H

Summary

Gene Symbol: H
Description: Hairless
Alias: CG5460, Dmel\CG5460, CG5460-PA, CG5460-PB, CG5460-PC, CG5460-PD, H-PA, H-PB, H-PC, H-PD, hairless, hairy
Species: fruit fly

Top Publications

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  2. ncbi Cell proliferation control by Notch signaling in Drosophila development
    M J Go
    Howard Hughes Medical Institute, Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 125:2031-40. 1998
  3. ncbi Hairless: the ignored antagonist of the Notch signalling pathway
    Dieter Maier
    Institute for Genetics 240, University of Hohenheim, Stuttgart, Germany
    Hereditas 143:212-21. 2006
  4. ncbi Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist Hairless
    J Marquart
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, D 70599 Stuttgart, Germany
    Dev Genes Evol 209:155-64. 1999
  5. ncbi Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila
    A C Nagel
    Institut für Genetik 240, Universitat Hohenheim, Stuttgart, Germany
    Mech Dev 94:3-12. 2000
  6. ncbi Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila
    V Morel
    Ecole Normale Superieure, Unite Mixte de Recherche 8544, 46 rue d Ulm, 75230, Cedex 05, Paris, France
    Curr Biol 11:789-92. 2001
  7. ncbi Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis
    H Lopez-Schier
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 15:1393-405. 2001
  8. ncbi Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila
    Simone L Schreiber
    Universitat Hohenheim, Institut fur Genetik, Stuttgart, Germany
    Genesis 33:141-52. 2002
  9. ncbi Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
    Scott Barolo
    Division of Biological Sciences Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093 0349, USA
    Genes Dev 16:1964-76. 2002
  10. ncbi Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation
    Dieter Maier
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, 70599 Stuttgart, Germany Europe
    Proc Natl Acad Sci U S A 99:15480-5. 2002

Research Grants

  1. QTLs in Drosophila
    Trudy Mackay; Fiscal Year: 2009
  2. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2007
  3. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2007
  4. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2006
  5. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
  6. THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS
    Trudy Mackay; Fiscal Year: 2007
  7. QTLs in Drosophila
    Eric A Stone; Fiscal Year: 2010
  8. Genetics of Alcohol Sensitivity in Drosophila
    Trudy F Mackay; Fiscal Year: 2010
  9. QTLs in Drosophila
    Trudy Mackay; Fiscal Year: 2009
  10. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications62

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  2. ncbi Cell proliferation control by Notch signaling in Drosophila development
    M J Go
    Howard Hughes Medical Institute, Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 125:2031-40. 1998
    ..Vestigial and Wingless, on the contrary, display synergistic effects with Notch signaling, resulting in the stimulation of cell proliferation in imaginal discs...
  3. ncbi Hairless: the ignored antagonist of the Notch signalling pathway
    Dieter Maier
    Institute for Genetics 240, University of Hohenheim, Stuttgart, Germany
    Hereditas 143:212-21. 2006
    ..Together with mastermind and CSL (CBF-1, Suppressor of Hairless, lag-2) DNA-binding proteins, Notch forms a complex that mediates transcriptional activation of the respective ..
  4. ncbi Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist Hairless
    J Marquart
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, D 70599 Stuttgart, Germany
    Dev Genes Evol 209:155-64. 1999
    b>Hairless is a member of the Notch signalling pathway, where it acts as antagonist by binding to Suppressor of Hairless [Su(H)], thereby inhibiting Notch target gene activation...
  5. ncbi Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila
    A C Nagel
    Institut für Genetik 240, Universitat Hohenheim, Stuttgart, Germany
    Mech Dev 94:3-12. 2000
    ..In contrast, the Notch antagonist Hairless, thought to act upon Su(H), influences strongly the entire cell lineage demonstrating that it functions through ..
  6. ncbi Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila
    V Morel
    Ecole Normale Superieure, Unite Mixte de Recherche 8544, 46 rue d Ulm, 75230, Cedex 05, Paris, France
    Curr Biol 11:789-92. 2001
    ..NICD associates with Suppressor of Hairless [Su(H)], a DNA binding protein, and Mastermind (Mam), a transcriptional coactivator [7-9]...
  7. ncbi Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis
    H Lopez-Schier
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 15:1393-405. 2001
    ..The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control...
  8. ncbi Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila
    Simone L Schreiber
    Universitat Hohenheim, Institut fur Genetik, Stuttgart, Germany
    Genesis 33:141-52. 2002
    b>Hairless was identified as antagonist in the Notch signaling pathway based on genetic interactions. Molecularly, Hairless inhibits Notch target gene activation by directly binding to the Notch signal transducer Su(H)...
  9. ncbi Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
    Scott Barolo
    Division of Biological Sciences Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093 0349, USA
    Genes Dev 16:1964-76. 2002
    The DNA-binding transcription factor Suppressor of Hairless [Su(H)] functions as an activator during Notch (N) pathway signaling, but can act as a repressor in the absence of signaling...
  10. ncbi Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation
    Dieter Maier
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, 70599 Stuttgart, Germany Europe
    Proc Natl Acad Sci U S A 99:15480-5. 2002
    ..Notch signals need to be tightly regulated, and in Drosophila they are antagonized by the Hairless (H) protein...
  11. ncbi Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors
    Anja C Nagel
    Anette Preiss, Institut für Genetik 240, Universitat Hohenheim, Garbenstr 30, D 70599 Stuttgart, Germany
    Mol Cell Biol 25:10433-41. 2005
    Notch signal transduction centers on a conserved DNA-binding protein called Suppressor of Hairless [Su(H)] in Drosophila species...
  12. ncbi In vivo structure-function analysis of Drosophila Hairless
    D Maier
    Universitat Hohenheim, Institut für Allgemeine Genetik, Stuttgart, Germany
    Mech Dev 67:97-106. 1997
    b>Hairless plays an important role as the major antagonist in the Notch signalling pathway in Drosophila. It appears to be a direct inhibitor of the signal transducer Su(H)...
  13. ncbi The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
    X Sun
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 122:2465-74. 1996
    ..Notch, Delta, mastermind, deltex and groucho, but are suppressed by a duplication of Delta or mutations in Hairless, a negative regulator of the pathway...
  14. ncbi Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 90:4037-41. 1993
    ..The basis for the genetic antimorphism of NM1 seems to reside in the titration of Notch wild-type products into NM1/N+ nonfunctional dimers and/or the titration of Delta products into nonfunctional ligand-receptor complexes...
  15. ncbi Nature versus nurture: asymmetric cell divisions in Drosophila bristle development
    J W Posakony
    Department of Biology, University of California, San Diego, La Jolla 92093-0322
    Cell 76:415-8. 1994
  16. ncbi Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein
    D Maier
    Biozentrum, Department of Cellbiology, University of Basel, Switzerland
    Mech Dev 38:143-56. 1992
    b>Hairless is a dominant loss of function mutation in Drosophila affecting the formation of adult sensory organs...
  17. ncbi The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development
    A G Bang
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Genes Dev 6:1752-69. 1992
    ..Loss-of-function mutations of Hairless (H) confer two distinct mutant phenotypes on adult bristles...
  18. ncbi Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless
    C Brou
    Unité de Biologie Moléculaire de l Expression Génique, URA 1149 Centre National de la Recherche Scientifique CNRS, Institut Pasteur, Paris, France
    Genes Dev 8:2491-503. 1994
    ..is derived from the previously described RBP-J kappa gene, the human homolog of the Drosophila Suppressor of Hairless [Su(H)] gene...
  19. ncbi A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila
    Dominik Muller
    Universitat Hohenheim, Institut für Genetik 240, Garbenstr 30, 70599 Stuttgart, Germany
    J Cell Sci 119:250-8. 2006
    ..4 from Drosophila melanogaster as a molecular interaction partner of Hairless. Hairless plays a major role as antagonist of Notch signalling in Drosophila, prompting our interest in the ..
  20. ncbi Subcellular localization of Hairless protein shows a major focus of activity within the nucleus
    D Maier
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, D 70599, Stuttgart, Germany
    Mech Dev 89:195-9. 1999
    b>Hairless, a major antagonist of the Notch signaling-pathway in Drosophila (Bang and Posakony, 1992; Maier et al., 1992), associates with Suppressor of Hairless [Su(H)], thereby inhibiting trans-activation of Notch target genes (Brou et al...
  21. ncbi The enhancer of split locus and neurogenesis in Drosophila melanogaster
    E Knust
    Dev Biol 122:262-73. 1987
    ..Therefore, E(spl) formally behaves as a gene switching between neural and epidermal pathways...
  22. ncbi rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways
    Hoda K Shamloula
    Department of Biology, City College and The Graduate Center, City University of New York, New York 10031, USA
    Genetics 161:693-710. 2002
    ..Our results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways...
  23. ncbi Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila
    Hildegard Tekotte
    Wellcome Trust Centre for Cell Biology, ICMB, King s Buildings, University of Edinburgh, Edinburgh, Scotland, EH9 3JR, UK
    Dev Biol 244:396-406. 2002
    ..We propose that mutations in house keeping genes often cause specific developmental phenotypes, such as those observed in many human genetic disorders...
  24. ncbi The determination of sense organs in Drosophila: a search for interacting genes
    C Dambly-Chaudiere
    Departement de Biologie Moleculaire, Universite Libre de Bruxelles, Rhode St Genese, Belgium
    Int J Dev Biol 36:85-91. 1992
    ..Our experience suggests that its efficiency should be substantially improved by the use of insertional mutagenesis...
  25. ncbi Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
    Robert Liefke
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Genes Dev 24:590-601. 2010
    ..KDM5A interacts physically with RBP-J; this interaction is conserved in Drosophila and is crucial for Notch-induced growth and tumorigenesis responses...
  26. ncbi A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila
    Stefan Koelzer
    Institute für Genetik, Universitaet zu Koeln, Weyertal 121, 50931 Koeln, Germany
    Development 130:1973-88. 2003
    Su(H)/CBF1 is a key component of the evolutionary conserved Notch signalling pathway. It is a transcription factor that acts as a repressor in the absence of the Notch signal...
  27. ncbi A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut
    D David Iwaki
    Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095 1606, USA
    Mech Dev 114:71-84. 2002
    ..This Notch-induced cell specification is distinguished by the fact that it does not appear to utilize the ligand Serrate and the modulator Fringe...
  28. ncbi The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway
    Shweta Chandra
    Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 256:302-16. 2003
    ..These phenotypes are suppressed by overexpression of Notch, Suppressor of Hairless [Su(H)], and Enhancer of split m7...
  29. ncbi An EP overexpression screen for genetic modifiers of Notch pathway function in Drosophila melanogaster
    Lauren E Hall
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Genet Res 83:71-82. 2004
    ..Our results suggest that a genetic screen that combines partial loss of function with random gene overexpression might be a useful strategy in the analysis of developmental pathways...
  30. ncbi Tramtrack regulates different morphogenetic events during Drosophila tracheal development
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 134:3665-76. 2007
    ..In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development...
  31. ncbi Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
    Muriel Grammont
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Clermont Ferrand F 63001, France
    J Cell Biol 177:139-50. 2007
    ..This provides new evidence that Notch, besides playing a key role in cell differentiation, also controls cell morphogenesis...
  32. ncbi Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
    Gunter Merdes
    ZMBH, University of Heidelberg, Heidelberg, Germany
    EMBO J 23:4082-95. 2004
    ....
  33. ncbi The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression
    Graham B Thomas
    Graduate Program in Neurological Sciences, Montreal, QC, Canada
    Development 134:591-600. 2007
    ....
  34. ncbi Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase
    Karen D Williams
    Department of Biology, University of Toronto, 3359 Mississauga Road, Mississauga, ON, Canada L5L 1C6
    Proc Natl Acad Sci U S A 103:15911-5. 2006
    ..melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses...
  35. ncbi Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling
    Yanlan Mao
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Development 136:473-81. 2009
    ..Our results introduce a new regulatory interaction between an adhesion protein and a Drosophila signalling pathway and highlight the extent to which the EGFR pathway must be regulated at multiple levels...
  36. ncbi Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless
    Brian Castro
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093 0349, USA
    Development 132:3333-44. 2005
    ..to direct regulation by both the proneural proteins and the N pathway transcription factor Suppressor of Hairless [Su(H)], and their activation is generally highly asymmetric; i.e...
  37. ncbi Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2
    Vern Twombly
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Genetics 183:563-79, 1SI-8SI. 2009
    ....
  38. ncbi CtBP is required for proper development of peripheral nervous system in Drosophila
    Mark D Stern
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Mech Dev 126:68-79. 2009
    ..These dCtBP phenotypes are more complex than those caused by Hairless, a known dCtBP-interacting factor that regulates bristle formation...
  39. ncbi The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants
    M Thumm
    Institut fur Biochemie, Universitat Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany
    Mol Genet Genomics 266:657-63. 2001
    ..with ct mutations, and also modifies the wing and eye phenotypes of Notch (N), Serrate (Ser), Delta (Dl), Hairless (H), deltex (dx), vestigial (vg) and strawberry notch (sno) mutants...
  40. ncbi Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis
    F Schweisguth
    Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla 92093 0322
    Development 120:1433-41. 1994
    ..We show here that the activity of Suppressor of Hairless is required for both the sensory organ precursor (SOP) versus epidermal cell fate decision, and for the trichogen ..
  41. ncbi Asymmetric cell division: from A to Z
    N Hawkins
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3204, USA
    Genes Dev 12:3625-38. 1998
  42. ncbi Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
    T L Jacobsen
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana, USA
    Development 125:4531-40. 1998
    ....
  43. ncbi A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development
    M J Go
    Department of Cell Biology and Biology, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Genetics 150:211-20. 1998
    ..These include known components in the pathway, Notch, mastermind, Delta, and Hairless, as well as two novel mutations. The first, A122, appears to interact with Notch only during bristle development...
  44. ncbi Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development
    M W Leviten
    Department of Biology, University of California San Diego, La Jolla, 92093 0366, USA
    Dev Biol 176:264-83. 1996
    ..Finally, we have found that Brd null mutants are viable and exhibit no mutant phenotypes, suggesting that Brd may be a component of an overlapping function...
  45. ncbi A genetic screen for elements of the network that regulates neurogenesis in Drosophila
    G Röttgen
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Mol Gen Genet 257:442-51. 1998
    ..Besides mutations in genes expected to modify the phenotype, we have isolated mutations in six genes not known so far to be involved in neurogenesis...
  46. ncbi The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction
    F Schweisguth
    Institut Jacques Monod, CNRS Université Paris 7, 2, place Jussieu, F 75251 Paris Cedex 05, France
    Dev Genes Evol 208:19-27. 1998
    Drosophila Hairless (H) encodes a negative regulator of Notch signalling. H activity antagonizes Notch (N) signalling during bristle development at the pupal stage...
  47. ncbi Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster
    F Schweisguth
    Institute Jacques Monod, University of Paris, France
    Dev Genet 18:28-39. 1996
    ..We also show that Notch, Hairless, and Suppressor of Hairless, three components of this intercellular signaling pathway, exhibit dose-dependent ..
  48. ncbi Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression
    D S Eastman
    Institute of Molecular Biology and Biotechnology, University of Crete, Heraklion, Greece
    Mol Cell Biol 17:5620-8. 1997
    ..regulatory regions of these two genes led to the identification of a number of target sites for the Suppressor of Hairless [Su(H)] protein, a transcription factor activated by Notch signaling...
  49. ncbi strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila
    A Majumdar
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles 90095, USA
    Genes Dev 11:1341-53. 1997
    ..In regulating these genes, sno functions in close cooperation with Suppressor of Hairless and Hairless...
  50. ncbi Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development
    D F Lyman
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA dlyman biology emory edu
    Genetics 141:1491-505. 1995
    ..Genetically, Hairless (H) acts as an antagonist of most neurogenic genes and may insulate neural precursor cells from inhibition...
  51. ncbi High nucleotide sequence variation in a region of low recombination in Drosophila simulans is consistent with the background selection model
    M T Hamblin
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Evol 13:1133-40. 1996
    ..melanogaster. Alternatively, the deleterious mutation rate may be smaller in D. simulans, or balancing selection may be acting nearby, thereby reducing the effect of background selection...
  52. ncbi The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development
    E M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, B C, V5A 1S6, Burnaby, Canada
    Mech Dev 101:119-32. 2001
    ..The expression of nemo during embryogenesis is dynamic and dsRNA inhibition and ectopic expression studies indicate that nemo is essential during embryogenesis...
  53. ncbi Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling
    S Ben-Yaacov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 152:1-13. 2001
    ..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway...
  54. ncbi A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology
    S Barolo
    Division of Biology CDB University of California, San Diego 92093, La Jolla, CA, USA
    Cell 103:957-69. 2000
    Suppressor of Hairless [Su(H)]/Lag-1/RBP-Jkappa/CBF1 is the only known transducing transcription factor for Notch receptor signaling...
  55. ncbi A screen for dominant modifiers of ro(Dom), a mutation that disrupts morphogenetic furrow progression in Drosophila, identifies groucho and hairless as regulators of atonal expression
    F Chanut
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    Genetics 156:1203-17. 2000
    ..In addition to mutations in several unknown loci, we recovered multiple alleles of groucho (gro) and Hairless (H)...
  56. ncbi Two different activities of Suppressor of Hairless during wing development in Drosophila
    T Klein
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, Germany
    Development 127:3553-66. 2000
    ..We also find that the Hairless protein interacts with Notch signalling during wing development and inhibits the activity of Su(H)...
  57. ncbi Quantitative trait loci affecting components of wing shape in Drosophila melanogaster
    E Zimmerman
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 155:671-83. 2000
    ....
  58. ncbi Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
    D Weinkove
    Ludwig Institute for Cancer Research 91 Riding House Street, W1P 8BT, Department of Biochemistry and Molecular Biology Gower Street, London, UK
    Curr Biol 9:1019-29. 1999
    ..These observations have led us to investigate the role of Dp100 and its adaptor, p60, in the control of imaginal disc cell size, cell number and organ size...
  59. ncbi Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
    F Schweisguth
    Ecole Normale Superieure, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8544, 46, rue d Ulm, 75230 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 96:11382-6. 1999
    ..These findings raise the possibility that the proteasome targets an active form of the Notch receptor for degradation in Drosophila...
  60. ncbi Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators
    D T Nellesen
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Dev Biol 213:33-53. 1999
    ..to be direct targets of transcriptional activation both by the N-signal-dependent activator Suppressor of Hairless [Su(H)] and by the proneural bHLH proteins achaete and scute...
  61. ncbi Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:1919-28. 1997
    ....

Research Grants43

  1. QTLs in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..
  2. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2007
    ..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..
  3. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2007
    ....
  4. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2006
    ..Identification of new genes affecting Drosophila behaviors will enrich our understanding of the network of genetic interactions required to produce these complex traits. ..
  5. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  6. THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS
    Trudy Mackay; Fiscal Year: 2007
    ..Trainees will receive formal training in ethics and professional development, including oral scientific presentation, and will participate in an annual student symposium as part of the training program. ..
  7. QTLs in Drosophila
    Eric A Stone; Fiscal Year: 2010
    ..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..
  8. Genetics of Alcohol Sensitivity in Drosophila
    Trudy F Mackay; Fiscal Year: 2010
    ..abstract_text> ..
  9. QTLs in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..
  10. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..
  11. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..abstract_text> ..
  12. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
    ....
  13. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
    ..Experiments are proposed to characterize signaling through Deltex. ..
  14. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2002
    ..Associations between phenotypic variation and molecular polymorphisms will be assessed. ..
  15. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 1999
    ..number loci: the achaete-scute complex (ASC), daughterless (da), scabrous (sca), extramacrochaetae (emc) and hairy (h)...
  16. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 1993
    ..Restriction map variation will be determined for the nine loci, and associations between molecular polymorphisms and phenotypic effects will be examined...