Ruojing Yang

Summary

Publications

  1. ncbi Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    Julie St-Pierre
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:26597-603. 2003
  2. ncbi Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
    Ruojing Yang
    Department of Metabolic Disease Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Biol Chem 282:22765-74. 2007
  3. ncbi Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1
    Rosa Gasa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 277:1524-30. 2002
  4. ncbi Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
  5. ncbi Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes
    Ruojing Yang
    Department of Biochemistry, the Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 277:1514-23. 2002
  6. ncbi Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression
    Ruojing Yang
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:23418-25. 2003
  7. ncbi PGC-1beta in the regulation of hepatic glucose and energy metabolism
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:30843-8. 2003
  8. ncbi Suppression of beta cell energy metabolism and insulin release by PGC-1alpha
    J Cliff Yoon
    Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 5:73-83. 2003

Collaborators

Detail Information

Publications8

  1. ncbi Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    Julie St-Pierre
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:26597-603. 2003
    ..Together, these data indicate that PGC-1alpha and PGC-1beta profoundly alter mitochondrial metabolism and suggest that these proteins are likely to play different physiological functions...
  2. ncbi Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
    Ruojing Yang
    Department of Metabolic Disease Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Biol Chem 282:22765-74. 2007
    ..Our results demonstrate that liver-specific knockdown of JNK1 lowers circulating glucose and insulin levels but increases triglyceride levels in DIO mice...
  3. ncbi Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1
    Rosa Gasa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 277:1524-30. 2002
    ..We conclude that G(M)DeltaC has a unique combination of glycogenic potency and responsiveness to glycogenolytic signals that allows it to be used to lower blood glucose levels in diabetes...
  4. ncbi Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 120:261-73. 2005
    ..These data suggest a mechanism through which dietary saturated fats can stimulate hyperlipidemia and atherogenesis...
  5. ncbi Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes
    Ruojing Yang
    Department of Biochemistry, the Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 277:1514-23. 2002
    ..We conclude that overexpression of the novel targeting subunit G(M)DeltaC confers unique regulation of glycogen metabolism. Furthermore, targeting subunits and GK stimulate glycogen synthesis by distinct pathways...
  6. ncbi Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression
    Ruojing Yang
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:23418-25. 2003
    ....
  7. ncbi PGC-1beta in the regulation of hepatic glucose and energy metabolism
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:30843-8. 2003
    ..These data illustrate that PGC-1beta and PGC-1alpha have distinct arrays of activities in hepatic energy metabolism...
  8. ncbi Suppression of beta cell energy metabolism and insulin release by PGC-1alpha
    J Cliff Yoon
    Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 5:73-83. 2003
    ..These results strongly suggest that PGC-1alpha plays a key functional role in the beta cell and is involved in the pathogenesis of the diabetic phenotype...