Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndromeJ Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Br J Biomed Sci 69:6-10. 2012
..03). vacA s1 was positive in 61 (53%) with IBS-D compared to 32 (36%) in the control group (P=0.02). cagA s1 was positive in 39 (34%) with IBS-D compared to 13 (15%) in the control group (P=0.002)...
Small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in PakistanJaved Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Saudi J Gastroenterol 17:371-5. 2011
..The aim of this study was to determine the frequency of SIBO and lactose intolerance (LI) occurrence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) according to Rome III criteria...
Prevalence of non Helicobacter pylori species in patients presenting with dyspepsiaJaved Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
BMC Gastroenterol 12:3. 2012
..abstract:..
Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi, PakistanWasim Jafri
Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
BMC Infect Dis 6:101. 2006
..This cross-sectional study estimated the prevalence and identified risk factors associated with Hepatitis B surface antigen (HBsAg) and HCV antibody (anti-HCV) sero-positivity among children 1 to 15 years of age...
In vitro sensitivity of Blastocystis hominis to garlic, ginger, white cumin, and black pepper used in dietJaved Yakoob
Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
Parasitol Res 109:379-85. 2011
..01 mg/ml of MTZ. However, this sensitivity did not increase as garlic concentration was increased to 0.1 mg/ml, for B. hominis cell count was 6,000 compared to 1,428 as MTZ was increased to 0.1 mg/ml...
Giardiasis in patients with dyspeptic symptomsJaved Yakoob
Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
World J Gastroenterol 11:6667-70. 2005
..To investigate the prevalence of giardiasis in patients with dyspeptic symptoms...
Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitorsJaved Yakoob
Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
World J Gastroenterol 14:1539-43. 2008
..To determine the efficacy of gastric juice polymerase chain reaction (PCR) for the detection of H pylori infection in comparison with histology and gastric antral biopsy PCR in patients on a proton pump inhibitor (PPI)...
Comparison of biopsy-based methods for the detection of Helicobacter pylori infectionJ Yakoob
Department of Medicine and Pathology, Aga Khan University Hospital, Karachi, Pakistan
Br J Biomed Sci 63:159-62. 2006
..Thus, the eUAB can be used as a rapid urease test. It is economical and has a sensitivity and specificity comparable to a commercially available rapid urease test to detect urease activity of H. pylori in gastric biopsy...
Gastric corpus polyps associated with Proton Pump Inhibitors therapyJaved Yakoob
Department of Medicine, The Aga Khan University Hospital, Karachi
J Coll Physicians Surg Pak 18:172-3. 2008
..pylori was also negative. This is the first report originating from an Asian country describing Fundal Gland Polyps (FGPs) in the corpus of stomach rather than fundus in a patient on long-term PPI therapy...
Low prevalence of the intact cag pathogenicity island in clinical isolates of Helicobacter pylori in Karachi, PakistanJ Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Br J Biomed Sci 66:137-42. 2009
..001). The presence of the cagA gene does not signify presence of an intact cag-PAI. Most of the H. pylori isolates studied had partial cag-PAI with missing cagE and cagA promoter regions...
Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in PakistanJaved Yakoob
Department of Medicine, Aga Khan University, Karachi, Pakistan
BMC Gastroenterol 9:87. 2009
..pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU)...
Helicobacter pylori: association with gall bladder disorders in PakistanJ Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Br J Biomed Sci 68:59-64. 2011
..pylori. In conclusion, H. pylori DNA was demonstrated in cases of chronic cholecystitis and gall bladder carcinoma associated with cholelithiasis, but this association requires further study...
Risk factors associated with Helicobacter pylori infection treatment failure in a high prevalence areaJ Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Epidemiol Infect 139:581-90. 2011
..Treatment failure was associated with younger mean age, point mutations in the 23S rRNA gene of H. pylori and vacA s1a and m1 when associated with cagA negativity...
Blastocystis hominis and Dientamoeba fragilis in patients fulfilling irritable bowel syndrome criteriaJaved Yakoob
Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
Parasitol Res 107:679-84. 2010
..030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR...
Prevalences of Giardia lamblia and Cryptosporidium parvum infection in adults presenting with chronic diarrhoeaJ Yakoob
Department of Medicine, Aga Khan University, Karachi B, Pakistan
Ann Trop Med Parasitol 104:505-10. 2010
..6%) of the 167 found smear-negative (k=0.954; P<0.001). Although C. parvum was associated with chronic diarrhoea in the present study, the carriage of G. lamblia often appeared asymptomatic...
Antibiotic susceptibility patterns of Helicobacter pylori and triple therapy in a high-prevalence areaJ Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Br J Biomed Sci 67:197-201. 2010
..001) and A2142C mutation in five (17%; P = 0.003). In conclusion, triple therapy failure was associated with CLR-R. Metronidazole resistance exceeded that of CLR, hence it cannot be substituted for CLR in a triple therapy...
Role of rapid urease test and histopathology in the diagnosis of Helicobacter pylori infection in a developing countryJaved Yakoob
Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan
BMC Gastroenterol 5:38. 2005
..The aim of this study was to determine the effect of commonly self-prescribed proton pump inhibitors (PPI) on the results of rapid urease test and histology for the diagnosis of H. pylori infection...
Helicobacter pylori cagA and vacA cytotoxin genes in Changsha, ChinaJ Yakoob
Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
Br J Biomed Sci 59:150-3. 2002
..vacAs1 allele was carried in 82.5% (33/40) isolates, of which 52.5% (21/40) were subtype vacAs1a/m2 and 17.5% (7/40) were subtype vacAs1b/m2...
Irritable bowel syndrome: in search of an etiology: role of Blastocystis hominisJaved Yakoob
Departments of Medicine and Pathology, Aga Khan University Hospital, Karachi, Pakistan
Am J Trop Med Hyg 70:383-5. 2004
..001). Blastocystis hominis was frequently demonstrated in the stool samples of IBS patients; however, its significance in IBS still needs to be investigated. Stool culture has a higher positive yield for B. hominis than stool microscopy...
Helicobacter pylori detection in Chinese subjects: a comparison of two common DNA fingerprinting methodsJ Yakoob
Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha, PR China
Br J Biomed Sci 58:239-43. 2001
..Diversity among H. pylori clinical isolates was demonstrated distinctly by both methods; however, RAPD-PCR showed greater discriminatory power in distinguishing between isolates...
Polycolonization of Helicobacter pylori among Chinese subjectsJ Yakoob
Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha, Hunan, P R China
Clin Microbiol Infect 7:187-92. 2001
..To investigate the situation among Chinese patients with regard to infection with multiple strains of Helicobacter pylori...
Candida esophagitis: risk factors in non-HIV population in PakistanJaved Yakoob
Section of Gastroenterology, Department of Medicine, Agha Khan University Hospital, Karachi, Pakistan
World J Gastroenterol 9:2328-31. 2003
..Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital...
Genetic and phenotype changes following in vitro interactions between Helicobacter pylori strainsJaved Yakoob
Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China
J Gastroenterol Hepatol 19:626-31. 2004
..The purpose of the present paper was to determine whether in vitro interaction between different Helicobacter pylori strains leads to changes in antibiotic susceptibility, cagA, vacAM2 and DNA fingerprint patterns...
Polymerase chain reaction in the detection of Helicobacter pylori infectionJaved Yakoob
Department of Medicine, Aga Khan University Hospital, Karachi 74800
J Coll Physicians Surg Pak 14:153-6. 2004
..To determine the presence of Helicobacter pylori (H. pylori) infection, in patients suffering from gastritis and peptic ulcer disease by polymerase chain reaction (PCR) and correlate the results with the histological diagnosis...
In vitro susceptibility of Blastocystis hominis isolated from patients with irritable bowel syndromeJ Yakoob
Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
Br J Biomed Sci 61:75-7. 2004
..B. hominis isolates varied in their degree of susceptibility to the three drugs studied, being greater with furazolidone than with metronidazole, and complete resistance with ciprofloxacin...
Helicobacter pylori infection and micronutrient deficienciesJaved Yakoob
Department of Medicine, Agha Khan University Hospital, Stadium Road, Karachi 74800, Pakistan
World J Gastroenterol 9:2137-9. 2003
..In this paper H pylori infection in associated with various micronutrients deficiencies is briefly reviewed...
Diversity of Helicobacter pylori among Chinese persons with H. pylori infectionJ Yakoob
Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha, PR China
APMIS 108:482-6. 2000
..pylori infection. PCR-RAPD fingerprinting is an efficient method of distinguishing between clinical isolates of H. pylori...
Candida oesophagitis with hepatitis C virus: an uncommon associationJaved Yakoob
Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
Eur J Gastroenterol Hepatol 15:701-3. 2003
..Evaluation of this case provides insight into various mechanisms of immune suppression associated with HCV infection...
Irritable bowel syndrome: is it associated with genotypes of Blastocystis hominisJaved Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Parasitol Res 106:1033-8. 2010
..30), respectively. Majority of our patients had typeable B. hominis infection. The genotype of B. hominis in IBS-D was type 1 while in control genotype 3 was predominant...
Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi, PakistanJaved Yakoob
Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi, Pakistan
World J Gastroenterol 11:3562-5. 2005
..To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases...
Antibiotic susceptibility of Helicobacter pylori in the Chinese populationJ Yakoob
Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, People s Republic of China
J Gastroenterol Hepatol 16:981-5. 2001
..pylori) strains to metronidazole, clarithromycin and tetracycline in the Chinese population, and to test the stability of antibiotic resistance in H. pylori 1 year after storage at -80 degrees C...
Entamoeba species associated with chronic diarrhoea in PakistanJ Yakoob
Department of Medicine, The Aga Khan University, Karachi, Pakistan
Epidemiol Infect 140:323-8. 2012
..dispar in 19% (24/129) (P=0·117) and E. moshkovskii in 19% (24/129) (P<0·001). E. histolytica and E. moshkovskii were significantly associated with diarrhoea while E. dispar was found equally in both groups...
Helicobacter pylori infection in children: population-based age-specific prevalence and risk factors in a developing countryW Jafri
Department of Medicine and Pediatrics, Aga Khan University, Karachi, Pakistan
Acta Paediatr 99:279-82. 2010
..We estimated the prevalence, age of acquisition and risk factors for Helicobacter pylori (H. pylori) seroprevalence in children aged 1-15 years...
The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugsJaved Yakoob
Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan
Dig Dis Sci 53:95-100. 2008
..8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology...
Irritable bowel syndrome in health care professionals in PakistanW Jafei
Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi
J Pak Med Assoc 53:405-7. 2003
..4% (33/41). Anxiety and depression was present in 80% (33/41) as an extraintestinal symptom. CONCLUSION: Irritable bowel syndrome is common in health care workers with intestinal and extraintestinal manifestations being equally common...
Helicobacter species ribosomal DNA recovered from the liver tissue of chinese patients with primary hepatocellular carcinomaXue Gong Fan
Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan, People s Republic of China
Clin Infect Dis 35:1555-7. 2002
..Four 16S rDNA fragments from positive PCR samples were directly sequenced. By sequence comparison, all were found to be 99% identical to the 16S rRNA of Helicobacter pylori...
An office-based serological test for detection of current Helicobacter pylori infection: is it useful?Khalid Mumtaz
Section of Gastroenterology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
Eur J Gastroenterol Hepatol 18:85-8. 2006
..pylori infection. This test is a useful tool for rapid diagnosis of H. pylori in out patients' setting...
Frequency of NSAID induced peptic ulcer diseaseSaeed Hamid
Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
J Pak Med Assoc 56:218-22. 2006
..009) respectively. CONCLUSION: NSAID-associated peptic ulcer disease is common in Pakistan and most frequently associated with gastric and duodenal ulcer. H. pylori infection is common in association with NSAID related peptic ulcers...
Irritable bowel syndrome in patients evaluated for organic bowel pathologyWasim Jafri
Department of Medicine, The Aga Khan University Hospital, Karachi-74800, Pakistan
J Coll Physicians Surg Pak 14:438-9. 2004
Frequency of irritable bowel syndrome in college studentsWasim Jafri
Department of Medicine, Aga Khan University Hospital, Karachi
J Ayub Med Coll Abbottabad 17:9-11. 2005
..001, OR 1.9, CI 1.3-2.8). CONCLUSION: IBS is common in younger adult population of Pakistan. Its prevalence is higher in non-medical college students but health care seeking behavior was more common in medical students...
Perception of gastroesophageal reflux disease in urban population in PakistanNadim Jafri
Section of Gastroenterology, Department of Medicine, Aga Khan Medical University Hospital, Karachi, Pakistan
J Coll Physicians Surg Pak 15:532-4. 2005
..Sixty-seven percent (152/228) did not seek health care advice, 32% (74/228) practiced self-medications and 33% (76/228) consulted a physician. CONCLUSION: Gastroesophageal reflux is a common problem in the urban population of Pakistan...
Furazolidone, co-amoxiclav, colloidal bismuth subcitrate, and esomeprazole for patients who failed to eradicate Helicobacter pylori with triple therapyZaigham Abbas
Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
Dig Dis Sci 54:1953-7. 2009
..On an intention-to-treat analysis, the eradication rate was 81% (42 out of 52) whereas on per-protocol basis, the eradication rate was 82.4% (42 out of 51). In conclusion, this new regimen represents a suitable second-line therapy...
Irritable bowel syndrome and health seeking behaviour in different communities of PakistanWasim Jafri
Department of Medicine, Aga Khan University Hospital, Karachi
J Pak Med Assoc 57:285-7. 2007
..To investigate the frequency of irritable bowel syndrome (IBS) and health seeking behaviour in patients belonging to different ethnic groups and their squatter settlements in two cities of Pakistan...
Phloroglucinol in irritable bowel syndromeWasim Jafri
Department of Medicine, Aga Khan University Hospital, Karachi
J Pak Med Assoc 56:5-8. 2006
..003). CONCLUSION: Phloroglucinol in a dose of 50mg three times daily is effective and well tolerated by the IBS patients. It relieves most of the symptoms of IBS...
Esophageal polypoidal mass: presentation of an uncommon pleomorphic carcinomaJaved Yakoob
Department of Medicine and Pathology, The Aga Khan University, Karachi, Pakistan
J Pak Med Assoc 59:639-41. 2009
..To our knowledge this is the first local report of spindle cell carcinoma occurring in the esophagus and describes its endoscopic and histopathological features with distinctive biphasic morphology...
Helicobacter pylori: a diverse bacteriumWasim Jafri
J Coll Physicians Surg Pak 13:553-4. 2003