ABCB1

Summary

Gene Symbol: ABCB1
Description: ATP-binding cassette, sub-family B (MDR/TAP), member 1
Alias: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1
Species: human

Top Publications

  1. ncbi P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines
    M Boiocchi
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 78:159-66. 1992
  2. ncbi Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells
    F Kugawa
    Department of Biopharmaceutics1, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan
    Pharmazie 64:296-300. 2009
  3. ncbi A "silent" polymorphism in the MDR1 gene changes substrate specificity
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 315:525-8. 2007
  4. ncbi A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
    R L Roberts
    Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand
    Pharmacogenomics J 2:191-6. 2002
  5. ncbi Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
  6. ncbi Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients
    Laure Elens
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 53 02, avenue E Mounier, 1200 Bruxelles, Belgium
    Pharmacogenomics 11:1223-34. 2010
  7. ncbi Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip
    Elisabet Cuyàs
    Human Pharmacology and Clinical Neurosciences Research Group of the Neuropsychopharmacology Program, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, c Dr Aiguader 88 08003 Barcelona, Spain
    Pharmacogenomics 11:257-66. 2010
  8. ncbi Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    Silke Vogelgesang
    Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
    Pharmacogenetics 12:535-41. 2002
  9. ncbi P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    John R Cirrito
    Department of Neurology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 115:3285-90. 2005
  10. ncbi UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan
    Jean Francois Cote
    Institut National de la Sante et de la Recherche Medicale UMR S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, France
    Clin Cancer Res 13:3269-75. 2007

Research Grants

  1. MDR Gene Polymorphisms in AML
    Maria Baer; Fiscal Year: 2007
  2. REGULATION OF MULTIDRUG RESISTANCE PHENOTYPE
    William Hait; Fiscal Year: 2002
  3. DEVELOPMENT OF NEW SEMISYNTHETIC TAXANES
    Ralph Bernacki; Fiscal Year: 2001
  4. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Moye Rowley; Fiscal Year: 1993
  5. MODULATION OF MULTIDRUG RESISTANCE MECHANISMS
    Branimir Sikic; Fiscal Year: 2002
  6. Vaginal Drug Delivery of P-glycoprotein Substrates
    Giovanni Pauletti; Fiscal Year: 2003
  7. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus Frank; Fiscal Year: 2007
  8. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
  9. XENOBIOTIC REGULATION OF LIVER P-GLYCOPROTEIN
    John Schuetz; Fiscal Year: 2001
  10. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005

Detail Information

Publications196 found, 100 shown here

  1. ncbi P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines
    M Boiocchi
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 78:159-66. 1992
    ..Involvement of mdr1, topoisomerase II and glutathione-S-transferase-pi (GST-pi) drug-resistance systems in intracellular drug ..
  2. ncbi Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells
    F Kugawa
    Department of Biopharmaceutics1, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan
    Pharmazie 64:296-300. 2009
    ..cells often become resistant to chemotherapy, and induction of the ABC transporter Multi-drug Resistance gene-1 (MDR1) is a major cause...
  3. ncbi A "silent" polymorphism in the MDR1 gene changes substrate specificity
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 315:525-8. 2007
    ..We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), ..
  4. ncbi A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
    R L Roberts
    Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand
    Pharmacogenomics J 2:191-6. 2002
    The multi-drug resistance gene ABCB1 (or MDR1) encodes a P-glycoprotein (P-gp) that regulates passage of many substances across the blood-brain barrier...
  5. ncbi Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
    ..We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients...
  6. ncbi Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients
    Laure Elens
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 53 02, avenue E Mounier, 1200 Bruxelles, Belgium
    Pharmacogenomics 11:1223-34. 2010
    ..Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored...
  7. ncbi Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip
    Elisabet Cuyàs
    Human Pharmacology and Clinical Neurosciences Research Group of the Neuropsychopharmacology Program, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, c Dr Aiguader 88 08003 Barcelona, Spain
    Pharmacogenomics 11:257-66. 2010
    ..The aim of this study was to assess the suitability of PHARMAchip for the genotyping of polymorphisms of genes associated with drug metabolism and response as an alternative to Jurilab Ltd's DrugMEt Test...
  8. ncbi Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    Silke Vogelgesang
    Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
    Pharmacogenetics 12:535-41. 2002
    ..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain...
  9. ncbi P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    John R Cirrito
    Department of Neurology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 115:3285-90. 2005
    ..These data establish a direct link between Pgp and Abeta metabolism in vivo and suggest that Pgp activity at the BBB could affect risk for developing AD as well as provide a novel diagnostic and therapeutic target...
  10. ncbi UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan
    Jean Francois Cote
    Institut National de la Sante et de la Recherche Medicale UMR S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, France
    Clin Cancer Res 13:3269-75. 2007
    ....
  11. ncbi Irinotecan pathway genotype analysis to predict pharmacokinetics
    Ron H J Mathijssen
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, 3075 EA Rotterdam, The Netherlands
    Clin Cancer Res 9:3246-53. 2003
    ..The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan...
  12. ncbi RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Daniel den Hoed Kliniek Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands
    Clin Cancer Res 9:827-36. 2003
    ..The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease...
  13. ncbi Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    Kimie Sai
    Project Team for Pharmacogenetics, Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Pharmacogenetics 13:741-57. 2003
    We performed comprehensive haplotyping of ABCB1/MDR1 gene blocks using 49 genetic polymorphisms, including seven novel ones, obtained from 145 Japanese subjects...
  14. ncbi P-glycoprotein: from genomics to mechanism
    Suresh V Ambudkar
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Building 37, Room 1A 09, Bethesda, MD 20892 4254, USA
    Oncogene 22:7468-85. 2003
    ..The first of these to be identified was P-glycoprotein (P-gp), the product of the human MDR1 gene, localized to chromosome 7q21. P-gp is a member of the large ATP-binding cassette (ABC) family of proteins...
  15. ncbi MDR1 polymorphism influences the outcome of multiple myeloma patients
    Gabriele Buda
    Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy
    Br J Haematol 137:454-6. 2007
    The multidrug resistance gene (MDR1) has been reported to be an additional prognostic factor in acute myeloid leukaemia patients...
  16. ncbi The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients
    S H Akbas
    Central Laboratory, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Transplant Proc 38:1290-2. 2006
    ..TRL is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1)(ABCB1) gene. P-gp acts as a membrane efflux pump, which affects TRL absorption from the gut...
  17. ncbi MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    M M Ameyaw
    University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Pharmacogenetics 11:217-21. 2001
    P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as an energy-dependent efflux pump that exports its substrates out of the cell...
  18. ncbi Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer
    Ji Youn Han
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Cancer 110:138-47. 2007
    The authors investigated whether ABCB1, ABCC2, and ABCG2 genetic polymorphisms affect pharmacokinetics (PK) of irinotecan and treatment outcome of patients with advanced nonsmall cell lung cancer (NSCLC).
  19. ncbi Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, 45 Rue des Saints Peres, 75006 Paris, France univ paris5 fr
    J Am Soc Nephrol 14:1889-96. 2003
    ..interindividual variations, is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1) gene...
  20. ncbi Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
    ..proteins, P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite form of curcuminoids (THC) ..
  21. ncbi Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes
    Sabine Spiegl-Kreinecker
    Department of Neurosurgery, Landesnervenklinik Wagner Jauregg Hospital, Linz, Austria
    J Neurooncol 57:27-36. 2002
    ..In contrast, MRP1 is demonstrated to play a constitutive role in the intrinsic chemoresistance of gliomas and their normal cell counterpart...
  22. ncbi MDR-1 C3435T polymorphism influences cyclosporine a dose requirement in liver-transplant recipients
    Laurence Bonhomme-Faivre
    Service Pharmacie Pharmacologie, Hopital Paul Brousse, Villejuif, France
    Transplantation 78:21-5. 2004
    ..CsA is a substrate for P-glycoprotein, a member of the ABC transporter family encoded by the multiple drug-resistant gene MDR1.
  23. ncbi Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow
    Annie Pang
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China
    Leuk Res 28:973-7. 2004
    ..The coordinate expression of caveolin-1 and MDR-1 suggests that they may either interact physically, or are involved in the same aberrant pathway(s) activated during MDR-1 up-regulation...
  24. ncbi Polymorphisms and haplotypes in the multidrug resistance 1 gene (MDR1/ABCB1) and risk of multiple myeloma
    Krzysztof Jamroziak
    Department of Hematology, Medical University of Lodz, Ciolkowskiego 2, 93 513 Lodz, Poland
    Leuk Res 33:332-5. 2009
    MDR1(ABCB1) gene encodes for P-glycoprotein (P-gp, MDR1, ABCB1), an ATP-binding cassette superfamily member involved in the transport of xenobiotics...
  25. ncbi Prognostic significance of the immunohistochemical expression of O6-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas
    Takao Nakagawa
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, Japan
    Neuropathology 29:379-88. 2009
    ....
  26. ncbi Detection of the four sequence variations of MDR1 gene using TaqMan MGB probe based real-time PCR and haplotype analysis in healthy Japanese subjects
    Katsuhiko Saito
    Division of Pharmaceutical Health Care and Sciences, Sapporo Medical University, South 1, West 16, Chuo Ku, Sapporo, 060 8543 Japan
    Clin Biochem 36:511-8. 2003
    P-glycoprotein (P-gp) is significant from the viewpoint of pharmacokinetics/pharmacodynamics (PK/PD). MDR1 gene encodes P-gp and has a wide variety of SNPs...
  27. ncbi CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation
    Maki Goto
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
    Pharmacogenetics 14:471-8. 2004
    ..We have previously reported that an intestinal P-glycoprotein (MDR1) contributes to this variation as an absorptive barrier, but the role of hepatic metabolism is not clear.
  28. ncbi ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
    ..Methadone is a substrate of the transporter P-glycoprotein (P-gp) 170 that is encoded by the ABCB1 (MDR1) gene. Thus, P-gp variants may play a role in methadone absorption and distribution...
  29. ncbi Frequency distribution of C3435T mutation in exon 26 of the MDR1 gene in a Spanish population
    Maria Luisa Bernal
    Department of Pharmacology and Physiology, University of Zaragoza, Spain
    Ther Drug Monit 25:107-11. 2003
    ..05, respectively). The great differences found between their population and others, such as the African and southwest Asian populations, could have important therapeutic implications when drugs that are a substrate of PGP are used...
  30. ncbi Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 93:1046-50. 2004
    ..Also, haplotype determination combined with these polymorphisms identified a subgroup that showed a striking response to treatment, which was not defined by a single polymorphism...
  31. ncbi Expression of functional multidrug-resistance protein 1 in Saccharomyces cerevisiae: effects of N- and C-terminal affinity tags
    Sung Haeng Lee
    Membrane Protein Laboratory, Sealy Center for Structural Biology, and Department of Physiology and Biophysics, The University of Texas Medical Branch, Galveston, TX 77555 0437, USA
    Biochem Biophys Res Commun 306:644-9. 2003
    ..We conclude that because of its low cost and simplicity, the S. cerevisiae-based MRP1-expression system will be useful for studies where a large number of mutants or milligram amounts of purified MRP1 are needed...
  32. ncbi Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
    L A Mickley
    Medicine Branch, Division of Clinical Sciences DCS, National Cancer Institute NCI, Bethesda, MD 20892, USA
    Blood 91:1749-56. 1998
    ..Acquired drug resistance in vitro and in patients is often associated with expression of a single MDR-1 allele, and this can be a marker of a hybrid MDR-1 gene...
  33. ncbi The significance of C3435T point mutation of the MDR1 gene in endometrial cancer
    P M Mrozikiewicz
    Department of Pharmacology and Biotechnology, Research Institute of Medicinal Plants, Poznan, Poland
    Int J Gynecol Cancer 17:728-31. 2007
    ..Interindividual differences in P-gp activity could modulate susceptibility to cancer development. The MDR1 gene, coding for P-gp, is highly polymorphic and some mutations modulate P-gp activity...
  34. ncbi ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals
    Janet K Coller
    Discipline of Pharmacology, School of Medical Sciences, The University of Adelaide, and Department of Clinical Pharmacology, Royal Adelaide Hospital, SA, Australia
    Clin Pharmacol Ther 80:682-90. 2006
    ..Methadone is a substrate for the P-glycoprotein transporter, encoded by the ABCB1 gene, which regulates central nervous system exposure...
  35. ncbi Molecular mechanism of chemoresistance by astrocyte elevated gene-1
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, and VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 70:3249-58. 2010
    ..gene 1 (MDR1) protein, resulting in increased efflux and decreased accumulation of doxorubicin, promoting doxorubicin resistance. Suppression of MDR1 by small interfering RNA or chemical reagents, or inhibition of AEG-1 or a ..
  36. ncbi Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia
    Hee Jin Huh
    Department of Laboratory Medicine, College of Medicine, University of Ulsan and Asan Medical Center, Pungnap dong, Seoul, Korea
    J Korean Med Sci 21:253-8. 2006
    ..We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with ..
  37. ncbi Expression of multidrug resistance 1 and glutathione-S-transferase-Pi protein in nasopharyngeal carcinoma
    C L Chen
    Department of Pathology, China Medical College Hospital, Taichung, Taiwan
    Hum Pathol 32:1240-4. 2001
    ..5%) of 43 with recurrent NPC, and 9 (45%) of 20 with metastatic NPC. Simultaneous expression of MDR1 and GST-Pi was observed in 13 (72.2%) of 18 patients with primary NPC and 12 (85.7%) of 14 with recurrent NPC...
  38. ncbi Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients
    Jean Nicholas Roy
    Laboratoire d Immunogénétique, Centre hospitalier de l Université de Montréal CHUM Hôpital Notre Dame, Montreal, Quebec, Canada
    Pharmacogenet Genomics 16:659-65. 2006
    ..The objective was to investigate the association between Cyp3A4, Cyp3A5, and MDR-1 polymorphisms and tacrolimus pharmacokinetics in the early period after renal transplantation...
  39. ncbi Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    I Cascorbi
    Institute of Clinical Pharmacology, University Medical Center Charite, Humboldt University Berlin
    Clin Pharmacol Ther 69:169-74. 2001
    P-glycoprotein, the gene product of MDR1, confers multidrug resistance against antineoplastic agents but also plays an important role in the bioavailability of common drugs in medical treatment...
  40. ncbi Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    S Hoffmeyer
    Epidauros Biotechnology, Pharmacogenetics Laboratory, Am Neuland 1, D 82347 Bernried, Germany
    Proc Natl Acad Sci U S A 97:3473-8. 2000
    ..Homozygosity for this variant was observed in 24% of our sample population (n = 188). This polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of MDR-1...
  41. ncbi MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer
    Chiho Komoto
    Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan
    Drug Metab Pharmacokinet 21:126-32. 2006
    The genotype frequencies of MDR1 T-129C, C1236T, G2677A,T and C3435T SNPs were compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic information on the inter-ethnic differences of pharmacotherapeutic outcome...
  42. ncbi MDR1 diplotypes as prognostic markers in multiple myeloma
    Valentina Maggini
    Department of Biology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy
    Pharmacogenet Genomics 18:383-9. 2008
    The aim of this study was to evaluate the effect of diplotypes of MDR1 polymorphisms at positions 2677 and 3435 on the clinical outcome of multiple myeloma, in terms of response to the therapy and overall survival (OS).
  43. ncbi Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis
    V Annese
    Unita di Gastroenterologia, Ospedale IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Fg, Italy
    World J Gastroenterol 12:3636-44. 2006
    The MDR1 gene is an attractive candidate gene for the pathogenesis of inflammatory bowel disease (IBD) and perhaps response to therapy, with evidences at both functional and genetic levels...
  44. ncbi Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis
    Chiara Mignogna
    Department of Biomorphological and Functional Sciences, Section of Pathology, University of Naples Federico II, Naples, Italy
    BMC Cancer 6:293. 2006
    ..We studied MDR-1 expression in selected cases of renal cell carcinoma (RCC), clear cell type, with long-term follow-up, in order to establish its prognostic role and its possible contribution in the choice of post-surgical therapy...
  45. ncbi MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic lymphocytic leukemia
    Krzysztof Jamroziak
    Department of Hematology, Medical University of Łódź, Ciołkowskiego 2, PL 93 510 Łódź, Poland
    Pharmacol Rep 58:720-8. 2006
    Functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the MDR1 ( ABCB1 ) gene encoding the xenobiotic transporter P-glycoprotein (P-gp, MDR1, ABCB1) may influence susceptibility to several diseases as well as clinical ..
  46. ncbi Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects
    Joy R Ross
    St Joseph s Hospice, and Department of Clinical Genomics, Imperial College, London, United Kingdom
    Cancer 112:1390-403. 2008
    ..Central side effects, such as drowsiness, confusion, and hallucinations, can limit the use of opioids in clinical practice...
  47. ncbi ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach
    G T Ho
    Molecular Medicine Unit and Gastrointestinal Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Hum Mol Genet 15:797-805. 2006
    Several lines of evidence suggest a role for the multidrug resistance gene (ABCB1/MDR1) and its product, P-glycoprotein 170, in the pathogenesis of inflammatory bowel disease (IBD)...
  48. ncbi The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium
    Tip W Loo
    CIHR Group in Membrane Biology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Biochemistry 43:12081-9. 2004
    ..By contrast, cross-linking of cysteine residues located outside the drug-binding pocket (such as G300C(TM5)/F770C(TM8)) was not affected by MTSES or MTSET. These results indicate that the drug-binding pocket is accessible to water...
  49. ncbi Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation
    Xin Zhang
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Clin Transplant 19:638-43. 2005
    ..Cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp, encoded by MDR1) play an important role in the absorption and metabolism of tacrolimus...
  50. ncbi Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72 str, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 61:389-94. 2005
    The P-glycoprotein, a product of MDR1 (multiple drug resistance 1) gene, is a membrane efflux pump localized in epithelial cells in the small and large intestine, a part of the gastrointestinal barrier that protects cells against ..
  51. ncbi A polymorphism C3435T of the MDR-1 gene associated with smoking or high body mass index increases the risk of sporadic breast cancer in women
    Pavol Zubor
    Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University, 03659 Martin, Slovak Republic
    Oncol Rep 18:211-7. 2007
    ..Our observations are the first that indicate this polymorphism as a modulator of health to be associated with an increased risk of breast cancer...
  52. ncbi Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene
    Hiroshi Takane
    Department of Hospital Pharmacy, Faculty of Medicine, Tottori University, 36 1, Nishi machi, Yonago, 683 8504, Japan
    J Pharmacol Exp Ther 311:1179-87. 2004
    Recently, a number of nucleotide variants have been described in the multidrug resistance 1 (MDR1/ABCB1) gene; however, most studies have focused on the coding region...
  53. ncbi Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia
    M Kourti
    Second Department of Pediatrics, Division of Hematology Oncology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int J Hematol 86:166-73. 2007
    The aim of this prospective study was to analyze the expression of messenger RNA of genes, such as MDR1, MRP1, BCRP, and LRP, implicated in the mechanism of multidrug resistance (MDR) in relation to the response to induction chemotherapy ..
  54. ncbi Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation
    Maocheng Zhan
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:4825-33. 2005
    ..More importantly, PKCalpha phosphorylates and activates MDR1 P-glycoprotein, whereas inhibition of PKCalpha by p53 leads to decreased MDR1 phosphorylation in STS cells, which ..
  55. ncbi Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia
    Lorena L de Figueiredo-Pontes
    Hematology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Cytometry B Clin Cytom 74:163-8. 2008
    ....
  56. ncbi Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population
    Mette Østergaard
    Medical Department, Viborg Regional Hospital, Viborg
    Scand J Gastroenterol 44:65-73. 2009
    ..The purpose of the study was to investigate whether single nucleotide polymorphisms (SNPs) in genes involved in these processes were associated with CD and UC...
  57. ncbi ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation
    Takeshi Asano
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Pharmacogenetics 13:675-82. 2003
    ..and investigated the relationship between single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1, MDR1) encoding P-gp and ONF. Subjects comprised 136 patients receiving kidney transplantation...
  58. ncbi The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence
    Tip W Loo
    Canadian Institutes for Health Research Group in Membrane Biology, Department of Medicine, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:41303-6. 2002
    The human multidrug resistance P-glycoprotein (P-gp, ABCB1), a member of the ATP-binding cassette (ABC) family of transport proteins, actively transports many cytotoxic compounds out of the cell...
  59. ncbi ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer
    Sara De Iudicibus
    Department of Life Sciences, University of Trieste, Italy
    Anticancer Res 28:3921-8. 2008
    P-glycoprotein (Pgp), encoded by the ATP-binding cassette B1 (ABCB1) gene, is an efflux transporter located on the luminal side of intestinal epithelial cells, which protects the gut from endogenous and exogenous toxins...
  60. ncbi Nucleotide binding, ATP hydrolysis, and mutation of the catalytic carboxylates of human P-glycoprotein cause distinct conformational changes in the transmembrane segments
    Tip W Loo
    Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Biochemistry 46:9328-36. 2007
    P-Glycoprotein (P-gp, ABCB1) transports a variety of structurally unrelated cytotoxic compounds out of the cell...
  61. ncbi Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments
    Tip W Loo
    Canadian Institutes for Health Research CIHR Group in Membrane Biology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:27585-8. 2002
    ..These results show that deletion at residue 490 disrupts packing of the TM segments possibly by affecting interaction between the first nucleotide-binding domain (Tyr(490)) and the first cytoplasmic loop (Glu(184))...
  62. ncbi Molecular models of human P-glycoprotein in two different catalytic states
    Jean Paul Becker
    Structure et Fonction des Membranes Biologiques, Universite Libre de Bruxelles, Boulevard du Triomphe CP 206 2, B 1050 Brussels, Belgium
    BMC Struct Biol 9:3. 2009
    ..In the absence of a high-resolution structure of P-glycoprotein, homology modeling is a useful tool to help interpretation of experimental data and potentially guide experimental studies...
  63. ncbi Transcription factor c-Jun activation represses mdr-1 gene expression
    Ze Hong Miao
    Division of Anti tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People s Republic of China
    Cancer Res 63:4527-32. 2003
    ..The findings also suggest that c-Jun might be a potential drug target for circumventing tumor MDR...
  64. ncbi Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects
    Yuka Moriya
    Department of Environmental Biochemistry, Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 25:1356-9. 2002
    In the present study, we examined whether polymorphisms in the ATP-binding cassette (ABC) transporter genes, MDR1, MRP1 and MRP2, were associated with their respective mRNA expression levels in duodenal enterocytes of 13 healthy Japanese ..
  65. ncbi Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
    S Jin
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center and the Weill Graduate School of Medical Sciences of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:6775-9. 2000
    ..We have shown that NF-Y is a central mediator of activation of transcription of the human P glycoprotein gene (MDR1) by a variety of inducers and that NF-Y functions by recruiting the histone acetyltransferase PCAF to the MDR1 ..
  66. ncbi Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy
    J Schneider
    Centro de Patologia de la Mama, Madrid, Spain
    Breast Cancer Res 3:183-91. 2001
    ..P-glycoprotein expression in the rescue mastectomy specimen has finally been identified as a significant predictor of patient survival...
  67. ncbi Antisense targeting of p-glycoprotein expression in tissue culture
    Kayoko Nakamura
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan
    J Nucl Med 46:509-13. 2005
    ..Radiolabeled antisense DNA has not previously been considered for the targeting of mdr1 mRNA, the product of the mdr1 gene controlling Pgp expression of MDR.
  68. ncbi Expression of functionally P-glycoprotein in MA104 kidney cells
    M A Capella
    , , Universidade Federal do Rio de Janeiro, Brazil
    Z Naturforsch C 54:119-27. 1999
    ..The mdr1-mRNA was detected by reverse transcription-polymerase chain reaction and a subcloned 283-bp product was identified...
  69. ncbi Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I
    Christine E Staatz
    School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia
    Clin Pharmacokinet 49:141-75. 2010
    ..P450 (CYP) 3A enzymes--in particular, CYP3A4 and CYP3A5--and are transported out of cells via P-glycoprotein (ABCB1)...
  70. ncbi Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II
    Christine E Staatz
    University of Queensland, Brisbane, Australia
    Clin Pharmacokinet 49:207-21. 2010
    ..P450 (CYP) 3A enzymes - in particular, CYP3A4 and CYP3A5 - and are transported out of cells via P-glycoprotein (ABCB1)...
  71. ncbi The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    T W Synold
    Department of Medical Oncology and Therapeutics Research, The Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA
    Nat Med 7:584-90. 2001
    ..also regulates drug efflux by activating expression of the gene MDR1, which encodes the protein P-glycoprotein (ABCB1)...
  72. ncbi Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL
    T Knutsen
    Medicine Branch, Division of Clinical Sciences, NCI, NIH, Bethesda, Maryland 20892, USA
    Genes Chromosomes Cancer 23:44-54. 1998
    ..PGY1 is encoded by the MDR1 gene located at 7q21.1...
  73. ncbi [Treatment of multidrug resistance in oncology and hematology]
    M Petrini
    U.O. Ematologia, , Italy
    Tumori 83:S17-20. 1997
    ..High levels of the mdr1 expression have been found in normal adrenal gland, kidney, colon, jejunum and liver, whereas low levels were ..
  74. ncbi Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells
    G J Schuurhuis
    Department of Medical Oncology, Free University, The Netherlands
    Br J Cancer 68:898-908. 1993
    ..Therefore additional mechanisms must be operative. In this paper we show by a quantitative approach that doxorubicin resistance in several P-glycoprotein-positive non-small cell lung cancer and breast cancer multidrug resistant cell ..
  75. ncbi Detection of the 170 kDa P-glycoprotein in neoplastic and normal tissues
    E Ronchi
    Division of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Tumori 75:542-6. 1989
    ..and an immunoblotting assay have been designed to allow screening of human solid tumors for overexpression of the GP170 glycoprotein without employing a disaggregation method to obtain cell suspensions...
  76. ncbi New mechanisms of hormone secretion: MDR-like gene products as extrusion pumps for hormones?
    K F Becker
    Department of Physiology, University of Munich, Germany
    Horm Metab Res 24:210-3. 1992
    P-glycoprotein, the product of the multidrug resistance (MDR1) gene, is an ATP-driven transmembrane pump that increases the resistance of cells by actively exporting toxic chemicals...
  77. ncbi Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo
    T Watanabe
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo
    Acta Oncol 34:235-41. 1995
    ..SDZ PSC 833 (PSC833), shows a reversal effect on multidrug resistance (MDR) by functional modulation of MDR1 gene product, P-glycoprotein...
  78. ncbi Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene
    K Oselin
    Institute of Clinical Pharmacology, University Medical Centre Charité, Humboldt University, Berlin
    Eur J Clin Invest 33:261-7. 2003
    ..In humans, P-glycoprotein is encoded by the MDR1 gene. Recently, several single nucleotide polymorphisms in the MDR1 gene were identified...
  79. ncbi Mechanisms of multidrug resistance in cancer treatment
    A L Harris
    Molecular Oncology Laboratory, University of Oxford, John Radcliffe Hospital, Headington, UK
    Acta Oncol 31:205-13. 1992
    ..HSP27 confers doxorubicin resistance. 3) Topoisomerase II...
  80. ncbi Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers
    Fuxing Tang
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA
    J Pharm Sci 93:1185-94. 2004
    ..probes of the binding sites on P-glycoprotein (P-gp), across monolayers of MDCK cells transfected with the human MDR1 gene (MDCK-MDR1) were investigated...
  81. ncbi ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Neuropsychopharmacology 28:1991-9. 2003
    Multidrug-resistance gene 1-type P-glycoproteins (ABCB1-type P-gps) protect the brain against the accumulation of many toxic xenobiotics and drugs...
  82. ncbi Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells
    J Y Zhao
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston 77030
    Endocrinology 133:521-8. 1993
    ..There are three mdr genes (mdr1, mdr2, and mdr3) in the mouse genome and two (MDR1 and MDR2) in the human genome; however, only two mouse genes (..
  83. ncbi Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress
    Christoph K Thoeringer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz 8010, Austria
    Psychoneuroendocrinology 32:1028-40. 2007
    The multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) is a major gate-keeper at the blood-brain barrier (BBB), protecting the central nervous system from accumulation of toxic xenobiotics and drugs...
  84. ncbi [Inhibition of multidrug resistance gene 1 expression in glioma by antisense oligodeoxynucleotides]
    Jian Xin Kong
    Department of Neurosurgery, the Second Affiliated Hospital of Shandong University, Jinan 250033, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:211-5. 2005
    To investigate the effectiveness of phosphorothioate multidrug resistance gene 1 (MDR1) antisense oligodeoxynucleotides (MDR1-AS) suppressing MDR1 expression in multidrug-resistant glioma cell line C6/adr.
  85. ncbi Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1
    Cuiping Chen
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, MS4044, Eastern Point Rd, Groton, CT 06340, USA
    Drug Metab Dispos 33:537-46. 2005
    ..simvastatin in acid and lactone forms, and pravastatin in acid form only) with multidrug resistance gene 1 (MDR1, ABCB1) P-glycoprotein, multidrug resistance-associated protein 2 (MRP2, ABCC2), and organic anion-transporting ..
  86. ncbi Reversal of multi-drug resistance by pSUPER-shRNA-mdr1 in vivo and in vitro
    Guang Dong Pan
    Department of General Surgery, People s Hospital of Liuzhou, Medical University of Guangxi, Liuzhou 545001, Guangxi Zhuang Autonomous Region, China
    World J Gastroenterol 15:431-40. 2009
    To explore the possibility of reversing multi-drug resistance (MDR) to HepG2/mdr1 in vitro and in vivo with RNA interference (RNAi).
  87. ncbi Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    S M Sisodiya
    Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
    Brain 125:22-31. 2002
    ..mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and multidrug resistance-associated protein 1 (MRP1), has been shown to correlate with cellular resistance to ..
  88. ncbi Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains
    Nico Dunkel
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Wurzburg, Germany
    Mol Microbiol 69:827-40. 2008
    Overexpression of the MDR1 gene, encoding a multi-drug efflux pump of the major facilitator superfamily, is a major cause of resistance to the widely used antifungal agent fluconazole and other toxic substances in the fungal pathogen ..
  89. ncbi [Steroid and xenobiotic receptor (SXR), multidrug resistance gene (MDR1) and GSTs, SULTs and CYP polymorphism expression in invasive bladder cancer, analysis of their expression and correlation with other prognostic factors]
    J Rioja Zuazu
    Departamento de Urologia, Clinica Universitaria, Universidad de Navarra, Pamplona
    Actas Urol Esp 31:1107-16. 2007
    ..lies regulating in a positive manner cytochrome P450 3A4 (CYP3A4) transcription and the multidrug resistance gene (MDR1), it's considered a key in the xenobiotic detoxification mechanism, being involved in all phases of the ..
  90. ncbi Construction of double suicide genes system controlled by MDR1 promoter with targeted expression in drug-resistant glioma cells
    Yuan Zhang
    School of Medicine, Shandong University, Ji Nan, Shandong Province, 250012, P R China
    J Neurooncol 86:3-11. 2008
    The multiple drug resistance protein (MDR1) is frequently overexpressed in human glioma...
  91. ncbi Applications of 99mTc-sestamibi in oncology
    L Maffioli
    Divison of Nuclear Medicine, National Cancer Institute, Milan, Italy
    Tumori 82:12-21. 1996
    ..This peculiar type of resistance is due to amplification of the mammalian MDR1 gene, located on chromosome 7...
  92. ncbi Reversal of multi-drug resistance by vector-based-ShRNA-Mdr1 In Vitro and In Vivo
    Shi Lu
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 29:620-4. 2009
    ..RNA (shRNA) on the reversal of multi-drug resistance (mdr) of A2780/Taxol cells, a novel vector pEGFP-H1/mdr1 containing mdr1-shRNA targeting at position 2943-2963 of mdr1 was designed and synthesized...
  93. ncbi Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    Nicola Marchi
    Cerebrovascular Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Med 2:37. 2004
    The multiple drug resistance protein (MDR1/P-glycoprotein) is overexpressed in glia and blood-brain barrier (BBB) endothelium in drug refractory human epileptic tissue...
  94. ncbi New horizon of MDR1 (P-glycoprotein) study
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:489-510. 2005
    MDR1 (once P-glycoprotein, now referred to as ABCB1) plays a role as a blood-brain barrier, preventing drug absorption into the brain, and is known to confer multiple drug resistance in cancer chemotherapy...
  95. ncbi The ABCB1-1Delta mutation is not responsible for subchronic neurotoxicity seen in dogs of non-collie breeds following macrocyclic lactone treatment for generalized demodicosis
    Stéphane Bissonnette
    Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, St Hyacinthe, Quebec, Canada
    Vet Dermatol 20:60-6. 2009
    P-glycoprotein (P-gp), encoded by the multiple drug resistance gene ABCB1 (also known as MDR1), is an integral component of the blood brain barrier crucial in limiting drug uptake into the central nervous system...
  96. ncbi [SDZ PSC 833: a novel modulator of MDR]
    A Covelli
    Clinical Research and Development, Novartis, Basel, Switzerland
    Tumori 83:S21-4. 1997
    ..The in vitro finding that treatment with SDZ PSC 833 may suppress the activation of the MDR1 gene and prevent the emergence of resistant cancer cell clones with the MDR phenotype might support the use of this ..
  97. ncbi Comparison of two educational interventions on pediatric resident auscultation skills
    C Becket Mahnke
    Division of Pediatric Cardiology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pediatrics 113:1331-5. 2004
    ..Multiple cross-sectional physician surveys have documented poor cardiac auscultation skills. We evaluated the impact of 2 different educational interventions on pediatric resident auscultation skills...
  98. ncbi [Expression of alpha-tubulin and MDR1 and their correlation with the biological features of non-small cell lung carcinoma]
    Qing yong Chen
    Department of Respiratory Diseases, the 117th Hospital of PLA, Hangzhou 310013, China
    Zhonghua Zhong Liu Za Zhi 32:278-82. 2010
    To detect the expression of alpha-tubulin and MDR1 in human non-small cell lung carcinoma (NSCLC), and to clarify their clinical significance.
  99. ncbi Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin
    Chantal Barthomeuf
    UMR INSERM U 484, Laboratoire de Pharmacognosie et Biotechnologies, Faculte de Pharmacie, Universite d Auvergne, Place H Dunant, 63001 Clermont Fd Cedex, France
    Cancer Chemother Pharmacol 56:173-81. 2005
    Overexpression of P-glycoprotein (Pgp) encoded by the MDR1 gene is one of the major obstacles to successful cancer chemotherapy...
  100. ncbi Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis
    F Thevenod
    Department of Physiology II, University of Saarland, 66421 Homburg, Germany
    J Biol Chem 275:1887-96. 2000
    ..correlated with a time-dependent up-regulation of the drug efflux pump multidrug resistance P-glycoprotein (mdr1) in cadmium-treated cells ( approximately 4-fold after 72 h), as determined by immunoblotting with the monoclonal ..
  101. ncbi [Reversal effect of MDR1 and MDR3 gene silencing on resistance of A2780/taxol cells to paclitaxel]
    Lan Xiao
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Fu Chan Ke Za Zhi 42:412-6. 2007
    To investigate the reversal effect of MDR1 and MDR3 gene silencing on resistance of A2780/taxol cells to paclitaxel.

Research Grants66

  1. MDR Gene Polymorphisms in AML
    Maria Baer; Fiscal Year: 2007
    The ATP-binding cassette (ABC) proteins P-glycoprotein (Pgp; MDR1; encoded by ABCB1), multidrug resistance-associated protein (MRP-1; encoded by ABCC1) and breast cancer resistance protein (BCRP; encoded by ABCG2) are energy-dependent ..
  2. REGULATION OF MULTIDRUG RESISTANCE PHENOTYPE
    William Hait; Fiscal Year: 2002
    ..One of the most exciting advances was the discovery of P-glycoprotein (P-gp), the MDR1 gene product, which can impart multi-drug resistance (MDR) by virtue of its ability to transport certain molecules ..
  3. DEVELOPMENT OF NEW SEMISYNTHETIC TAXANES
    Ralph Bernacki; Fiscal Year: 2001
    ..Clearly, second generation taxanes that have improved therapeutic activity against multi-drug resistant (MDR1 gene mediated) tumors would be advantageous...
  4. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Moye Rowley; Fiscal Year: 1993
    ..Animal cells often acquire this property by amplifying the expression of a P-glycoprotein-encoding gene, MDR1. Yeast cells also possess a phenotype, known as pleiotropic drug resistance (Pdr), analogous to mammalian Mdr...
  5. MODULATION OF MULTIDRUG RESISTANCE MECHANISMS
    Branimir Sikic; Fiscal Year: 2002
    ..Studies of new modulators of MDR1/P-glycoprotein (P-gp) multidrug resistance (MDR) will continue...
  6. Vaginal Drug Delivery of P-glycoprotein Substrates
    Giovanni Pauletti; Fiscal Year: 2003
    ..The MDR1 gene product P-gp is a prototype of membrane efflux systems that limit transcellular transport of drug molecules ..
  7. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus Frank; Fiscal Year: 2007
    Multidrug resistance (MDR) mediated by MDR1 (ABCB1) P-glycoprotein and related ATP-binding cassette (ABC) transporters is an impediment to successful cancer therapy...
  8. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
    Multidrug resistance (MDR) mediated by MDR1 (ABCB1) P-glycoprotein and related ATP-binding cassette (ABC) transporters is an impediment to successful cancer therapy...
  9. XENOBIOTIC REGULATION OF LIVER P-GLYCOPROTEIN
    John Schuetz; Fiscal Year: 2001
    In our previous funding period we established that expression of the hepatic multidrug resistance (MDR1) gene product, P-glycoprotein, varies over 50-fold among individuals...
  10. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ..The most prominent gene of the ABC cassette family of transporters, ABCB1 (also known as MDR1), is highly polymorphic and encodes for P-glycoprotein (PGP)...
  11. Role of the ABC Transporter ABCB6 in Cytotoxicity
    John Schuetz; Fiscal Year: 2006
    ..Our studies have sought to understand the function and regulation of ABC transporters with a focus on the MDR1 gene that encodes a protein conferring resistance to a large number of therapeutic drugs and cytotoxic compounds...
  12. MDR1 GENE THERAPY IN CD34+ CELLS AND SCID MICE
    James Doroshow; Fiscal Year: 2002
    The human MDR1 gene encodes a multispecific drug transporter, P- glycoprotein (Pgp), that prevents drug accumulation in resistant cells. Overexpression of MDR1 is sufficient for conferring multidrug resistance on otherwise normal cells...
  13. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2002
    ..Emergence of multidrug resistance (MDR) in breast cancer mediated by the MDR1 P-glycoprotein has been associated with poor response to chemotherapy and a shorter overall survival...
  14. INTERACTIONS OF P GLYCOPROTEIN WITH CYTOCHROME P4503A
    Erin Schuetz; Fiscal Year: 2001
    ..Our recent studies have established that the product of the multidrug resistance gene (MDR1), the drug efflux transporter P-glycoprotein (Pgp), influences the pharmacological disposition of rifampicin and is ..
  15. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    The overall goal of the proposed research is to validate a P-glycoprotein (P-gp) deficient canine model [MDR1(mut/mut)] for delineating the role of P-gp in restricting access of therapeutic agents to the central nervous system (CNS)...
  16. MDR1 GENE THERAPY IN CD34+ CELLS AND SCID MICE
    Susan Kane; Fiscal Year: 2001
    The human MDR1 gene encodes a multispecific drug transporter, P- glycoprotein (Pgp), that prevents drug accumulation in resistant cells. Overexpression of MDR1 is sufficient for conferring multidrug resistance on otherwise normal cells...