Proteomics and diagnostics: Let's Get Specific, againDom Zichi
SomaLogic, 1775 38th Street, Boulder, CO 80301, USA
Curr Opin Chem Biol 12:78-85. 2008
..In this paper we explore some possible ways to increase the content of proteomic analysis...
From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assayStephan Kraemer
SomaLogic, Inc, Boulder, Colorado, United States of America
PLoS ONE 6:e26332. 2011
..We demonstrate that quantification by microarray-based hybridization, Luminex bead-based methods, and qPCR are each compatible with our platform, further expanding the breadth of proteomic applications for a wide user community...
High-content affinity-based proteomics: unlocking protein biomarker discoveryEdward N Brody
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Expert Rev Mol Diagn 10:1013-22. 2010
..Based on a new generation of slow off-rate modified aptamers (SOMAmers), this technology is unlocking biomarker discovery...
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancerRachel M Ostroff
SomaLogic, Boulder, Colorado, United States of America
PLoS ONE 5:e15003. 2010
..Here we present a comprehensive clinical biomarker study of lung cancer and the first large-scale clinical application of a new aptamer-based proteomic technology to discover blood protein biomarkers in disease...
Aptamer-based multiplexed proteomic technology for biomarker discoveryLarry Gold
SomaLogic, Boulder, Colorado, USA
PLoS ONE 5:e15004. 2010
..The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine...
The stability of the circulating human proteome to variations in sample collection and handling procedures measured with an aptamer-based proteomics arrayRachel Ostroff
SomaLogic, 2945 Wilderness Place, Boulder, CO 80301, USA
J Proteomics 73:649-66. 2010
..Even at the longest timepoints, 20 h, approximately 82% of the proteins, on average for the three collection tube types, showed no significant change. These results are encouraging for proteomic biomarker discovery...