Clinical epidemiology of ulcerative colitis in Mexico: a single hospital-based study in a 20-year period (1987-2006)Jesus K Yamamoto-Furusho
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
J Clin Gastroenterol 43:221-4. 2009
..Ulcerative colitis (UC) is a chronic disease with a heterogeneous clinical evolution. The prevalence and incidence of UC vary widely and depend on multiple factors including ethnicity and geographic location...
- Genetic factors associated with the development of inflammatory bowel disease
Jesus K Yamamoto-Furusho
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Col Seccion XVI, Tlalpan, Mexico, D F, Mexico
World J Gastroenterol 13:5594-7. 2007
..The application of genetic testing into clinical practice is close and all genetic markers may have several clinical implications: prediction of disease phenotype, molecular classification, prevention of complications, and prognosis...
- Innovative therapeutics for inflammatory bowel disease
Jesus K Yamamoto-Furusho
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Vasco de Quiroga 15, Col Seccion XVI, Tlalpan, Mexico CP 14000, DF Mexico
World J Gastroenterol 13:1893-6. 2007
..All treatments have the potential to provide more effective and safe treatment for IBD...
- Infliximab as a rescue therapy for hospitalized patients with severe ulcerative colitis refractory to systemic corticosteroids
Jesus K Yamamoto-Furusho
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Dig Surg 25:383-6. 2008
..However, it has not been studied extensively in hospitalized patients who require colectomy as a rescue therapy for severe ulcerative colitis refractory to intravenous corticosteroids...
- Crohn's disease: innate immunodeficiency?
Jesus K Yamamoto-Furusho
Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
World J Gastroenterol 12:6751-5. 2006
....
- HLA-DRB1 alleles are associated with the clinical course of disease and steroid dependence in Mexican patients with ulcerative colitis
J K Yamamoto-Furusho
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
Colorectal Dis 12:1231-5. 2010
..The aim of this study was to study the association between the HLA-DRB1 alleles and the clinical course of ulcerative colitis (UC)...
- Intestinal protozoa infections among patients with ulcerative colitis: prevalence and impact on clinical disease course
Jesus K Yamamoto-Furusho
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Digestion 82:18-23. 2010
..Epidemiological and microbiologic studies suggest that enteropathogenic microorganisms play a substantial role in the clinical initiation and relapses of inflammatory bowel disease...
- [Serum levels of beta2 microglobulin and ultrasensitive c-reactive protein as markers of histological activity in ulcerative colitis]
Jesus K Yamamoto-Furusho
Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, SSA, Mexico D F, Mexico
Gac Med Mex 146:31-5. 2010
..In the present study, we determined the diagnostic utility of high sensitive C-reactive protein (hs CRP) and beta2 microglobulin (beta2M) levels and analyzed their correlation with the histological activity of ulcerative colitis (UC)...
- Prevalence and factors associated with the presence of abnormal function liver tests in patients with ulcerative colitis
Jesus K Yamamoto-Furusho
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan C P, Mexico
Ann Hepatol 9:397-401. 2010
..To investigate the prevalence of abnormal function liver tests and risk factors associated with their development in Mexican patients with UC...
- [Immunogenetics of chronic ulcerative colitis]
Jesus K Yamamoto-Furusho
Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, DF
Rev Invest Clin 55:705-10. 2003
..Recent data suggests that TNF polymorphism may be more important in determining susceptibility to UC and these TNF markers could predict response to infusion with chimeric anti-TNF antibody...
- Innate immunity in inflammatory bowel disease
Jesus K Yamamoto-Furusho
Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
World J Gastroenterol 13:5577-80. 2007
..Several mutations in these receptors have been associated with development of IBD...
- Polymorphisms in the promoter region of tumor necrosis factor alpha (TNF-alpha) and the HLA-DRB1 locus in Mexican mestizo patients with ulcerative colitis
Jesus K Yamamoto-Furusho
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, DF, Mexico
Immunol Lett 95:31-5. 2004
..In conclusion, this clinical differential pattern of association distinguished in two neighboring loci within the MHC region suggest an independent role of the TNF locus in the genetic susceptibility to develop UC...
- Clinical and genetic heterogeneity in Mexican patients with ulcerative colitis
Jesus K Yamamoto-Furusho
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico
Hum Immunol 64:119-23. 2003
..HLA-DR15 distinguishes a subgroup of patients with extensive colitis and the HLA-DRB1*0103 allele distinguishes a subgroup of severe form of disease that might require surgical management...
- Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos
Jaqueline Ramírez-Anguiano
Department of Otolaryngology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Privada de San Francisco No 47 1 Barrio San Francisco, San Jerónimo Magdalena Contreras, CP 10810, Mexico City DF, Mexico
Otolaryngol Head Neck Surg 135:90-3. 2006
..The purpose of the study was to determine the association of HLA-DRB1 alleles with sinonasal polyposis in the Mexican Mestizo population...
- Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia
Cristina García-Corona
Department of Dermatology, Hospital General Dr Manuel Gea Gonzalez, Tlalpan, Mexico
Arch Dermatol 140:1227-31. 2004
....
- Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients
Roberto Herrera-Goepfert
Department of Pathology, Instituto Nacional de Cancerologia, Mexico City, Mexico
World J Gastroenterol 12:7762-7. 2006
..To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma...
- Protective role of interleukin-19 gene polymorphisms in patients with ulcerative colitis
Jesus K Yamamoto-Furusho
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Hum Immunol 72:1029-32. 2011
..The results suggest that IL-19 polymorphisms (rs2243188 and rs2243193) might have a protective role in the development of UC in Mexican individuals...
- HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children
Ana L Rodríguez-Ventura
Department of Pediatric Endocrinology, Hospital Infantil de Mexico, Mexico City, Mexico
Pediatr Diabetes 8:5-10. 2007
..The human leukocyte antigen (HLA)-DR genotype has been associated with T1DM and with T2DM only in adults and in determined cases...
- MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function
Jesus K Yamamoto-Furusho
Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Inflamm Bowel Dis 16:736-42. 2010
..The aim of the present study was to investigate the relationship between antibacterial activity of NOD2 and HNP-1 expression in epithelial cell lines...
- Factors that influence outcome in non-invasive and invasive treatment in polycystic liver disease patients
Josue Barahona-Garrido
Department of Gastroenterology, National Institute of Health Sciences and Nutrition Salvador Zubiran, Mexico City 14000, Mexico
World J Gastroenterol 14:3195-200. 2008
..To evaluate the factors that influence outcome of both non-invasive and invasive treatment of polycystic liver disease...
- Perinuclear anti-neutrophil cytoplasmic antibodies (p-anca) in chronic ulcerative colitis: experience in a Mexican institution
Jesus K Yamamoto-Furusho
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
World J Gastroenterol 12:3406-9. 2006
..0001; OR = 9; CI 95% = 3.2-24.7). CONCLUSION: The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods...
- Association of the HLA-DRB1*0701 allele with perinuclear anti-neutrophil cytoplasmatic antibodies in Mexican patients with severe ulcerative colitis
Jesus K Yamamoto-Furusho
Department of Gastroenterology, , Vasco de Quiroga 15, , D F, Mexico
World J Gastroenterol 12:1617-20. 2006
..CONCLUSION: The HLA-DRB1*07 is associated with p-ANCA positive UC Mexican patients...
- Interleukin 1 ? (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis
Jesus K Yamamoto-Furusho
Department of Gastroenterology, Inflammatory Bowel Disease Clinic, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
J Clin Gastroenterol 45:531-5. 2011
..Among cytokines induced in UC, interleukin 1 antagonist (IL-1ra) and interleukin 1 ? (IL-1?) seems to have a central role because of its immunoregulatory and proinflammatory activities...
- Transcript levels of Toll-Like Receptors 5, 8 and 9 correlate with inflammatory activity in Ulcerative Colitis
Fausto Sanchez-Munoz
Universidad Autonoma Metropolitana, D F, Mexico
BMC Gastroenterol 11:138. 2011
..However, few studies have explored other TLRs. Therefore, the aim of this study was to evaluate the mRNA profiles of TLR1 to 9 in colonic mucosa of UC patients, according to disease activity...
- Growth factors as treatment for inflammatory bowel disease: a concise review of the evidence toward their potential clinical utility
Josue Barahona-Garrido
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City Universidad Nacional Autónoma de México, Mexico City, Mexico
Saudi J Gastroenterol 15:208-12. 2009
..In this concise review, we provide a summary of the most recent and relevant evidence regarding the potential therapeutic effects of growth factors in IBD...
- Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation
Jesus K Yamamoto-Furusho
Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 281:36060-70. 2006
..In conclusion, CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses...
- Novel genetic markers in inflammatory bowel disease
Lorena Rodriguez Bores
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15 colonia Seccion XVI, Tlalpan, CP 14000, Mexico
World J Gastroenterol 13:5560-70. 2007
..The characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD...
- Basic and clinical aspects of osteoporosis in inflammatory bowel disease
Lorena Rodriguez Bores
IBD Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 colonia Seccion XVI, Tlalpan, CP 14000, Mexico
World J Gastroenterol 13:6156-65. 2007
..There are several treatments options that have proven their effectiveness, while new emergent therapies such as calcitonin and teriparatide among others remain to be assessed...
