Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulationD Zohlnhofer
Micromet AG, Munchen, Germany
Circulation 103:1396-402. 2001
..This study sought to establish a method for profiling gene expression in human in-stent neointima and to identify differentially expressed genes that may serve as novel therapeutic targets...
Transcriptome analysis reveals a role of interferon-gamma in human neointima formationD Zohlnhofer
Micromet AG, D 82152 Martinsried, Technische Universitat Munchen, D 81675 Munich, Germany
Mol Cell 7:1059-69. 2001
..Genetic disruption of IFN-gamma signaling in a mouse model of restenosis significantly reduced the vascular proliferative response. Our data suggest an important role of IFN-gamma in the control of neointima proliferation...
Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left ventricular dysfunctionDietlind Zohlnhofer
Medizinische Klinik und Deutsches Herzzentrum, Technischen Universitat Munchen, Munich, Germany
Heart Vessels 23:230-42. 2008
..Impaired intercellular communication as suggested by decreased expression of desmoplakin may be an important feature of contractile dysfunction in HM...
Effect of glycoprotein IIb-IIIa receptor antagonism on platelet membrane glycoproteins after coronary stent placementM Gawaz
Medizinische Klinik, Klinikum rechts der Isar and Deutsches Herzzentrum, Technische Universitat Munchen, Germany
Thromb Haemost 80:994-1001. 1998
..Significant alterations of platelet membrane glycoproteins during GPIIb-IIIa antagonism might contribute to development of acute profound thrombocytopenia...
Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarctionF J Neumann
Deutsches Herzzentrum and 1 Medizinische Klinik der Technischen Universität München, Munich, Germany
J Am Coll Cardiol 34:1420-6. 1999
..This prospective randomized study investigated platelet-induced upregulation of Mac-1 on monocytes and its inhibition by glycoprotein (GP) IIb/IIIa blockage in patients with acute myocardial infarction (AMI)...
Adhesion of monocyte very late antigen-4 to endothelial vascular cell adhesion molecule-1 induces interleukin-1beta-dependent expression of interleukin-6 in endothelial cellsD Zohlnhofer
Medizinische Klinik and Deutsches Herzzentrum, Technische Universitat Munchen, Germany
Arterioscler Thromb Vasc Biol 20:353-9. 2000
..The beta(1)-integrin-mediated expression of IL-1beta and IL-6 could contribute to local and systemic inflammatory reactions in atherosclerosis...
Bivalirudin versus unfractionated heparin during percutaneous coronary interventionAdnan Kastrati
Deutsches Herzzentrum, Technische Universitat, Munich, Germany
N Engl J Med 359:688-96. 2008
..Whether bivalirudin is superior to unfractionated heparin in patients with stable or unstable angina who undergo percutaneous coronary intervention (PCI) after pretreatment with clopidogrel is unknown...