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Genomes and GenesSpecies | EAF1SummaryGene Symbol: EAF1 Description: Eaf1p Alias: VID21 Species: Top Publications
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Publications
Telomeric heterochromatin boundaries require NuA4-dependent acetylation of histone variant H2A.Z in Saccharomyces cerevisiaeJoshua E Babiarz
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3202, USA
Genes Dev 20:700-10. 2006..Taken together, these results show a role for H2A.Z acetylation in restricting silent chromatin, and reveal that acetylation of H2A.Z and H4 can contribute to a common function essential to life...- Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variantsAndréanne Auger
Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, 9 McMahon St, Quebec City, Quebec G1R 2J6, Canada
Mol Cell Biol 28:2257-70. 2008b>Eaf1 (for Esa1-associated factor 1) and Eaf2 have been identified as stable subunits of NuA4, a yeast histone H4/H2A acetyltransferase complex implicated in gene regulation and DNA repair... - Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complexA Nourani
Laval University Cancer Research Center, Hotel Dieu de Quebec, Quebec City, Quebec G1R 2J6, Canada
Mol Cell Biol 21:7629-40. 2001..They also suggest that regulation of mammalian cell proliferation by p53-dependent transcriptional activation functions through recruitment of an ING1-containing histone acetyltransferase complex... - Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1Stephen M T Hoke
Department of Biochemistry, University of Western Ontario, London, Canada
Curr Genet 56:447-65. 2010..These findings demonstrate the regulatory potential of mechanisms targeting the FATC domains of PIKK proteins... - Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylationAlice Y Wang
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4
Proc Natl Acad Sci U S A 106:21573-8. 2009..Using structure-function analysis, we found that the YEATS domain was required for Yaf9 function, histone variant H2A.Z chromatin deposition at specific promoters, and H2A.Z acetylation... - NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5Daniel S Ginsburg
Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Mol Cell Biol 29:6473-87. 2009..Pol II) phosphorylated on the C-terminal domain by cyclin-dependent kinase 7/Kin28, but independently of subunits (Eaf1 and Tra1) required for NuA4 recruitment to promoters... - Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiaeKitty F Verzijlbergen
Fred van Leeuwen, Division of Gene Regulation B4, Netherlands Cancer Institute, The Netherlands
BMC Mol Biol 10:76. 2009.... - The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPasesHeather Szerlong
Howard Hughes Medical Institute, Department of Oncological Sciences, Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, Utah 84112, USA
Nat Struct Mol Biol 15:469-76. 2008..Taken together, we define the role of the HSA domain and provide evidence for a regulatory relationship involving the ARP-HSA module and two new functional domains conserved in remodeler ATPases that contain ARPs... - Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repressionKimberly C Lindstrom
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell Biol 26:6117-29. 2006..In contrast to a recruitment-based model, we find that the NuA4 and Swr1 complexes act throughout the genome while only a specific subset of the genome shows alterations in transcription... - Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processesFusheng Tang
Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Traffic 7:1368-77. 2006..These findings suggest that a major role of Vac8p is to spatially separate multiple functions thereby enabling vacuole inheritance to occur concurrently with other vacuolar processes... - Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4Rhea T Utley
Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, 9 McMahon Street, Quebec City, QC, Canada G1R 2J6
Mol Cell Biol 25:8179-90. 2005..These findings demonstrate that H4 phospho-serine 1 regulates chromatin acetylation by the NuA4 complex and that this process is important for normal gene expression and DNA repair... - The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeresHaiying Zhang
Department of Oncological Sciences, School of Medicine, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
Mol Cell Biol 24:9424-36. 2004..Taken together, these data indicate that Yaf9 may function in NuA4 and SWR1 complexes to help antagonize silencing near telomeres... - A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatinMichael S Kobor
Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
PLoS Biol 2:E131. 2004..H2A.Z and SWR1 were essential for viability of cells lacking the EAF1 component of NuA4, pointing to a close functional connection between these two complexes... - RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiaeCatherine Berset
Institute for Biochemistry and Molecular Biology, University of Berne, CH 3012 Bern, Switzerland
RNA 9:871-80. 2003..These data suggest that RNA-binding activity is required for eIF4G1 function... - Opposite role of yeast ING family members in p53-dependent transcriptional activationAmine Nourani
Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, Quebec City, Quebec G1R 2J6, Canada
J Biol Chem 278:19171-5. 2003..They also demonstrate the key specific role of ING proteins in different chromatin modifying complexes and their opposite functions in p53-dependent transcription... - Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexesBruce A Knutson
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, WA 98109, USA
Mol Cell Biol 31:818-31. 2011..Our results show that Tra1 recruitment at Gcn4-dependent and Rap1-dependent promoters requires the same regions of Tra1 and that separate regions of Tra1 contribute to the HAT activity and stability of the SAGA and NuA4 HAT modules...