CG8188

Summary

Gene Symbol: CG8188
Description: CG8188 gene product from transcript CG8188-RB
Alias: Dmel\CG8188, Ubc, CG8188-PA, CG8188-PB
Species: fruit fly

Top Publications

  1. ncbi DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    M Petronczki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Cell Biol 3:43-9. 2001
  2. ncbi Photic signaling by cryptochrome in the Drosophila circadian system
    F J Lin
    Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:7287-94. 2001
  3. ncbi Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila
    Lei Xue
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06536, USA
    Dev Cell 13:446-54. 2007
  4. ncbi Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination
    M Guy Roukens
    Leiden University Medical Center LUMC, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 28:4394-406. 2008
  5. ncbi Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein
    Margarita E Kaplow
    Department of Biology, City College and The Graduate Center, City University of New York, New York 10031, USA
    Genetics 178:2003-16. 2008
  6. ncbi Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
    Jop Kind
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 133:813-28. 2008
  7. ncbi Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases
    Margherita Galletti
    Department of Biology, City College of the City University of New York, 138th at Convent Ave, New York, NY 10031, USA
    Mol Cell Biol 29:3424-34. 2009
  8. ncbi NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
    Yousuf O Ali
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Hum Mol Genet 21:237-50. 2012

Scientific Experts

  • David A Baker
  • Yousuf O Ali
  • Margherita Galletti
  • M Guy Roukens
  • Jop Kind
  • Margarita E Kaplow
  • Lei Xue
  • M Petronczki
  • R Grace Zhai
  • F J Lin
  • Kai Ruan
  • Daniela Grifoni
  • Florenci Serras
  • Paola Bellosta
  • Mahesh Kumar Saqcena
  • Federica Parisi
  • Sara Riccardo
  • Bonnie Wong
  • Leinny Rivas
  • PierGiuseppe Pelicci
  • Jin Jiang
  • Alexis Serra
  • Carlina Lora
  • Marc Gentzel
  • Paul Bertone
  • Juan M Vaquerizas
  • Nicholas M Luscombe
  • Philipp Gebhardt
  • Asifa Akhtar
  • Mariam Alloul-Ramdhani
  • Tadmiri R Venkatesh
  • Adam H Korayem
  • Marjolein Op den Brouw
  • Setareh Moghadasi
  • Tatsushi Igaki
  • Masayuki Miura
  • Tian Xu
  • Hiroshi Kanda
  • Erina Kuranaga
  • N Naidoo
  • W Song
  • A Sehgal
  • J A Knoblich
  • E Meyer-Bernstein

Detail Information

Publications8

  1. ncbi DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    M Petronczki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Cell Biol 3:43-9. 2001
    ....
  2. ncbi Photic signaling by cryptochrome in the Drosophila circadian system
    F J Lin
    Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:7287-94. 2001
    ..High levels of CRY block TIM ubiquitination, suggesting a mechanism by which light-driven changes in CRY could control TIM ubiquitination...
  3. ncbi Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila
    Lei Xue
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06536, USA
    Dev Cell 13:446-54. 2007
    ..These data provide a molecular mechanism for the tumor suppressor function of this evolutionary conserved molecule by indicating that dCYLD plays a critical role in modulating TNF-JNK-mediated cell death...
  4. ncbi Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination
    M Guy Roukens
    Leiden University Medical Center LUMC, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 28:4394-406. 2008
    ..Here, we found that Fbl6 regulates Tel/Yan protein stability and allows appropriate spatiotemporal control of gene expression by these repressors...
  5. ncbi Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein
    Margarita E Kaplow
    Department of Biology, City College and The Graduate Center, City University of New York, New York 10031, USA
    Genetics 178:2003-16. 2008
    ..We propose that Rap/Fzr targets Loco for ubiquitination, thereby regulating glial differentiation in the developing nervous system...
  6. ncbi Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
    Jop Kind
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 133:813-28. 2008
    ..Therefore, MOF is not only involved in the onset of dosage compensation, but also acts as a regulator of gene expression in the Drosophila genome...
  7. ncbi Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases
    Margherita Galletti
    Department of Biology, City College of the City University of New York, 138th at Convent Ave, New York, NY 10031, USA
    Mol Cell Biol 29:3424-34. 2009
    ..Expression of the dMyc mutants in the compound eye of the adult fly results in a visible defect that is attributed to the effect of dMyc on growth, cell death, and inhibition of ommatidial differentiation...
  8. ncbi NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
    Yousuf O Ali
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Hum Mol Genet 21:237-50. 2012
    ..Our report on the molecular basis of NMNAT-mediated neuroprotection in tauopathies opens future investigation of this factor in other protein foldopathies...