David C Zappulla

Summary

Publications

  1. ncbi Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs
    David C Zappulla
    Department of Biochemistry and Cellular Biology, Stony Brook University, Stony Brook, NY 11794, USA
    BMC Mol Biol 7:40. 2006
  2. ncbi Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning
    Erik D Andrulis
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Mol Cell Biol 22:8292-301. 2002
  3. ncbi One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors
    Erik D Andrulis
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA
    Genetics 166:631-5. 2004
  4. ncbi Control of replication timing by a transcriptional silencer
    David C Zappulla
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA
    Curr Biol 12:869-75. 2002
  5. ncbi Yeast telomerase RNA: a flexible scaffold for protein subunits
    David C Zappulla
    Howard Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA
    Proc Natl Acad Sci U S A 101:10024-9. 2004
  6. ncbi A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro
    David C Zappulla
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA
    Nat Struct Mol Biol 12:1072-7. 2005

Detail Information

Publications6

  1. ncbi Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs
    David C Zappulla
    Department of Biochemistry and Cellular Biology, Stony Brook University, Stony Brook, NY 11794, USA
    BMC Mol Biol 7:40. 2006
    ..In this study we aimed to determine the mechanism of Rtt107/Esc4 targeted silencing and also learn more about its biological functions...
  2. ncbi Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning
    Erik D Andrulis
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Mol Cell Biol 22:8292-301. 2002
    ..Our data suggest that Esc1 is a component of a redundant pathway that functions to localize silencing complexes to the nuclear periphery...
  3. ncbi One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors
    Erik D Andrulis
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA
    Genetics 166:631-5. 2004
    ..Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus...
  4. ncbi Control of replication timing by a transcriptional silencer
    David C Zappulla
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA
    Curr Biol 12:869-75. 2002
    ..Presumably, the tight chromatin structure promoted by Sir proteins favors both transcriptional inactivity and late replication...
  5. ncbi Yeast telomerase RNA: a flexible scaffold for protein subunits
    David C Zappulla
    Howard Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA
    Proc Natl Acad Sci U S A 101:10024-9. 2004
    ..In the case of yeast telomerase, we propose that the RNA serves a very different function, providing a flexible tether for the protein subunits...
  6. ncbi A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro
    David C Zappulla
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA
    Nat Struct Mol Biol 12:1072-7. 2005
    ..We find that substitution of Mini-T for wild-type TLC1 in a reconstituted system yields robust activity, allowing the contributions of individual yeast telomerase components to be directly assessed...