to assess the role of these receptors in mediating immune responses...
  51. ncbi 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    Jaime Pei Pei Foong
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 298:G384-94. 2010
    ..The specific SSTR(2) antagonist CYN 154806 (100 nM) and a specific SSTR(1) antagonist SRA 880 (3 microM) each reduced the amplitude of nonadrenergic IPSPs and hyperpolarizations evoked by somatostatin...
  52. ncbi [Guillain-Barré syndrome in the northern area of Gran Canaria and the island of Lanzarote]
    Y Aladro-Benito
    Servicio de Neurologia, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Espana
    Rev Neurol 35:705-10. 2002
    ..The objective of this study is to analyse the incidence and clinical characteristics of Guillain Barre syndrome (GBS) in the Canary Islands...
  53. ncbi Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, and Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
    J Neurosci 28:8354-60. 2008
    ..have a twofold to fivefold decrease in expression of the Abeta-binding scavenger receptors scavenger receptor A (SRA), CD36, and RAGE (receptor for advanced-glycosylation endproducts), and the Abeta-degrading enzymes insulysin, ..
  54. ncbi Effects of fluorescent light and vacuum packaging on the rate of decomposition of pigments in paprika (Capsicum annuum) powder determined by reversed-phase high-performance liquid chromatography
    H Morais
    Instituto Nacional de Investigacao Agraria, Oeiras, Portugal
    J Chromatogr A 936:139-44. 2001
    ..various storage conditions was elucidated by principal component analysis (PCA) and stepwise regression analysis (SRA)...
  55. ncbi Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN
    Mihaela Anitei
    Biotechnology Center, Dresden University of Technology, Tatzberg 47 51, 01307 Dresden, Germany
    Nat Cell Biol 12:330-40. 2010
    ..coats and protein complexes comprising CYFIP (cytoplasmic fragile-X mental retardation interacting protein; Sra, PIR121), a clathrin heavy chain binding protein associated with mental retardation...
  56. ncbi [Dissection of the neck: a wax anatomical sample of the Spitzner Collection (no 23) in the Delmas, Orfila and Rouvière Museum of Anatomy: an observation and photographical tri-dimensional reconstruction]
    P Le Floch-Prigent
    Laboratoire d Anatomie, UFR de médecine Paris Île de France Ouest, Universite de Versailles Saint Quentin, 45, rue des Saints Pères, 75270 Paris Cedex 06, France
    Morphologie 94:81-6. 2010
    ..and Rouvière museums, 45, rue des Saints-Pères, Paris 6(e), université Paris-Descartes (catalog n(o): 1222, SRA-1995). It measured 36cm in width and 27cm in height...
  57. ncbi Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eye
    Baohe Tian
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI 53792 3220, USA
    J Ocul Pharmacol Ther 26:533-9. 2010
    ..This study is aimed to determine if the serine-threonine kinase inhibitor H-7 inhibits secondary cataract after phacoemulsification in the live rabbit eye...
  58. ncbi The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells
    Celine Beauvillain
    Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre de Recherche en Cancérologie Nantes Angers, Bâtiment Montéclair, 4 rue Larrey, Angers 49933, France
    J Hepatol 52:644-51. 2010
    ..This study aimed to identify the endocytic receptor(s) involved in the uptake of NS3 by myeloid cells and its relation with TLR2...
  59. ncbi Surface replacement arthroplasty of the hip
    Aaron K Schachter
    Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    Bull NYU Hosp Jt Dis 67:75-82. 2009
    ..Surface replacement arthroplasty (SRA) was initially developed over 50 years ago to treat degenerative disease of the hip...
  60. ncbi SRA and its binding partners: an expanding role for RNA-binding coregulators in nuclear receptor-mediated gene regulation
    Shane M Colley
    University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
    Crit Rev Biochem Mol Biol 44:25-33. 2009
    The discovery that SRA RNA can function as a nuclear receptor (NR) coactivator resulted in a fundamental change in the perception of how NRs and their coregulators may regulate hormone signaling pathways...
  61. ncbi Absence of scavenger receptor A promotes dendritic cell-mediated cross-presentation of cell-associated antigen and antitumor immune response
    Chunqing Guo
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Immunol Cell Biol 90:101-8. 2012
    Given the primary expression of scavenger receptor A (SRA) or CD204 on antigen-presenting cells, we investigate the immunoregulatory activities of SRA/CD204 in the context of cross-presentation of cell-associated antigen and the ..
  62. ncbi Surface replacement arthroplasty of the proximal interphalangeal joint using the PIP-SRA implant: results, complications, and revisions
    Charles D Jennings
    Great Falls Orthopedic Associates, Great Falls, MT, USA
    J Hand Surg Am 33:1565.e1-11. 2008
    To evaluate the subjective and objective results of surface replacement arthroplasty (SRA) for arthritis of the proximal interphalangeal (PIP) joint using the PIP-SRA implant...
  63. ncbi Structure and hemimethylated CpG binding of the SRA domain from human UHRF1
    Chengmin Qian
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    J Biol Chem 283:34490-4. 2008
    ..Recent studies show that UHRF1 binds selectively to hemimethylated CpG via its conserved SRA (SET- and RING finger-associated) domain. However, the underlying molecular mechanism is not known...
  64. ncbi Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties
    Mahmoud Alhosin
    CNRS UMR 7213 Laboratoire de Biophotonique et Pharmacologie, Universite de Strasbourg, Faculte de Pharmacie, 74 route du Rhin, 67401 Illkirch, France
    J Exp Clin Cancer Res 30:41. 2011
    ..cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF family...
  65. ncbi Equine influenza immunity in the Special Restricted Area (Purple Zone) of New South Wales, Australia
    G Wilson
    Elizabeth Macarthur Agricultural Institute, Menangle, New South Wales 2568, Australia
    Aust Vet J 89:116-20. 2011
    ..The central area was assigned the status of a Purple Zone (Special Restricted Area, SRA) approximately 1 month after the outbreak commenced...
  66. ncbi Normal radiographic values of the forefoot in the Thai women population
    Suriyapong Saowaprut
    Arthroscopic and Sports Medicine Unit, Institute of Orthopaedics, Lerdsin Hospital, Bangkok, Thailand
    J Med Assoc Thai 92:S251-7. 2009
    ..Evaluation of forefoot radiography has played an important role to determine the forefoot deformity. Previous studies have shown that normal radiographic values of the western population were different from the Asian population values...
  67. ncbi A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia
    Kathryn M Ruf
    University of Kentucky HealthCare, Chandler Medical Center, Lexington, KY 40536, USA
    Thromb Haemost 105:553-9. 2011
    ..Utilisation of this algorithm was hypothesised to improve the identification of patients without SRA confirmed HIT and improve overall specificity compared to other diagnostic strategies...
  68. ncbi Whole blood impedance aggregometry detects heparin-induced thrombocytopenia antibodies
    Marie Christine Morel-Kopp
    Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, Northern Blood Research Centre, University of Sydney, St Leonards, NSW, Australia
    Thromb Res 125:e234-9. 2010
    ..Heparin-induced platelet aggregation (HIPA) and (14)C-serotonin release (SRA) assays for HIT are time-consuming and complex to perform...
  69. ncbi Quantitative and qualitative methods using fluorescence microscopy for the study of modified low density lipoproteins uptake
    Francisco J Leyva
    Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Scanning 31:167-73. 2009
    ..Scavenger Receptors A-I and II (SRA-I/II) have an important role of in foam cell formation and atherogenesis...
  70. ncbi Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis
    Motoko Unoki
    Laboratory for Biomarker Development, The Institute of Physical and Chemical Research, Center for Genomic Medicine, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Pharmacol 78:1279-88. 2009
    UHRF1 plays a central role in transferring methylation status from mother cells to daughter cells. Its SRA domain recognizes hemi-methylated DNA that appears in daughter DNA strands during duplication of DNA...
  71. ncbi The sequence read archive
    Rasko Leinonen
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 39:D19-21. 2011
    ..growth of data submitted into the primary next-generation sequence data archive, the Sequence Read Archive (SRA)...
  72. ncbi Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans
    Neda Rasouli
    Central Arkansas Veterans Healthcare System, 111J, 4300 West 7th Street, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 29:1328-35. 2009
    ..We hypothesized that scavenger receptors are present in human adipose tissue resident macrophages, and their gene expression is regulated by adiponectin and thaizolidinediones...
  73. ncbi The evaluation of novel chromogenic substrates for the detection of lipolytic activity in clinical isolates of Staphylococcus aureus and MRSA from two European study groups
    Simon W J Gould
    School of Life Sciences, Kingston University, Kingston upon Thames, Surrey, UK
    FEMS Microbiol Lett 297:10-6. 2009
    ..lipase substrates 5-(4-hydroxy-3,5-dimethoxyphenylmethylene)-2-thioxothia-zolidin-4-one-3-ethanoic acid (SRA)-propionate, SRA-butyrate, SRA-octanoate and 2-[2-(4-hydroxy-3,5-dimethoxyphenyl)-vinyl]-3-methy-benzothiazolium ..
  74. ncbi Coactivator selective regulation of androgen receptor activity
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, M130, One Baylor Plaza, Houston, TX 77030, United States
    Steroids 74:669-74. 2009
    ..We compared the actions of the p160 coactivators SRC-1 and SRC-3/RAC3 with SRA (steroid receptor RNA activator). All three coactivate AR in the presence of agonist as expected...
  75. ncbi Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e14199. 2010
    ..We show that the non-coding RNA, Steroid receptor RNA Activator (SRA), associates with PPAR? and coactivates PPAR?-dependent reporter gene expression...
  76. ncbi Web-based sharing of electrocardiogram: a framework for information publishing
    Shizhong Yuan
    Biomedical Information Technology Laboratory, University of Aizu, Aizu Wakamatsu, Fukushima 965 8580, Japan
    Conf Proc IEEE Eng Med Biol Soc 2009:1671-4. 2009
    Network-based data sharing is a current trend in medicine and healthcare. The search and retrieval architecture (SRA) we previously proposed for web-based sharing of electrocardiogram (ECG) facilitates the search and retrieval of ECG ..
  77. ncbi Evaluating the effects of granular and membrane filtrations on chlorine demand in drinking water
    Veeriah Jegatheesan
    School of Engineering, James Cook University, Townsville, Qld 4811, Australia
    J Environ Sci (China) 21:23-9. 2009
    ..It was found that the chlorine demand due to fast and slow reacting (FRA and SRA) organic/inorganic substances was not reduced significantly by sand as well as GAC filters...
  78. ncbi Induction of abortion with aglepristone significantly changed the expression of progesterone and estrogen receptors in canine endometrial stromal cells
    H Kanca
    Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Ankara, 06110 Ankara, Turkey
    Theriogenology 70:1439-48. 2008
    ..progesterone (PR) and estrogen receptors (ER), in comparison to a group of spontaneous resorptions/abortions (group SRA, n=5), and a further group of normal healthy pregnant animals, ovariohysterectomized between days 25 and 45 of ..
  79. ncbi Bioinformatic insights to the ESAG5 and GRESAG5 gene families in kinetoplastid parasites
    Amy R Barker
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Biochem Parasitol 162:112-22. 2008
    ..Thus far, the function of most ESAGs is unknown. One ES contains the serum resistance associated gene (SRA), which confers resistance to trypanosome lytic factor in T. b. rhodesiense...
  80. ncbi The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled
    K S Ermekova
    Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 272:32869-77. 1997
    ....
  81. ncbi Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), compared with oxybutynin in the treatment of patients with overactive bladder
    Norman Zinner
    Western Clinical Research, Inc, Los Angeles, California, USA
    World J Urol 23:248-52. 2005
    ..Darifenacin (15 mg q.d.) provides comparable efficacy with improved tolerability versus oxybutynin (5 mg t.i.d.) in the treatment of patients with OAB...
  82. ncbi Dose response with darifenacin, a novel once-daily M3 selective receptor antagonist for the treatment of overactive bladder: results of a fixed dose study
    Simon Hill
    Department of Obstetrics and Gynaecology, Queen s Park Hospital, Haslingden Road, Blackburn, UK
    Int Urogynecol J Pelvic Floor Dysfunct 17:239-47. 2006
    This study evaluated the efficacy, tolerability, and safety of darifenacin, an M3 selective receptor antagonist (M3 SRA), in patients with overactive bladder (OAB)...
  83. ncbi A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder
    Christopher Chapple
    Urology Research, Royal Hallamshire Hospital, Sheffield, UK
    BJU Int 95:993-1001. 2005
    To evaluate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), from an analysis of pooled data from three phase III, multicentre, double-blind clinical trials in patients with ..
  84. ncbi Identification of a nematode chemosensory gene family
    Nansheng Chen
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 102:146-51. 2005
    ..The srab family is similar to, but distinct from, the previously described serpentine receptor class a (sra) family and shows a differential expansion in C. elegans similar to that previously described for sra...
  85. ncbi Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster
    Aki Ejima
    Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192 0397, Japan
    Genetics 168:2077-87. 2004
    ..melanogaster females, we screened a collection of P{GS} insertion lines and identified two insertions in sarah (sra), whose misexpression in the nervous system induced high levels of ovulation in virgins...
  86. ncbi An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation
    Bin Xu
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 279:33051-6. 2004
    ..domain was necessary and sufficient for thyroid hormone receptor binding to the steroid receptor RNA activator (SRA)...
  87. ncbi Detection of Trypanosoma brucei rhodesiense in animals from sleeping sickness foci in East Africa using the serum resistance associated (SRA) gene
    Z K Njiru
    Kenya Trypanosomiasis Research Institute, P O Box 362, Kikuyu, Kenya
    Acta Trop 90:249-54. 2004
    The human serum resistance associated (SRA) gene has been found exclusively in Trypanosoma brucei rhodesiense, allowing the unequivocal detection of this pathogen in reservoir hosts and the tsetse vector without recourse to laborious ..
  88. ncbi The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development
    Gopal Battu
    Zoologisches Institut, Universitaet Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Development 130:2567-77. 2003
    ..We demonstrate a link between a G-protein-coupled receptor signalling pathway and the RAS/MAPK cascade. SRA-13, a member of the SRA family of chemosensory receptors, negatively regulates RAS/MAPK signalling during vulval ..
  89. ncbi Retinal venous oxygen saturation and cardiac output during controlled hemorrhage and resuscitation
    Kurt R Denninghoff
    Department of Emergency Medicine, The University of Alabama at Birmingham, Birmingham 35249, USA
    J Appl Physiol 94:891-6. 2003
    ..At each oxygen level, femoral artery oxygen saturation (Sa(O(2))) and retinal artery oxygen saturation (Sra(O(2))) were obtained. After equilibration on 100% O(2), subjects were bled at 1.4 ml. kg(-1). min(-1) for 20 min...
  90. ncbi Identification of new human coding steroid receptor RNA activator isoforms
    Ethan Emberley
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3EOW3
    Biochem Biophys Res Commun 301:509-15. 2003
    b>SRA is a steroid receptor co-activator which acts as a functional RNA and is classified as belonging to the growing family of functional non-coding RNAs...
  91. ncbi Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression
    Paola Bruni
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, 80131 Napoli, Italy
    J Biol Chem 277:35481-8. 2002
    ..Similarly, the two other members of the Fe65 protein family, Fe65L1 and Fe65L2, have been found to translocate into the nucleus and to prevent the activation of the TS gene promoter induced by ..
  92. ncbi Prevalence of short-root anomaly in healthy young adults
    Satu Apajalahti
    Departments of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland
    Acta Odontol Scand 60:56-9. 2002
    Short-root anomaly (SRA), occurring mostly in maxillary incisors, is defined as developmentally very short, blunt dental roots. The condition has a genetic background and is related to hypodontia...
  93. ncbi The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides
    F G Zhu
    Medical Research Service, Durham Veterans Administration Hospital and Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Durham, NC, USA
    Immunology 103:226-34. 2001
    To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice...
  94. ncbi Morphological observation on cell death and phagocytosis induced by ultraviolet irradiation in a cultured human lens epithelial cell line
    Y B Shui
    Department of Ophthalmology, Kanazawa Medical University, Uchinada, Japan
    Exp Eye Res 71:609-18. 2000
    ..Human lens epithelial cell line SRA 01-04 was cultured in Dulbecco's Modified Eagle Medium (DMEM) containing 20% fetal bovine serum...
  95. ncbi Suppression of temperature-sensitive defects of polypeptide release factors RF-1 and RF-2 by mutations or by an excess of RF-3 in Escherichia coli
    K Matsumura
    Department of Tumor Biology, University of Tokyo, Japan
    J Mol Biol 258:588-99. 1996
    ..The RF-3 mutations that suppress prfA1 were isolated and named sra. They were classified into four specific alleles; two each in the N and C-terminal regions...
  96. ncbi A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex
    R B Lanz
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 97:17-27. 1999
    ..and functional characterization of a novel transcriptional coactivator, termed steroid receptor RNA activator (SRA)...
  97. ncbi p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
    K Kobayashi
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    J Biol Chem 273:291-5. 1998
    ..We denoted this protein as Sra-1 (Specifically Rac1-associated protein). Recombinant Sra-1 interacted with GTPgammaS.GST-Rac1 and weakly with GDP...
  98. ncbi The steroid receptor RNA activator protein is expressed in breast tumor tissues
    Shilpa Chooniedass-Kothari
    Department of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Int J Cancer 118:1054-9. 2006
    The steroid receptor RNA activator (SRA) was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors...
  99. ncbi Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
    Tracie DeVries-Seimon
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 171:61-73. 2005
    ..One involves the type A scavenger receptor (SRA). As evidence, FC loading by non-SRA mechanisms activates p38 and CHOP, but not apoptosis unless the SRA is engaged...
  100. ncbi Ribosome binding proteins YhbH and YfiA have opposite functions during 100S formation in the stationary phase of Escherichia coli
    Masami Ueta
    Department of Physics, Osaka Medical College, Takatsuki, Japan
    Genes Cells 10:1103-12. 2005
    ..Proteins RMF, YhbH, YfiA and SRA are expressed and bind to ribosome particles...
  101. ncbi Ultrastructural study of Rac1 and its effectors beneath the substratum-facing membrane
    Takashi Watanabe
    Institute for Advanced Research, Nagoya University, Aichi, Japan
    Cell Struct Funct 33:101-7. 2008
    ..on the cytoplasmic surface of the substratum-facing plasma membrane, focusing on Rac1 and its effectors, IQGAP1 and Sra-1, by electron microscopy...

Research Grants65

  1. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2010
    ..T. b. rhodesiense produces a potent inhibitor of TLF, Serum Resistance Associated protein (SRA), which binds apoL-1 and neutralizes the activity of TLF...
  2. Origin of Virulence Factors in African Trypanosomes
    ANDREW MCARTHUR; Fiscal Year: 2004
    ..The serum resistance associated (SRA) gone is highly conserved in T. b...
  3. Trypanosome Lysis by Human Haptoglobin Related Protein
    STEPHEN HAJDUK; Fiscal Year: 2007
    ..Expression of a single protein, Serum Resistance Associated (SRA) is sufficient to confer resistance to TLF-l in vitro and in vivo...
  4. RNA Modification Enzymes: Methyltransferase/psi-synthase
    Robert M Stroud; Fiscal Year: 2010
    ..receptor signaling by pseudouridylating an RNA activator of nuclear receptors (steroid receptor RNA activator, SRA). Defects in these enzymes cause sideroblastic anemia...
  5. Role of FKBP52 in androgen signaling and hypospadias
    Weinian Shou; Fiscal Year: 2007
    ..FKBP52 is also known as a steroid receptor associated-tetratricorpeptide repeat domain protein (SRA-TPR) based on its ability to enter into heterocomplexes with steroid receptors via a direct interaction with heat ..
  6. DNA SEQUENCES IMPACT ESTROGEN AND ANTIESTROGEN ACTIVITY
    CAROLYN KLINGE; Fiscal Year: 2006
    ..to different ERE sequences modulates ER interaction with coactivators SRC-1, SRC-2 (GRIP1), SRC-3 (AIB1), PRMT, and SRA; ERE regulated ER-coactivator interaction in turn modulates acetylation of histones H3 and H4, and the assembly of ..
  7. Role of FKBP52 in androgen signaling and hypospadias
    Weinian Shou; Fiscal Year: 2009
    ..FKBP52 is also known as a steroid receptor associated-tetratricorjeptide repeat domain protein (SRA-TPR) based on its ability to enter into heterocomplexes with steroid receptors via a direct interaction with heat ..
  8. OSTEOGENIC REGULATION OF VASCULAR CALCIFICATION
    Dwight A Towler; Fiscal Year: 2010
    ..OPN in regulation of diabetic aortic calcification and compliance, using SM22- OPNTg(+);OPN-/-;LDLR-/- and SRA-OPNTg(+);OPN-/-;LDLR-/- mice as models for study...
  9. OSTEOGENIC REGULATION OF VASCULAR CALCIFICATION
    Dwight Towler; Fiscal Year: 2009
    ..OPN in regulation of diabetic aortic calcification and compliance, using SM22- OPNTg(+);OPN-/-;LDLR-/- and SRA-OPNTg(+);OPN-/-;LDLR-/- mice as models for study...
  10. Scavenger receptors and inhaled particles
    Lester Kobzik; Fiscal Year: 2005
    ..e. SRA I/II and MARCO) are the dominant mediators of alveolar macrophage binding of environmental particles in vitro and ..
  11. Post-transcriptional regulation of gene expression by thyroid hormone receptors
    Bin Xu; Fiscal Year: 2007
    ..receptor was necessary and sufficient for thyroid hormone receptor binding to the steroid receptor RNA activator (SRA)...
  12. MOLECULAR BASIS OF SIGNALING BY THE CABL PROTO-ONCOGENE
    Ann Marie Pendergast; Fiscal Year: 2010
    ..dependent actin polymerization, is comprised of two Abl-binding proteins, Abi and Wave, as well as Nap1 and PIR121/Sra. A fundamental gap in knowledge exists regarding the mechanisms whereby tyrosine kinases regulate cell-cell ..
  13. MOLECULAR BASIS OF SIGNALING BY THE CABL PROTO-ONCOGENE
    Ann Marie Pendergast; Fiscal Year: 2009
    ..dependent actin polymerization, is comprised of two Abl-binding proteins, Abi and Wave, as well as Nap1 and PIR121/Sra. A fundamental gap in knowledge exists regarding the mechanisms whereby tyrosine kinases regulate cell-cell ..
  14. MOLECULAR BASIS OF SIGNALING BY THE CABL PROTO-ONCOGENE
    Ann Marie Pendergast; Fiscal Year: 2007
    ..actin polymerization, is comprised of two Abl-binding proteins, Abi and Wave, as well as Nap1 and PIR121/Sra. A fundamental gap in knowledge exists regarding the mechanisms whereby tyrosine kinases regulate cell-cell ..
  15. Intranuclear dynamics and steroid receptor function
    Marilyn Mielke; Fiscal Year: 2003
    ..GFP-ER, AR, PR, TR, SRC- 1, SMRT, and a novel indirect means to visualize the non-coding mRNA coactivator, SRA. Cell lines with integrated lac operators (heterochromatic or euchromatic) will be used with lac repressor fusions ..