Su(Tpl)

Summary

Gene Symbol: Su(Tpl)
Description: CG32217 gene product from transcript CG32217-RB
Alias: 0854/01, CG32217, CG8037, CR32216, Dmel\CG32217, ELL, Ell, SR3-4A, SS3-4, SY3-1, dELL, l (3)76BD, l(3)76BDs, l(3)S000606, l(3)S085401, CG32217-PA, CG32217-PB, Su(Tpl)-PA, Su(Tpl)-PB, suppressor of GMR-sina 3-4, suppressor of triplolethal
Species: fruit fly

Top Publications

  1. ncbi The unusual spectrum of mutations induced by hybrid dysgenesis at the Triplo-lethal locus of Drosophila melanogaster
    D R Dorer
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799
    Genetics 125:795-801. 1990
  2. ncbi Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Genet Genomics 277:101-14. 2007
  3. ncbi Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster
    Mark A Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Mol Cell Biol 25:7803-11. 2005
  4. ncbi Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans
    Xianjun Zhu
    Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 132:3813-22. 2005
  5. ncbi Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia
    Laura K Smoyer
    School of Biological Sciences, University of Nebraska, Lincoln 68588 0118, USA
    Genet Res 82:163-70. 2003
  6. ncbi Genetic characterization of Drosophila Mi-2 ATPase
    Shahryar Khattak
    Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, South Korea
    Gene 293:107-14. 2002
  7. ncbi dELL is an essential RNA polymerase II elongation factor with a general role in development
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 99:9894-9. 2002
  8. ncbi Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo
    M Gerber
    The Edward Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, USA
    EMBO J 20:6104-14. 2001
  9. ncbi A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein
    I Rebay
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genetics 154:695-712. 2000
  10. ncbi The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function
    A Prado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Genetics 151:163-75. 1999

Scientific Experts

  • J C Eissenberg
  • ILARIA L REBAY
  • Edwin R Smith
  • Ali Shilatifard
  • Mark A Gerber
  • Xianjun Zhu
  • Laura K Smoyer
  • Shahryar Khattak
  • M Gerber
  • D R Dorer
  • A Prado
  • Benjamin Winter
  • T P Neufeld
  • David Stein
  • Jason S Goltz
  • Jonaki Sen
  • Leslie Stevens
  • G M Rubin
  • Alan C Christensen
  • Kenneth W Nickerson
  • Douglas R Dorer
  • F D Karim
  • Nikolaus A Spoerel
  • Sung Hoon Cho
  • Joohong Ahnn
  • Bo Ra Lee
  • K Dean
  • A Shilatifard
  • J Ma
  • A C Christensen
  • A Ferrus
  • I Canal
  • A H Tang
  • M Therrien
  • H C Chang
  • D A Wassarman
  • T Laverty
  • D H Ezekiel
  • G Harries
  • B Gordesky-Gold
  • M A Cadden
  • T Homyk
  • C P Emerson
  • D H Johnson

Detail Information

Publications18

  1. ncbi The unusual spectrum of mutations induced by hybrid dysgenesis at the Triplo-lethal locus of Drosophila melanogaster
    D R Dorer
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 6799
    Genetics 125:795-801. 1990
    ..A higher mutation rate with hybrid dysgenesis than with radiation or chemicals also suggests a peculiar genetic organization for the locus...
  2. ncbi Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Genet Genomics 277:101-14. 2007
    ..Binding of the RNA Polymerase II elongation factor ELL was reduced in knockdown chromosomes, suggesting that ELL is recruited to active polymerase via CTD phosphorylation.
  3. ncbi Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster
    Mark A Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Mol Cell Biol 25:7803-11. 2005
    ..of this study was to identify domains required for chromosome targeting and viability in the unique Drosophila ELL (dELL) protein...
  4. ncbi Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans
    Xianjun Zhu
    Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Development 132:3813-22. 2005
    ..Taken together, our data provide evidence that Pipe acts as a sulfotransferase, but argue against the hypothesis that the target of Pipe is a heparan sulfate glycosaminoglycan...
  5. ncbi Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia
    Laura K Smoyer
    School of Biological Sciences, University of Nebraska, Lincoln 68588 0118, USA
    Genet Res 82:163-70. 2003
    ..This is the first report of a phenotype associated with the Tpl locus and the first report of an environmental condition that suppresses the phenotype...
  6. ncbi Genetic characterization of Drosophila Mi-2 ATPase
    Shahryar Khattak
    Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, South Korea
    Gene 293:107-14. 2002
    ..The expression pattern of dMi-2 and the embryonic lethal phenotypes of mutants indicate that dMi-2 is essential for embryonic development in Drosophila melanagaster...
  7. ncbi dELL is an essential RNA polymerase II elongation factor with a general role in development
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 99:9894-9. 2002
    ..The ELL family of proteins promote Pol II elongation in vitro, and the Drosophila ELL homolog (dELL) is associated with Pol II at sites of transcription in vivo...
  8. ncbi Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo
    M Gerber
    The Edward Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, USA
    EMBO J 20:6104-14. 2001
    ..We have cloned the Drosophila homolog (dELL) in order to test whether ELL family proteins are actually associated with the elongating Pol II in vivo...
  9. ncbi A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein
    I Rebay
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genetics 154:695-712. 2000
    ..We also isolated mutations in five previously uncharacterized genes, one of which, split ends, we have characterized molecularly and have shown to encode a member of the RRM family of RNA-binding proteins...
  10. ncbi The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function
    A Prado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Genetics 151:163-75. 1999
    ..We propose that the HL at 16F represents a long-range cis regulatory region that acts upon a number of functionally related genes whose combined haploidy would yield the dominant-lethal effect...
  11. ncbi A genetic screen to identify components of the sina signaling pathway in Drosophila eye development
    T P Neufeld
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Genetics 148:277-86. 1998
    ....
  12. ncbi A screen for genes that function downstream of Ras1 during Drosophila eye development
    F D Karim
    Howard Hughes Medical Institute, University of California, Berkeley 94720 3200, USA
    Genetics 143:315-29. 1996
    ..At least two suppressors appear to function either between Ras1 and Raf or in parallel to Raf...
  13. ncbi The Triplo-lethal locus of Drosophila: reexamination of mutants and discovery of a second-site suppressor
    D R Dorer
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
    Genetics 141:1037-42. 1995
    ..Su(Tpl) mutations suppress the lethality associated with three copies of the Triplo-lethal locus and are recessive lethal. We have mapped Su(Tpl) to the approximate map position 3-46.5, within the cytological region 76B-76D...
  14. ncbi Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus
    D R Dorer
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541
    Genetics 134:243-9. 1993
    ..By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl...
  15. ncbi Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome
    T Homyk
    Department of Biology, University of Virginia, Charlottesville 22901
    Genetics 119:105-21. 1988
    ....
  16. ncbi A recombinational hotspot at the triplo-lethal locus of Drosophila melanogaster
    D R Dorer
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Genetics 122:397-401. 1989
    ..We have also observed premeiotic recombination occurring at the Tpl hypomorphic alleles in male heterozygotes. We hypothesize that transposons are responsible for both the hypomorphic phenotype and the high frequency of recombination...
  17. ncbi A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila
    D R Dorer
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107
    Nucleic Acids Res 18:5489-94. 1990
    ..Curiously, genetic analysis shows that the P element inserted into this gene is not responsible for the Tpl mutant phenotype. We present possible explanations for these findings...
  18. ncbi Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 105:8575-9. 2008
    ..Drosophila ELL (dELL) is a Pol II elongation factor capable of stimulating the rate of transcription both in vivo and in vitro...