C15

Summary

Gene Symbol: C15
Description: CG7937 gene product from transcript CG7937-RA
Alias: 311, 93Bal, CG7937, Cll, Dmel\CG7937, Ect5, Hox11-311, c15, cll, C15-PA, CG7937-PA, clawless
Species: fruit fly

Top Publications

  1. ncbi A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes
    T N Dear
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Gene 141:225-9. 1994
  2. ncbi Stalled Hox promoters as chromosomal boundaries
    Vivek S Chopra
    Department of Molecular and Cellular Biology, Division of Genetics, Genomics, and Development, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 23:1505-9. 2009
  3. ncbi Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites
    Jiandong Liu
    Development and Aging Program, Center for Neuroscienes, Aging and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 313:876-86. 2008
  4. ncbi Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus
    Reiko Tajiri
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Biol 303:461-73. 2007
  5. ncbi Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues
    Meng chi Lin
    Department of Biology, New York University, New York, NY 10003, USA
    Development 133:4805-13. 2006
  6. ncbi Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes
    Keiichiro Yasunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 123:893-906. 2006
  7. ncbi Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila
    Mayuko Takahashi
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 132:2547-59. 2005
  8. ncbi A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg
    Tetsuya Kojima
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Biol 279:434-45. 2005
  9. ncbi Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15
    Gerard Campbell
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Dev Biol 278:607-18. 2005
  10. ncbi The ladybird homeobox genes are essential for the specification of a subpopulation of neural cells
    Fabienne De Graeve
    Faculte de Medecine, UMR INSERM 384, 63000 Clermont Ferrand, France
    Dev Biol 270:122-34. 2004

Research Grants

  1. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
  2. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Gerard Campbell; Fiscal Year: 2007
  3. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Gerard Campbell; Fiscal Year: 2009
  4. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010

Scientific Experts

  • Tetsuya Kojima
  • GERARD L CAMPBELL
  • Fabienne De Graeve
  • Vivek S Chopra
  • Kaoru Saigo
  • Ken Ichi Miyazono
  • Jiandong Liu
  • Reiko Tajiri
  • Meng chi Lin
  • Keiichiro Yasunaga
  • Mayuko Takahashi
  • Martina Zikova
  • Masaru Tanokura
  • Yuehua Zhi
  • Yuriko Takamura
  • Koji Nagata
  • Rolf Bodmer
  • Xiushan Wu
  • Li Qian
  • Zhe Han
  • Ryu Ueda
  • Takuya Tsuji
  • Nikolai Kirov
  • Meng-Chi Lin
  • Christine Rushlow
  • Jeongsook Park
  • Fumitaka Takahashi
  • Kumiko Ui-Tei
  • T N Dear
  • Jean-Philippe Da Ponte
  • Bernard Dastugue
  • Krzysztof Jagla
  • Jean Philippe Da Ponte
  • T H Rabbitts
  • I Sanchez-Garcia

Detail Information

Publications13

  1. ncbi A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes
    T N Dear
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Gene 141:225-9. 1994
    ..To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the ..
  2. ncbi Stalled Hox promoters as chromosomal boundaries
    Vivek S Chopra
    Department of Molecular and Cellular Biology, Division of Genetics, Genomics, and Development, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 23:1505-9. 2009
    ..Thus, promoter-proximal stalling factors might help promote insulator-promoter interactions. We propose that stalled promoters help organize gene complexes within chromosomal loop domains...
  3. ncbi Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites
    Jiandong Liu
    Development and Aging Program, Center for Neuroscienes, Aging and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 313:876-86. 2008
    ..Our data suggest that a combination of factors is likely to interact with multiple essential repressor sites to confer precise spatial specificity of eve expression in the cardiac mesoderm...
  4. ncbi Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus
    Reiko Tajiri
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Biol 303:461-73. 2007
    ..by interactions between tarsus homeobox genes (BarH1 and BarH2) and pretarsus homeobox genes (aristaless, clawless, and Lim1)...
  5. ncbi Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues
    Meng chi Lin
    Department of Biology, New York University, New York, NY 10003, USA
    Development 133:4805-13. 2006
    ..We analyzed the regulation of the C15 gene, which can be activated in cells containing intermediate levels of Dpp...
  6. ncbi Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes
    Keiichiro Yasunaga
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 123:893-906. 2006
    ..In wild-type labial discs, clawless, one of the two homeobox genes expressed in distal cells receiving maximum (Decapentaplegic+Wingless) signaling ..
  7. ncbi Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila
    Mayuko Takahashi
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 132:2547-59. 2005
    ..Src42A and Src64 were required for Armadillo tyrosine residue phosphorylation but Src activity may not be directly involved in Armadillo tyrosine residue phosphorylation at the adherens junction...
  8. ncbi A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg
    Tetsuya Kojima
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Biol 279:434-45. 2005
    ..Here, we show that one additional gene, clawless, which is a homolog of vertebrate Hox11/tlx homeobox gene family and formerly known as C15, is specifically ..
  9. ncbi Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15
    Gerard Campbell
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Dev Biol 278:607-18. 2005
    ..Here, this factor is identified as the product of the C15 gene, which is another homeodomain protein, a homolog of the human Hox11 oncogene...
  10. ncbi The ladybird homeobox genes are essential for the specification of a subpopulation of neural cells
    Fabienne De Graeve
    Faculte de Medecine, UMR INSERM 384, 63000 Clermont Ferrand, France
    Dev Biol 270:122-34. 2004
    ....
  11. ncbi Patterning of the cardiac outflow region in Drosophila
    Martina Zikova
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Faculte de Medecine, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Proc Natl Acad Sci U S A 100:12189-94. 2003
    ....
  12. ncbi The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes
    T N Dear
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 90:4431-5. 1993
    ..These all contain a threonine residue in place of the more common isoleucine or valine in helix 3 of the homeodomain. HOX11 therefore appears to belong to a family of DNA-binding transactivators of transcription...
  13. ncbi Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless
    Ken Ichi Miyazono
    Department of Applied Biological Chemistry, University of Tokyo, Bunkyo ku, Tokyo, Japan
    EMBO J 29:1613-23. 2010
    ..We report a ternary complex structure containing two homeodomain proteins, aristaless (Al) and clawless (Cll), bound to DNA...

Research Grants9

  1. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  2. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Gerard Campbell; Fiscal Year: 2007
    ..provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one corepressor...
  3. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Gerard Campbell; Fiscal Year: 2009
    ..provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one corepressor...
  4. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..provide all the activity required for a TF to function, but real TFs such as the Brinker (Brk), Engrailed (En) and C15 proteins of Drosophila possess multiple RDs and appear to be able to recruit more than one corepressor...