Research TopicsGenomes and Genes | spn-FSummaryGene Symbol: spn-F Description: CG12114 gene product from transcript CG12114-RA Alias: 1130/03, CG12114, Dmel\CG12114, Spn-F, l(3)S113003b, CG12114-PA, Spindle-F, lethal (3) S113003b, spindle F, spn-F-PA Species: fruit fly Top Publications
Research Grants
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Publications
spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in DrosophilaUri Abdu
Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben Gurion University, Beer Sheva 84105, Israel
Development 133:1477-84. 2006..Our results show that we have identified a novel protein that affects oocyte axis determination and the organization of microtubules during Drosophila oogenesis...- Subcellular localization of Bic-D::GFP is linked to an asymmetric oocyte nucleusC Pare
McGill University, Department of Biology, Montreal, Quebec, Canada, H3A 1B1
J Cell Sci 113:2119-27. 2000..The subcellular polarity defined by the Bic-D focus and the nuclear polarity marks some of the first steps in antero-posterior and subsequently in dorso-ventral polarity formation... - IKK epsilon signaling: not just NF-kappaBAndreas Bergmann
The University of Texas MD Anderson Cancer Center, Department of Biochemistry and Molecular Biology, 1515 Holcombe Blvd Unit 1000, Houston, Texas 77030, USA
Curr Biol 16:R588-90. 2006..Surprisingly, three recent reports implicate IKKs in Drosophila in seemingly unrelated functions, including non-apoptotic caspase activation and cytoskeleton organization... - The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesisDikla Dubin-Bar
Department of Life Science, National Institute for Biotechnology in Negev, Ben Gurion University, Beer Sheva, 84105 Israel
BMC Cell Biol 9:51. 2008..Since spn-F mutants display oocyte defects similar to those of ik2 mutant, we decided to investigate whether Spn-F could be a direct regulatory target of Ik2... - PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyteLouis Gervais
Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris 7, 2 place Jussieu, F 75251, Paris Cedex 05, France
Development 135:3829-38. 2008.... - Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristleAmir Bitan
Department of Life Sciences and National Institute for Biotechnology, Negev, Ben Gurion University, Beer Sheva 84105, Israel
Mol Cell Biol 30:496-507. 2010..Thus, our results show that MTs are organized in a polarized manner within the highly elongated bristle and that this organization is essential for biased bristle axial growth...
Research Grants
- Genetic Control of Non-Autonomous Survival in DrosophilaAndreas Bergmann; Fiscal Year: 2010..The characterization of these genes may have significant implications for the understanding of human diseases, and may help developing drugs and therapies to treat these diseases. ..
- Genetic Control of Programmed Cell Death in DrosophilaAndreas Bergmann; Fiscal Year: 2010..Understanding the mechanisms of this genes will lead to new therapeutic interventions for cancer, and may also be relevant for treatment of neurodegenerative diseases. ..
- Genetic Control of Non-Autonomous Survival in DrosophilaAndreas Bergmann; Fiscal Year: 2009..The characterization of these genes may have significant implications for the understanding of human diseases, and may help developing drugs and therapies to treat these diseases. ..
- Induction of Programmed Cell Death by cellular Mis-specificationAndreas Bergmann; Fiscal Year: 2007..Understanding the mechanisms of this process may lead to new therapeutic interventions for cancer, and may also be relevant for treatment of neurodegenerative diseases. ..
- Genetic Control of Non-Autonomous Survival in DrosophilaAndreas Bergmann; Fiscal Year: 2007..The characterization of these genes may have significant implications for the understanding of human diseases, and may help developing drugs and therapies to treat these diseases. ..
- Programmed Cell Death (Apoptosis) in DrosophilaAndreas Bergmann; Fiscal Year: 2007..The information obtained in these experiments will provide new insights into human diseases where deregulation of apoptosis is known to occur and may lead to new strategies for therapeutic intervention. ..
- Induction of Programmed Cell Death by cellular Mis-specificationAndreas Bergmann; Fiscal Year: 2010..Understanding the mechanisms of this process may lead to new therapeutic interventions for cancer, and may also be relevant for treatment of neurodegenerative diseases. ..