BRE5

Summary

Gene Symbol: BRE5
Description: Bre5p
Species:

Top Publications

  1. ncbi Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23
    Mickael Cohen
    Nucleocytoplasmic transport group, Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI and VII, 2 Place Jussieu Tour 43 75251, Paris, Cedex 05, France
    Nat Cell Biol 5:661-7. 2003
  2. ncbi Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3
    Kristian Kvint
    Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Mol Cell 30:498-506. 2008
  3. ncbi Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
    Claudine Kraft
    Institute of Biochemistry, HPM, ETH Honggerberg, 8093 Zurich, Switzerland
    Nat Cell Biol 10:602-10. 2008
  4. ncbi Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme
    Keqin Li
    The Wistar Institute University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Biol 372:194-204. 2007
  5. ncbi The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage
    Elizabeth Bilsland
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, United Kingdom
    DNA Repair (Amst) 6:1471-84. 2007
  6. ncbi Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
    Hidekazu Takahashi
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell 23:207-17. 2006
  7. ncbi Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor
    Keqin Li
    The Wistar Institute, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 280:29176-85. 2005
  8. ncbi Purification of active TFIID from Saccharomyces cerevisiae. Extensive promoter contacts and co-activator function
    Roy Auty
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 279:49973-81. 2004
  9. ncbi Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport
    Mickael Cohen
    Nucleocytoplasmic transport group, Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI and VII, 2 place Jussieu, Tour 43, 75251 Paris Cedex 05, France
    J Biol Chem 278:51989-92. 2003
  10. ncbi The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections
    Enrico Ragni
    University of Heidelberg, Centre for Organismal Studies COS Heidelberg, Cell Chemistry, Im Neuenheimer Feld 360, D 69120 Heidelberg, Germany
    BMC Genomics 12:107. 2011

Scientific Experts

  • Claudine Kraft
  • Keqin Li
  • Catherine Dargemont
  • Mickael Cohen
  • Enrico Ragni
  • Kristian Kvint
  • Elizabeth Bilsland
  • Batool Ossareh-Nazari
  • Ronen Marmorstein
  • Hidekazu Takahashi
  • Roy Auty
  • Francoise Stutz
  • Jesús García-Cantalejo
  • Sabine Strahl
  • Heidi Piberger
  • Laura Popolo
  • Markus Aebi
  • Christine Neupert
  • Javier Arroyo
  • Stefan Sigurdsson
  • Michael J Taschner
  • Jay P Uhler
  • Jesper Q Svejstrup
  • Hediye Erdjument-Bromage
  • Paul Tempst
  • Per Sunnerhagen
  • Malin Hult
  • Jessica A Downs
  • Xin Liu
  • Stephen D Bell
  • Jef D Boeke
  • J Michael McCaffery
  • Rafael A Irizarry
  • Guoping Da
  • Kehao Zhao
  • Stephen Buratowski
  • Lawrence C Myers
  • Jim Persinger
  • Blaine Bartholomew
  • Steven P Gygi
  • Hanno Steen
  • Naïma Belgareh
  • Rosine Haguenauer-Tsapis

Detail Information

Publications10

  1. ncbi Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23
    Mickael Cohen
    Nucleocytoplasmic transport group, Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI and VII, 2 Place Jussieu Tour 43 75251, Paris, Cedex 05, France
    Nat Cell Biol 5:661-7. 2003
    ..Here, we show that the Saccharomyces cerevisiae ubiquitin protease Ubp3 requires an additional protein, Bre5, to form an active de-ubiquitination complex that cleaves ubiquitin from specific substrates...
  2. ncbi Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3
    Kristian Kvint
    Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Mol Cell 30:498-506. 2008
    ..In agreement with this, cells with compromised DNA repair are better equipped to survive UV damage when UPB3 is deleted...
  3. ncbi Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
    Claudine Kraft
    Institute of Biochemistry, HPM, ETH Honggerberg, 8093 Zurich, Switzerland
    Nat Cell Biol 10:602-10. 2008
    ..Taken together, our results suggest a link between ubiquitination and the regulated degradation of mature ribosomes by autophagy...
  4. ncbi Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme
    Keqin Li
    The Wistar Institute University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Biol 372:194-204. 2007
    Yeast Ubp3 and its co-factor Bre5 form a deubiquitylation complex to regulate protein transport between the endoplasmic reticulum and Golgi compartments of the cell...
  5. ncbi The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage
    Elizabeth Bilsland
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, United Kingdom
    DNA Repair (Amst) 6:1471-84. 2007
    ..One such ubiquitin protease, Ubp3, exists in a complex with a partner protein: Bre5. This complex has been implicated in a variety of cellular activities, and was recently identified in large-scale ..
  6. ncbi Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
    Hidekazu Takahashi
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell 23:207-17. 2006
    ..Thus, acetyl-CoA metabolism is directly linked to chromatin regulation and may affect diverse cellular processes in which acetylation and metabolism intersect, such as disease states and aging...
  7. ncbi Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor
    Keqin Li
    The Wistar Institute, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 280:29176-85. 2005
    The Bre5 protein is a cofactor for the deubiquitinating enzyme Ubp3, and it contains a nuclear transfer factor 2 (NTF2)-like protein recognition module that is essential for Ubp3 activity...
  8. ncbi Purification of active TFIID from Saccharomyces cerevisiae. Extensive promoter contacts and co-activator function
    Roy Auty
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 279:49973-81. 2004
    ..elution by mass spectrometry confirms the presence of all the known TAFs and TBP, as well as Rsp5, Bul1, Ubp3, Bre5, Cka1, and Cka2...
  9. ncbi Deubiquitination, a new player in Golgi to endoplasmic reticulum retrograde transport
    Mickael Cohen
    Nucleocytoplasmic transport group, Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI and VII, 2 place Jussieu, Tour 43, 75251 Paris Cedex 05, France
    J Biol Chem 278:51989-92. 2003
    ..In the present report, we show that disruption of BRE5 gene also led to a defect in the retrograde transport from the Golgi to the endoplasmic reticulum...
  10. ncbi The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections
    Enrico Ragni
    University of Heidelberg, Centre for Organismal Studies COS Heidelberg, Cell Chemistry, Im Neuenheimer Feld 360, D 69120 Heidelberg, Germany
    BMC Genomics 12:107. 2011
    ..It is considered as crucial structural cell wall component since in baker's yeast the lack of CCW12 results in severe cell wall damage and reduced mating efficiency...