Systematic drug repositioning based on clinical side-effectsLun Yang
Computational Biology, Quantitative Sciences, Medicines Discovery and Development, GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e28025. 2011
..7. This suggests that closer attention should be paid to the SEs observed in trials not just to evaluate the harmful effects, but also to rationally explore the repositioning potential based on this "clinical phenotypic assay"...
- Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study
Lun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
PLoS Comput Biol 7:e1002016. 2011
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- Chemical-protein interactome and its application in off-target identification
Lun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China
Interdiscip Sci 3:22-30. 2011
..Such studies present prospect of large scale in silico methodologies for off-target discovery with low cost and high efficiency...
- Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling
Yi Xing
Bio X Center, Shanghai Jiao Tong University, Shanghai, China
Pharmacogenomics 10:741-52. 2009
..The present study was designed to determine the allele frequencies and haplotypes of this gene in the population and predict the candidate functional mutations...
- DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome
Heng Luo
Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
Nucleic Acids Res 39:W492-8. 2011
..This server is freely available at http://cpi.bio-x.cn/drar/...
- SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome
Lun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
Nucleic Acids Res 37:W406-12. 2009
..The server is freely available at http://SePreSA.Bio-X.cn/...
- Identifying unexpected therapeutic targets via chemical-protein interactome
Lun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
PLoS ONE 5:e9568. 2010
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- Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China
Shengying Qin
Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, Shanghai 200030, China
Genomics 92:152-8. 2008
..Tag SNP selection and haplotype distributions showed differences across the four populations. This is the first large-scale study to analyze polymorphisms systematically across the whole CYP2D6 gene in the Chinese Han population...
- Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
Lun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
PLoS Comput Biol 5:e1000441. 2009
..In conclusion, SADR targets and the patient-specific off-targets could be identified through a systematic investigation of the CPI, generating important hypotheses for prospective experimental validation of the candidate genes...
- Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action
Jiekun Xuan
Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China
J Proteome Res 10:5433-43. 2011
..Further study of these metabolites may facilitate the development of noninvasive biomarkers and more efficient therapeutic strategies for schizophrenia...
- A CitationRank algorithm inheriting Google technology designed to highlight genes responsible for serious adverse drug reaction
Lun Yang
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
Bioinformatics 25:2244-50. 2009
..The database also provides users with visualized gene-gene knowledge chain networks, helping them to systematize their gene-oriented knowledge chain whilst navigating these networks...
- Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients
Zhiyun Wei
Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China
Prog Neuropsychopharmacol Biol Psychiatry 33:547-51. 2009
..These results demonstrate that variations in the HTR7 gene may not be good genetic markers for predicting the therapeutic efficacy of risperidone...
- Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis
Yue Xiao
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China
J Genet Genomics 38:333-9. 2011
..The characterization of the new mutation expanded our understanding the transactivation and DNA-binding structure of Pax3 protein...
- ReCGiP, a database of reproduction candidate genes in pigs based on bibliomics
Lun Yang
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China
Reprod Biol Endocrinol 8:96. 2010
..So we have developed a database providing candidate genes for reproductive researches in pig by mining and processing existing biological literatures in human and pigs, named as ReCGiP...
- Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China
Lingling Chen
Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, Shanghai 200030, China
Pharmacogenomics 9:691-702. 2008
..A comprehensive search for genetic polymorphisms of the CYP2C19 gene in the Chinese Han population has rarely been conducted. The present study was designed to determine the genetic basis of CYP2C19 polymorphisms...
