APBA2

Summary

Gene Symbol: APBA2
Description: amyloid beta (A4) precursor protein-binding, family A, member 2
Alias: D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L, X11-like protein, adapter protein X11beta, amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like), amyloid beta A4 precursor protein-binding family A member 2, mint-2, neuron-specific X11L protein, neuronal munc18-1-interacting protein 2, phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
Species: human

Top Publications

  1. ncbi Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association
    Jun Kitano
    Department of Biological Sciences, Faculty of Medicine, and the Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Biol Chem 278:14762-8. 2003
  2. ncbi Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions
    Leonora F Ciufo
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Mol Biol Cell 16:470-82. 2005
  3. ncbi Mints as adaptors. Direct binding to neurexins and recruitment of munc18
    T Biederer
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39803-6. 2000
  4. ncbi X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains
    K F Lau
    Department of Neuroscience, Institute of Psychiatry, Denmark Hill, London SE5 8AF, United Kingdom
    Mol Cell Neurosci 16:557-65. 2000
  5. ncbi Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:458-65. 2008
  6. ncbi Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2
    M Okamoto
    Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical School, Dallas 75235, USA
    Eur J Cell Biol 77:161-5. 1998
  7. ncbi The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    EMBO J 26:1475-86. 2007
  8. ncbi Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor prote
    G Blanco
    MRC Mouse Genome Centre and MRC Mammalian Genetics Unit, Harwell, Didcot, Oxon OX11 ORD, UK
    Mamm Genome 9:473-5. 1998
  9. ncbi Evaluation of the rodent Hershberger bioassay on intact juvenile males--testing of coded chemicals and supplementary biochemical investigations
    A Freyberger
    Bayer Schering Pharma AG, GDD GED General Toxicology, Aprather Weg 18, D 42096 Wuppertal, Germany
    Toxicology 262:114-20. 2009
  10. ncbi Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy
    Kana Saito
    Departments of General Surgical Science, Graduate School of Medicine, Gunma University, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:253-9. 2008

Research Grants

  1. Targeting By mLin-7 Binding Partners In Renal Epithelia
    Benjamin Margolis; Fiscal Year: 2004
  2. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard Kahn; Fiscal Year: 2009
  3. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard A Kahn; Fiscal Year: 2010
  4. EDRN: Clinical Epidemiology & Validation Centers
    Henry Lynch; Fiscal Year: 2007
  5. NMR APPROACHES TO MEMBRANE ASSOCIATED ARF STRUCTURES
    James Prestegard; Fiscal Year: 2007
  6. NMR APPROACHES TO MEMBRANE ASSOCIATED ARF STRUCTURES
    James Prestegard; Fiscal Year: 2009
  7. Molecular and genetic analysis of CDK-5 function in synaptic transmission
    PETER C JUO; Fiscal Year: 2010
  8. GENETIC CONTROL OF VULVAL CELL FATES IN C ELEGANS
    Stuart Kim; Fiscal Year: 1993
  9. Mechanotransduction in C. elegans
    Joshua Kaplan; Fiscal Year: 2007
  10. Synaptic signaling regulated by MALS family PDZ proteins
    David Bredt; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications102 found, 100 shown here

  1. ncbi Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association
    Jun Kitano
    Department of Biological Sciences, Faculty of Medicine, and the Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Biol Chem 278:14762-8. 2003
    ..In addition, tamalin forms a complex with PSD-95 and Mint2/X11beta/X11L by mechanisms different from the PDZ-mediated interaction...
  2. ncbi Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions
    Leonora F Ciufo
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Mol Biol Cell 16:470-82. 2005
    ..These results clarify the data on the function of SM proteins in mutant organisms and indicate that Munc18-1 controls multiple stages of exocytosis via both syntaxin-dependent and -independent protein interactions...
  3. ncbi Mints as adaptors. Direct binding to neurexins and recruitment of munc18
    T Biederer
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39803-6. 2000
    Mint1 (X11/human Lin-10) and Mint2 are neuronal adaptor proteins that bind to Munc18-1 (n/rb-sec1), a protein essential for synaptic vesicle exocytosis...
  4. ncbi X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains
    K F Lau
    Department of Neuroscience, Institute of Psychiatry, Denmark Hill, London SE5 8AF, United Kingdom
    Mol Cell Neurosci 16:557-65. 2000
    X11 alpha and X11 beta are two neuronal adaptor proteins that interact with the Alzheimer's disease amyloid precursor protein (APP)...
  5. ncbi Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:458-65. 2008
    ..The second one is a de novo duplication at 15q13.1 spanning APBA2. The proteins of these two genes interact directly and play a role in synaptic development and function...
  6. ncbi Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2
    M Okamoto
    Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical School, Dallas 75235, USA
    Eur J Cell Biol 77:161-5. 1998
    ..Our data suggest that mints form a diverse family of proteins with specialized neuronal and ubiquitous isoforms...
  7. ncbi The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    EMBO J 26:1475-86. 2007
    ..Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease...
  8. ncbi Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor prote
    G Blanco
    MRC Mouse Genome Centre and MRC Mammalian Genetics Unit, Harwell, Didcot, Oxon OX11 ORD, UK
    Mamm Genome 9:473-5. 1998
  9. ncbi Evaluation of the rodent Hershberger bioassay on intact juvenile males--testing of coded chemicals and supplementary biochemical investigations
    A Freyberger
    Bayer Schering Pharma AG, GDD GED General Toxicology, Aprather Weg 18, D 42096 Wuppertal, Germany
    Toxicology 262:114-20. 2009
    ..Finally, p,p'-DDE may affect AST weights by several mechanisms including enhanced testosterone metabolism...
  10. ncbi Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy
    Kana Saito
    Departments of General Surgical Science, Graduate School of Medicine, Gunma University, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:253-9. 2008
    ..E-cadherin, mutL homolog 1, colon cancer nonpolyposis type 2 (escherichia), methylated in tumors [MINT]1, MINT2, and MINT31), and compared the results with the malignant potential and gain-of-function mutation types of GIST...
  11. ncbi The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine and Baylor Charles A Sammons Cancer Center, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Gastroenterology 132:127-38. 2007
    ..The majority of MSS CRCs demonstrate chromosomal instability (CIN) with frequent loss of heterozygosity (LOH) at key tumor suppressor genes. We hypothesized that the majority of sporadic CRCs without CIN would be associated with CIMP...
  12. ncbi RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway
    Doreen R Glodowski
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Mol Biol Cell 18:4387-96. 2007
    ..We propose that RAB-10 and LIN-10 recycle AMPARs from intracellular endosomal compartments to synapses along distinct pathways, each with distinct sensitivities to cholesterol and the clathrin-mediated endocytosis machinery...
  13. ncbi Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    Naoshi Nishida
    Division of Gastroenterology, Department of Internal Medicine and Charles A Sammons Cancer Center, Dallas, TX, USA
    Hepatology 47:908-18. 2008
    ..higher than group 2 (CDH1, RUNX3, RIZ1, SFRP2, MINT31) and group 3 markers (COX2, MINT1, CACNA1G, RASSF2, MINT2, Reprimo, DCC) (P < 0.0001)...
  14. ncbi [Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes]
    Luis Zavala G
    Departamento de Anatomia Patologica, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 135:17-25. 2007
    ..Methylation is an inactivation mechanism for tumor suppressor genes, that can have important clinical implications...
  15. ncbi Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    Gyeong Hoon Kang
    Department of Pathology, Seoul NationalUniversity College of Medicine and Cancer Research Institute, Seoul, Korea
    Am J Pathol 160:787-94. 2002
    ..The PTEN, RASSF1A, GSTP1, MGMT, and MINT2 were methylated in EBV-positive GCs at a frequency of more than three times that of the EBV-negative GCs...
  16. ncbi DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer
    D L Worthley
    Royal Brisbane and Women s Hospital Research Foundation Clinical Research Centre, Brisbane, Queensland, Australia
    Oncogene 29:1653-62. 2010
    ..methylation was quantified at 'type A' (ESR1, GATA5, HIC1, HPP1, SFRP1) and 'type C' markers (MGMT, MLH1, CDKN2A, MINT2, MINT31, IGF2, CACNA1G, NEUROG1, SOCS1, RUNX3), and LINE-1...
  17. ncbi Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network
    Punya Shrivastava-Ranjan
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 3050, USA
    Mol Biol Cell 19:51-64. 2008
    ..our hypothesis, we purified APP-containing vesicles from human neuroblastoma SH-SY5Y cells, and we showed that Mint2/3 are specifically enriched and that Mint3 and APP are present in the same vesicles...
  18. ncbi X11-like protein deficiency is associated with impaired conflict resolution in mice
    Yoshitake Sano
    Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 29:5884-96. 2009
    ..Here, we describe a novel mouse model that withdraws in approach-avoidance conflicts. X11-like (X11L)/Mint2 is a neuronal adapter protein with multiple protein-protein interaction domains that interacts with several ..
  19. ncbi CpG island methylation in colorectal adenomas
    A Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 159:1129-35. 2001
    ..CpG island methylation has not been well characterized in adenomas. We evaluated methylation status at p16, MINT2, and MINT31 loci, which are frequently methylated in colorectal carcinomas, in 108 colorectal adenomas from a ..
  20. ncbi Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa
    T Ishii
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Gut 56:13-9. 2007
    ..However, the molecular changes occurring in premalignant lesions are not well understood. An epigenetic change is an example of OSCC that may occur within the epithelium...
  21. ncbi Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth
    Yong Zhang
    Institute of Neuroscience and Key Laboratory of Molecular Neurobiology, Ministry of Education, Second Military Medical University, Shanghai 200433, China
    J Biol Chem 284:12469-79. 2009
    ..We identified muc18-1-interacting protein 2 (Mint2) as a novel TrkA-binding protein and found that the phosphotyrosine binding domain of Mint2 interacted with TrkA ..
  22. ncbi CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels
    Sun Lee
    Department of Pathology, Kyung Hee University College of Medicine, Seoul, Korea
    Arch Pathol Lab Med 132:1657-65. 2008
    ..Little is known about the clinical outcome or histologic characteristics of CIMP-positive colorectal cancers defined by recently identified CpG island methylator phenotype panels...
  23. ncbi Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas
    Mi Jung Kim
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 22:442-9. 2009
    ..islands including p16, cyclooxygenase-2, T-type calcium channel, and estrogen receptor genes, and MINT31, MINT1, MINT2, and MINT27, as well as CpG island methylator phenotype and p53 gene mutation...
  24. ncbi Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas
    Tamotsu Sugai
    Division of Pathology, Central Clinical Laboratory, Iwate Medical University, 19 1 Morioka, 020 8505, Japan
    J Mol Diagn 8:193-201. 2006
    ..Statuses of LOH (at 5q, 8p, 17p, 18q, and 22q), MSI, and CIMP (MINT1, MINT2, MINT31, MLH-1, MGMT, p14, p16, and RASSF1A) were determined using microsatellite polymerase chain reaction and ..
  25. ncbi Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
    Y P Hsueh
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Nature 404:298-302. 2000
    ..Our findings show that a MAGUK which is usually associated with cell junctions has a transcription regulation function...
  26. ncbi Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila
    Garrett G Gross
    Department of Neurology, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 3:e2495. 2008
    ..activity and/or APP levels (GAMAREP), and for the APP intracellular domain (AICDREP), we identified mutations in X11L and ubiquilin (ubqn) as genetic modifiers of APP...
  27. ncbi The ubiquitin ligase RPM-1 and the p38 MAPK PMK-3 regulate AMPA receptor trafficking
    Eun Chan Park
    Department of Genetics, The Waksman Institute, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 4:e4284. 2009
    ..Moreover, rpm-1 mutations enhance the endosomal accumulation of GLR-1 observed in mutants for lin-10, a Mint2 ortholog that promotes GLR-1 recycling from Syntaxin-13 containing endosomes...
  28. ncbi Ultrastructural localization of mint1 at synapses in mouse hippocampus
    M Okamoto
    Fifth Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Eur J Neurosci 12:3067-72. 2000
    Mint1 and mint2 were isolated in the course of seeking the protein ligands to munc18-1, a neuronal protein essential for synaptic vesicle exocytosis...
  29. ncbi Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability
    Robyn Lynne Ward
    Department of Medical Oncology and Colorectal Surgery, St Vincent s Hospital, Darlinghurst, Australia
    J Clin Oncol 21:3729-36. 2003
    ..In this study, we sought to determine the prognostic significance of DNA methylation, both in univariate analysis and in concert with other clinicopathologic factors known to influence outcome...
  30. ncbi Accumulation of aberrant CpG hypermethylation by Helicobacter pylori infection promotes development and progression of gastric MALT lymphoma
    Takami Kondo
    Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Int J Oncol 35:547-57. 2009
    ..to analyze the DNA methylation status of 11 tumor-related genes (Kip2, p16, hMLH-1, p15, p73, MGMT, DAPK, MINT1, MINT2, MINT31 and HCAD) in 21 specimens of MALT lymphoma, 5 specimens of MALT lymphoma with large cell component (high-..
  31. ncbi Hypermethylation status of APC inversely correlates with the presence of submucosal invasion in laterally spreading colorectal tumors
    Kazuo Hashimoto
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, Japan
    Mol Carcinog 47:1-8. 2008
    ..Methylation of MINT1, MINT2, MINT31, p16, O(6)-methylguanine-DNA methyltransferase (MGMT), adenomatous polyposis coli (APC), and human MutL ..
  32. ncbi CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein
    Katsuhiko Tabuchi
    The Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 22:4264-73. 2002
    ..Our data suggest that in the vertebrate brain, CASK and Velis form alternative tripartite complexes with either Mint 1 or Caskin 1 that may couple CASK to distinct downstream effectors...
  33. ncbi Mammalian LIN-7 PDZ proteins associate with beta-catenin at the cell-cell junctions of epithelia and neurons
    C Perego
    CNR Cellular and Molecular Pharmacology Center, Department of Pharmacology, University of Milan, Via Vanvitelli 32, Italy
    EMBO J 19:3978-89. 2000
    ..Moreover, when LIN-7 is present at the beta-catenin-containing junctions, it determines the accumulation of binding partners, thus suggesting the mechanism by which beta-catenin mediates the organization of the junctional domain...
  34. ncbi Somatic alterations, metabolizing genes and smoking in rectal cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 125:158-64. 2009
    ..BRAF mutations, MSI (BAT26 and TGFbetaRII analysis), and CIMP (methylation of CpG islands in CDKN2A, MLH1, MINT1, MINT2 and MINT31)...
  35. ncbi Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 120:656-63. 2007
    ..The BRAF V600E mutation and 5 CpG island markers (MINT1, MINT2, MINT31, p16 and hMLH1) were assessed in 1154 cases of colon cancer...
  36. ncbi Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy
    Lanlan Shen
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:6093-8. 2007
    ..We sought to determine the prognostic significance of CIMP in advanced colorectal cancer patients treated with 5-fluorouracil (5-FU) in an Eastern Cooperative Oncology Group clinical trial...
  37. ncbi Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
    Maho Kondo
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Kita ku, Sapporo 060 0812, Japan
    Mol Neurodegener 5:35. 2010
    X11-family proteins, including X11, X11-like (X11L) and X11-like 2 (X11L2), bind to the cytoplasmic domain of amyloid ?-protein precursor (APP) and regulate APP metabolism...
  38. ncbi Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis
    Haruhiko Aoyagi
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Oncol Rep 25:789-94. 2011
    ..We used the Methylight method to determine the methylation status of hMLH1, p16, MINT1, MINT2 and MINT31. Both BRAF and AKT1 mutations were found in only one case (0.75%)...
  39. ncbi Evaluation of the rodent Hershberger bioassay: testing of coded chemicals and supplementary molecular-biological and biochemical investigations
    A Freyberger
    Bayer HealthCare AG, Pharmaceuticals, GDD Toxicology, D 42096, Wuppertal, Germany
    Toxicology 239:77-88. 2007
    ..Finally, p,p'-DDE may affect ASTWs by several mechanisms including enhanced testosterone metabolism...
  40. ncbi Expression and ultrastructural localization of Mint2 in the spinal cord of rats
    Ling Ling Yao
    Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, and Neurology Department of ShangHai Tenth People Hospital, Shanghai, 200032, China
    Mol Biol Rep 38:667-73. 2011
    Mint protein family, as adaptor molecules, contains three members, Mint1, Mint2 and Mint3. Although Mint3 is ubiquitously expressed, Mint1 and Mint2 have been reported to express specifically in neuron...
  41. ncbi Assessment of methylation events during colorectal tumor progression by absolute quantitative analysis of methylated alleles
    Michiel F G de Maat
    Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Mol Cancer Res 5:461-71. 2007
    ..AQAMA assays were used to measure methylation levels at MINT (methylated in tumor) loci MINT1, MINT2, MINT12, and MINT31. Assay performance was verified on cell line DNA and standard cDNA...
  42. ncbi Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..CIMP- or CIMP+ phenotype was based on five CpG island markers: MINT1, MINT2, MINT31, p16 and MLH1...
  43. ncbi APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
    Sascha W Weyer
    Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany
    EMBO J 30:2266-80. 2011
    ..We show that these defects may be due to loss of an APP/Mint2/Munc18 complex...
  44. ncbi Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias
    Kazuo Konishi
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 132:1254-60. 2007
    ..Whether this translates into hypermethylation in UC-associated cancers (UC-Cs) is not known...
  45. ncbi Intracellular trafficking of the amyloid ?-protein precursor (APP) regulated by novel function of X11-like
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
    PLoS ONE 6:e22108. 2011
    ..X11-like (X11L) is a neural adaptor protein composed of a phosphotyrosine-binding (PTB) and two C-terminal PDZ domains...
  46. ncbi Copy number and sequence variants implicate APBA2 as an autism candidate gene
    Timothy D Babatz
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637 5415, USA
    Autism Res 2:359-64. 2009
    ..1 and 15q13.3 regions that contain a total of 4 genes. The amyloid precursor protein-binding protein A2 (APBA2) gene is located within the 15q13...
  47. ncbi Novel mediators of amyloid precursor protein signaling
    Andrzej Swistowski
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 29:15703-12. 2009
    ..a novel consensus sequence for interaction with the PDZ-1 and PDZ-2 domains of the APP-interacting proteins Mint1, Mint2, and Mint3 (X11alpha, X11beta, and X11gamma), and multiple novel interactors for these proteins, with the finding ..
  48. ncbi Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma
    Shing Jyh Chang
    Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan
    BMC Genomics 10:613. 2009
    ..Identifying genes shared between advanced tumors and stem cells will not only unmask the mechanisms of tumor malignancy but also provide novel therapeutic targets...
  49. ncbi Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease
    Angela Ho
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 28:14392-400. 2008
    ..Here, we crossed conditional and constitutive Mint1, Mint2, and Mint3 knock-out mice with transgenic mouse models of Alzheimer's disease overproducing human Abeta peptides...
  50. ncbi Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma
    Dong H Sinn
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Mod Pathol 22:314-20. 2009
    ..For methylation analyses, 7 independent CpG islands (p15, p16, DAP kinase, hMLH1, MINT1, MINT2, and MINT31) were examined and RT-PCR for detection of API2/MALT1 fusion transcripts were performed in 15 ..
  51. ncbi A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
    ..further evidence for some smaller, previously reported, schizophrenia-associated CNVs, such as those in NRXN1 and APBA2. We could not provide strong support for the hypothesis that schizophrenia patients have a significantly greater &..
  52. ncbi X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain
    Yuhki Saito
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita12 Nishi6, Sapporo 060 0812, Japan
    J Biol Chem 283:35763-71. 2008
    X11 and X11-like proteins (X11L) are neuronal adaptor proteins whose association to the cytoplasmic domain of amyloid beta-protein precursor (APP) suppresses the generation of amyloid beta-protein (Abeta) implicated in Alzheimer disease ..
  53. ncbi A comparison of colon and rectal somatic DNA alterations
    Martha L Slattery
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Dis Colon Rectum 52:1304-11. 2009
    ..Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and differences in somatic alterations in colon and rectal tumors...
  54. ncbi CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteria
    Hee Cheol Kim
    Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Korean Med Sci 23:270-7. 2008
    ..The methylation status of COX2, MGMT, hMLH1, TIMP3, p16, and MINT2 in normal mucosa and tumor were assessed using methylation-specific PCR...
  55. ncbi Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases
    Ludovic Barault
    Service d Anatomie Pathologique, Institut National de la Sante et de la Recherche Medicale, Universite de Bourgogne, Dijon, France
    Cancer Res 68:8541-6. 2008
    ..total of 582 colon adenocarcinomas were evaluated using methylation-specific PCR for 5 markers (hMLH1, P16, MINT1, MINT2, and MINT31)...
  56. ncbi CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans
    Daisuke D Ikeda
    Molecular Genetics Research Laboratory and Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:5260-5. 2008
    ..They form a tripartite complex with X11/X11L and APP (amyloid precursor protein) and are proteolytically processed in a similar fashion to APP...
  57. ncbi HRP-2, the Caenorhabditis elegans homolog of mammalian heterogeneous nuclear ribonucleoproteins Q and R, is an alternative splicing factor that binds to UCUAUC splicing regulatory elements
    Jennifer L Kabat
    Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA
    J Biol Chem 284:28490-7. 2009
    ..We propose that HRP-2 is a protein responsible for regulating alternative splicing through binding interactions with the UCUAUC sequence...
  58. ncbi X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice
    Jacqueline C Mitchell
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Hum Mol Genet 18:4492-500. 2009
    ..These findings support the notion that modulation of X11beta function represents a therapeutic target for Abeta-mediated neuronal dysfunction in Alzheimer's disease...
  59. ncbi The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm
    Akio Sumioka
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Exp Cell Res 314:1155-62. 2008
    ..We found that a significant portion of X11L and X11L2 are recovered in nuclear fraction of mouse brain homogenates...
  60. ncbi Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea
    Kyoung Mee Kim
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Surg Pathol 35:1274-86. 2011
    ..methyltransferase (MGMT), hMLH1, adenomatous polyposis coli (APC), p16, methylated in tumor-1 (MINT-1), MINT2, and MINT31. Methylation of hMLH1 was performed using 2 different sets of primers...
  61. ncbi Molecular cloning and characterization of rat lin-10
    N Ide
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, Kobe, Japan
    Biochem Biophys Res Commun 243:634-8. 1998
    ..These results suggest that rat lin-10 is involved at least in synaptic functions in brain...
  62. ncbi CpG island methylation in carcinoid and pancreatic endocrine tumors
    Annie On On Chan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:924-34. 2003
    ..2 (RARbeta), T-type calcium channel (CACNA1G), and multiple endocrine neoplasia type-1 (MEN1) genes, and of MINT1, MINT2, MINT25, MINT27 and MINT31 loci was evaluated by methylation-specific-PCR (MSP) or combined bisulfite restriction ..
  63. ncbi Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms
    Thomas Biederer
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas Texas 75390 9111, USA
    J Neurosci 22:7340-51. 2002
    ..In view of their biochemical similarity, the functional differences among Mints are unexpected, suggesting that Mints 1 and 2 have a brain-specific function related to APP that is not executed by the ubiquitous Mint 3...
  64. ncbi Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane
    M Okamoto
    Fifth Department of Internal Medicine, Hyogo College of Medicine, 663 8501, Hyogo, Japan
    Neuroscience 104:653-65. 2001
    ..The present findings give morphological evidence and a molecular framework of how mint interacts with amyloid precursor protein and modifies its processing on the secretory pathway...
  65. ncbi VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain
    T C Tseng
    Section of Hematology Oncology Research, Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA
    Biochim Biophys Acta 1518:249-59. 2001
    ..Our results therefore suggest that VAM-1 may function by promoting the assembly of a Veli-1 containing protein complex in neuronal as well as epithelial cells...
  66. ncbi The PTB domain: a new protein module implicated in signal transduction
    P van der Geer
    Program in Molecular Biology and Cancer, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Biochem Sci 20:277-80. 1995
    ....
  67. ncbi PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein
    S Tomita
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 275:13056-60. 2000
    ..production of Abeta42 was suppressed by binding of NF-kappaB/p65 to the PDZ domain of the X11-like protein (X11L), which a human homologue protein of LIN-10...
  68. ncbi Hypermethylation of multiple genes in pancreatic adenocarcinoma
    T Ueki
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 60:1835-9. 2000
    ..Hypermethylation was largely confined to the carcinomas with only three loci (E-cad, DAP kinase, and MINT2) harboring methylation in some normal pancreata (36, 21, and 14%, respectively)...
  69. ncbi Molecular cloning and characterization of Pals, proteins associated with mLin-7
    E Kamberov
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 275:11425-31. 2000
    ..Pals proteins represent a new subfamily of membrane-associated guanylate kinases that allow for multiple targeting complexes containing mLin-7...
  70. ncbi The function of PTB domain proteins
    B Margolis
    Department of Internal Medicine and Biological Chemistry, Howard HughesMedical Institute, University of Michigan Medical School, Ann Arbor 48109 0650, USA
    Kidney Int 56:1230-7. 1999
    ..The ability of the PTB domain to bind peptides in a phosphotyrosine-dependent and -independent fashion allows this domain to be involved in diverse cellular functions...
  71. ncbi Primitive hematopoietic cells in murine bone marrow express the CD34 antigen
    F Morel
    SyStemix Inc, Palo Alto, CA 94304, USA
    Blood 88:3774-84. 1996
    ..These findings should facilitate more direct comparisons of the biology of CD34+ murine and human stem and progenitor cells...
  72. ncbi Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein
    S Tomita
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033 Japan
    J Biol Chem 274:2243-54. 1999
    A novel protein, human X11-like (human X11L), contains a phosphotyrosine interaction (PI) domain and two PDZ domains and displays 55.2% amino acid homology with the human X11 (human X11)...
  73. ncbi The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells
    S M Kaech
    Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
    Cell 94:761-71. 1998
    ..Each of the binding interactions within this complex is conserved, suggesting that this complex may also mediate basolateral localization in mammals...
  74. ncbi LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia
    C Rongo
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Cell 94:751-9. 1998
    ..Thus, these interneurons utilize at least two separate postsynaptic localization pathways...
  75. ncbi Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin
    N Ide
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, Kobe
    Biochem Biophys Res Commun 244:258-62. 1998
    ..We discuss the physiological significance of the interaction of rat lin-10 with neurabin-II/spinophilin...
  76. ncbi Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein
    D S Lee
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 275:23134-8. 2000
    ..a novel protein, XB51, that interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L)...
  77. ncbi Aberrant CpG island methylation in early-onset sporadic gastric carcinoma
    Hee Cheol Kim
    Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Asan Medical Center 388 1, Pungnap dong, Songpa Gu, Seoul, Korea
    J Cancer Res Clin Oncol 131:733-40. 2005
    ....
  78. ncbi Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development
    Attila Stetak
    Institute of Zoology, University of Zurich, Zurich, Switzerland
    EMBO J 25:2347-57. 2006
    ..Extracellular signals thus regulate EGFR trafficking in a cell type-specific manner to control pattern formation during organogenesis...
  79. ncbi The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila
    Smitha Vishnu
    Institut fur Biologie III, Albert Ludwigs Universitat, D 79104 Freiburg im Breisgau, Germany
    Dev Biol 289:296-307. 2006
    ..Using genetic, cell biological, and biochemical approaches, we show that the interaction of Rst with X11Lalpha is of biological significance. The proteins interact, for example, in the context of cell sorting in the pupal retina...
  80. ncbi CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans
    Peter Juo
    Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Mol Biol Cell 18:3883-93. 2007
    ..We propose that CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process...
  81. ncbi Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    James Ashley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 25:5943-55. 2005
    ..These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development...
  82. ncbi Cytosolic tail sequences and subunit interactions are critical for synaptic localization of glutamate receptors
    Howard Chia Hao Chang
    The Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    J Cell Sci 118:1945-56. 2005
    ....
  83. ncbi Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data
    Hui Juan Yang
    Department of Gynecologic Oncology, Fudan University Cancer Hospital, Shanghai, China
    BMC Cancer 6:212. 2006
    ..The abnormal promoter methylation might be a potential molecular marker for cancer management...
  84. ncbi Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain
    Yoshitake Sano
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 281:37853-60. 2006
    b>X11L, a neuronal adaptor protein, associates with the cytoplasmic domain of APP and suppresses APP cellular metabolism. APP is the precursor of Abeta, whose metabolism is strongly implicated in Alzheimer disease pathogenesis...
  85. ncbi Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    Michael J O'Brien
    Department of Pathology, Boston University Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 30:1491-501. 2006
    ..from the selected samples and assayed for BRAF, KRAS2 codon12, 13, CIMP using markers hMLH1, MGMT, MINT1, MINT2, p16, and MSI using an assay for BAT25 and BAT26...
  86. ncbi Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization
    Doreen R Glodowski
    The Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Mol Biol Cell 16:1417-26. 2005
    ..Finally, we show that human Mint2 can substitute for LIN-10 to facilitate GLR-1 localization in neurons and that the Mint2 amino terminus is ..
  87. ncbi Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction
    Kouji Kimura
    Department of Biological Sciences, Faculty of Medicine, and Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, 606 8501, Japan
    Genes Cells 9:631-40. 2004
    ..In this investigation, we report that HCN2 forms a protein assembly with tamalin, S-SCAM and Mint2 scaffold proteins, using several different approaches including immunoprecipitation of rat brain and ..
  88. ncbi Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype
    Michael J O'Brien
    Department of Pathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 28:423-34. 2004
    We investigated the frequency of promoter region CpG island methylation (CIM) of hMLH1, MGMT, MINT1, MINT2, and p16 and K-ras mutations in a total of 79 hyperplastic (serrated) polyps (HPs) from 75 patients and correlated the molecular ..
  89. ncbi The PDZ domains of mLin-10 regulate its trans-Golgi network targeting and the surface expression of AMPA receptors
    Nicole L Stricker
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuropharmacology 45:837-48. 2003
    ..A PDZ point mutation enhances surface delivery of exogenous glutamate receptors in transfected neurons, suggesting that mLin-10 may regulate AMPA receptor trafficking in vivo...
  90. ncbi The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion
    J P Borg
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:14761-6. 1998
    ..X11alpha may be involved in APP trafficking and metabolism in neurons and thus may be implicated in amyloidogenesis in normal aging and Alzheimer's disease brain...
  91. ncbi Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
    M Okamoto
    Howard Hughes Medical Institute and the Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas, Texas 75235, USA
    J Biol Chem 272:31459-64. 1997
    ..We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1...
  92. ncbi The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system
    D M McLoughlin
    Department of Neurology, The Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    FEBS Lett 397:197-200. 1996
    ..APP contains such a motif. These results are consistent with a role for APP in signal transduction mechanisms...
  93. ncbi Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting
    J P Borg
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:31633-6. 1998
    ..This complex may play an important role in the trafficking and processing of APP in neurons...
  94. ncbi Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 279:24343-54. 2004
    ..beta-protein precursor (APP) associate with each other in the brain by binding via their cytoplasmic domains to X11L (the X11-like protein)...
  95. ncbi XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms
    Akio Sumioka
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem J 374:261-8. 2003
    ..binding protein of clone number 51) was isolated by yeast two-hybrid cDNA screening using the N-terminal domain of X11L (X11-like protein) as a bait...
  96. ncbi Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
    M Gotthardt
    Department of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas 75390-9046, USA
    J Biol Chem 275:25616-24. 2000
    ..They form the basis for the elucidation of the molecular pathways by which cells respond to the diversity of ligands that bind to these multifunctional receptors on the cell surface...
  97. ncbi Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism
    Yoichi Araki
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 278:49448-58. 2003
    Previously we found that X11-like protein (X11L) associates with amyloid beta-protein precursor (APP)...
  98. ncbi RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    J Biol Chem 280:15413-21. 2005
    ..domains, including X11alpha (MINT1, encoded by gene APBA1) and X11beta (MINT2, encoded by gene APBA2), can bind to the conserved YENPTY motif in the APP C terminus...
  99. ncbi Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP
    Megumi Sakuma
    Hokkaido University, Kita ku, Sapporo, Japan
    J Neurochem 109:465-75. 2009
    X11-like (X11L) is neuronal adaptor protein that interacts with the amyloid beta-protein precursor (APP) and regulates its metabolism...
  100. ncbi Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein
    Hidenori Taru
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    J Biol Chem 279:21628-36. 2004
    ..X11-like (X11L, also referred to as X11beta and Mint2), which is a member of the mammalian LIN-10 protein family and a possible regulator of Abeta production, elevated ..
  101. ncbi Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures
    James S Sutcliffe
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    BMC Genomics 4:15. 2003
    ..The gene encoding an amyloid precursor protein-binding protein (APBA2) was previously mapped to the distal portion of the interval commonly deleted in Prader-Willi and Angelman ..

Research Grants63

  1. Targeting By mLin-7 Binding Partners In Renal Epithelia
    Benjamin Margolis; Fiscal Year: 2004
    ..This work will allow new insights into the function of the mLin-7 system in renal epithelia and increase our understanding of the basic mechanisms underlying protein targeting in polarized cells. ..
  2. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard Kahn; Fiscal Year: 2009
    ..In the second aim we will determine the sites of phosphorylation of Mint3 and Mint2 and the impact on cargo binding and localization to the TGN...
  3. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard A Kahn; Fiscal Year: 2010
    ..In the second aim we will determine the sites of phosphorylation of Mint3 and Mint2 and the impact on cargo binding and localization to the TGN...
  4. EDRN: Clinical Epidemiology & Validation Centers
    Henry Lynch; Fiscal Year: 2007
    ..a study of the frequency of CDKN2A, MGMT, HLTF, APC, HIC1, p14 ARF, MINT31, MINT2, TIMP3, THBS1, and MLH1 methylation in Lynch syndrome colon adenomas and early colorectal cancers, and of the ..
  5. NMR APPROACHES TO MEMBRANE ASSOCIATED ARF STRUCTURES
    James Prestegard; Fiscal Year: 2007
    ..a GEF from Legionella pneumophila called RalF, and a construct of the Alzheimers associated coat protein, MINT2. The work will also include a structural investigation of the interaction of MINT2 with beta amyloid precursor ..
  6. NMR APPROACHES TO MEMBRANE ASSOCIATED ARF STRUCTURES
    James Prestegard; Fiscal Year: 2009
    ..a GEF from Legionella pneumophila called RalF, and a construct of the Alzheimers associated coat protein, MINT2. The work will also include a structural investigation of the interaction of MINT2 with beta amyloid precursor ..
  7. Molecular and genetic analysis of CDK-5 function in synaptic transmission
    PETER C JUO; Fiscal Year: 2010
    ....
  8. GENETIC CONTROL OF VULVAL CELL FATES IN C ELEGANS
    Stuart Kim; Fiscal Year: 1993
    ..Studies using this simple model system should further our knowledge about these processes, possibly revealing how they become deregulated and also identifying genes that may interact with disease-causing genes such as oncogenes...
  9. Mechanotransduction in C. elegans
    Joshua Kaplan; Fiscal Year: 2007
    ..Given the strong conservation of these pathways across phylogeny, it is likely that our experiments will provide new insights into the mechanisms underlying these fundamental aspects of synaptic cell biology. ..
  10. Synaptic signaling regulated by MALS family PDZ proteins
    David Bredt; Fiscal Year: 2006
    ..Because MALS proteins regulate growth factor receptors and interact with NMDA type glutamate receptors at synapses, this work will be relevant to both tissue development and synaptic plasticity. ..
  11. Synaptic signaling regulated by MALS family PDZ proteins
    Roger Nicoll; Fiscal Year: 2007
    ..Because MALS proteins regulate growth factor receptors and interact with NMDA type glutamate receptors at synapses, this work will be relevant to both tissue development and synaptic plasticity. ..
  12. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
    ..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
  13. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  14. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  15. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
    ..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..
  16. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  17. Molecular and genetic analysis of CDK-5 function in synaptic transmission
    Peter Juo; Fiscal Year: 2007
    ....
  18. DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..abstract_text> ..
  19. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..