ADAMTS1

Summary

Gene Symbol: ADAMTS1
Description: ADAM metallopeptidase with thrombospondin type 1 motif, 1
Alias: C3-C5, METH1, A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, METH-1, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1, human metalloproteinase with thrombospondin type 1 motifs
Species: human

Top Publications

  1. ncbi Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1
    Yoon Jin Lee
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 70:948-56. 2010
  2. ncbi ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function
    T Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 105:1345-52. 2000
  3. ncbi Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation
    Darryl L Russell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 278:42330-9. 2003
  4. ncbi ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta
    Lydia Wachsmuth
    Cartilage Research Unit, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    J Rheumatol 31:315-20. 2004
  5. ncbi Identification of prodomain determinants involved in ADAMTS-1 biosynthesis
    Jean Michel Longpre
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 279:33237-45. 2004
  6. ncbi The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican
    N A Cross
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Prostate 63:269-75. 2005
  7. ncbi Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development
    Willy Günther
    Department of Neurosurgery, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Acta Histochem 107:121-31. 2005
  8. ncbi Altered expression of genes regulating angiogenesis in experimental androgen-independent prostate cancer
    Heléne Gustavsson
    Department of Urology, Lundberg Laboratory for Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Prostate 68:161-70. 2008
  9. ncbi ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing
    Anders P Rehn
    Center for Oral Biology, Karolinska Institute, PO Box 4064, SE 141 04 Huddinge, Sweden
    Bone 41:231-8. 2007
  10. ncbi Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1
    Nathan V Lee
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 280:34796-804. 2005

Research Grants

  1. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2010
  2. INHIBITION OF THE ANGIOGENIC RESPONSE
    Luisa Iruela Arispe; Fiscal Year: 2006
  3. Angiogenesis and Microcirculation Gordon Conference
    Luisa Iruela Arispe; Fiscal Year: 2005
  4. Vascular Biology Training Grant
    Luisa Iruela Arispe; Fiscal Year: 2007
  5. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2007
  6. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2010
  7. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2009
  8. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2007
  9. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2007
  10. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1
    Yoon Jin Lee
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 70:948-56. 2010
    ..a domain containing three TSP1 repeats (3TSR), and TSP1 cleavage is regulated, in part, by the metalloproteinase ADAMTS1. In this study, we examined the role of TSP1 and ADAMTS1 in controlling metastatic disease in the liver and lung...
  2. ncbi ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function
    T Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 105:1345-52. 2000
    ..Moreover, the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease...
  3. ncbi Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation
    Darryl L Russell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 278:42330-9. 2003
    ..These observations suggest that one function of ADAMTS-1 in ovulation is to cleave versican in the expanded COC matrix and that the anovulatory phenotype of PRKO mice is at least partially due to loss of this function...
  4. ncbi ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta
    Lydia Wachsmuth
    Cartilage Research Unit, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    J Rheumatol 31:315-20. 2004
    ....
  5. ncbi Identification of prodomain determinants involved in ADAMTS-1 biosynthesis
    Jean Michel Longpre
    Department of Pharmacology, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 279:33237-45. 2004
    ..Our results suggest that conserved residues other than the furin cleavage site in the prodomain of ADAMTS-1 are involved in its biosynthesis...
  6. ncbi The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican
    N A Cross
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Prostate 63:269-75. 2005
    ..These enzymes have one major inhibitor in the ECM, tissue inhibitor of metalloproteinases (TIMP)-3...
  7. ncbi Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development
    Willy Günther
    Department of Neurosurgery, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Acta Histochem 107:121-31. 2005
    ..The results were confirmed by real-time PCR. The specific distribution pattern of ADAMTS-1 in a variety of organs during embryogenesis suggests a role of the molecule in tissue remodelling, vasculogenesis and angiogenesis...
  8. ncbi Altered expression of genes regulating angiogenesis in experimental androgen-independent prostate cancer
    Heléne Gustavsson
    Department of Urology, Lundberg Laboratory for Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Prostate 68:161-70. 2008
    ..The aim of this study was to investigate how the expression of genes regulating angiogenesis is altered when prostate cancer cells progress into androgen-independency...
  9. ncbi ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing
    Anders P Rehn
    Center for Oral Biology, Karolinska Institute, PO Box 4064, SE 141 04 Huddinge, Sweden
    Bone 41:231-8. 2007
    ..These findings further establish ADAMTS-1 as a potentially important protein in PTH induced bone remodeling...
  10. ncbi Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1
    Nathan V Lee
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 280:34796-804. 2005
    ..Together, these findings indicate that fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and thus may play an important role in proteoglycan turnover in tissues where there is overlapping expression...
  11. ncbi The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration
    Cary Esselens
    Medical Oncology Research Program, Research Institute Foundation and Vall d Hebron Institute of Oncology, Vall d Hebron University Hospital, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Biol Chem 285:2463-73. 2010
    ..However, the function of certain metalloproteases, such as ADAMTS1, is not clear and seems to depend on the cellular environment and/or the stage of tumor progression...
  12. ncbi Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively
    Y J Liu
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Oncogene 25:2452-67. 2006
    ....
  13. ncbi ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo
    Natacha Rocks
    Laboratory of Biology of Tumors and Development, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Research, GIGA Cancer and GIGA I, University of Liege and CHU of Liege, Liege, Belgium
    Cancer Res 68:9541-50. 2008
    ..In conclusion, we propose a new paradigm for catalytically active ADAMTS-1 contribution to tumor development, which consists of the recruitment of fibroblasts involved in tumor growth and tumor-associated stroma remodeling...
  14. ncbi Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC)
    N Rocks
    Laboratory of Pneumology, Center for Biomedical Integrative Genoproteomics CBIG, University of Liège and Centre Hospitalier Universitaire de Liège CHU Liège, Avenue de l Hopital, CHU Sart Tilman, Liege 4000, Belgium
    Br J Cancer 94:724-30. 2006
    ..Taken together, these results providing evidence for an overexpression of ADAM-12 and a lower expression of ADAMTS-1 in non-small-cell lung cancer suggest that these proteases play different functions in cancer progression...
  15. ncbi ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells
    Omer F Hatipoglu
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    J Biol Chem 284:16325-33. 2009
    ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is a member of the matrix metalloproteinase family. We have previously reported that ADAMTS1 was strongly expressed in myocardial infarction...
  16. ncbi Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion
    Juan Carlos Rodriguez-Manzaneque
    Medical Oncology Research Program, Vall d Hebron University Hospital Research Institute Universidad Autónoma de Barcelona, Barcelona 08035, Spain
    Int J Biochem Cell Biol 41:800-10. 2009
    ..Here, we show that the secreted metalloprotease ADAMTS1, involved in angiogenesis and inflammatory processes, cleaves the ectodomain of syndecan-4...
  17. ncbi ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165
    Alfonso Luque
    Department of Molecular, University of California, Los Angeles, California 90095, USA
    J Biol Chem 278:23656-65. 2003
    b>ADAMTS1 is a metalloprotease previously shown to inhibit angiogenesis in a variety of in vitro and in vivo assays...
  18. ncbi METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity
    F Vazquez
    Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 274:23349-57. 1999
    ..The distinct distribution of each gene product suggests that each has evolved distinct regulatory mechanisms that potentially allow for fine control of activity during distinct physiological and pathological states...
  19. ncbi ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
    K Kuno
    Department of Molecular Membrane Biology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
    FEBS Lett 478:241-5. 2000
    ..In addition, deletional analysis demonstrated that the C-terminal spacer region of ADAMTS-1 is necessary to degrade aggrecan. These results suggest that ADAMTS-1 may be involved in the turnover of aggrecan in vivo...
  20. ncbi Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4
    J D Sandy
    Shriners Hospital for Children, Tampa, Florida 33612, USA
    J Biol Chem 276:13372-8. 2001
    ..We conclude that versican V1 proteolysis in vivo can be catalyzed by one or more members of the ADAMTS family of metalloproteinases...
  21. ncbi ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats
    B L Tang
    Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore, Singapore
    FEBS Lett 445:223-5. 1999
  22. ncbi ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region
    K Kuno
    Department of Pharmacology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920, Japan
    J Biol Chem 273:13912-7. 1998
    ..These results suggest that the ADAMTS-1 is a unique ADAM family protein that anchors at the ECM...
  23. ncbi Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene
    K Kuno
    Department of Pharmacology, Cancer Research Institute, Kanazawa University, Japan
    J Biol Chem 272:556-62. 1997
    ..We named this cDNA clone A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-1). ADAMTS1 consists of six domains, 1) a pro- and 2) a metalloproteinase, 3) a disintegrin-like, 4) a thrombospondin (TSP) ..
  24. ncbi ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
    Juan Carlos Rodriguez-Manzaneque
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, University of California at Los Angeles, 611, Charles E Young Drive, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 293:501-8. 2002
    b>ADAMTS1 is a secreted protein that belongs to the recently described ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteases...
  25. ncbi Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro
    York Hunt Ng
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada
    Hum Reprod 21:1990-9. 2006
    ..In view of these observations, we have hypothesized that ADAMTS-1 contributes to the cytokine-mediated remodelling of decidual ECM...
  26. ncbi High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Matrix Biol 22:557-60. 2004
    ..Since ADAMTS-1 has recently been shown to inhibit endothelial cell proliferation, the result of the present work may represent a new mechanism by which HDL could have a positive effect on endothelial cell and vascular wall function...
  27. ncbi ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
    K Kuno
    Department of Molecular Pharmacology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 274:18821-6. 1999
    ..Consequently, ADAMTS-1 is an active metalloprotease that is associated with the extracellular matrix. This study strongly suggests that ADAMTS-1 may play a role in the inflammatory process through its protease activity...
  28. ncbi [Angiogenesis in hypertrophic scar of rabbit ears and effect of extracellular protein with metalloprotease and thrombospondin 1 domains on hypertrophic scar]
    Baoqiang Song
    Department of PlasticSurgery, Xijing Hospital, Fourth Military Medical University, Xi an Shaanxi, 710032, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:70-4. 2008
    ..To investigate the angiogenesis in hypertropic scar tissue of rabbit ears at different periods and to explore a new method to prevent hyperplastic scar...
  29. ncbi S100A8 and S100A9 in experimental osteoarthritis
    Hala Zreiqat
    Tissue Engineering and Biomaterials Research Unit, School of AMME J07, Faculty of Engineering, Bosch Institute, University of Sydney, Corner of Shepherd and Cleavland Street, New South Wales 2006, Australia
    Arthritis Res Ther 12:R16. 2010
    ..The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis...
  30. ncbi Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats
    W Yuan
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa 33612 4799, USA
    Neuroscience 114:1091-101. 2002
    ..of this study, using kainate-induced CNS lesion, was to examine the spatial and quantitative relationship between ADAMTS1 and 4 mRNA expression and ADAMTS-mediated cleavage of brevican (as determined by the abundance of the neo-epitope ..
  31. ncbi A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 49:342-52. 2010
    ..expression profiling of 19 lung cancer cell lines also indicated that some of the 176 genes, such as KANK and ADAMTS1, are preferentially inactivated by epigenetic alterations...
  32. ncbi The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep
    Kathrin A Dunlap
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 82:876-87. 2010
    ..reported that delta-like 4 (DLL4) and A disintegrin and metalloproteinase with thrombospondin-like repeats 1 (ADAMTS1) participate in endothelial cell invasion stimulated by S1P and growth factors in vitro, and thus investigated ..
  33. ncbi Characterization of proADAMTS5 processing by proprotein convertases
    Jean Michel Longpre
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Que J1H 5N4, Canada
    Int J Biochem Cell Biol 41:1116-26. 2009
    ..When compared to other ADAMTS proteases, proADAMTS5 processing has several distinct features. In contrast to ADAMTS1, whose furin processing products were clearly present intracellularly, cleaved ADAMTS5 propeptide and mature ..
  34. ncbi Modulatory effect of interleukin-1? on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Matrix Biol 29:613-20. 2010
    ..Conversely, IL-1? reduced mRNA and protein expression of ADAMTS1, a metalloproteinase that suppresses neovascularization...
  35. ncbi ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice
    Hannah M Brown
    School of Paediatrics and Reproductive Health, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 83:549-57. 2010
    ..b>ADAMTS1 is an extracellular metalloprotease induced in ovarian follicles by ovulatory hormones and is required for ..
  36. ncbi ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Hum Pathol 38:86-94. 2007
    ..growth factor A (VEGF-A) in cartilage tumors, we analyzed the expression of a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), which has been identified as a potent inhibitor of VEGF-A...
  37. ncbi Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP
    Brenda M Luken
    Department of Plasma Proteins, Sanquin Research and AMC Landsteiner Laboratory, Amsterdam, The Netherlands
    Thromb Haemost 96:295-301. 2006
    ..designated A-O) in which 5-10 amino acids of the spacer domain were exchanged for the corresponding region of ADAMTS1. Plasma from six patients with antibodies directed against the spacer domain was analyzed for reactivity with the ..
  38. ncbi Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity
    Akiko Suga
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Dev Biol 295:26-39. 2006
    We have isolated the Xenopus ortholog of ADAMTS1 (a disintegrin and metalloprotease with thrombospondin motifs), XADAMTS1, which is expressed in the presumptive ectoderm, then the Spemann organizer, and later in the trunk organizer ..
  39. ncbi Inflammatory gene expression patterns revealed by DNA microarray analysis in TNF-alpha-treated SGBS human adipocytes
    Myoung Sool Do
    School of Life and Food Sciences, Handong Global University Pohang, Korea
    Yonsei Med J 47:729-36. 2006
    ..only IL-1 family member 5 (IL1F5), a disintegrin and metalloprotease with thrombospondin motifs-1 preproprotein (ADAMTS1), fibronectin 1 isoform 1 preprotein (FN1), and matrix metalloproteinase 15 preprotein (MMP15) were confirmed by ..
  40. ncbi Oligomeric procyanidins inhibit cell migration and modulate the expression of migration and proliferation associated genes in human umbilical vascular endothelial cells
    María Teresa García-Conesa
    Phytochemicals and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 53:266-76. 2009
    ..In particular, the expression of genes such as ADAMTS1, THBS1, ANGPT2, CYR61, ET-1, EDG3, and PDE4B involved in endothelial cell migration and proliferation, were ..
  41. ncbi ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells
    Bon Hun Koo
    Department of Biomedical Engineering ND20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 176:1494-504. 2010
    ..However, unlike the related metalloprotease ADAMTS1, which exerts anti-angiogenic effects by cleavage of thrombospondins and sequestration of vascular endothelial ..
  42. ncbi Effects of FG7142 and immobilization stress on the gene expression in the neocortex of mice
    Akeo Kurumaji
    Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyou ku, Tokyo 113 8519, Japan
    Neurosci Res 62:155-9. 2008
    ..In addition, there was an increase in the mRNAs of five of the seven genes (Fos, Cyr61, Btg2, Adamts1, and Gem) in the neocortex of mice exposed to the stress for 1h...
  43. ncbi Lactoferrin is associated with a decrease in oocyte depletion in mice receiving cyclophosphamide
    Yuka Horiuchi
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Fertil Steril 91:2069-2078.e1. 2009
    ..To investigate new important molecules involved in the regulation of chemotherapy-induced ovarian damage and, based on those results, to examine the effect of lactoferrin on cyclophosphamide (CPM)-induced ovarian failure...
  44. ncbi DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
    Qinghua Wu
    Department of Pathology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Mol Cancer 6:45. 2007
    ..Direct bisulphite sequencing analysis was used to confirm the methylation status of individual genes. The MSP results were compared with clinico- pathological features...
  45. ncbi Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling?
    Geza Fejes-Toth
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756 0001, USA
    Endocrinology 148:1502-10. 2007
    ..These include genes related to extracellular matrix regulation (tenascin-X, ADAMTS1, PAI-1, UPAR, and hyaluronic acid synthase-2), signaling, and regulation of vascular tone (RGS2, adrenomedullin) ..
  46. ncbi FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis
    Lin Wang
    Center for Biomedical Engineering, Beijing University of Posts and Telecommunications, China
    Cancer Invest 27:816-24. 2009
    ..In the control, we found no proliferating subnetwork. In CRC, we identified one FOS proliferating module (SFRP2, ADAMTS1, SYNPO2, VIP, ADAM33 inhibition to FOS and MGP, FOSB activation to FOS...
  47. ncbi Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries
    Margret Hohberg
    Shear Stress and Vascular Biology Research Group, Institute of Physiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cell Physiol 226:350-61. 2011
    b>ADAMTS1 inhibits capillary sprouting, and since capillary sprouts do not experience the shear stress caused by blood flow, this study undertook to clarify the relationship between shear stress and ADAMTS1...
  48. ncbi ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells
    Monika Krampert
    Department of Biology, Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Hönggerberg CH 8093, Switzerland
    J Biol Chem 280:23844-52. 2005
    The metalloproteinase ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs) is induced under inflammatory conditions, and it is also a potent inhibitor of angiogenesis...
  49. ncbi Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
    Kryn Stankunas
    Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 14:298-311. 2008
    ..We show that trabeculation requires Brg1, a chromatin remodeling protein, to repress ADAMTS1 expression in the endocardium that overlies the developing trabeculae...
  50. ncbi Methamphetamine, morphine, and their combination: acute changes in striatal dopaminergic transmission evaluated by microdialysis in awake rats
    Frederico C Pereira
    Instituto de Farmacologia e Terapêutica, Medical School, University of Coimbra, Rua Larga, Coimbra 3004 504, Portugal
    Ann N Y Acad Sci 1074:160-73. 2006
    ..p.; [METH1: hyperlocomotion-inducing] and [METH5: stereotypy-inducing], respectively) and MOR (10 mg/kg, i.p...
  51. ncbi ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
    Nathan V Lee
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
    EMBO J 25:5270-83. 2006
    ..b>ADAMTS1 in particular is required for normal ovulation and renal function and has been shown to modulate angiogenesis...
  52. ncbi Identification of substrates of the extracellular protease ADAMTS1 by DIGE proteomic analysis
    Francesc Canals
    Medical Oncology Research Program, Vall d Hebron University Hospital Research Institute, Barcelona, Spain
    Proteomics 6:S28-35. 2006
    ..b>ADAMTS1 is a secreted enzyme of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of ..
  53. ncbi Adenovirus-mediated METH1 gene expression inhibits hypertrophic scarring in a rabbit ear model
    Baoqiang Song
    Institute of Plastic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Wound Repair Regen 17:559-68. 2009
    ..In this study, we assessed the effect of anti-angiogenesis resulting from adenovirus-mediated METH1 (metalloprotease and thrombospondin1) gene expression on the hypertrophic scar formation in a rabbit ear model of ..
  54. ncbi Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction
    Keigo Nakamura
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Biochem 136:439-46. 2004
    ..b>ADAMTS1 (A disintegrin and metalloprotease with thrombospondin motifs), a newly discovered metalloprotease, was ..
  55. ncbi AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo
    Mehmet Zeynel Cilek
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Biol Int 35:1-8. 2011
    ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an early immediate gene. We have previously reported that ADAMTS1 was strongly induced by hypoxia...
  56. ncbi ADAMTS1: a matrix metalloprotease with angioinhibitory properties
    M Luisa Iruela-Arispe
    Department of Molecular, UCLA, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 995:183-90. 2003
    ..Using the antiangiogenic motifs in thrombospondin-1, we have recently cloned METH1/ADAMTS1, a secreted metalloproteinase with three thrombospondin-1, and shown that the protein inhibits endothelial cell ..
  57. ncbi Development and hormonal regulation of the ovarian lymphatic vasculature
    Hannah M Brown
    School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    Endocrinology 151:5446-55. 2010
    ..ovary, clearly demonstrating both the involvement of FSH/estradiol and the Adamts1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) protease in ovarian lymphangiogenesis...
  58. ncbi Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
    T Yatabe
    Department of Pathology, Keio University, Tokyo, Japan
    Ann Rheum Dis 68:1051-8. 2009
    ..Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms...
  59. ncbi ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells
    Carmen Casal
    GENYO Pfizer University of Granada Andalusian Government Centre for Genomics and Oncological Research, Armilla, Granada, Spain
    Cancer Res 70:4676-86. 2010
    ..Here, we report the identification of the extracellular protease ADAMTS1 as a critical molecule for tumor cells to acquire endothelial-like properties...
  60. ncbi The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity
    Rens de Groot
    Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    Blood 116:3064-72. 2010
    ..Eight composite sequence swaps (to residues in ADAMTS1 or ADAMTS2) and 18 single-point mutants were generated in these VRs and expressed...
  61. ncbi Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer
    Cristina G Viloria
    Departamento de Bioquímica y Biología Molecular and Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Servicio de Anatomia Patologica, Hospital Central de Asturias, Oviedo, Spain
    Cancer Res 69:4926-34. 2009
    ..In particular, ADAMTS1, ADAMTS9, and ADAMTS18 have been found to be epigenetically silenced in malignant tumors of different sources, ..
  62. ncbi Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
    Terje Ahlquist
    Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Mol Cancer 7:94. 2008
    ..e. markers with diagnostic potential. The methylation status of eleven genes (ADAMTS1, CDKN2A, CRABP1, HOXA9, MAL, MGMT, MLH1, NR3C1, PTEN, RUNX3, and SCGB3A1) was determined in 154 tissue samples ..
  63. ncbi ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    Heather Stanton
    University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, 3052 Victoria, Australia
    Nature 434:648-52. 2005
    ..b>ADAMTS1, 8 and 9 have weak aggrecan-degrading activity...
  64. ncbi ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Int J Cancer 118:1241-7. 2006
    ..We identified a subgroup of ADAMTSs, based on functional and amino acid sequence similarity (ADAMTS1, 4, 5, 8 and 15), to be the focus of further study in breast carcinoma...
  65. ncbi Airway responsiveness to methacholine after inhalation of nebulized hypertonic saline in bronchial asthma
    S P O'Hickey
    Department of Allergy, United Medical School, London, England
    J Allergy Clin Immunol 83:472-6. 1989
    ..of (1) an HS challenge (HS1) followed 1 hour later by a second HS challenge (HS2), (2) a Meth challenge alone (Meth1), and (3) an HS challenge followed 1 hour later by a Meth challenge (Meth2)...
  66. ncbi Genetic and molecular aspects of acromelic dysplasia
    Carine Le Goff
    Department of Genetics, Universite Paris Descartes, INSERM U781, Hopital Necker Enfants Malades, Paris, France
    Pediatr Endocrinol Rev 6:418-23. 2009
    ..More recently, we have identified ADAMTSL2 mutations in GD. The function of ADAMTS1 0 and AD AMTSL 2 are unknown...
  67. ncbi The prostatic environment suppresses growth of androgen-independent prostate cancer xenografts: an effect influenced by testosterone
    Karin Jennbacken
    Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Goteborg SE 413 45, Sweden
    Prostate 69:1164-75. 2009
    ..To elucidate this further, we investigated how growth of androgen-dependent (AD) LNCaP and androgen-independent (AI) LNCaP-19 prostate tumors was affected by different microenvironments and androgen levels...
  68. ncbi Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature
    Gloria Bonuccelli
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 174:1650-62. 2009
    ..matrix proteins (Cyr61, Plf, Pthlh, Serpinb5, Tnc, and Wnt10a), ii) proteases that generate EGF and HGF (Adamts1 and St14), and iii) tyrosine kinase substrates and integrin signaling/adapter proteins (Akap13, Cdcp1, Ddef1, ..
  69. ncbi HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells
    Karen Grigo
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, D 45122 Essen, Germany
    Biol Chem 389:179-87. 2008
    ..of HNF4 alpha on cell proliferation, including well-known cancer genes, such as CDKN1A (p21), TGFA, MME (NEP) and ADAMTS1. In addition, the genes SEPP1, THEM2, BPHL, DSC2, ANK3, ALDH6A1, EPHX2, NELL2, EFHD1 and PROS1 are also part of ..
  70. ncbi ADAMs in cancer cell proliferation and progression
    Satsuki Mochizuki
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    Cancer Sci 98:621-8. 2007
    ..Many ADAM species, including ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19, ADAM28, ADAMTS1, ADAMTS4 and ADAMTS5, are expressed in human malignant tumors...
  71. ncbi Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma
    Angela Stokes
    Biomedical Research Centre, University of East Anglia
    Clin Cancer Res 16:2022-35. 2010
    ..Proteinases have been implicated in several aspects of tumor growth and metastasis in a broad range of tumors including HNSCC...
  72. ncbi Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 72:1241-55. 2005
    Protease cascades are essential for many biological events, including the LH-induced process of ovulation. ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin-like repeats-1) is expressed and hormonally regulated in the ..
  73. ncbi Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors
    Sandra Casimiro
    Clinical and Translational Oncology Research Unit, Instituto de Medicina Molecular FML, Lisbon, Portugal
    Clin Exp Metastasis 29:155-64. 2012
    ..and cell surface proteins implicated in bone-homing (CXCR4), angiogenesis (CTGF and FGF5), invasion (MMP-1 and ADAMTS1), and osteoclast recruitment (IL11)...
  74. ncbi Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization
    Ainsley C Nicholson
    Laboratory of Molecular Neuro Oncology, Neurosurgery Department and Winship Cancer Institute, 1365 C Clifton Road, Room C5078, Emory University, Atlanta, GA 30322, USA
    BMC Evol Biol 5:11. 2005
    ....
  75. ncbi Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor
    Sheng Yu Jin
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    Blood 115:2300-10. 2010
    ..sequence alignment of the ADAMTS13 spacer domains of human, mouse, and zebrafish with these of human and murine ADAMTS1, a closely related member of ADAMTS family, have provided hints to investigate the role of the amino acid ..
  76. ncbi [Identification of biomarkers for early detection in gastric cancer and its clinical biological significance.]
    Rui fang Guo
    Molecular Oncology Laboratory, Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100142
    Beijing Da Xue Xue Bao 41:353-60. 2009
    ..To systematically understand the cellular and molecular mechanism of gastric cancer (GC) development and to discover early diagnosis and predictive biomarkers, which will be used for early diagnosis and novel treatment targets...
  77. ncbi Expression profiling of metalloproteinases and their inhibitors in cartilage
    Lara Kevorkian
    University of East Anglia, Norwich, UK
    Arthritis Rheum 50:131-41. 2004
    ..To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA)...
  78. ncbi Expression of ADAMTS1 during murine development
    Shelley N M Thai
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Room 559, UCLA, Los Angeles, CA 90095 1570, USA
    Mech Dev 115:181-5. 2002
    b>ADAMTS1/METH1 belongs to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteins that currently comprises 18 members...
  79. ncbi ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
    Xin Lu
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genes Dev 23:1882-94. 2009
    ..whereby two distinct metalloproteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS1) and matrix metalloproteinase-1 (MMP1), orchestrate a paracrine signaling cascade to modulate the bone ..
  80. ncbi Inhibition of tumor growth by antibody to ADAMTS1 in mouse xenografts of breast cancer
    Tomohiro Hirano
    Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Anticancer Res 31:3839-42. 2011
    A disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS1), a member of the ADAMTS family of proteases, is involved in the shedding of epidermal growth factor (EGF)-like ligands such as amphiregulin, which activate the ..
  81. ncbi The ADAMTS(L) family and human genetic disorders
    Carine Le Goff
    Département de génétique, Unité INSERM U781, Universite Paris Descartes, Sorbonne Paris Cité, Tour Lavoisier, 149 rue de Sevres, Paris, France
    Hum Mol Genet 20:R163-7. 2011
    ADAMTS designates a family of 19 secreted enzymes, whose the first member ADAMTS1 was described in 1997...
  82. ncbi Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
    Katia Bourd-Boittin
    Institut de Recherche en Santé, Environnement et Travail EA4427 SeRAIC, Universite de Rennes 1, IFR14, Rennes, France
    Hepatology 54:2173-84. 2011
    ..fibrosis samples using a dedicated gene array selected for relevance to protease activities, identifying the ADAMTS1 (A Disintegrin And Metalloproteinase [ADAM] with thrombospondin type 1 motif, 1) gene as an important node of the ..
  83. ncbi Increased beta-oxidation and improved oocyte developmental competence in response to l-carnitine during ovarian in vitro follicle development in mice
    Kylie R Dunning
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 85:548-55. 2011
    ..androstenedione, estradiol, and progesterone) and the induction of cumulus matrix proteins (hyaluronan and ADAMTS1) were similar to in vivo follicles, indicating that appropriate differentiation of follicular cells occurs in ..
  84. ncbi Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla
    Derek Boerboom
    Départment de Biomédecine Vétérinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Dev Dyn 240:1806-14. 2011
    ..Adamts4(-/-) mice were, therefore, crossed with a strain lacking Adamts1, whose pattern of expression and substrate specificity overlap that of Adamts4...
  85. ncbi Mouse cumulus-oocyte complexes from in vitro-cultured preantral follicles suggest an anti-luteinizing role for the EGF cascade in the cumulus cells
    Sergio Romero
    Follicle Biology Laboratory, Vrije Universiteit Brussel, Belgium
    Biol Reprod 84:1164-70. 2011
    ..Analysis of transcript levels of Egfr, Ereg, Cyp19a1, Hsd3b1, Adamts1, and Has2 in cumulus cells further indicate that the triggers for the EGFR cascade preserve the expression ..
  86. ncbi Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction
    Bas J M Peters
    Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
    Pharmacogenet Genomics 20:766-74. 2010
    ....
  87. ncbi Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
    I Abbaszade
    Department of Applied Biotechnology, The DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware 19880, USA
    J Biol Chem 274:23443-50. 1999
    ..aggrecanase-2), which has extensive homology to ADAMTS4 (aggrecanase-1) and the inflammation-associated gene ADAMTS1. ADAMTS11 possesses a number of conserved domains that have been shown to play a role in integrin binding, cell-..
  88. ncbi PGF2?-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer
    Margaret C Keightley
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK
    BMC Cancer 10:488. 2010
    ..This study investigates the expression, regulation and role of a disintegrin and metalloproteinase with thrombospondin repeat 1 (ADAMTS1) in endometrial adenocarcinoma cells by PGF2? via the FP receptor.
  89. ncbi ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity
    Yuval Yung
    IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Centre, Tel Hashomer, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Cell Endocrinol 328:104-8. 2010
    ..The correlation between its expression in cumulus GCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function...
  90. ncbi Expression of versican and ADAMTS during rat tooth eruption
    Shinya Sone
    Division of Pediatric Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, 980 8575, Japan
    J Mol Histol 36:281-8. 2005
    ..Rat maxillary first molars in weeks 1, 2, 3, 4 and 6 were examined. The mRNA expression of ADAMTS1, ADAMTS4, ADAMTS5 and versican was localized using in situ hybridization...
  91. ncbi Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities
    Thomas Lind
    Musculoskeletal Research Group SCMS, University of Newcastle Medical School, Newcastle, UK
    Mol Cell Biochem 281:95-102. 2006
    ..Furthermore, we show that MMP2 but not MMP13 remove ADAMTS-1 specific gelatin zymopraphic zones...
  92. ncbi Hyaluronan and its binding proteins during cervical ripening and parturition: dynamic changes in size, distribution and temporal sequence
    Monika Ruscheinsky
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, United States
    Matrix Biol 27:487-97. 2008
    ..Upregulation of the versican degrading protease, ADAMTS1 occurs in the cervix prior to birth...
  93. ncbi Differential expression of VEGFA, TIE2, and ANG2 but not ADAMTS1 in rat mesenteric microvascular arteries and veins
    N Mecha Disassa
    Charite Berlin, Campus Benjamin Franklin, Department of Physiology, Berlin, Germany
    Physiol Res 58:193-202. 2009
    ..The results show higher expression of VEGFA, TIE2, and ANG2 in arteries than in veins, but equal expression of ADAMTS1. Higher availability of VEGFA mRNA in endothelial cells of arteries shown here could contribute to the ..
  94. ncbi [Effect of METH1 gene transfection on the proliferation of rabbit's ear scar]
    Bao Qiang Song
    Department of Plastic Surgery, Xijing Hospital, The Fourth Military Medical University Xi an 710032, China
    Zhonghua Zheng Xing Wai Ke Za Zhi 24:148-50. 2008
    To investigate the effect of METH1 gene transfection on fibroblast proliferation and I, III collagen synthesis in rabbit ear scar.
  95. ncbi Dynamic variation of genes profiles and pathways in the hippocampus of ischemic mice: a genomic study
    Liying Wang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei Nanxiaojie, Beijing 100700, China
    Brain Res 1372:13-21. 2011
    ..there were 2 specific altered genes in the 3h group (casp8ap2 and mmp2), 6 in the 24h group (daxx, gadd45a, adamts1, adcy8, cyp51, dusp16), but none in the 12h group...
  96. ncbi Altered composition of the cumulus-oocyte complex matrix during in vitro maturation of oocytes
    Kylie R Dunning
    Discipline of Obstetrics and Gynaecology, Research Centre for Reproductive Health, The University of Adelaide, Adelaide, SA, Australia
    Hum Reprod 22:2842-50. 2007
    ..We have previously identified two extracellular matrix proteins, the protease Adamts1 and hyaluronan-binding proteoglycan Versican, produced by mural granulosa cells that selectively incorporate into ..
  97. ncbi BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells
    Matthias D Kaeser
    Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 283:32254-63. 2008
    ..in pluripotent cells, regulating expression of developmental modifiers and signaling components such as Nodal, ADAMTS1, BMI-1, CRABP1, and thyroid releasing hormone...
  98. ncbi Caspase 1 deficiency reduces inflammation-induced brain transcription
    Claudio Mastronardi
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:7205-10. 2007
    ..During SIRS, the expression of several genes, such as chemokines, GTPases, the metalloprotease ADAMTS1, IL-1RA, the inducible nitric oxide synthase, and cyclooxygenase-2, was differentially increased in casp1(-/-) ..
  99. ncbi Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages
    A Plaas
    Department of Internal Medicine, College of Medicine, University of South Florida, Tampa, FL, USA
    Osteoarthritis Cartilage 15:719-34. 2007
    ..We have examined the abundance, location and some biochemical properties of the six known aggrecanases (A disintegrin and metalloproteinase with thrombospondin-like motifs 1 (ADAMTS1) 4, 5, 8, 9 and 15) in normal and OA human cartilages.
  100. ncbi The quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR
    Y F Tian
    Institute of Neurobiology, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, China
    Acta Anaesthesiol Scand 51:158-64. 2007
    b>ADAMTS1 and ADAMTS8 are proteases involved in extracellular matrix proteolysis and antiangiogenesis, but little is known about their expression and function in cerebral ischemia...
  101. ncbi Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes
    Masayuki Takizawa
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    FEBS Lett 582:2945-9. 2008
    Aggrecanases that include ADAMTS1, 4, 5, 8, 9 and 15 are considered to play key roles in aggrecan degradation in osteoarthritic cartilage...

Research Grants62

  1. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2010
    ..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
  2. INHIBITION OF THE ANGIOGENIC RESPONSE
    Luisa Iruela Arispe; Fiscal Year: 2006
    ..abstract_text> ..
  3. Angiogenesis and Microcirculation Gordon Conference
    Luisa Iruela Arispe; Fiscal Year: 2005
    ..The conference will be held in Salve Regina University from August 10-15, 2003. ..
  4. Vascular Biology Training Grant
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..End of Abstract) ..
  5. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..they also contained metalloproteinase and disintegrin domains and because of this structure, they are named: ADAMTS1 and ADAMTS8...
  6. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2010
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  7. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2009
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  8. Notch Signaling in Vascular Development and Homeostasis
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..Thus, this information is central to the generation of novel and more effective therapies that will enable manipulation of vascular function during pathological conditions. ..
  9. VEGF Signaling and Tumor Microenvironment
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..These data will aid in further refinement of therapeutic strategies to inhibit angiogenesis in tumors. ..
  10. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..abstract_text> ..
  11. THERAPEUTIC ANTIANGIOGENESIS
    Luisa Iruela Arispe; Fiscal Year: 2002
    ..abstract_text> ..
  12. SUPPRESSION OF VASCULAR GROWTH
    Luisa Iruela Arispe; Fiscal Year: 2003
    ..We believe that identification and characterization of potent and novel inhibitors of angiogenesis is of significant biological and therapeutic relevance for pharmacological intervention to suppress vascular growth in tumors. ..
  13. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 1993
    ..Understanding the regulation of these genes should provide greater insight into the events controlling ovulation and luteinization, and perhaps the broader areas of inflammation and terminal cell differentiation, respectively...
  14. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2009
    ..This information should help us understand the basis for infertility in women who have abnormal menstrual cycles, reduced ovarian function and are anovulatory. ..
  15. The role of hypoxia in venous neointimal hyperplasia in hemodialysis grafts
    Sanjay Misra; Fiscal Year: 2010
    ..The long term goal of this current proposal and research program is to improve the care of patients with ESRD, the vast majority of who use long-term hemodialysis as their mode of renal replacement therapy. ..
  16. The Role of Cardiovascular Mineralocorticoid Receptors in Health and Disease
    Geza Fejes Toth; Fiscal Year: 2010
    ....
  17. OVARIAN FOLLICULAR DEVELOPMENT AND HORMONE ACTION
    Joanne Richards; Fiscal Year: 2002
    ....
  18. Mechanism of sgk action in the collecting duct
    Geza Fejes Toth; Fiscal Year: 2005
    ..abstract_text> ..
  19. Ovarian Follicular Developmental and Hormone Action
    Joanne Richards; Fiscal Year: 2007
    ..3) Determine the molecular, cellular and hormonal basis of the altered ovarian phenotype of the TAFII105 null mice. 4) Determine the function of Wnt-4 in the adult ovary. ..
  20. MOLECULAR MECHANISM OF MINERALOCORTICOID RECEPTOR ACTION
    Geza Fejes Toth; Fiscal Year: 2003
    ..abstract_text> ..
  21. OVARIAN FOLLICULAR DEVELOPMENT AND HORMONE ACTION
    Joanne Richards; Fiscal Year: 1993
    ..Using these approaches we hope to determine the molecular events that mediate cAMP and estradiol action during granulosa cell differentiation...
  22. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2010
    ..This information should help us understand the basis for infertility in women who have abnormal menstrual cycles, reduced ovarian function and are anovulatory. ..