ADRB1

Summary

Gene Symbol: ADRB1
Description: adrenergic, beta-1-, receptor
Alias: ADRB1R, B1AR, BETA1AR, RHR, beta-1 adrenergic receptor, beta-1 adrenoceptor, beta-1 adrenoreceptor
Species: human

Top Publications

  1. ncbi beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart
    M Brito-Martins
    National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 153:751-9. 2008
  2. ncbi Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy
    Catherine Lavoie
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, Quebec, H1T 1C8, Canada
    J Biol Chem 277:35402-10. 2002
  3. ncbi An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study
    Hazel L White
    Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    Eur J Heart Fail 5:463-8. 2003
  4. ncbi Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
    K Bengtsson
    Department of Endocrinology, Malmo University Hospital, Lund University, Sweden
    Circulation 104:187-90. 2001
  5. ncbi The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines
    Karl La Rosee
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Pharmacogenetics 14:711-6. 2004
  6. ncbi The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis
    M Ryden
    Department of Medicine, Karolinska Institutet at Huddinge Hospital, Huddinge, Sweden
    Int J Obes Relat Metab Disord 25:1599-603. 2001
  7. ncbi Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women
    I J Dionne
    Clinical Pharmacology and Metabolic Research Unit, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Int J Obes Relat Metab Disord 26:633-9. 2002
  8. ncbi A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure
    M Borjesson
    Wallenberg Laboratory for Cardiovascular Research, Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur Heart J 21:1853-8. 2000
  9. ncbi Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography
    C L Aquilante
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Pharmacogenomics J 8:408-15. 2008
  10. ncbi Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo
    H G Xie
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacogenetics 11:191-7. 2001

Research Grants

  1. PKA targeting: A novel mechanism for GPCR resensitization
    SULEIMAN BAHOUTH; Fiscal Year: 2009
  2. PKA targeting: A novel mechanism for GPCR resensitization
    SULEIMAN WAKIM BAHOUTH; Fiscal Year: 2010
  3. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
  4. CENTRAL BETA ADRENERGIC RECEPTORS
    JAMES O DONNELL; Fiscal Year: 2002
  5. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2007
  6. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
  7. MECHANISM OF SITE SPECIFIC DNA RECOMBINATION
    Makkuni Jayaram; Fiscal Year: 2001
  8. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
  9. Targeting and Function of Golgi Membrane Proteins
    Carolyn Machamer; Fiscal Year: 2009
  10. Targeting and Function of Golgi Membrane Proteins
    Carolyn E Machamer; Fiscal Year: 2010

Detail Information

Publications170 found, 100 shown here

  1. ncbi beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart
    M Brito-Martins
    National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 153:751-9. 2008
    ..We have therefore performed detailed pharmacological analysis of the beta-adrenoceptor responses in developing hESC-CM...
  2. ncbi Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy
    Catherine Lavoie
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, Quebec, H1T 1C8, Canada
    J Biol Chem 277:35402-10. 2002
    ..Taken together, our data suggest that heterodimerization between beta(1)AR and beta(2)AR inhibits the agonist-promoted internalization of the beta(2)AR and its ability to activate the ERK1/2 MAPK signaling pathway...
  3. ncbi An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study
    Hazel L White
    Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    Eur J Heart Fail 5:463-8. 2003
    The Glycine389 variant of the beta-1 adrenergic receptor (beta1AR) generates markedly less cAMP when stimulated in vitro than the more prevalent Arginine389 variant.
  4. ncbi Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
    K Bengtsson
    Department of Endocrinology, Malmo University Hospital, Lund University, Sweden
    Circulation 104:187-90. 2001
    ..The Ser49Gly polymorphism was not associated with hypertension. CONCLUSION: Our data suggest that individuals homozygous for the Arg389 allele of the beta(1)-adrenergic receptor gene are at increased risk to develop hypertension...
  5. ncbi The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines
    Karl La Rosee
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Pharmacogenetics 14:711-6. 2004
    Recently, the Arg389Gly beta1-adrenoceptor (beta1AR) gene polymorphism has been detected. The Arg variant exhibited increased responsiveness to agonist-induced stimulation in vitro...
  6. ncbi The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis
    M Ryden
    Department of Medicine, Karolinska Institutet at Huddinge Hospital, Huddinge, Sweden
    Int J Obes Relat Metab Disord 25:1599-603. 2001
    ..The beta1-adrenoceptor is a candidate gene for obesity because of its role in catecholamine-induced energy homeostasis. A common Arg 389 Gly variant polymorphism has been shown in recombinant cells to influence its-coupling properties...
  7. ncbi Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women
    I J Dionne
    Clinical Pharmacology and Metabolic Research Unit, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Int J Obes Relat Metab Disord 26:633-9. 2002
    ..A putative gain-of-function polymorphism in the beta(1)-adrenoceptor was recently discovered (Gly389Arg ADRB1)...
  8. ncbi A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure
    M Borjesson
    Wallenberg Laboratory for Cardiovascular Research, Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur Heart J 21:1853-8. 2000
    ..No genetic polymorphism has previously been identified in the beta(1)-adrenergic receptor gene. The aim of this study was to find possible mutations in this gene and to relate such findings to morbidity and prognosis in heart failure...
  9. ncbi Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography
    C L Aquilante
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Pharmacogenomics J 8:408-15. 2008
    ..These data suggest that the four selected beta(1)- and beta(2)-AR polymorphisms do not substantially influence the magnitude of hemodynamic response to dobutamine during DSE...
  10. ncbi Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo
    H G Xie
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacogenetics 11:191-7. 2001
    ....
  11. ncbi Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males
    Tetsuro Matsunaga
    Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Am Heart J 154:759-66. 2007
    ..Several functional genetic variations in the beta-AR genes (ADRB1 or ADRB2) have been identified and implicated as causes of hypertension and cardiovascular disease...
  12. ncbi G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95
    Liaoyuan A Hu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:1607-13. 2002
    ..Regulation of protein association through receptor phosphorylation may be a general mechanism used by G protein-coupled receptors that associate via PDZ domain-mediated protein/protein interactions...
  13. ncbi Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    Kersten M Small
    Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
    N Engl J Med 347:1135-42. 2002
    ..We hypothesized that this combination of receptor variants, which results in increased synaptic norepinephrine release and enhanced receptor function at the myocyte, would predispose persons to heart failure...
  14. ncbi Heterodimerization of alpha 2A- and beta 1-adrenergic receptors
    Jianguo Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:10770-7. 2003
    ..These data reveal an interaction between beta(1)AR and alpha(2A)AR that is regulated by glycosylation and that may play a key role in cross-talk and mutual regulation between these receptors...
  15. ncbi Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome
    James J Crowley
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Psychiatr Genet 18:248-51. 2008
    ..k.a. VMAT2) and ADRB1 (encoding beta-1 adrenergic receptor) as candidate genes for a human pharmacogenetic study...
  16. ncbi Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects
    Yan Mei Mao
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, People s Republic of China
    J Clin Pharmacol 49:929-36. 2009
    ..9% +/- 4.0% vs 36.4% +/- 2.1%; 95% CI, 18.8%-38.9%; P = .046). These data suggested that the 393T>C polymorphism of GNAS1 was functionally relevant in vivo...
  17. ncbi Effects of polymorphisms in beta1-adrenoceptor and alpha-subunit of G protein on heart rate and blood pressure during exercise test. The Finnish Cardiovascular Study
    Tuomo Nieminen
    Dept of Pharmacological Sciences, Medical School, Univ of Tampere, Tampere FI 33014, Finland
    J Appl Physiol 100:507-11. 2006
    We tested whether the Arg389Gly and Ser49Gly polymorphisms of the beta1-adrenergic receptor gene ADRB1 and the T393C polymorphism of the G protein alpha-subunit gene GNAS1 modulate heart rate (HR) and blood pressure responses during an ..
  18. ncbi Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010
    The beta-1 adrenergic receptor (beta1AR) plays a fundamental role in the regulation of cardiovascular functions...
  19. ncbi CRM 1-mediated degradation and agonist-induced down-regulation of beta-adrenergic receptor mRNAs
    Ying Bai
    Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97239, USA
    Biochim Biophys Acta 1763:1076-89. 2006
    ..Our results suggest that CRM 1-dependent NES-mediated mechanisms influence the degradation and agonist-mediated down-regulation of the beta1-AR mRNAs...
  20. ncbi Receptor specific crosstalk and modulation of signaling upon heterodimerization between ?1-adrenergic receptor and somatostatin receptor-5
    Rishi K Somvanshi
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, BC, Canada
    Cell Signal 23:794-811. 2011
    ..Taken together, the functional consequences of results described here might have relevance in the cardiovascular system where SSTR and AR subtypes play important roles...
  21. ncbi Beta1-adrenergic receptor polymorphisms, QTc interval and occurrence of symptoms in type 1 of long QT syndrome
    Kristian J Paavonen
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Int J Cardiol 118:197-202. 2007
    ....
  22. ncbi Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer
    Jean Francois Mercier
    Département de Biochimie and Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 277:44925-31. 2002
    ....
  23. ncbi Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:31-7. 2004
    ..that have previously been implicated in hypertension: the alpha-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein beta3 subunit (GNB3/C825T) gene polymorphisms...
  24. ncbi Differences in endosomal targeting of human (beta)1- and (beta)2-adrenergic receptors following clathrin-mediated endocytosis
    Wei Liang
    Membrane Biochemistry Section, Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 117:723-34. 2004
    ..But during or after endocytosis, beta(1)AR and beta(2)AR are sorted into different endosomal compartments...
  25. ncbi Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome
    David E Lanfear
    Departments of Medicine, Genetics, and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO
    JAMA 294:1526-33. 2005
    Previous data support an association between polymorphisms of the beta1- and beta2-adrenergic receptors (ADRB1 and ADRB2) and surrogate end points of response to beta-adrenergic blocker therapy...
  26. ncbi A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate
    Koustubh Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 70:935-42. 2002
    ..Neither the Arg389Gly polymorphism in the beta1 adrenergic receptor nor polymorphisms in the beta2 and beta3 adrenergic receptors were associated with resting heart rate. The heritability of heart rate was 39.7% +/- 7.1% (P<10-7)...
  27. ncbi Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure
    Maximilian T Lobmeyer
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32610, USA
    Pharmacogenet Genomics 17:277-82. 2007
    The Arg389Gly polymorphism (Arg389Gly) in the beta1-adrenergic receptor gene (ADRB1) has been associated with improvement in left-ventricular remodeling with beta-blocker treatment...
  28. ncbi Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects
    A P Gjesing
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 24:392-7. 2007
    Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output...
  29. ncbi A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure
    Stephen B Liggett
    Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:11288-93. 2006
    ..We conclude that beta(1)AR-389 variation alters signaling in multiple models and affects the beta-blocker therapeutic response in HF and, thus, might be used to individualize treatment of the syndrome...
  30. ncbi An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy
    H L White
    Institute for Cardiovascular Research, University of Leeds, UK
    Eur Heart J 23:1087-92. 2002
    ..The aim of this study was to ascertain whether this Glycine389 variant protects against coronary events...
  31. ncbi Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study
    J B Wilk
    Boston University School of Medicine, MA 02118, USA
    Ann Hum Genet 70:566-73. 2006
    The association between polymorphisms in the beta1, beta2 and alpha2B adrenergic receptor (ADR) genes (ADRB1, ADRB2 and ADRA2B) and resting heart rate was examined in white and African-American participants of the HyperGEN Study...
  32. ncbi Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor
    Stuart W Hicks
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 Wolfe Street, Baltimore, MD 21205, USA
    Traffic 7:1666-77. 2006
    ..leads to significantly decreased cell surface levels of exogenously expressed beta1-adrenergic receptor (beta1AR), which can be rescued by expression of RNAi-resistant forms of golgin-160...
  33. ncbi Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks
    Kristin J Meyers
    Department of Epidemiology, University of Michigan, Ann Arbor, USA
    Hypertension 49:992-9. 2007
    ..One in the ADRB1 gene was significantly associated with relative wall thickness with replicate effects in both samples...
  34. ncbi Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure
    Lynne E Wagoner
    Department of Cardiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0564, USA
    Am Heart J 144:840-6. 2002
    ..in patients with congestive heart failure is partially dependent on cardiac beta1-adrenergic receptor (beta1AR) function...
  35. ncbi Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure
    Tony Stanton
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Scotland, UK
    J Nephrol 15:512-8. 2002
    To examine the relationship between this variation in the beta1AR gene and the effect on LV mass.
  36. ncbi The genetic determination of left ventricular mass in healthy adults
    L Swan
    Department of Medicine and Therapeutics, University of Glasgow, UK
    Eur Heart J 24:577-82. 2003
    ..The aim of this study was to assess the heritability of LV mass and its association with three potential candidate genes...
  37. ncbi Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
    S G Terra
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Int J Obes (Lond) 29:746-54. 2005
    ..Objective is to determine the association between obesity and polymorphisms in genes of the beta(1)AR (ADRB1), beta(2)AR (ADRB2), beta(3)AR (ADRB3), Gs protein alpha (GNAS1), to which all three beta-receptors couple and the ..
  38. ncbi Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction
    Chikao Iwai
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am Heart J 146:106-9. 2003
    We sought to investigate the relation between the Arg389Gly polymorphism in the human beta1-adrenergic receptor (ADRB1) gene and acute myocardial infarction (AMI)...
  39. ncbi A pilot study of the pharmacodynamic impact of SSRI drug selection and beta-1 receptor genotype (ADRB1) on cardiac vital signs in depressed patients: a novel pharmacogenetic approach
    Kelan L H Thomas
    University of Michigan, Ann Arbor, MI, USA
    Psychopharmacol Bull 43:11-22. 2010
    OBJECTIVE: The adrenergic beta-1 receptor gene (ADRB1) Ser49Gly and Arg389Gly variants differentially affect blood pressure response to beta-blocker therapy...
  40. ncbi Cloning of the cDNA for the human beta 1-adrenergic receptor
    T Frielle
    Department of Medicine Cardiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 84:7920-4. 1987
    ..Mammalian beta 1AR and beta 2AR are thus products of distinct genes, both of which are apparently related to the putative G-21 receptor...
  41. ncbi Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C
    J D Moore
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0564, USA
    Hum Mutat 14:271. 1999
  42. ncbi Association of beta 1-adrenergic receptor gene polymorphisms with left ventricular hypertrophy in human essential hypertension
    Chunyan Fu
    Sino German Laboratory for Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of Ministry of Education, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing 100037, China
    Clin Biochem 41:773-8. 2008
    Experimental evidence support a key role for beta (1)-adrenergic receptor (ADRB1) in the modulation of cardiac mass. This relationship has not yet been described in Chinese population...
  43. ncbi Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes
    Kersten M Small
    Merck Research Laboratories, Cardiovascular Diseases, Rahway, NJ, USA
    J Cardiovasc Pharmacol 51:106-10. 2008
    Cardiac beta1-adrenergic receptor (beta1AR) responsiveness in heart failure exhibits interindividual variation that may be attributable to polymorphisms of the intronless beta1AR gene...
  44. ncbi beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors
    L A Hu
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:38659-66. 2000
    ....
  45. ncbi Genetic mapping of adrenergic receptor genes in humans
    M R Hoehe
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 73:299-306. 1995
    ..mapped to the interval between D4S126 and D4S62; and the alpha 2-C10 (alpha 2A AR)/beta 1 haplotype (loci ADRA2A/ADRB1) mapped to the interval between D10S259 and D10S187...
  46. ncbi Polymorphisms of the beta1-adrenergic receptor gene are associated with essential hypertension in Chinese
    Yingxin Peng
    Cardiac Center, Hebei Provincial People s Hospital, Shijiazhuang, People s Republic of China
    Clin Chem Lab Med 47:1227-31. 2009
    The beta1-adrenergic receptor (ADRB1) plays a pivotal role in mediating signal transduction of the sympathetic-adrenal system, which is involved in the regulation of cardiac output and peripheral resistance...
  47. ncbi Association of ADRB1 gene polymorphism with atrial fibrillation
    Svetlana Nicoulina
    Krasnoyarsk State Medical University, Krasnoyarsk, Russia
    Genet Test Mol Biomarkers 14:249-53. 2010
    ..study was to establish the probability and patterns of atrial fibrillation (AF) inheritance in families, and to find an association of primary and secondary AF with polymorphism Ser49Gly of the gene encoding beta1-adrenoreceptor (ADRB1).
  48. ncbi Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure
    Jeanne Mialet Perez
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Nat Med 9:1300-5. 2003
    ....
  49. ncbi Modifying effects of the R389G beta1-adrenoceptor polymorphism on resting heart rate and blood pressure in patients with obstructive sleep apnoea
    Jan Borgel
    Medical Clinic 2, Cardiology and Angiology, St Josef Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Clin Sci (Lond) 110:117-23. 2006
    ..2) beats/min for G389G]. In conclusion, although the R389G polymorphism of the beta1-adrenoceptor gene did not influence resting HR or BP in untreated OSA patients, it may modify the beneficial effects of CPAP therapy on these parameters...
  50. ncbi Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  51. ncbi A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade
    G G Sofowora
    Division of Clinival Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 373232 6602, USA
    Clin Pharmacol Ther 73:366-71. 2003
    ..A common polymorphism of the beta(1)-adrenergic receptor Arg389Gly markedly affects function in vitro, but little is known about its in vivo significance...
  52. ncbi Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  53. ncbi Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol
    Julie A Johnson
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, 32610, USA
    Clin Pharmacol Ther 74:44-52. 2003
    ..We tested the hypothesis that 2 common polymorphisms in the gene for beta(1)-adrenergic receptor are associated with antihypertensive response to metoprolol in patients with uncomplicated hypertension...
  54. ncbi A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor
    D A Mason
    Departments of Medicine and Pharmacology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 274:12670-4. 1999
    The beta1-adrenergic receptor (beta1AR) is a key cell surface signaling protein expressed in the heart and other organs that mediates the actions of catecholamines of the sympathetic nervous system...
  55. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
    ..It is concluded that the tail library provides useful information on the general importance of certain adaptor proteins, for example, in this case, ruling out EBP50 as being a broad spectrum-recycling adaptor...
  56. ncbi Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol
    Jie Liu
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China
    Clin Pharmacol Ther 74:372-9. 2003
    ....
  57. ncbi Mechanisms of beta-adrenergic receptor-mediated venodilation in humans
    Christoph Schindler
    Institute of Clinical Pharmacology, Medical Faculty, Dresden University of Technology, Germany
    Clin Pharmacol Ther 75:49-59. 2004
    ..This study was designed to elucidate the underlying mechanisms of isoproterenol (INN, isoprenaline)-induced venodilation by investigation of dorsal hand vein responses...
  58. ncbi Fenoterol but not dobutamine increases erythropoietin production in humans
    C H Gleiter
    Abteilung Klinische Pharmakologie, Universitat Gottingen, Germany
    Clin Pharmacol Ther 61:669-76. 1997
    ..This study assessed the role of adrenergic signal transmission in the control of renal erythropoietin (EPO) production in humans...
  59. ncbi Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats
    C A Rudoy
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1119-29. 2007
    ....
  60. ncbi [The effects of combined beta(1) adrenergic receptor antagonist and beta(2) adrenergic receptor agonist therapy on cardiac function and myocardial apoptosis in heart failure rats]
    Wei Min Li
    Department of Cardiology, First Clinical Hospital, Harbin Medical University, Harbin 150001, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:615-9. 2007
    ..To observe the effects of combined beta(1) adrenergic receptor (AR) antagonist with beta(2)AR agonist therapy on cardiac function and cardiomyocyte apoptosis in heart failure rats...
  61. ncbi Molecular cloning and expression of the rat beta 1-adrenergic receptor gene
    C A Machida
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 97006
    J Biol Chem 265:12960-5. 1990
    ....
  62. ncbi [Serum autoantibodies against the cardiac beta(1)-adrenergic receptor in patients with chronic heart failure: clinical characteristics and response to carvedilol]
    Jin Chen
    Heart Centre, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:599-602. 2007
    ..To detect the serum autoantibodies against the cardiac beta(1)-adrenergic receptor and observe the clinical characteristics and response to carvedilol use in patients with chronic heart failure (CHF)...
  63. ncbi Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats
    N Kobayashi
    Department of Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 12:483-91. 1999
    ..LV) and its relation to coronary flow reserve, and microvascular remodeling in renovascular hypertensive rats (RHR: 2K-1C Goldblatt). Benidipine (5 mg/kg/day) was given to RHR (B-RHR, n = 11) for 6 weeks...
  64. ncbi Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits
    Yukiko Fukuda
    Cardiopulmonary Division of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    J Am Coll Cardiol 43:1090-100. 2004
    ..We sought to define the electrophysiologic property of the rabbit heart associated with autoimmunity against the second extracellular loop of the beta(1)-adrenergic receptor...
  65. ncbi Evidence for beta1-adrenergic receptor involvement in amygdalar corticotropin-releasing factor gene expression: implications for cocaine withdrawal
    CARLA A RUDOY
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neuropsychopharmacology 34:1135-48. 2009
    ....
  66. ncbi Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
    Leif Erik Vinge
    Institute for Surgical Research, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Mol Pharmacol 72:582-91. 2007
    ....
  67. ncbi Impaired hippocampal LTP in inbred mouse strains can be rescued by beta-adrenergic receptor activation
    Lesley A Schimanski
    Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Eur J Neurosci 25:1589-98. 2007
    ....
  68. ncbi Interaction between noradrenaline or adrenaline and the beta 1-adrenergic receptor in the nervous system triggers early metamorphosis of larvae in the ascidian, Ciona savignyi
    Yukiko Kimura
    Misaki Marine Biological Station, Graduate School of Science, The University of Tokyo, Miura, Kanagawa 238 0225, Japan
    Dev Biol 258:129-40. 2003
    ..We propose that interactions between noradrenaline or adrenaline and the beta(1)-adrenergic receptor in the nervous system mediate the process of metamorphosis of Ciona larvae...
  69. ncbi Age-related increase of beta1-adrenergic receptor gene expression in rat liver: a potential mechanism contributing to increased beta-adrenergic receptor density and responsiveness during aging
    Wei Jin
    GRECC, Audie L Murphy Memorial Veterans Hospital, and Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Recept Signal Transduct Res 30:24-30. 2010
    ..These results suggest that an age-related increase of beta(1)AR gene expression contributes to increased betaAR density and beta adrenergic responsiveness in rat liver during aging...
  70. ncbi Localization and characterization of three different beta-adrenergic receptors expressed in Escherichia coli
    M P Chapot
    Laboratoire de Biologie Moléculaire des Récepteurs, Universite Paris VII, France
    Eur J Biochem 187:137-44. 1990
    ..Constructions of new hybrid proteins, in combination with expression in protease mutants of E. coli, should help in controlling such processes...
  71. ncbi Chronic hypoxia increases beta 1-adrenergic receptor mRNA and density but not signaling in neonatal rat cardiac myocytes
    H T Li
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Circulation 94:3303-10. 1996
    ..However, there are no data regarding either regulation of beta-adrenergic receptors, particularly at the mRNA level, or adenylylcyclase activity in isolated cardiac myocytes exposed to chronic hypoxia...
  72. ncbi Antibodies against the beta1-adrenergic receptor induce progressive development of cardiomyopathy
    Lisa Buvall
    Department of Molecular and Clinical Medicine Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Goteborg, Sweden
    J Mol Cell Cardiol 42:1001-7. 2007
    ....
  73. ncbi Change in beta1-adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss
    Mads Rasmussen
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark
    Clin Sci (Lond) 108:323-9. 2005
    ..This relationship is not directly related to energy expenditure and deserves further investigation...
  74. ncbi Reciprocal regulation of beta(1)-adrenergic receptor gene transcription by Sp1 and early growth response gene 1: induction of EGR-1 inhibits the expression of the beta(1)-adrenergic receptor gene
    Suleiman W Bahouth
    Department of Pharmacology, College of Medicine, The University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
    Mol Pharmacol 61:379-90. 2002
    ..These results reveal a novel physiologically relevant transcriptional mechanism for reciprocal regulation of beta(1)-AR gene expression...
  75. ncbi Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
    ..In this study, we report that mice with no beta1- or beta2-adrenergic receptors (beta1AR-/-/beta2AR-/-) have reduced distal lung Na,K-ATPase function and diminished basal and amiloride-sensitive AFC...
  76. ncbi Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms
    M R Bristow
    Heart Failure Treatment Program, University of Utah Medical Center, Salt Lake City 84132
    J Clin Invest 89:803-15. 1992
    ..b) Pressure-overloaded failing right ventricles of PPH subjects exhibit decreased activity of the catalytic subunit of adenylate cyclase, an abnormality not previously described in the failing human heart...
  77. ncbi Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors
    Shai Gavi
    Department of Pharmacology, Diabetes and Metabolic Diseases Research Center, School of Medicine HSC, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Endocrinology 148:2653-62. 2007
    ..IGF-I attenuates the ability of beta(1)-adrenergic receptors to accumulate intracellular cAMP in response to Iso and promotes internalization of beta(1)-adrenergic receptors in these cardiac myocytes...
  78. ncbi Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes
    R P Xiao
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Circ Res 84:43-52. 1999
    ..In contrast, beta2AR stimulation by zinterol or isoproterenol plus a selective beta1-adrenergic receptor (beta1AR) antagonist CGP 20712A failed to enhance the contractility in TG4 myocytes, and more surprisingly, beta2AR ..
  79. ncbi Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy
    Natalia Petrashevskaya
    Cardiopulmonary Genomics Program, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Transl Sci 1:221-7. 2008
    ..Taken together, the unique signaling effects of enhanced beta(2)AR and AC5, which have the potential to afford benefit in heart failure, failed to salvage ventricular function in beta(1)AR-mediated cardiomyopathy...
  80. ncbi Cardiovascular mass and ventricular function after celiprolol in Wistar-Kyoto and spontaneously hypertensive rats
    S Horinaka
    Alton Ochsner Medical Foundation, New Orleans, LA 70121
    Cardiovasc Res 26:396-400. 1992
    The effects of a new beta 1 adrenergic receptor blocking agent with beta 2 receptor agonistic properties on cardiovascular mass, left ventricular function, and aortic distensibility were studied in Wistar-Kyoto (WKY) and spontaneously ..
  81. ncbi Beta-adrenoceptor subtypes in young and old rat ventricular myocytes: a combined patch-clamp and binding study
    E Cerbai
    Institute of Pharmacology, University of Ferrara, Italy
    Br J Pharmacol 116:1835-42. 1995
    ..4 By combining electrophysiological and binding measurements, we calculated beta1AR and beta2ARdensities as number of receptors per microM2 of cell surface...
  82. ncbi Pharmacogenetics of antihypertensive drug responses
    Gary L Schwartz
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Pharmacogenomics 4:151-60. 2004
    ..in genes encoding alpha-adducin (ADD1), subunits of G-proteins (GNB3 and GNAS1), the beta(1)-adrenergic receptor (ADRB1), endothelial nitric oxide synthase (NOS3), and components of the renin-angiotensin-aldosterone system (..
  83. ncbi The enteric parasite Entamoeba uses an autocrine catecholamine system during differentiation into the infectious cyst stage
    Alida Coppi
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA
    J Biol Chem 277:8083-90. 2002
    ..This enteric protozoan parasite, therefore, contains the components of an autocrine catecholamine ligand-receptor system that may act in conjunction with a galactose lectin to regulate differentiation into the infectious cyst stage...
  84. ncbi Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium
    D R Varma
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Br J Pharmacol 127:895-902. 1999
    ..2. Beta1AR antagonists acebutolol, atenolol and metoprolol, beta2AR antagonist ICI-181,551 and nonselective betaAR ..
  85. ncbi The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients
    J A Foekens
    Department of Medical Oncology, Rotterdam Cancer Institute Daniel den Hoed Kliniek Academic Hospital, The Netherlands
    Cancer Res 60:636-43. 2000
    ..Compared with tumors with low levels, those with intermediate and high levels showed a relative hazard rate (RHR) and 95% confidence interval (95% CI) of 1.22 (1.02-1.45) and 1.69 (1.39-2.05) for uPA, and 1.32 (1.14-1.54) and 2...
  86. ncbi C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loc
    Jennifer Wessel
    Department of Medicine, University of California at San Diego, California 92093 0838, USA
    J Hypertens 25:329-43. 2007
    ..C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion...
  87. ncbi [Effects of nicardipine on left ventricular hypertrophy of the rat with renovascular arterial hypertension]
    J Grellet
    , , Pessac
    Arch Mal Coeur Vaiss 81:45-9. 1988
    ..male rats were divided into 3 groups: sham operated rats control group (SHC), untreated hypertensive rats group (RHR-U), treated hypertensive rats group (RHR-N)...
  88. ncbi Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors
    M Lopez-Barahona
    Departamento de Investigacion, Pharmacia Antibióticos, SA, Madrid, Spain
    Eur J Endocrinol 135:709-15. 1996
    ..We conclude that lack of responsiveness of the beta 1-AR gene in C6 cells to T3 is not due to high expression of c-erbA alpha 2 but to undefined cell-specific factors...
  89. ncbi beta1-Adrenoreceptor activation contributes to ischemia-reperfusion damage as well as playing a role in ischemic preconditioning
    Joseph F Spear
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia PA 19104 6046, USA
    Am J Physiol Heart Circ Physiol 292:H2459-66. 2007
    ..Thus the beta(1)-AR plays a dual role in myocardial ischemic damage. Our findings may lead to therapeutic strategies for preserving myocardium at risk for infarction, especially in coronary reperfusion intervention...
  90. ncbi [Effects of praeruptorin C on vascular hypertrophy, [Ca2+]i, collagen content and NO in renovascular and spontaneously hypertensive rats]
    M R Rao
    Department of Cardiovascular Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Yao Xue Xue Bao 36:165-9. 2001
    ..Umbelliferae), on vascular hypertrophy, collagen content, transient [Ca2+]i, NO and vascular response of the thoracic aorta of renovascular and spontaneously hypertensive rats (RHR, SHR).
  91. ncbi Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats
    Toshihiro Koyama
    Department of Clinical and Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama, Japan
    Hypertens Res 33:485-91. 2010
    ..nerves (nitrergic nerves) in mesenteric vascular beds of 2-kidney, 1-clip renovascular hypertensive rats (2K1C-RHR)...
  92. ncbi Beta-adrenergic receptor subtypes that mediate ractopamine stimulation of lipolysis
    S E Mills
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Anim Sci 81:662-8. 2003
    ..In order to confirm the predominant role of the beta1AR in porcine adipocytes, isoproterenol-stimulated lipolysis was inhibited by increasing doses of subtype-selective ..
  93. ncbi Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia
    Dong xing Cao
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
    Cancer Sci 101:1639-45. 2010
    ..Gene expressions of beta1-adrenoceptor (ADRB1), beta2-adrenoceptor (ADRB2), beta3-adrenoceptor (ADRB3), alpha2C-adrenoceptor (ADRA2C), natriuretic peptide ..
  94. ncbi Stereoselectivity of porcine beta-adrenergic receptors for ractopamine stereoisomers
    S E Mills
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Anim Sci 81:122-9. 2003
    ..Ractopamine stereoisomers did not significantly (P > 0.05) stimulate adenylyl cyclase through the beta1AR at moderate (near Kd) or high (10(-4) M) concentrations...
  95. ncbi Polymorphisms in the angiotensinogen and angiotensin II type 1 receptor gene are related to change in left ventricular mass during antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (
    Lisa Kurland
    Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
    J Hypertens 20:657-63. 2002
    ..Our aim was to determine if gene polymorphisms in the renin-angiotensin-aldosterone system (RAAS) were related to the degree of change in left ventricular hypertrophy (LVH) during antihypertensive treatment...
  96. ncbi Beta 1-adrenergic and dopamine (D1)-receptors coupled to adenylyl cyclase activation in GT1 gonadotropin-releasing hormone neurosecretory cells
    P R Findell
    Institute of Immunology and Biological Sciences, Syntex Research, Palo Alto, California 94304
    Endocrinology 132:682-8. 1993
    ..The existence of these receptors suggests that the noradrenergic and dopaminergic regulation of gonadotropin secretion may be mediated at least in part via direct synapses on GnRH neurons...
  97. ncbi Improvement of left ventricular contractility and relaxation with the beta 1-adrenergic receptor partial agonist xamoterol at rest and during exercise in patients with postinfarction left ventricular dysfunction. A placebo-controlled randomized trial
    P J de Feyter
    Catheterization Laboratory, Thoraxcenter, Erasmus University, Rotterdam, The Netherlands
    Circulation 81:III99-106. 1990
    ..Thus, xamoterol can be a useful addition for the treatment of left ventricular dysfunction because of long-term ischemic heart disease...
  98. ncbi Antihypertensive effects of a new transdermal delivery system for clonidine in genetic and experimental hypertensive rats
    R Ishii
    Research and Development Laboratories, Maruho Co, Ltd, Osaka, Japan
    Arzneimittelforschung 46:261-8. 1996
    ..M-5041T) were investigated in spontaneously hypertensive rats (SHR), 2-kidney, 1-clip renal hypertensive rats (RHR) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. M-5041T (0.5-4...
  99. ncbi Critique of "Precipitation in light extinction reconstruction" by P.A. Ryan
    Bret A Schichtel
    National Park Service, Colorado State University Cooperative Institute for Research in the Atmosphere, Fort Collins 80523, USA
    J Air Waste Manag Assoc 56:539-46. 2006
    The goal of the Regional Haze Rule (RHR) is to return visibility in class I areas (CIAs) to natural levels, excluding weather-related events, by 2064...
  100. ncbi Anti-apolipoprotein A-1 IgG as an independent cardiovascular prognostic marker affecting basal heart rate in myocardial infarction
    Nicolas Vuilleumier
    Service of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva 14, Switzerland
    Eur Heart J 31:815-23. 2010
    ..with major cardiovascular events (MACEs) at 12 months and to determine their association with resting heart rate (RHR), a well-established prognostic feature after MI...
  101. ncbi Platelet glycoprotein IIb/IIIa receptor inhibitor preserves coronary flow reserve during progressive coronary arteriostenosis in swine
    Y T Shen
    Department of Pharmacology, Merck Research Laboratories, West Point, PA, USA
    Arterioscler Thromb Vasc Biol 20:2309-15. 2000
    ..between the 4 groups in mean arterial pressure, resting coronary blood flow (CBF), or reactive hyperemic response (RHR), which was induced by brief coronary artery occlusion and expressed as flow debt repayment...

Research Grants63

  1. PKA targeting: A novel mechanism for GPCR resensitization
    SULEIMAN BAHOUTH; Fiscal Year: 2009
    ..By investigating the function of these networks, we believe that we can improve on the performance of beta-blockers, which are widely-used in treating two major health problems in America, namely hypertension and heart failure. ..
  2. PKA targeting: A novel mechanism for GPCR resensitization
    SULEIMAN WAKIM BAHOUTH; Fiscal Year: 2010
    ..By investigating the function of these networks, we believe that we can improve on the performance of beta-blockers, which are widely-used in treating two major health problems in America, namely hypertension and heart failure. ..
  3. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
    ..My laboratory has examined the molecular mechanisms underlying beta1AR mRNA down-regulation following agonist induction, and have identified potential transcriptional and post-..
  4. CENTRAL BETA ADRENERGIC RECEPTORS
    JAMES O DONNELL; Fiscal Year: 2002
    ....
  5. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2007
    ..3) beta2-Adrenergic receptors (beta2AR) are targeted to endothelial caveolae and are more efficient than beta1AR in regulating BK channel function...
  6. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
    ..3) beta2-Adrenergic receptors (beta2AR) are targeted to endothelial caveolae and are more efficient than beta1AR in regulating BK channel function...
  7. MECHANISM OF SITE SPECIFIC DNA RECOMBINATION
    Makkuni Jayaram; Fiscal Year: 2001
    ..The Arg-His-Arg (RHR) triad appears to form part of the catalytic pocket as well...
  8. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..in this aim will also test the hypothesis that alterations in the profile of C/EBP proteins contribute to the obesity/diabetes dependent down-regulation of expression of the beta3AR and beta1AR genes in adipocytes.
  9. Targeting and Function of Golgi Membrane Proteins
    Carolyn Machamer; Fiscal Year: 2009
    ..The proposed experiments on golgin-160 will add to our understanding of cargo delivery to the cell surface and to the role of the Golgi complex in transducing stress signals to the rest of the cell. ..
  10. Targeting and Function of Golgi Membrane Proteins
    Carolyn E Machamer; Fiscal Year: 2010
    ..The proposed experiments on golgin-160 will add to our understanding of cargo delivery to the cell surface and to the role of the Golgi complex in transducing stress signals to the rest of the cell. ..
  11. Regulatory subunits of PP2A in neuronal function
    Stefan Strack; Fiscal Year: 2007
    ..2A (PP2A) is a ubiquitous and abundant enzyme with roles in most cellular processes that involve reversible Ser/'rhr phosphorylation...
  12. Regulatory subunits of PP2A in neuronal function
    Stefan Strack; Fiscal Year: 2006
    ..2A (PP2A) is a ubiquitous and abundant enzyme with roles in most cellular processes that involve reversible Ser/'rhr phosphorylation...
  13. Regulatory subunits of PP2A in neuronal function
    Stefan Strack; Fiscal Year: 2003
    ..2A (PP2A) is a ubiquitous and abundant enzyme with roles in most cellular processes that involve reversible Ser/'rhr phosphorylation...
  14. BETA ADRENERGIC RECEPTOR PHOSPHORYLATION--HEART FAILURE
    Howard Rockman; Fiscal Year: 2003
    ..The overall hypothesis of this proposal is that increased beta1AR phosphorylation, as a consequence of elevated betaARK1 levels, not only contributes to, but is a primary cause of ..
  15. TRANSCRIPTION & FUNCTION OF ADIPOCYTE BETA 3AR IN OBESIT
    Sheila Collins; Fiscal Year: 2000
    ..We have shown that depressed cAMP induction in obesity is linked to impaired expression of beta3AR and beta1AR in WAT and BAT...
  16. Molecular Mechanisms of Cardiac beta1AR-EGFR Association and Signaling
    DOUGLAS TILLEY; Fiscal Year: 2011
    ..Beta1-adrenergic receptor (beta1AR) signaling is critical to the regulation of cardiac function in response to sympathetic input but becomes ..
  17. B ADRENOCEPTOR SIGNALING COMPLEXES IN CARDIAC MYOCYTES
    Brian Kobilka; Fiscal Year: 2005
    ..Beta1 and beta2 Adrenergic receptors (beta1AR and beta2AR) are highly homologous GPCRs activated by adrenaline and noradrenaline...