Fer2LCH

Summary

Gene Symbol: Fer2LCH
Description: Ferritin 2 light chain homologue
Alias: 2LCH, CG1469, Dmel\CG1469, Fer-H, Fer2LC, LCH, anon-EST:ParkEST264, fer2lch, l(3)00035, l(3)07016, l(3)j2A3, l(3)neo60, l(3)neo63, l(3)s2083, CG1469-PA, CG1469-PB, CG1469-PC, Fer2LCH-PA, Fer2LCH-PB, Fer2LCH-PC, Ferritin-Heavy, Ferritin-Light, ferritin, ferritin 2 light chain homologue
Species: fruit fly

Top Publications

  1. ncbi Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression
    Christoph Metzendorf
    Department of Comparative Physiology, Uppsala University, Norbyv 18A, Uppsala, Sweden
    Biochem J 421:463-71. 2009
  2. ncbi Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin
    Fanis Missirlis
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Genetics 177:89-100. 2007
  3. ncbi Characterization of mitochondrial ferritin in Drosophila
    Fanis Missirlis
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5893-8. 2006
  4. ncbi Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis
    Christoph Metzendorf
    Comparative Physiology, Uppsala University, Norbyvagen 18A, 752 36 Uppsala, Sweden
    BMC Dev Biol 10:68. 2010
  5. ncbi Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease
    Thomas Rival
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, UK
    Eur J Neurosci 29:1335-47. 2009
  6. ncbi ER stress protects from retinal degeneration
    César S Mendes
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA
    EMBO J 28:1296-307. 2009
  7. ncbi Insect iron binding proteins: insights from the genomes
    Boris Dunkov
    Department of Biochemistry and Molecular Biophysics, and Center for Insect Science, The University of Arizona, Tucson, AZ 85721, USA
    Insect Biochem Mol Biol 36:300-9. 2006
  8. ncbi Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types
    T Georgieva
    The Department of Biochemistry, University of Arizona, Tucson, AZ 85721 0088, USA
    Insect Biochem Mol Biol 32:295-302. 2002
  9. ncbi Organization of the ferritin genes in Drosophila melanogaster
    B C Dunkov
    Department of Biochemistry and the Center for Insect Science, University of Arizona, Tuscon 85721, USA
    DNA Cell Biol 18:937-44. 1999
  10. ncbi Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster
    T Georgieva
    Department of Biochemistry and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 96:2716-21. 1999

Research Grants

  1. INSECT HEME OXYGENASE
    Boris Dunkov; Fiscal Year: 2004

Scientific Experts

  • Boris C Dunkov
  • Fanis Missirlis
  • Thomas Rival
  • Christoph Metzendorf
  • T Georgieva
  • Maria I Lind
  • César S Mendes
  • K Ralchev
  • J H Law
  • Hermann Steller
  • Marie Laure Dichtel-Danjoy
  • Clémence Levet
  • Bertrand Mollereau
  • Gilles Chatelain
  • Alexis Gambis
  • Wenlin Wu
  • Antoine Fouillet
  • Pierre Dourlen
  • Hyung Don Ryoo
  • P Carrera
  • A Charlesworth
  • S Dimov
  • N Harizanova
  • A Preiss
  • S Abrell
  • B Kerber
  • H Jackle
  • M Hoch
  • U Walldorf
  • F C Kafatos
  • I Gospodov
  • C Barillas-Mury
  • N Ralcheva
  • C A Berg
  • A C Spradling

Detail Information

Publications13

  1. ncbi Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression
    Christoph Metzendorf
    Department of Comparative Physiology, Uppsala University, Norbyv 18A, Uppsala, Sweden
    Biochem J 421:463-71. 2009
    ..Compared with control cell lines, mbn-dmfrn cells had higher Fer1HCH (ferritin 1 heavy chain homologue) transcript and protein levels...
  2. ncbi Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin
    Fanis Missirlis
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Genetics 177:89-100. 2007
    b>Ferritin is a symmetric, 24-subunit iron-storage complex assembled of H and L chains...
  3. ncbi Characterization of mitochondrial ferritin in Drosophila
    Fanis Missirlis
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5893-8. 2006
    ..is known about how mitochondrial iron homeostasis is maintained, although the recent discovery of a mitochondrial ferritin in mammals and plants has uncovered a potential key player in the process...
  4. ncbi Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis
    Christoph Metzendorf
    Comparative Physiology, Uppsala University, Norbyvagen 18A, 752 36 Uppsala, Sweden
    BMC Dev Biol 10:68. 2010
    ..Here we investigate the role of Drosophila mitoferrin (dmfrn), which is a mitochondrial carrier protein with an established role in the mitochondrial iron metabolism, during spermatogenesis...
  5. ncbi Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease
    Thomas Rival
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, UK
    Eur J Neurosci 29:1335-47. 2009
    ..The effect of iron appears to be mediated by oxidative stress as ferritin heavy chain co-expression reduced carbonyl levels in Abeta(1-42) flies by 65% and restored the survival and ..
  6. ncbi ER stress protects from retinal degeneration
    César S Mendes
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA
    EMBO J 28:1296-307. 2009
    ..We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses...
  7. ncbi Insect iron binding proteins: insights from the genomes
    Boris Dunkov
    Department of Biochemistry and Molecular Biophysics, and Center for Insect Science, The University of Arizona, Tucson, AZ 85721, USA
    Insect Biochem Mol Biol 36:300-9. 2006
    ..Analysis of genes encoding new members of the Tsf family and non-secreted ferritin subunits allows making preliminary hypotheses about their possible functions and opens possibilities to study ..
  8. ncbi Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types
    T Georgieva
    The Department of Biochemistry, University of Arizona, Tucson, AZ 85721 0088, USA
    Insect Biochem Mol Biol 32:295-302. 2002
    Drosophila melanogaster secreted ferritin like the cytosolic ferritins of other organisms is composed of two subunits, a heavy chain homologue (HCH) and a light chain homologue (LCH)...
  9. ncbi Organization of the ferritin genes in Drosophila melanogaster
    B C Dunkov
    Department of Biochemistry and the Center for Insect Science, University of Arizona, Tuscon 85721, USA
    DNA Cell Biol 18:937-44. 1999
    ..encoding the heavy-chain homolog (HCH) and the light-chain homolog (LCH) subunits of Drosophila melanogaster ferritin are reported here...
  10. ncbi Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster
    T Georgieva
    Department of Biochemistry and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 96:2716-21. 1999
    ..Cloning and sequence of the heavy chain homologue (HCH) of Drosophila melanogaster ferritin subunit have been reported earlier. When Northern blots of D...
  11. ncbi A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo
    P Carrera
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 95:10779-84. 1998
    ..The results indicate that the Kr gain-of-function mutation If provides a tool to identify genes that are active during eye development and that a number of them function also in the control of Kr-dependent developmental processes...
  12. ncbi Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome
    A Charlesworth
    The European Molecular Biology Laboratory, Heidelberg, Germany
    Eur J Biochem 247:470-5. 1997
    b>Ferritin was purified from iron-fed Drosophila melanogaster extracts by centrifugation in a gradient of potassium bromide...
  13. ncbi Studies on the rate and site-specificity of P element transposition
    C A Berg
    Howard Hughes Medical Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genetics 127:515-24. 1991
    ..During the course of these experiments, Y-linked insertions expressing rosy+ were recovered, suggesting that marked P elements can sometimes insert and function at heterochromatic sites...

Research Grants4

  1. INSECT HEME OXYGENASE
    Boris Dunkov; Fiscal Year: 2004
    ..The organ specific expression will be studied in larvae and in female mosquitoes at various stages before and after blood feeding. ..