14 3 3

Summary

Gene Symbol: 14 3 3
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Alias: 14-3-3, 1C5, HS1, 14-3-3 protein T-cell, 14-3-3 protein tau, 14-3-3 protein theta, protein tau
Species: human

Top Publications

  1. ncbi p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor
    Frank T Zenke
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:18392-400. 2004
  2. ncbi 14-3-3Tau regulates Beclin 1 and is required for autophagy
    Bing Wang
    Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e10409. 2010
  3. ncbi A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord
    A Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, England
    J Neurochem 75:2511-20. 2000
  4. ncbi Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest
    Tomoshige Kino
    Human Retrovirus Section, Center for Cancer Research, National Cancer Institute Frederick, Bldg 535, Rm 210, Frederick, MD 21702 1201, USA
    J Virol 79:2780-7. 2005
  5. ncbi Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins
    Marylou Zuzarte
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 587:929-52. 2009
  6. ncbi Involvement of 14-3-3 proteins in nuclear localization of telomerase
    H Seimiya
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    EMBO J 19:2652-61. 2000
  7. ncbi Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3
    Sindhu Rajan
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 545:13-26. 2002
  8. ncbi Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
  9. ncbi 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer
    Bing Wang
    Division of Hematology and Oncology, Department of Medicine, 1 Medical Statistics Section, University of Alabama at Birmingham, Birmingham, Alabama 35294 2182, USA
    Mol Cell Biol 30:1508-27. 2010
  10. ncbi 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation
    P C van der Hoeven
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 345:297-306. 2000

Research Grants

  1. Tau missplicing caused by RNA processing proteins located on chromosome 21
    Athena Andreadis; Fiscal Year: 2007
  2. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 2004
  3. Genomic Analysis of Alzheimer's Disease Genes
    Gerard Schellenberg; Fiscal Year: 2007
  4. CELL-CELL TRANSFER AND PROPAGATION OF TAU AGGREGATES
    Marc I Diamond; Fiscal Year: 2010
  5. Human tau neurodegeneration in Alzheimer's
    SALLY FRAUTSCHY; Fiscal Year: 2007
  6. AGING AND DEMENTIA: CHOLINERGIC NEURON BIOCHEMISTRY
    Peter Davies; Fiscal Year: 2004
  7. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 1999
  8. Tau polymerization as a target for Alzheimer's disease
    TRUMAN GAMBLIN; Fiscal Year: 2007
  9. ROLE OF PROLYL ISOMERASE PIN1 IN ALZHEIMER'S DISEASE
    Kun Ping Lu; Fiscal Year: 2006
  10. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    PAUL E contact SAWCHENKO; Fiscal Year: 2010

Detail Information

Publications180 found, 100 shown here

  1. ncbi p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor
    Frank T Zenke
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:18392-400. 2004
    ..Phosphorylation of GEF-H1 by PAK may be involved in regulation of GEF-H1 activity and may serve to coordinate Rho-, Rac-, and Cdc42-mediated signaling pathways...
  2. ncbi 14-3-3Tau regulates Beclin 1 and is required for autophagy
    Bing Wang
    Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e10409. 2010
    ..14-3-3 proteins mediate many cellular signaling processes, but its role in autophagy has not been investigated. We hypothesize that 14-3-3tau could regulate Beclin 1 expression through E2F1 and thus regulate autophagy...
  3. ncbi A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord
    A Malaspina
    Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, England
    J Neurochem 75:2511-20. 2000
    We have recently isolated a 2.2-kb cDNA clone (1C5) from a human spinal cord cDNA library with partial identity to the 14-3-3 protein mRNA encoding the theta protein (YWHAQ)...
  4. ncbi Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest
    Tomoshige Kino
    Human Retrovirus Section, Center for Cancer Research, National Cancer Institute Frederick, Bldg 535, Rm 210, Frederick, MD 21702 1201, USA
    J Virol 79:2780-7. 2005
    ..These results indicate that Vpr promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C independently of the latter's phosphorylation status...
  5. ncbi Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins
    Marylou Zuzarte
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 587:929-52. 2009
    ..Our results give a comprehensive description of the mechanisms by which 14-3-3 proteins, together with N- and C-terminal sorting signals, control the intracellular traffic of TASK-1 and TASK-3...
  6. ncbi Involvement of 14-3-3 proteins in nuclear localization of telomerase
    H Seimiya
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    EMBO J 19:2652-61. 2000
    ..14-3-3 binding was not required for telomerase activity either in vitro or in cell extracts. These observations suggest that 14-3-3 enhances nuclear localization of TERT by inhibiting the CRM1 binding to the TERT NES-like motif...
  7. ncbi Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3
    Sindhu Rajan
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 545:13-26. 2002
    ..Our findings suggest that interaction of 14-3-3 with TASK-1 or TASK-3 may promote the trafficking of the channels to the surface membrane...
  8. ncbi Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
    ..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents...
  9. ncbi 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer
    Bing Wang
    Division of Hematology and Oncology, Department of Medicine, 1 Medical Statistics Section, University of Alabama at Birmingham, Birmingham, Alabama 35294 2182, USA
    Mol Cell Biol 30:1508-27. 2010
    ..Together, the findings of our studies strongly suggest a novel oncogenic role of 14-3-3tau by downregulating p21 in breast cancer. Therefore, 14-3-3tau may be a potential therapeutic target in breast cancer...
  10. ncbi 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation
    P C van der Hoeven
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 345:297-306. 2000
    ..We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta...
  11. ncbi The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins
    F Sladeczek
    CNRS UPR 2212, Institut Alfred Fessard, Gif sur Yvette
    Mol Gen Genet 254:571-7. 1997
    ....
  12. ncbi Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3
    Saori Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 277:39360-7. 2002
    ..These data indicate that PDK1 kinase activity is negatively regulated by binding to 14-3-3 through the PDK1 autophosphorylation site Ser-241...
  13. ncbi HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases
    Y Suzuki
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 158:2736-44. 1997
    Cross-linking of the Ag receptors on lymphocytes initiates activation of the receptor-coupled tyrosine kinases. HS1 is one of the substrates of these kinases and has been shown to transduce the signals for both clonal expansion and ..
  14. ncbi New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium
    Venice Calinisan
    Life Sciences Division, Department of Genome Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Front Biosci 11:1646-66. 2006
    ..We also discuss the functional relevance of another member of the protein 4.1 superfamily, ezrin, in kidney physio-pathology...
  15. ncbi A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis
    Bing Wang
    Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Alabama 35294 3300, USA
    J Biol Chem 279:54140-52. 2004
    ..Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage...
  16. ncbi Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways
    B Xiao
    Division of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK
    Nature 376:188-91. 1995
    ..At the base of this channel is a 16-residue segment of 14-3-3 which has been implicated in the binding of 14-3-3 to protein kinase C...
  17. ncbi Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins
    Romesh R Subramanian
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Cell Res 294:581-91. 2004
    ..These data support a model that 14-3-3 proteins regulate the proapoptotic function of ASK1 in part by controlling its subcellular distribution...
  18. ncbi Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
    Kathryn M Geraghty
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 407:231-41. 2007
    ..Thus, although AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases...
  19. ncbi New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases
    Franck Dequiedt
    Cellular and Molecular Biology Unit, Faculty of Agronomy, B 5030, Gembloux, Belgium
    Mol Cell Biol 26:7086-102. 2006
    ..e., Ser155, is a prerequisite for the phosphorylation of the nearby 14-3-3 site, Ser181. We propose that this multisite hierarchical phosphorylation by a variety of kinases allows for sophisticated regulation of class IIa HDACs function...
  20. ncbi Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation
    Golam Sadik
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurochem 108:33-43. 2009
    The microtubule associated protein tau is a major component of neurofibrillary tangles in Alzheimer disease brain, however the neuropathological processes behind the formation of neurofibrillary tangles are still unclear...
  21. ncbi An evolutionarily conserved family of virion tail needles related to bacteriophage P22 gp26: correlation between structural stability and length of the alpha-helical trimeric coiled coil
    Anshul Bhardwaj
    Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    J Mol Biol 391:227-45. 2009
    ..this idea experimentally and to explore their diversity, we cloned the gp26-like gene from phages HK620, Sf6 and HS1, and characterized these gene products in solution...
  22. ncbi Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies
    Kunimasa Arima
    Department of Laboratory Medicine, Musashi Hospital, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Neuropathology 26:475-83. 2006
    The microtubule-associated protein tau aggregates into filaments in the form of neurofibrillary tangles, neuropil threads and argyrophilic grains in neurons, in the form of variable astrocytic tangles in astrocytes and in the form of ..
  23. ncbi Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein
    J Menendez
    Servicio de Neurobiologia, Departamento de Investogación 1D Hospital Ramón y Cajal, Spain
    Hum Mol Genet 15:2045-58. 2006
    Abnormal deposition of protein tau takes place in the brain of patients with several neurodegenerative diseases...
  24. ncbi Proline-directed phosphorylation of human Tau protein
    R Vulliet
    Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis 95616
    J Biol Chem 267:22570-4. 1992
    The primary sequence of the microtubule-associated protein tau contains multiple repeats of the sequence -X-Ser/Thr-Pro-X-, the consensus sequence for the proline-directed protein kinase (p34cdc2/p58cyclin A)...
  25. ncbi The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase
    Y L Woods
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 355:609-15. 2001
    ..The DYRK isoforms also phosphorylate human microtubule-associated protein tau at Thr(212) in vitro, a residue that is phosphorylated in foetal tau and hyperphosphorylated in filamentous tau ..
  26. ncbi Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 409:57-62. 1997
    ..the neurofibrillary lesions of Alzheimer's disease, is composed of hyperphosphorylated microtubule-associated protein tau. Many of the hyperphosphorylated sites in tau are serine/threonine-prolines...
  27. ncbi Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation
    M L Selenica
    Division of Biological Research, H Lundbeck A S, Copenhagen, Denmark
    Br J Pharmacol 152:959-79. 2007
    ..Here, we assess five GSK-3beta inhibitors and lithium in lowering phosphorylated tau (p-tau) and GSK-3beta enzyme activity levels in 12-day old postnatal rats...
  28. ncbi Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta
    Tong Li
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    Biochemistry 45:3134-45. 2006
    ..Within the complex, Cdk5 phosphorylates tau at S(235) and primes it for phosphorylation of T(231) by GSK3beta. Similarly, Cdk5 by phosphorylating tau at S(404) primes tau for a sequential phosphorylation of S(400) and S(396) by GSK3beta...
  29. ncbi A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn
    P Agostinis
    Afdeling Biochemie, Faculteit der Geneeskunde, Katholieke Universiteit Leuven, Belgium
    Eur J Biochem 236:548-57. 1996
    ..examined in vitro using phosphotyrosine-containing peptides, derived from the phosphorylation sites of p34cdc2, p50/HS1 protein, Abl, c-Src and c-Fgr, as well as the intact phosphoprotein p50/HS1 and the Src-related tyrosine kinases, ..
  30. ncbi Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins
    B J Hinnebusch
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 66:432-40. 1998
    ..The type strain, B. hermsii HS1, has at least 40 complete genes and pseudogenes that participate in this multiphasic antigenic variation...
  31. ncbi Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter
    K F Lau
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Genomics 60:121-8. 1999
    ..Recent studies have shown that GSK-3beta phosphorylates the microtubule-associated protein tau in vitro and in cell culture...
  32. ncbi Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism
    Tong Li
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    Biochemistry 45:3125-33. 2006
    ..Phosphorylation of S(396), on the other hand, occurs sequentially. Once a priming kinase phosphorylates S(404), GSK3beta sequentially phosphorylates S(400) and then S(396)...
  33. ncbi HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells
    E Ingley
    Laboratory for Cancer Medicine, Department of Biochemistry, The University of Western Australia and Royal Perth Hospital, WA 6001, Western Australia, Australia
    J Biol Chem 275:7887-93. 2000
    ..Here we show that the hemopoietic-specific protein HS1 interacted directly with the SH3 domain of Lyn, via its proline-rich region...
  34. ncbi The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia
    G Benitez-King
    Instituto Nacional de Psiquiatria, Departamento de Neurofarmacologia, Subdirección de Investigaciones Clínicas, Mexico, D F, Mexico
    Curr Drug Targets CNS Neurol Disord 3:515-33. 2004
    ..tangles are formed of paired helical filaments consisting nearly entirely of the microtubule-associated protein tau. Under normal conditions tau binds to microtubules, stabilizing neuron structure and integrity...
  35. ncbi Metabolites of hirsuteine and hirsutine, the major indole alkaloids of Uncaria rhynchophylla, in rats
    Takahiro Nakazawa
    Department of Natural Products Chemistry, Tohoku Pharmaceutical University, Japan
    Biol Pharm Bull 29:1671-7. 2006
    ..Similarly HS also was metabolized to two compounds (HS1 and HS2)...
  36. ncbi NMR investigation of the interaction between the neuronal protein tau and the microtubules
    Alain Sillen
    CNRS UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, 59655, Villeneuve d Ascq Cedex, France
    Biochemistry 46:3055-64. 2007
    ..Here, we present a nuclear magnetic resonance (NMR) study of the interaction between the full-length neuronal protein Tau and paclitaxel-stabilized microtubules (MTs)...
  37. ncbi Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia
    M G Spillantini
    MRC Brain Repair Centre and Department of Neurology, University of Cambridge, UK
    Acta Neuropathol 97:585-94. 1999
    Microtubule-associated protein tau forms neurofibrillary lesions in Alzheimer's disease and several other neurodegenerative disorders, such as Niemann-Pick disease type C, subacute sclerosing panencephalitis, argyrophilic grain disease, ..
  38. ncbi Isolation and characterization of Helicobacter suis sp. nov. from pig stomachs
    M Baele
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 58:1350-8. 2008
    ..Three isolates, HS1(T), HS2 and HS3, were subcultured from the stomach mucosa of three pigs after slaughter and were analysed using a ..
  39. ncbi Alzheimer disease hyperphosphorylated tau aggregates hydrophobically
    G C Ruben
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Synapse 27:208-29. 1997
    The chemical interaction that condenses the hyperphosphorylated protein tau in Alzheimer's disease (AD P-tau) into neurofibrillary tangles and cripples synaptic transmission remains unknown...
  40. ncbi Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro
    H K Paudel
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3T 1E2, Canada
    J Biol Chem 272:28328-34. 1997
    In Alzheimer's disease, the microtubule-associated protein tau forms paired helical filaments (PHFs) that are the major structural component of neurofibrillary tangles...
  41. ncbi ACTH enhances chondrogenesis in multipotential progenitor cells and matrix production in chondrocytes
    Jodi F Evans
    Department of Medicine, Winthrop University Hospital, Mineola, NY 11501, USA
    Bone 35:96-107. 2004
    ..b>1C5.18 (C5.18), were cultured in differentiation medium plus or minus ACTH...
  42. ncbi Expression of BvGLP-1 encoding a germin-like protein from sugar beet in Arabidopsis thaliana leads to resistance against phytopathogenic fungi
    Katrin Knecht
    Department of Molecular Phytopathology, Institute of Phytopathology Chrstian Albrechts University of Kiel, Hermann Rodewald Str 9, Kiel, Germany
    Mol Plant Microbe Interact 23:446-57. 2010
    ..Heterodera schachtii) resistance in sugar beet (Beta vulgaris) is controlled by a single dominant resistance gene, Hs1(pro-1). BvGLP-1 was cloned from resistant sugar beet...
  43. ncbi Tau pathology in Alzheimer disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Biochim Biophys Acta 1739:198-210. 2005
    Just as neuronal activity is essential to normal brain function, microtubule-associated protein tau appears to be critical to normal neuronal activity in the mammalian brain, especially in the evolutionary most advanced species, the homo ..
  44. ncbi The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau
    Johanne Bertrand
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 114:1353-67. 2010
    In tauopathies including Alzheimer's disease, the axonal microtubule-associated protein tau becomes hyperphosphorylated at pathological epitopes and accumulates in the somato-dendritic compartment...
  45. ncbi What is the rationale for new treatment strategies in Alzheimer's disease?
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    CNS Spectr 9:6-12. 2004
    ..beta-peptide (Abeta) into neuritic plaques and the intraneuronal aggregation of the microtubule-associated protein tau to form neurofibrillary tangles...
  46. ncbi The proline-rich domain of tau plays a role in interactions with actin
    Hai Jin He
    Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China
    BMC Cell Biol 10:81. 2009
    The microtubule-associated protein tau is able to interact with actin and serves as a cross-linker between the microtubule and actin networks. The microtubule-binding domain of tau is known to be involved in its interaction with actin...
  47. ncbi The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase
    H K Paudel
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
    J Biol Chem 272:1777-85. 1997
    ..Taken together, these results suggest that in neurons, phosphorylase kinase may be one of the kinases that participate in the phosphorylation of tau...
  48. ncbi Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: a quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trial
    George Pentheroudakis
    Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
    Breast Cancer Res Treat 116:131-43. 2009
    ..We sought to study the predictive significance and correlations of transcriptional profiling of the ER, PgR and microtubule-associated protein Tau (MAP-Tau) genes in early breast cancer.
  49. ncbi The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination
    Edmund C Kim
    Center for Immunology, College of Medicine and School of Biological Sciences, University of California, Irvine, California 92697 4120, USA
    J Biol Chem 279:42258-69. 2004
    ..CSR and SHM are central to the maturation of the antibody response. In contrast to the single 5'-hs3a-hs1,2-hs3b-hs4-3 ' mouse IgH 3 ' regulatory region, the human IgH 3 ' regulatory region exists as a 5'-hs3-hs1,2-hs4-3' ..
  50. ncbi HS1-BP3 gene variant is common in familial essential tremor
    Joseph J Higgins
    Center for Human Genetics and Child Neurology, Mid Hudson Family Health Institute, New Paltz, New York, USA
    Mov Disord 21:306-9. 2006
    ..A variant (828C-->G) in exon 7 of the hematopoietic-specific protein 1 binding protein 3 gene (HS1-BP3) on chromosome 2p recently has been found to segregate with ET in 2 families...
  51. ncbi Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei
    Mathias Dutschmann
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 30:1810-21. 2010
    Tauopathy comprises hyperphosphorylation of the microtubule-associated protein tau, causing intracellular aggregation and accumulation as neurofibrillary tangles and neuropil treads...
  52. ncbi Temporal expression of a V(H) promoter-Cmu transgene linked to the IgH HS1,2 enhancer
    T Andersson
    Center for Genomics Research, Karolinska Institutet, Stockholm, Sweden
    Mol Immunol 36:19-29. 1999
    ..One of these cis-acting elements is the IgH HS1,2 enhancer and previous studies in transgenic mice have revealed a temporally restricted activity of an HS1,2 ..
  53. ncbi Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases
    I Taniuchi
    Department of Molecular Immunology, Kyushu University, Fukuoka, Japan
    EMBO J 14:3664-78. 1995
    b>HS1, an intracellular protein expressed specifically in hematopoietic cells, is rapidly tyrosine phosphorylated after cross-linking of antigen receptors on B and T lymphocytes, implicating involvement of this molecule in the signal ..
  54. ncbi Syk-mediated tyrosine phosphorylation is required for the association of hematopoietic lineage cell-specific protein 1 with lipid rafts and B cell antigen receptor signalosome complex
    Jian Jiang Hao
    Departments of Experimental Pathology and Immunology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 279:33413-20. 2004
    Hematopoietic lineage cell-specific protein 1 (HS1) is an F-actin- and actin-related proteins 2 and 3 (Arp2/3)-binding protein that undergoes a rapid tyrosine phosphorylation upon B cell antigen receptor (BCR) activation...
  55. ncbi Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA-DR and DQ allele frequency
    D Frezza
    Department of Biology Enrico Calef, University of Tor Vergata, Rome, Italy
    Ann Rheum Dis 66:1210-5. 2007
    To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and ..
  56. ncbi Glycogen synthase kinase-3?2 has lower phosphorylation activity to tau than glycogen synthase kinase-3?1
    Kazunori Saeki
    Department of Biochemistry, Faculty of Pharmaceutical Science, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Biol Pharm Bull 34:146-9. 2011
    ..that phosphorylate protein substrates involved in Alzheimer's disease (AD), such as microtubule-associated protein tau and amyloid precursor protein (APP)...
  57. ncbi Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing
    C M Dhaenens
    INSERM, U837 1, Alzheimer and Tauopathies, Place de Verdun, F 59045 Lille, France
    Biochim Biophys Acta 1812:732-42. 2011
    ..In myotonic dystrophy type 1, the presence of microtubule-associated protein Tau aggregates is associated with a mis-splicing of Tau...
  58. ncbi DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice
    Motoshi Shimotsuma
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 285:14495-503. 2010
    ..locus depends on enhancement by the locus control region, which consists of five DNase I hypersensitive sites (5'HS1 through 5'HS5)...
  59. ncbi Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation
    K M Tumas Brundage
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson Medical College, Philadelphia, PA 19107
    Mol Immunol 34:367-78. 1997
    ..To examine whether the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] is required for somatic hypermutation of VH genes, we generated two types of transgenic mice...
  60. ncbi Tau exon 10 alternative splicing and tauopathies
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Mol Neurodegener 3:8. 2008
    ABSTRACT: Abnormalities of microtubule-associated protein tau play a central role in neurofibrillary degeneration in several neurodegenerative disorders that collectively called tauopathies...
  61. ncbi Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A
    Inka Pawlitzky
    Immunology Program, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 176:6839-51. 2006
    ..Detection of one site, HS1, is restricted to pro-B cell lines and HS1 is accessible to restriction enzyme digestion exclusively in normal pro-..
  62. ncbi The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains
    M F Chau
    Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Biochemistry 37:17692-703. 1998
    ..Integrating these and earlier data with the 3.7 A resolution model of the alphabeta tubulin dimer recently presented by E. Nogales et al. [(1998), Nature 391, 199-203], we propose a new model for the tau-microtubule interaction...
  63. ncbi Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease
    John B J Kwok
    Prince of Wales Medical Research Institute, Randwick, Sydney, Australia
    Ann Neurol 64:446-54. 2008
    We examined the epistatic effect between haplotypes of glycogen synthase kinase-3beta (GSK3B) gene and microtubule-associated protein Tau (MAPT) gene in Alzheimer's disease (AD).
  64. ncbi Antiproliferative effects of insulin-like growth factor-binding protein-3 in mesenchymal chondrogenic cell line RCJ3.1C5.18. relationship to differentiation stage
    A Spagnoli
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, The Research Department, Shriners Hospital for Children, Portland, Oregon 97201, USA
    J Biol Chem 276:5533-40. 2001
    ..We used the RCJ3.1C5.18 nontransformed mesenchymal chondrogenic cell line, which, over 2 weeks of culture, progresses through the ..
  65. ncbi Molecular analysis of gamma-globin promoters, HS-111 and 3'HS1, in beta-thalassemia intermedia patients associated with high levels of Hb F
    Mohammad Hamid
    Department of Clinical Genetics, National Institute of Genetic Engineering and Biotechnology NIGEB, Tehran, Iran
    Hemoglobin 33:428-38. 2009
    The nucleotide (nt) variations in the promoter region of the gamma-globin genes, HS-111 and 3'HS1 regions, were studied in Iranian patients with beta-thalassemia intermedia (beta-TI), beta-thalassemia major (beta-TM) and healthy ..
  66. ncbi A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Neurol 64:421-4. 2007
    Mutations in the parkin gene cause autosomal recessive early-onset Parkinson disease (EOPD). The A265G variant in the HS1 binding protein 3 gene (HS1BP3) is common in essential tremor (ET).
  67. ncbi Differently phosphorylated forms of the cortactin homolog HS1 mediate distinct functions in natural killer cells
    Boyd Butler
    Department of Cell Biology and Physiology, Washington University, Saint Louis, Missouri 63110, USA
    Nat Immunol 9:887-97. 2008
    Here we investigated the involvement of HS1, the hematopoietic cell-specific homolog of cortactin, in the actin-based functions of natural killer cells...
  68. ncbi Differential regulation of chromatin structure of the murine 3' IgH enhancer and IgG2b germline promoter in response to lipopolysaccharide and CD40 signaling
    Xincheng Qin
    The Center for Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Immunol 43:1211-20. 2006
    ..two essential subunits of murine SWI/SNF complex, differentially associate with the DNase I hypersensitive region HS1/2 of 3'E and the IgG2b germline promoter in response to LPS activation or CD40 engagement...
  69. ncbi The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    Florian Plattner
    Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 281:25457-65. 2006
    Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of neurodegenerative tauopathies including Alzheimer disease...
  70. ncbi Amyloid-? 1-42 levels are modified by apolipoprotein E ?4 in Creutzfeldt-Jakob disease in a similar manner as in Alzheimer's disease
    Daniela Varges
    National Reference Center for TSE Surveillance at Department of Neurology, University Medical School, Gottingen, Germany
    J Alzheimers Dis 23:717-26. 2011
    ..Based on our results in sCJD patients, we hypothesize that the ApoE ?4 effect on A?1-42 values might not be disease-specific...
  71. ncbi Antigen-antibody interaction. Synthetic peptides define linear antigenic determinants recognized by monoclonal antibodies directed to the cytoplasmic carboxyl terminus of rhodopsin
    R S Hodges
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    J Biol Chem 263:11768-75. 1988
    The specificities of four monoclonal antibodies rho 1D4, 1C5, 3A6, and 3D6 prepared by immunization of rod outer segments containing rhodopsin have been defined using synthetic peptides...
  72. ncbi Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders
    Amy Webb
    Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    Arch Neurol 65:1473-8. 2008
    ..Due to the inversion, an exact causal locus has been difficult to identify, but the microtubule-associated protein tau gene is a likely candidate gene for its involvement in these diseases with tau inclusion.
  73. ncbi Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury
    George J Shaw
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0769, USA
    Ann Emerg Med 39:254-7. 2002
    ..We determine the relationship between the presence or absence of a detectable cleaved serum tau protein (tau(c)), ICI, and outcome at hospital discharge in adults with closed head injuries (CHI)...
  74. ncbi 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions
    Kirk C Wilhelmsen
    Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
    Arch Neurol 61:398-406. 2004
    ..The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with neuronal or glial tau inclusions.
  75. ncbi Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation
    Diane Cripps
    Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 281:10825-38. 2006
    ..AD) is the accumulation of paired helical filaments (PHFs) of hyperphosphorylated microtubule-associated protein Tau. Tandem mass spectrometry was employed to examine PHF-Tau post-translational modifications, in particular ..
  76. ncbi Decreased slow-wave and paradoxical sleep in a rat chronic pain model
    C A Landis
    Department of Physiological Nursing, School of Nursing, University of California, San Francisco 94143-0724
    Sleep 12:167-77. 1989
    ..increase in wakefulness (Wake), a shift to non-rapid-eye-movement (NREM) stages with lower amplitudes (LS and HS1), and a large reduction of NREM sleep with the highest-amplitude (HS2) and paradoxical sleep...
  77. ncbi Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3
    Carsten Brock
    CNRS UMR5203, Montpellier F 34094 France
    Mol Biol Cell 16:5572-8. 2005
    ..Accordingly, competition between 14-3-3 and COPI cannot be considered as a general trafficking control mechanism. A possible other role for competition between COPI and 14-3-3 binding is discussed...
  78. ncbi 14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4
    Jan Silhan
    Departments of Physical and Macromolecular Chemistry, Charles University, 12843 Prague
    J Biol Chem 284:19349-60. 2009
    ..The model of the complex suggests that the forkhead domain of FOXO4 is docked within the central channel of the 14-3-3 protein dimer, consistent with our hypothesis that 14-3-3 masks the DNA binding interface of FOXO4...
  79. ncbi Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading
    Esteban Carrizosa
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 183:7352-61. 2009
    ..We showed previously that the actin-regulatory protein, hematopoietic lineage cell-specific protein 1 (HS1), is required for the stabilization of F-actin and Vav1 at the immunological synapse and for efficient calcium ..
  80. ncbi Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital Universitari de Bellvitge, carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain
    Neurobiol Dis 20:392-400. 2005
    ..Dyrk1 phosphorylates the human microtubule-associated protein tau at Thr212 in vitro, a residue that is phosphorylated in fetal tau and hyper-phosphorylated in Alzheimer disease ..
  81. ncbi Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains
    Mariana Castanheira
    JMI Laboratories, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 54:2655-9. 2010
    ..008 to >8 microg/ml). Only 4 (2.9%) strains displayed FKS1 HS1 amino acid substitutions: 1 C. albicans (F641Y) among 32 isolates tested (3.1%), 1 C...
  82. ncbi Phosphorylation of microtubule-associated protein tau by AMPK-related kinases
    Hirotaka Yoshida
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Neurochem 120:165-76. 2012
    Microtubule-associated protein tau is abnormally hyperphosphorylated in the intracellular filamentous inclusions seen in neurodegenerative disorders with dementia, such as Alzheimer's disease and other tauopathies...
  83. ncbi Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease
    B Kovacech
    Institute of Neuroimmunology, AD Centre, Slovak Academy of Sciences, Bratislava, Slovakia
    Curr Alzheimer Res 7:708-16. 2010
    Deposits of the misfolded neuronal protein tau are major hallmarks of neurodegeneration in Alzheimer's disease (AD) and other tauopathies...
  84. ncbi Microtubule-associated protein tau (MAPT) influences the risk of Parkinson's disease among Indians
    Gautami Das
    S N Pradhan Centre for Neurosciences, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, India
    Neurosci Lett 460:16-20. 2009
    ..Microtubule-associated protein tau (MAPT), a neuronal protein is involved in the pathogenesis of several neurodegenerative diseases including PD...
  85. ncbi Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model
    Monika Zilkova
    Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic Axon Neuroscience GmbH, Vienna, Austria
    J Alzheimers Dis 23:161-9. 2011
    ..These results show that posttranslationally modified truncated tau protein induces caspase-3-independent apoptosis-like programmed cell death, a phenomenon we term tauoptosis...
  86. ncbi Novel drugs affecting tau behavior in the treatment of Alzheimer's disease and tauopathies
    L P Navarrete
    Laboratory of Cellular and Molecular Neurosciences, University of Chile and International Center for Biomedicine, Edificio Milenio, Las Encinas 3370, Nunoa, Santiago, Chile
    Curr Alzheimer Res 8:678-85. 2011
    ..tangles (NFTs) and neuropil threads consists of filaments of the modified microtubule-associated protein tau, while extracellular amyloid plaques consists of filaments of A?-peptide...
  87. ncbi Studies on the actin-binding protein HS1 in platelets
    Steven G Thomas
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    BMC Cell Biol 8:46. 2007
    ..The Arp2/3 complex is highly regulated by a number of actin-binding proteins including the haematopoietic-specific protein HS1 and its homologue cortactin. The present study investigates the role of HS1 in platelets using HS1-/- mice.
  88. ncbi Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions
    Ming Cheng Liu
    Center of Innovative Research, Banyan Biomarkers Inc, 12085 Research Drive, Alachua, FL 32615, USA
    ASN Neuro 3:e00051. 2011
    Axonally specific microtubule-associated protein tau is an important component of neurofibrillary tangles found in AD (Alzheimer's disease) and other tauopathy diseases such as CTE (chronic traumatic encephalopathy)...
  89. ncbi [Effects of granulocyte-macrophage colony stimulating factor on nuclear factor-KappaB activation in multiple organs of hemorrhage-induced acute lung injury in mice]
    Qian Wang
    Department of Respiratory Diseases, Clinical School of First Military Medical University Guangzhou South Medical University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19:295-8. 2007
    ....
  90. ncbi Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer
    Fabrice Andre
    Breast Cancer Unit and Translational Research Unit, UPRES03535, Institut Gustave Roussy, Villejuif, France
    Clin Cancer Res 13:2061-7. 2007
    ..A molecular marker may be prognostic of outcome or predictive of response to therapy, or a combination of both...
  91. ncbi Microtubule-associated protein tau in development, degeneration and protection of neurons
    Jian Zhi Wang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Prog Neurobiol 85:148-75. 2008
    ..The primary aim of this review is to summarize the latest developments and perspectives in our understanding about the roles of tau, especially hyperphosphorylation, in the development, degeneration and protection of neurons...
  92. ncbi Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding
    Heikki Takala
    Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland
    Blood 112:1853-62. 2008
    ..Our results suggest that the phosphorylation of beta2 integrins on Thr758 acts as a molecular switch to inhibit filamin binding and allow 14-3-3 protein binding to the integrin cytoplasmic domain, thereby modulating T-cell adhesion...
  93. ncbi [Effects of HS1-associated protein X-1 on the lupus activities: experiment with MRL/lpr lupus-like mice]
    Zhi Fang Zhai
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Zhonghua Yi Xue Za Zhi 88:406-10. 2008
    To investigate the effects of HS1-associated protein X-1 (HAX-1) on the lupus activity of MRL/lpr lupus-like mice.
  94. ncbi From tangles to tau protein
    K Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    Bratisl Lek Listy 107:341-2. 2006
    ..It took another 23 years before microtubule associated protein tau was immunohistochemically identified as the part of neurofibrillary tangles (Grundke-lqbal, 1986 a)...
  95. ncbi Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
    Purnima Desai Sundar
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98195, USA
    Hum Mol Genet 16:295-306. 2007
    ..To determine if variation in the gene that encodes microtubule-associated protein tau gene (MAPT) contributes to risk for these disorders, we genotyped nine single nucleotide polymorphism (SNP) ..
  96. ncbi MRI correlates of protein deposition and disease severity in postmortem frontotemporal lobar degeneration
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic Rochester, Rochester, Minn 55905, USA
    Neurodegener Dis 6:106-17. 2009
    Frontotemporal lobar degeneration (FTLD) can be classified based on the presence of the microtubule-associated protein tau and the TAR DNA binding protein-43 (TDP-43)...
  97. ncbi PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation
    Ming Zhang
    Medical College of Nankai University, Tianjin 300071, PR China
    J Cell Sci 122:1382-9. 2009
    ..b>1C5.18 cells...
  98. ncbi Increased levels of CSF heart-type fatty acid-binding protein and tau protein after aneurysmal subarachnoid hemorrhage
    E R Zanier
    Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milano, Milano, Italy
    Acta Neurochir Suppl 102:339-43. 2008
    ..The goal of this study was to measure H-FABP and tau in cerebrospinal fluid (CSF) following SAH to test the hypothesis that a relationship exists between SAH severity and H-FABP/tau values...
  99. ncbi Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in beta-thalassemic mice
    Leszek Lisowski
    Center for Cell Engineering, Gene Transfer and Somatic Cell Engineering Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 110:4175-8. 2007
    ..We show here the major roles played by 2 lesser-known locus control region elements, termed HS1 and HS4...
  100. ncbi Polymorphism of the human alpha1 immunoglobulin gene 3' enhancer hs1,2 and its relation to gene expression
    Y Denizot
    Laboratoire d Immunologie UMR CNRS 6101, Faculte de Medecine, Limoges, France
    Immunology 103:35-40. 2001
    We studied the hs1,2 transcriptional enhancer identified downstream of the human alpha1 gene of the immunoglobulin H (IgH) locus, for which two different allelic configurations (a and b) were previously reported by Southern blotting...

Research Grants101 found, 100 shown here

  1. Tau missplicing caused by RNA processing proteins located on chromosome 21
    Athena Andreadis; Fiscal Year: 2007
    ..The major component of tangles is abnormally phosphorylated tau protein. The neuronal microtubule-associated protein tau undergoes complex alternative splicing and differential phosphorylation, producing isoforms with different ..
  2. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 2004
    ..Signal transduction pathways involving tau and A-beta may go awry during neurodegenerative diseases, leading to inappropriate cross talk between pathways that may culminate in abnormal tau phosphorylation and polymerization. ..
  3. Genomic Analysis of Alzheimer's Disease Genes
    Gerard Schellenberg; Fiscal Year: 2007
    Abnormally aggregates of the protein tau in the form of neurofibrillary tangles (NFT's) and glial tangles are found in a number of neurodegenerative diseases including Alzheimer's disease (AD) and frontotemporal dementia with ..
  4. CELL-CELL TRANSFER AND PROPAGATION OF TAU AGGREGATES
    Marc I Diamond; Fiscal Year: 2010
    ..All are linked pathologically to misfolding and aggregation of the microtubule-associated protein tau, and include common disorders such as Alzheimer disease and frontotemporal dementia...
  5. Human tau neurodegeneration in Alzheimer's
    SALLY FRAUTSCHY; Fiscal Year: 2007
    ..Successful results may have profound implications for treatment of Alzheimer's and other inclusion-related neurodegenerative diseases. ..
  6. AGING AND DEMENTIA: CHOLINERGIC NEURON BIOCHEMISTRY
    Peter Davies; Fiscal Year: 2004
    ..The guiding hypothesis of this work is that alterations in the conformation of the microtubule associated protein tau are an important part of a cascade of events that leads to cell death in Alzheimer's disease and certain other ..
  7. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 1999
    ..These studies will provide new insights into the function of tau's amino terminus and into tau's role in the transduction of extracellular signals to the cytoskeleton. ..
  8. Tau polymerization as a target for Alzheimer's disease
    TRUMAN GAMBLIN; Fiscal Year: 2007
    ..I plan to reach this objective by studying the changes in the microtubule-associated protein tau that lead to a decrease in its normal functions and increase its pathological ability to self-assemble into ..
  9. ROLE OF PROLYL ISOMERASE PIN1 IN ALZHEIMER'S DISEASE
    Kun Ping Lu; Fiscal Year: 2006
    ..neurofibrillary tangles and senile plaques in Alzheimer's disease (AD) consist of the microtubule-associated protein tau in a hyperphosphorylated state, and A-beta, a fragment of the amyloid precursor protein (APP), respectively...
  10. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    PAUL E contact SAWCHENKO; Fiscal Year: 2010
    ....
  11. APO E Receptors and Modulation of Fast Axonal Transport
    Joachim Herz; Fiscal Year: 2006
    ..Disruption of this pathway results in abnormal phosphorylation of the microtubule-associated protein tau and therefore is likely to impair axonal transport processes, which are dependent on the normal function of ..
  12. Four Repeat Tauopathy Neuroimaging Initiative
    Adam L Boxer; Fiscal Year: 2010
    New treatments that target the protein tau, a neuronal scaffolding protein that accumulates in neurodegenerative diseases including Alzheimer's (AD), are rapidly entering human clinical trials...
  13. Neuron Target Interaction - a Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2010
    ..The second specific aim is to test both the microtubule associated protein tau and Cdk5 as potential mechanistic links between cell cycle and cell death...
  14. Gene engineering of nerve stem using HSV amplicon vector
    Yoshinaga Saeki; Fiscal Year: 2003
    ..nestin, myelin basic protein, glial fibrillary acidic protein, and microtubule-associated protein tau as a housekeeping, NSC-specific, oligodendrocyte-specific, astrocyte-specific, and neuron-specific gene, ..
  15. Gene therapy for Cooley's anemia in a new mouse model
    Stefano Rivella; Fiscal Year: 2007
    ..from TNS9 by extending the beta-globin promoter by 1 Kb and inserting a 1 Kb genomic region corresponding to the HS1 of the LCR...
  16. Beta-Amyloid & Cell Death Mechanisms in Skeletal Muscle
    Henry Querfurth; Fiscal Year: 2005
    ..of beta-amyloid precursor protein, hyperphosphorylated filaments comprised of the microtubule-associated protein tau, ubiquitin, the cellular prion protein, and cyclin dependent kinase 5 (cdk5)...
  17. RECEPTOR/G-PROTEIN COUPLING IN ALZHEIMER'S DISEASE
    John Lee; Fiscal Year: 2001
    ..a disease-related increase in the phosphorylation state of many proteins, including the microtubule-associated protein tau. The phosphorylation state of proteins is determined by the balance of kinase and phosphatase activities...
  18. Locus control region function on inactive x-chromosomes
    JORG BUNGERT; Fiscal Year: 2003
    ..of five subregions that reveal strong sensitivity to deoxyribonuclease I in erythroid cells (hypersensitive sites HS1 to HS5)...
  19. Novel calpain inhibitors based on phage display
    RODNEY GUTTMANN; Fiscal Year: 2005
    ..initial library (LSEAL) is a potent inhibitor of calpain's actions on proteolysis of the microtubule-associated protein tau, a known calpain substrate...
  20. CYTOSKELETAL PROTEIN PHOSPHORYLATION IN APOPTOSIS
    Gail Johnson; Fiscal Year: 2003
    ..PC12 cells by withdrawal of serum and nerve growth factor (NGF), we demonstrated that the neuronal cytoskeletal protein tau is hyperphosphorylated at specific epitopes during apoptosis...
  21. The Molecular Structure and Function of Tau Protein
    Stuart Feinstein; Fiscal Year: 2007
    The microtubule associated protein tau is essential for the development and maintenance of the nervous system...
  22. TAU GLYCOSYLATION IN ALZHEIMERS DISEASE
    Cheng Xin Gong; Fiscal Year: 2001
    ..specific aims of this project are to reveal the nature and extent of glycosylation of microtubule associated protein tau during various stages of Alzheimer neurofibrillary degeneration, and to understand the role of tau ..