plu

Summary

Gene Symbol: plu
Description: plutonium
Alias: CG9183, Dmel\CG9183, PLU, Plu, CG9183-PA, plu-PA
Species: fruit fly

Top Publications

  1. ncbi Developmental regulation of the cell cycle
    R Saint
    Department of Biochemistry, University of Adelaide, Australia
    Curr Opin Genet Dev 2:614-20. 1992
  2. ncbi The Drosophila PNG kinase complex regulates the translation of cyclin B
    Leah Vardy
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Dev Cell 12:157-66. 2007
  3. ncbi The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions
    Laura A Lee
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 17:2979-91. 2003
  4. ncbi giant nuclei is essential in the cell cycle transition from meiosis to mitosis
    Andrew D Renault
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Development 130:2997-3005. 2003
  5. ncbi Identification of plu genes and cis-acting elements of PCNA in the Drosophila genus using conservation of gene order
    Andrew D Renault
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Gene 307:77-86. 2003
  6. ncbi The Drosophila maternal gene sésame is required for sperm chromatin remodeling at fertilization
    B Loppin
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon, Villeurbanne, France
    Chromosoma 110:430-40. 2001
  7. ncbi DNA replication control through interaction of E2F-RB and the origin recognition complex
    G Bosco
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 3:289-95. 2001
  8. ncbi PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development
    D D Fenger
    Department of Biology, Massachusetts Institute of Technology and Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, USA
    Development 127:4763-74. 2000
  9. ncbi Drosophila PLUTONIUM protein is a specialized cell cycle regulator required at the onset of embryogenesis
    L K Elfring
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Mol Biol Cell 8:583-93. 1997
  10. ncbi Formation of the male pronuclear lamina in Drosophila melanogaster
    J Liu
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853 2703, USA
    Dev Biol 184:187-96. 1997

Research Grants

  1. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 2004
  2. Regulation of the endo cell cycle in Drosophila
    Terry Orr Weaver; Fiscal Year: 2006
  3. Differential DNA Replication in Drosophila Development
    Terry L Orr Weaver; Fiscal Year: 2010
  4. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 2009
  5. REGULATION OF THE ENDO CELL CYCLE IN DROSOPHILA
    Terry Orr Weaver; Fiscal Year: 2002
  6. REPLICATION AND POLYTENIZATION IN DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 1993
  7. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 2000
  8. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry L Orr Weaver; Fiscal Year: 2010

Scientific Experts

  • B Loppin
  • Terry Orr Weaver
  • Leah Vardy
  • Andrew D Renault
  • Terry L Orr-Weaver
  • T L Orr-Weaver
  • D D Fenger
  • Wael Tadros
  • J Myles Axton
  • Laura A Lee
  • L K Elfring
  • G Bosco
  • Jillian A Pesin
  • J L Carminati
  • J M Axton
  • J Liu
  • A Pellicena-Palle
  • Jennifer L Semotok
  • Howard D Lipshitz
  • Bruce H Reed
  • Simon A Houston
  • Douglas Van Hoewyk
  • Xiao Hua Zhang
  • Robert D C Saunders
  • David M Glover
  • Arash Bashirullah
  • Xiao-Hua Zhang
  • Luke S Alphey
  • Ramona L Cooperstock
  • Lisa M Frenz
  • W Du
  • H Kashevsky
  • D L Burney-Sigman
  • J L Dines
  • H K Salz
  • J M Lopez
  • S M Stitzinger
  • A W Page
  • M F Wolfner
  • H Lin
  • F L Shamanski
  • L M Young
  • D S Henderson
  • R Saint
  • J B Boyd
  • P L Wigley

Detail Information

Publications15

  1. ncbi Developmental regulation of the cell cycle
    R Saint
    Department of Biochemistry, University of Adelaide, Australia
    Curr Opin Genet Dev 2:614-20. 1992
    ..Surprisingly, developmental regulation is mediated at a variety of cell-cycle stages. Highly conserved cell-cycle control mechanisms provide a focus for studying the regulatory processes involved...
  2. ncbi The Drosophila PNG kinase complex regulates the translation of cyclin B
    Leah Vardy
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Dev Cell 12:157-66. 2007
    ..Our data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila...
  3. ncbi The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions
    Laura A Lee
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 17:2979-91. 2003
    ..Three genes, pan gu (png), plutonium (plu), and giant nuclei (gnu) coordinate these early S-M cycles by ensuring adequate Cyclin B protein levels...
  4. ncbi giant nuclei is essential in the cell cycle transition from meiosis to mitosis
    Andrew D Renault
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Development 130:2997-3005. 2003
    ..mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png)...
  5. ncbi Identification of plu genes and cis-acting elements of PCNA in the Drosophila genus using conservation of gene order
    Andrew D Renault
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Gene 307:77-86. 2003
    In Drosophila melanogaster, the cell cycle control gene, plutonium (plu), is located between the PCNA and RpS18 genes at position 56F on chromosome arm 2R...
  6. ncbi The Drosophila maternal gene sésame is required for sperm chromatin remodeling at fertilization
    B Loppin
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon, Villeurbanne, France
    Chromosoma 110:430-40. 2001
    ..The abnormal chromatin organization of the male pronucleus does not prevent the formation of a male pronuclear envelope, which breaks down and reassembles in synchrony with maternally derived nuclei present in the same cytoplasm...
  7. ncbi DNA replication control through interaction of E2F-RB and the origin recognition complex
    G Bosco
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 3:289-95. 2001
    ..Our results indicate that dE2F1 and Rbf function together at replication origins to limit DNA replication through interactions with DmORC...
  8. ncbi PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development
    D D Fenger
    Department of Biology, Massachusetts Institute of Technology and Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, USA
    Development 127:4763-74. 2000
    ..In Drosophila, this replication block requires the products of the pan gu (png), plutonium (plu) and giant nuclei (gnu) genes...
  9. ncbi Drosophila PLUTONIUM protein is a specialized cell cycle regulator required at the onset of embryogenesis
    L K Elfring
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Mol Biol Cell 8:583-93. 1997
    Unfertilized eggs and fertilized embryos from Drosophila mothers mutant for the plutonium (plu) gene contain giant polyploid nuclei resulting from unregulated S-phase...
  10. ncbi Formation of the male pronuclear lamina in Drosophila melanogaster
    J Liu
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853 2703, USA
    Dev Biol 184:187-96. 1997
    ..embryos defective for the function of either the male pronucleus (mh, K81, and pal or both pronuclei (gnu, png, and plu)...
  11. ncbi The function of the Drosophila thioredoxin homologue encoded by the deadhead gene is redox-dependent and blocks the initiation of development but not DNA synthesis
    A Pellicena-Palle
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Mech Dev 62:61-5. 1997
    ..The observed epistatic relationship between these mutations clearly indicates that deadhead is not essential for DNA metabolism. The possibility of a regulatory role in controlling the initiation of S-phase is discussed...
  12. ncbi The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein
    J M Axton
    Whitehead Institute, Cambridge, MA
    EMBO J 13:462-70. 1994
    The plutonium (plu) gene product controls DNA replication early in Drosophila development. plu mutant females lay unfertilized eggs that have undergone extensive DNA synthesis...
  13. ncbi The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization
    F L Shamanski
    Department of Biology, Massachusetts Institute of Technology, Cambridge
    Cell 66:1289-300. 1991
    Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs...
  14. ncbi Regulation of Cyclin A protein in meiosis and early embryogenesis
    Leah Vardy
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:1838-43. 2009
    ..These studies reveal multiple levels of posttranscriptional regulation of Cyclin A protein by translational and proteolytic control during oocyte maturation and the onset of embryogenesis...
  15. ncbi Regulation of maternal transcript destabilization during egg activation in Drosophila
    Wael Tadros
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Genetics 164:989-1001. 2003
    ....

Research Grants30

  1. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 2004
    ..It is in complex with the PLUTONIUM (PLU) protein that is essential also to regulate these cycles...
  2. Regulation of the endo cell cycle in Drosophila
    Terry Orr Weaver; Fiscal Year: 2006
    ..In the final aim, the mechanisms that inhibit mitosis to permit formation of polyploid or polytene chromosomes will be delineated, and it will be determined how proliferating cells are protected from becoming polyploid. ..
  3. Differential DNA Replication in Drosophila Development
    Terry L Orr Weaver; Fiscal Year: 2010
    ....
  4. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 2009
    ..The protein products of other genes necessary for the completion of meiosis and the restart of the cell cycle at fertilization will be isolated. ..
  5. REGULATION OF THE ENDO CELL CYCLE IN DROSOPHILA
    Terry Orr Weaver; Fiscal Year: 2002
    ..The hypothesis that the l(2)51Ec protein is a component of the origin complex and necessary for downregulation of previously induced genes will be tested. ..
  6. REPLICATION AND POLYTENIZATION IN DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 1993
    ..Two genes have been identified, plutonium (plu) and pan gu (png), that regulate DNA replication at the onset of development...
  7. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 2000
    ..Two genes have been identified, plutonium (plu) and pan gu (png), that regulate DNA replication at the onset of development...
  8. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry L Orr Weaver; Fiscal Year: 2010
    ..Birth defects and infertility result from failure to properly regulate meiosis and embryonic cell division. Our research will identify new regulatory proteins essential for the proper control of meiosis and the onset of development. ..