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Genomes and Genes | c(3)GSummaryGene Symbol: c(3)G Description: crossover suppressor on 3 of Gowen Alias: C3G, CG17604, Dmel\CG17604, c3G, CG17604-PA, CG17604-PB, CG17604-PC, c(3)G-PA, c(3)G-PB, c(3)G-PC, crossover suppressor in chromosome 3 of gowen, crossover suppressor on 3 of gowan, crossover suppressor on 3 of gowen Species: fruit fly Top Publications
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Publications
All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygoteWei J Gong
Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
PLoS Genet 1:e67. 2005....- An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint controlEric Staeva-Vieira
Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, Sackler Institute for Graduate Biomedical Sciences, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
EMBO J 22:5863-74. 2003..We therefore propose that under normal conditions a second, Rad51-independent, repair pathway prevents the lethal effects of DNA damage... - Drosophila BubR1 is essential for meiotic sister-chromatid cohesion and maintenance of synaptonemal complexNicolas Malmanche
Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180, Porto, Portugal
Curr Biol 17:1489-97. 2007..Our results demonstrate that BubR1 is essential to maintain sister-chromatid cohesion during meiotic progression in both sexes and for normal maintenance of SC in females... - Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila femalesS Mehrotra
Waksman Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
PLoS Genet 2:e200. 2006..From a comparison of the frequency of gamma-His2Av foci and crossovers, it appears that Drosophila females have only a weak mechanism to ensure a crossover in the presence of a low number of DSBs... - Regulation of meiotic cohesion and chromosome core morphogenesis during pachytene in Drosophila oocytesRadhika S Khetani
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
J Cell Sci 120:3123-37. 2007..We present a model for how chromosome cores are assembled during Drosophila meiosis and the role of ORD in meiotic cohesion, chromosome core maintenance and homologous recombination... - Meiotic recombination in Drosophila females depends on chromosome continuity between genetically defined boundariesDalia Sherizen
Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
Genetics 169:767-81. 2005..These sites are not required for homolog pairing. Instead, the initiation of meiotic recombination requires continuity of the meiotic chromosome structure within each of these domains... - c(3)G encodes a Drosophila synaptonemal complex proteinS L Page
Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
Genes Dev 15:3130-43. 2001The meiotic mutant c(3)G (crossover suppressor on 3 of Gowen) abolishes both synaptonemal complex (SC) formation and meiotic recombination, whereas mutations in the mei-W68 and mei-P22 genes prevent recombination but allow normal SC to .. - Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complexLorinda K Anderson
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
Proc Natl Acad Sci U S A 102:4482-7. 2005..Based on our data and the known phenotypes of C(2)M and C(3)G mutants, we propose a model of SC structure in which C(2)M links C(3)G to the LEs... - Relationship of DNA double-strand breaks to synapsis in DrosophilaJanet K Jang
Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, 190 Frelinghuysen Rd, Piscataway, New Jersey 08854 8020, USA
J Cell Sci 116:3069-77. 2003..There may also be an interaction between the recruitment of repair proteins and phosphorylation... - Chromosome segregation influenced by two alleles of the meiotic mutant c(3)G in Drosophila melanogasterJ C Hall
Genetics 71:367-400. 1972 - The Synaptonemal complex component C(2)M regulates meiotic crossing over in DrosophilaElizabeth A Manheim
Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Curr Biol 13:276-85. 2003..Previous studies have suggested that the SC is required for meiotic crossing over in Drosophila. However, only one component of this structure, C(3)G, has been identified in Drosophila... - A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytesIrena Ivanovska
Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genes Dev 19:2571-82. 2005..These studies reveal a critical role for histone modifications in chromosome dynamics in meiosis and mitosis... - The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombinationJennifer K Jeffress
Stowers Institute for Medical Research, Kansas City, Kansas, USA
Genetics 177:2445-56. 2007.... - mei-P22 encodes a chromosome-associated protein required for the initiation of meiotic recombination in Drosophila melanogasterHao Liu
Waksman Institute and Department of Genetics, Rutgers State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
Genetics 162:245-58. 2002..We propose that MEI-P22 interacts with meiosis-specific chromosome proteins to facilitate DSB creation by MEI-W68... - The cohesion protein ORD is required for homologue bias during meiotic recombinationHayley A Webber
Dept of Biological Sciences, Dartmouth College, 6044 Gilman, Hanover, NH 03755, USA
J Cell Biol 164:819-29. 2004..We conclude that ORD activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, thereby promoting homologue bias during meiotic recombination in Drosophila... - The effects of inversions and the C(3)G mutation on intragenic recombination in DrosophilaP S Carlson
Genet Res 19:129-32. 1972 - The Drosophila meiotic mutant mei-352 is an allele of klp3A and reveals a role for a kinesin-like protein in crossover distributionScott L Page
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Genetics 170:1797-807. 2005.... - Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogasterAi Khim Lim
Germ Line Biology Laboratory, Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, 1 Research Link, Singapore
Proc Natl Acad Sci U S A 104:6714-9. 2007..Hence, our data suggest that the nuage functions as a specialized center that protects the genome in the germ-line cells via gene regulation mediated by repeat-associated small interfering RNAs... - Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in DrosophilaYu Chen
Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Curr Biol 17:637-42. 2007.... - Interaction between Polo and BicD proteins links oocyte determination and meiosis control in DrosophilaVincent Mirouse
INSERM, U384, Clermont Ferrand, F 63001 France
Development 133:4005-13. 2006..Taken together, our data indicate the existence of a positive feedback loop between BicD and Polo, and we propose that this loop represents a functional link between oocyte specification and the control of meiosis... - Drosophila mus301/spindle-C encodes a helicase with an essential role in double-strand DNA break repair and meiotic progressionRuth McCaffrey
MRC Laboratory of Molecular Biology, The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, United Kingdom
Genetics 174:1273-85. 2006..However, neither mei-W68 nor mei-41 rescue the defects in oocyte specification of mus301 mutants, suggesting that this helicase has another function in oocyte selection that is independent from its role in meiotic recombination... - fused regulates germline cyst mitosis and differentiation during Drosophila oogenesisKarine Narbonne-Reveau
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Mech Dev 123:197-209. 2006.... - A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progressionVitor Barbosa
Howard Hughes Medical Institute and the Kimmel Center for Biology and Medicine, Skirball Institute, 540 First Avenue, New York, NY 10016, USA
Genetics 176:1967-77. 2007.... - A genetic analysis of the Drosophila mcm5 gene defines a domain specifically required for meiotic recombinationCathleen M Lake
Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
Genetics 176:2151-63. 2007..These results strengthen the observation that members of the prereplicative complex have multiple functions and provide evidence that mcm5 plays a critical role in the meiotic recombination pathway... - Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogasterJordan P Lewandowski
Cell and Molecular Biology Graduate Program, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
Dev Biol 339:307-19. 2010..Our results indicate that Ranshi interacts with the exon junction complex to localize components essential for oocyte differentiation within the posterior pole of the presumptive oocyte... - The Drosophila hus1 gene is required for homologous recombination repair during meiosisGabriella Peretz
Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben Gurion University, POB 653, Beer Sheva 84105, Israel
Mech Dev 126:677-86. 2009..Together, our results imply that hus1 is required for repair of DSBs during meiotic recombination... - Heterochromatic genome stability requires regulators of histone H3 K9 methylationJamy C Peng
Lawrence Berkeley National Laboratory, Department of Genome and Computational Biology, Berkeley, California, USA
PLoS Genet 5:e1000435. 2009..Similar effects of lower magnitude were observed in animals that lack the RNA interference pathway component Dcr2. These results suggest that the H3K9 methylation and RNAi pathways ensure heterochromatin stability... - The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phaseKarine Narbonne-Reveau
Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 20:1960-9. 2009..Finally, we report that dap(-/-) ovarian cysts frequently undergo an extramitotic division before meiotic entry, indicating that Dap influences the timing of the mitotic/meiotic transition... - Mutations in the chromosomal passenger complex and the condensin complex differentially affect synaptonemal complex disassembly and metaphase I configuration in Drosophila female meiosisTamar D Resnick
Whitehead Institute for Biomedical Research, and the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genetics 181:875-87. 2009..The dcap-g and incenp mutations cause maternal effect lethality, with embryos from mutant mothers arrested in the initial mitotic divisions... - Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formationEric F Joyce
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
Genetics 181:39-51. 2009..Interestingly, PCH2-dependent delays in prophase may allow additional crossovers to form... - A germline clone screen for meiotic mutants in Drosophila melanogasterScott L Page
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Fly (Austin) 1:172-81. 2007..This study demonstrates the utility of germline clone-based screens for the discovery of strong meiotic mutants, including mutations in essential genes, and the use of molecular genetic techniques to map the loci... - Corona is required for higher-order assembly of transverse filaments into full-length synaptonemal complex in Drosophila oocytesScott L Page
Comparative Genomics Centre, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia
PLoS Genet 4:e1000194. 2008.... - Components of the RNAi machinery that mediate long-distance chromosomal associations are dispensable for meiotic and early somatic homolog pairing in Drosophila melanogasterJustin P Blumenstiel
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Genetics 180:1355-65. 2008..Thus, there appears to be at least two mechanisms that bring homologous sequences together within the nucleus: those that act between dispersed homologous sequences and those that act to align and pair homologous chromosomes... - PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in DrosophilaPerrine Benoit
mRNA Regulation and Development, Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
Development 135:1969-79. 2008..We conclude that two distinct poly(A) polymerases have a role in cytoplasmic polyadenylation in the female germline, each of them being specifically required for different steps of oogenesis... - Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cellsMaria Gause
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
Chromosoma 117:51-66. 2008..These results support the idea that direct regulation of cohesin function underlies the diverse functions of Nipped-B and its orthologs... - Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specificationDavid H Parma
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
Dev Biol 308:507-19. 2007..On the other hand, Tsunagi/Y14 is essential for restricting oocyte fate to a single cell and may function with mago nashi in this process... - MAMO, a maternal BTB/POZ-Zn-finger protein enriched in germline progenitors is required for the production of functional eggs in DrosophilaMasanori Mukai
Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
Mech Dev 124:570-83. 2007..We propose that maternal MAMO activates downstream genes to promote specialized morphological changes of both female meiotic chromosomes and the sperm nucleus, which are critical in zygote formation... - Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein TejasVeena S Patil
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore
Curr Biol 20:724-30. 2010..Aub and Spn-E also bind to the tudor domain at the C terminus. Our data suggest that Tej contributes to the formation of a macromolecular complex at perinuclear region and engages it in the production of germline piRNAs... - Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytesIsamu Sugimura
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Dev Cell 10:127-35. 2006.... - Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosisSharon E Thomas
Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
Cell 123:555-68. 2005..SNM and MNM do not colocalize with SMC1, suggesting that the homolog conjunction mechanism is independent of cohesin... - Damage control: the pleiotropy of DNA repair genes in Drosophila melanogasterJ J Sekelsky
Department of Genetics, Section of Molecular and Cellular Biology, University of California, Davis 95616, USA
Genetics 148:1587-98. 1998 - Meiosis as an "M" thing: twenty-five years of meiotic mutants in DrosophilaR S Hawley
Department of Genetics, University of California, Davis 95616
Genetics 135:613-8. 1993 - Meiotic segregation in Drosophila melanogaster females: molecules, mechanisms, and mythsR S Hawley
Department of Genetics, University of California at Davis 95616
Annu Rev Genet 27:281-317. 1993 - Enhancement of recombination associated with the c3G mutant of Drosophila melanogasterC W Hinton
Genetics 53:157-64. 1966 - The meiotic mechanics of ring chromosomes in female Drosophila melanogasterL Sandler
Natl Cancer Inst Monogr 18:243-73. 1965 - Genetic control of synaptonemal complexes in Drosophila melanogasterP A Smith
Genetics 60:335-51. 1968 - Some components of x ray-induced crossing over in females of Drosophila melanogasterP A Roberts
Genetics 63:387-404. 1969 - X-ray induced mitotic recombination in Drosophila melanogaster. 3. Dose dependence of the "pairing" componentJ Haendle
Mol Gen Genet 128:233-9. 1974 - An enhancement of the yield of X-ray-induced Minute mutations in the c3G female-ywmf-2 male system of Drosophila melanogasterT Miyamoto
Laboratory of Natural Sciences, Takamatsu Junior College, Japan
Mutat Res 283:271-8. 1992The possible enhancement of the yield of X-ray-induced Minute mutations in the c3G female-ywmf-2 male system which is proposed to be responsible for the high production of spontaneous Minute mutations was investigated... - Cytogenetic analysis of chromosome region 89A of Drosophila melanogaster: isolation of deficiencies and mapping of Po, Aldox-1 and transposon insertionsC R Nelson
Department of Biological Chemistry, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
Mol Gen Genet 235:11-21. 1992..A revised cytogenetic map of the 88F-89B region is presented... - Dissection of chromosome region 89A of Drosophila melanogaster by local transposition of P elementsH Matsubayashi
Department of Applied Biology, Kyoto Institute of Technology, Japan
Genes Genet Syst 73:95-103. 1998In the chromosome region 89A of Drosophila melanogaster, a few meiotic genes have been suggested to exist besides c3G and rec... - The role of BicD, Egl, Orb and the microtubules in the restriction of meiosis to the Drosophila oocyteJ R Huynh
The Wellcome CRC Institute and the Department of Genetics, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QR, UK
Development 127:2785-94. 2000..These results lead us to propose a model in which BicD, Egl and Orb control entry into meiosis by regulating translation... - Hanging on to your homolog: the roles of pairing, synapsis and recombination in the maintenance of homolog adhesionM Y Walker
Department of Genetics, University of California at Davis 95616, USA
Chromosoma 109:3-9. 2000..It thus seems possible that the synaptonemal complex plays a role both in maintaining homolog adhesion during meiotic prophase and, more speculatively, in facilitating meiotic exchange... - Studies on a recombination-deficient mutant of Drosophila. I. Dominant lethalsW A Watson
Mutat Res 8:91-100. 1969 - The Drosophila meiotic kleisin C(2)M functions before the meiotic divisionsDoris Heidmann
Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
Chromosoma 113:177-87. 2004..Therefore, C(2)M appears to function within the synaptonemal complex during prophase I but possibly not thereafter. This suggests that C(2)M may not confer sister chromatid cohesion needed for meiosis I and II chromosome segregation... - Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fateCaryn Navarro
Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute and Howard Hughes Medical Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Nat Cell Biol 6:427-35. 2004..Our data provide a direct link between a molecule necessary for oocyte specification and the microtubule motor complex, and supports the hypothesis that microtubule-mediated transport is important for preserving oocyte fate... - A spectraplakin is enriched on the fusome and organizes microtubules during oocyte specification in DrosophilaKatja Röper
Wellcome Trust Cancer Research UK Institute and Department of Anatomy, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
Curr Biol 14:99-110. 2004..The fusome is necessary for the microtubule-driven restriction of markers of oocyte fate to the oocyte, but the mechanism by which the fusome organizes the microtubules is not known... - The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis IAmy Hong
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 130:1235-42. 2003..Our data indicate that it is through the differential regulation of the cki Dacapo that two modes of cell-cycle regulation are independently maintained within the common cytoplasm of ovarian cysts... - Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuageSeth D Findley
Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195 7350, USA
Development 130:859-71. 2003..Furthermore, maelstrom mutant ovaries show mislocalization of two proteins involved in the microRNA and/or RNAi pathways, Dicer and Argonaute2, suggesting a potential connection between nuage and the microRNA-pathway... - [CG17604 gene from Drosophila melanogaster--possible functional homolog of the yeast ZIP1 and SCP1 (SYCP1) mammalian genes, coding for synaptonemal complex proteins]Iu F Bogdanov
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia
Genetika 38:108-12. 2002..the locus of this gene (sections 88E-89B) and containing 78 predicted genes has revealed only one gene, CG17604, whose protein meets all requirements for the transverse filament protein of the SC... - The isolation of a mutation causing abnormal cytokinesis in male and split chromocenter in female meiosis in Drosophila melanogasterS Fedorova
Institute Cytology and Genetics, Novosibirsk, Russia
Hereditas 134:125-34. 2001..The cases of the spindle fragmentation revealed the processes acting in female meiotic metaphase. Premeiotic and mitotic defects of the mutation have also been detected... - mei-41 is required for precocious anaphase in Drosophila femalesK S McKim
Section of Molecular and Cellular Biology, University of California at Davis, 95616, USA
Chromosoma 109:44-9. 2000..The effect of mei-41 is dependent on double-strand break formation. Thus, in mutants that fail to initiate meiotic recombination the absence of mei-41 has no effect... - missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in DrosophilaTakako Iida
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 131:1029-39. 2004..Our data strongly suggest that the product of the missing oocyte gene acts in the oocyte nucleus to facilitate the execution of the unique cell cycle and developmental programs that produce the mature haploid gamete...