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Genomes and Genes | wdbSummaryGene Symbol: wdb Description: widerborst Alias: 0318/07, B56-2, BEST:LD02456, BcDNA:LD34343, CG5643, Dmel\CG5643, EP3559, LD02456, PP2-AB, PP2A, PP2a, Wdb, dB56-2, dPP2A, l(3)S031807, CG5643-PA, CG5643-PB, CG5643-PC, CG5643-PD, CG5643-PE, PP2A B subunit, PP2A regulatory subunit, protein phosphatase 2a, protein phosphatase PP2A, wdb-PA, wdb-PB, wdb-PC, wdb-PD, wdb-PE, wiederborst Species: fruit fly Top Publications
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Publications
B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogasterXinghai Li
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
Mol Cell Biol 22:3674-84. 2002..Using double-stranded RNA-mediated interference (RNAi), the role of protein phosphatase 2A (PP2A) in cellular signaling was investigated...- Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogasterHoda Moazzen
Department of Biology, University of Western Ontario, 1151 Richmond St, London, Ontario, Canada
Mech Dev 126:605-10. 2009..A Protein Phosphatase 2A holoenzyme assembled with the PP2A-B' regulatory subunit is proposed to specifically interact with, and .. - PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylationHongge Jia
Sealy Center for Cancer Cell Biology, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Development 136:307-16. 2009..We also provide evidence that PP2A is a Ci phosphatase. Inactivating PP2A regulatory subunit (Wdb) by RNAi or by loss-of-function mutation downregulates, whereas overexpressing regulatory subunit .. - The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in DrosophilaNatalia Vereshchagina
Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK
J Cell Sci 121:3383-92. 2008..However, it remains unclear how this pool is regulated. Here we show that the protein phosphatase PP2A-B' regulatory subunit Widerborst (Wdb), which coimmunoprecipitates with Akt in vivo, selectively .. - Par-1 and PP2A: Yin-Yang of Bazooka localizationKwang Wook Choi
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Fly (Austin) 1:235-7. 2007..Our study suggests that in photoreceptors, Par-1 blocks the localization of Baz to AJ whereas protein phosphatase 2A (PP2A) promotes Baz localization by antagonizing the Par-1 effects... - Multiple protein phosphatases are required for mitosis in DrosophilaFeng Chen
Cancer Research United Kingdom, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
Curr Biol 17:293-303. 2007..Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles... - Circadian oscillators of Drosophila and mammalsWangjie Yu
Department of Biology and Center for Research on Biological Clocks, Texas A and M University, College Station, TX 77843-3258, USA
J Cell Sci 119:4793-5. 2006 - The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junctionNatasha M Viquez
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 26:9293-303. 2006..We isolated a B' regulatory subunit of protein phosphatase 2A (PP2A) that we have named well-rounded (wrd)... - Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK proteinEun Young Kim
Department of Molecular Biology and Biochemistry, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 103:6178-83. 2006..Intriguingly, DBT seems to function in close partnership with the PER-relevant protein phosphatase 2A, resulting in dynamic equilibrium between hypo- and hyperphosphorylated isoforms of CLK... - Long-range coordination of planar polarity in DrosophilaHelen Strutt
Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
Bioessays 27:1218-27. 2005..Subsequently, this long-range polarity signal is refined by local cell-cell interactions involving the transmembrane molecules Frizzled, Strabismus and Flamingo. The role of these factors in coordinating polarity will be discussed... - The circadian timekeeping system of DrosophilaPaul E Hardin
Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 5001, USA
Curr Biol 15:R714-22. 2005..I will also discuss where work remains to be done to give a comprehensive picture of the circadian clock in Drosophila and likely many other organisms... - At the pulse of time: protein interactions determine the pace of circadian clocksJan C Schöning
Molekulare Zellphysiologie, Fakultat fur Biologie, Universitat Bielefeld, D 33615 Bielefeld, Germany
FEBS Lett 579:3246-52. 2005..Based on the model organisms Drosophila melanogaster and Arabidopsis thaliana molecular principles of circadian clocks are discussed in this review... - Mathematical modeling of planar cell polarity to understand domineering nonautonomyKeith Amonlirdviman
Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
Science 307:423-6. 2005..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy... - Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2ASriram Sathyanarayanan
Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell 116:603-15. 2004..Here we demonstrate a role for protein phosphatase 2A (PP2A) in the cyclic expression of the PER protein... - Frizzled signalling and cell polarisation in Drosophila and vertebratesDavid Strutt
Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Development 130:4501-13. 2003..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation... - Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila developmentDaimark Bennett
Department of Zoology, Oxford University, Oxford OX1 3PS, United Kingdom
Genetics 164:235-45. 2003..These studies demonstrate that inhibitors of PP1 can be used in a tissue- and developmental-specific manner to examine the developmental roles of PP1... - Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2AMichael Hannus
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Development 129:3493-503. 2002We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish... - A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in DrosophilaMasabumi Funakoshi
Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Biochem Biophys Res Commun 405:667-72. 2011..screen in Drosophila, we found that overexpression of the wdb gene encoding a regulatory subunit of PP2A, and overexpression of the lkb1 gene encoding a serine/threonine kinase, reduced organ size and extended lifespan...
Research Grants
- ORGANIZATION OF APICAL CELL JUNCTIONS IN EYEKwang Wook Choi; Fiscal Year: 2005..Therefore, studies on novel interaction of Crb and Par complexes will provide important insights into the mechanism of human CRB 1 in normal retinal development and diseases associated with CRB1 mutations. ..
- DISCS-LOST IN APICAL CELL JUNCTIONS IN DROSOPHILA EYEKwang Wook Choi; Fiscal Year: 2002..Vertebrate protein sequences similar to Dlt have been found. These studies on Dlt and Notch signaling proteins will provide useful insights into the function of vertebrate homologs in cell-cell interaction and signaling. ..
- Genetic Control of Symmetry in the EyeKwang Wook Choi; Fiscal Year: 2007..Thus, our study will also contribute to the understanding of mammalian eye development and etiology of early childhood retinal diseases. ..