CycC

Summary

Gene Symbol: CycC
Description: Cyclin C
Alias: CG1C_DROME, CG7281, Cln3, Cyc-C, DmcycC, Dmel\CG7281, SRB11, cycC, cyclinC, dTRAP33, CG7281-PA, CycC-PA, cyclin C
Species: fruit fly

Top Publications

  1. ncbi An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins
    P Leopold
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 66:1207-16. 1991
  2. ncbi A genetic screen identifies novel polycomb group genes in Drosophila
    Andrés Gaytán de Ayala Alonso
    EMBL, Gene Expression Programme, Meyerhoffstrasse 1, 69117 Heidelberg, Germany
    Genetics 176:2099-108. 2007
  3. ncbi Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    Nicolas Loncle
    Centre de Biologie du Developpement, UMR5544 du CNRS, Universite Paul Sabatier, Toulouse Cedex 09, France
    EMBO J 26:1045-54. 2007
  4. ncbi SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex
    Claudia B Zraly
    Oncology Institute, Cardinal Bernardin Cancer Center, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA
    Genetics 168:199-214. 2004
  5. ncbi Transcription regulation and animal diversity
    Michael Levine
    Department of Molecular and Cell Biology, Division of Genetics and Development, Center for Integrative Genomics, University of California, Berkeley, 401 Barker Hall, Berkeley, California 94720, USA
    Nature 424:147-51. 2003
  6. ncbi Endoreplication cell cycles: more for less
    B A Edgar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA 98109, USA
    Cell 105:297-306. 2001
  7. ncbi Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development
    J Secombe
    Department of Genetics, University of Adelaide, South Australia, Australia, 5005
    Genetics 149:1867-82. 1998
  8. ncbi Identification of a cyclin subunit required for the function of Drosophila P-TEFb
    J Peng
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 273:13855-60. 1998
  9. ncbi roughex down-regulates G2 cyclins in G1
    B J Thomas
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 11:1289-98. 1997
  10. ncbi Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II
    V Leclerc
    URA 671 Centre National de la Recherche Scientifique, Villefranche sur Mer, France
    Mol Biol Cell 7:505-13. 1996

Research Grants

  1. Growth Regulation during Drosophila Development
    BRUCE EDGAR; Fiscal Year: 2006
  2. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2006
  3. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2007
  4. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
  5. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2007
  6. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2007
  7. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
  8. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 2002
  9. GROWTH-REGULATORY TARGETS OF DROSOPHILA CYCLIND/CDK4
    BRUCE EDGAR; Fiscal Year: 2003
  10. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2009

Scientific Experts

  • Michael Levine
  • BRUCE EDGAR
  • B J Thomas
  • Ines Carrera
  • Nicolas Loncle
  • Andrés Gaytán de Ayala Alonso
  • Claudia B Zraly
  • Nina Leeds
  • Jessica E Treisman
  • H Richardson
  • Fabien Duveau
  • Florence Janody
  • Claire Boschiero
  • Bernadett Papp
  • Michel Werner
  • Muriel Boube
  • Dirk Beuchle
  • Luis Gutierrez
  • David L Cribbs
  • Jurg Muller
  • Cornelia Fritsch
  • Laurent Joulia
  • Henri-Marc Bourbon
  • Henri Marc Bourbon
  • J Secombe
  • J Peng
  • Daniel R Marenda
  • Andrew K Dingwall
  • R Saint
  • V Leclerc
  • T L Orr-Weaver
  • D H Price
  • N F Marshall
  • P Leopold
  • J Pispa
  • P H O'Farrell
  • J P Tassan
  • E A Nigg
  • T Marty
  • L V O'Keefe
  • E E Lahue
  • A V Smith

Detail Information

Publications14

  1. ncbi An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins
    P Leopold
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 66:1207-16. 1991
    ..The second encodes a distant and new member of the cyclin family of proteins, cyclin C. It is highly homologous (72% identity) to a human clone isolated in a similar screen...
  2. ncbi A genetic screen identifies novel polycomb group genes in Drosophila
    Andrés Gaytán de Ayala Alonso
    EMBL, Gene Expression Programme, Meyerhoffstrasse 1, 69117 Heidelberg, Germany
    Genetics 176:2099-108. 2007
    ..In addition, our studies reveal that the Kto/Med12 and Skd/Med13 subunits of the Med12.Med13.Cdk8.CycC repressor subcomplex of Mediator are needed for repression of the HOX gene Ubx...
  3. ncbi Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    Nicolas Loncle
    Centre de Biologie du Developpement, UMR5544 du CNRS, Universite Paul Sabatier, Toulouse Cedex 09, France
    EMBO J 26:1045-54. 2007
    ..in three core modules and a separable 'Cdk8 module' consisting of the cyclin-dependent kinase Cdk8, its partner CycC, Med12 and Med13...
  4. ncbi SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex
    Claudia B Zraly
    Oncology Institute, Cardinal Bernardin Cancer Center, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA
    Genetics 168:199-214. 2004
    ..Thus, in addition to important functions of the Brm complex in G1-S control, the complex also appears to be important for transcription of genes required for cell cycle progression...
  5. ncbi Transcription regulation and animal diversity
    Michael Levine
    Department of Molecular and Cell Biology, Division of Genetics and Development, Center for Integrative Genomics, University of California, Berkeley, 401 Barker Hall, Berkeley, California 94720, USA
    Nature 424:147-51. 2003
    ..How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression...
  6. ncbi Endoreplication cell cycles: more for less
    B A Edgar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA 98109, USA
    Cell 105:297-306. 2001
  7. ncbi Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development
    J Secombe
    Department of Genetics, University of Adelaide, South Australia, Australia, 5005
    Genetics 149:1867-82. 1998
    ..In addition, this analysis has identified cyclin A and string as DmcycEJP interactors, suggesting a novel role for cyclin E in the regulation of Cyclin A and String function during eye development...
  8. ncbi Identification of a cyclin subunit required for the function of Drosophila P-TEFb
    J Peng
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 273:13855-60. 1998
    ..Deletion of the carboxyl-terminal domain of cyclin T in P-TEFb reduced both the kinase and transcription activity to about 10%. The CDK-activating kinase in TFIIH was unable to activate the CTD kinase activity of P-TEFb...
  9. ncbi roughex down-regulates G2 cyclins in G1
    B J Thomas
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 11:1289-98. 1997
    ..These data argue that Roughex inhibits Cyclin A accumulation in early G1 by targeting Cyclin A for destruction. In late G1, Roughex is destabilized in a Cyclin E-dependent process, releasing Cyclin A for its role in S/G2...
  10. ncbi Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II
    V Leclerc
    URA 671 Centre National de la Recherche Scientifique, Villefranche sur Mer, France
    Mol Biol Cell 7:505-13. 1996
    ..b>Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock-out ..
  11. ncbi Developmental modification of the Drosophila cell cycle
    T L Orr-Weaver
    Whitehead Institute, Cambridge, MA
    Trends Genet 10:321-7. 1994
    ..The field is now poised for the identification of the intervening steps between the developmental signals and their ultimate effects on known cell cycle regulators...
  12. ncbi Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc
    H Richardson
    Department of Genetics, University of Adelaide, South Australia
    Development 121:3371-9. 1995
    ..These results demonstrate that the role of cyclin E in regulating progression into S phase in mammalian tissue culture cells applies to some, but not all, cells during Drosophila development.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi A novel cyclin gene from Drosophila complements CLN function in yeast
    E E Lahue
    Whitehead Institute, Cambridge, Massachusetts
    Genes Dev 5:2166-75. 1991
    ..Drosophila embryos hybridized in situ to this cyclin gene show uniform expression of the message throughout the embryo, with diminishing expression as embryogenesis proceeds...
  14. ncbi Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
    Ines Carrera
    Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:6644-9. 2008
    ..II-dependent genes; it associates with an accessory subcomplex consisting of the Med12, Med13, Cdk8, and Cyclin C subunits...

Research Grants33

  1. Growth Regulation during Drosophila Development
    BRUCE EDGAR; Fiscal Year: 2006
    ..It has relevance to medical conditions involving cell and tissue growth including cancer diagnosis and therapy, regeneration, wound healing, diabetes and other metabolic diseases. ..
  2. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2006
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..
  3. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2007
    ....
  4. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. ..
  5. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2007
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..
  6. Developmental control of cell cycle exit
    BRUCE EDGAR; Fiscal Year: 2007
    ..abstract_text> ..
  7. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  8. GROWTH CONTROL IN THE DROSOPHILA WING
    BRUCE EDGAR; Fiscal Year: 2002
    ..Thus we expect this work to be highly relevant to growth control in human development, tissue homeostasis, wound healing, and regeneration. ..
  9. GROWTH-REGULATORY TARGETS OF DROSOPHILA CYCLIND/CDK4
    BRUCE EDGAR; Fiscal Year: 2003
    ..The identification of growth regulatory genes in flies should also provide entry points for studies of cell growth control in humans during both normal and neoplastic development. ..
  10. Growth regulatory targets of the Tuberous Sclerosis Complex
    BRUCE EDGAR; Fiscal Year: 2009
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..