A reconsideration of the relevance of systemic low-dose ketamine to the pathophysiology of fibromyalgiaPatrick B Wood
Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
J Pain 7:611-4. 2006
..Accumulating evidence suggests that fibromyalgia may represent a dysregulation of dopaminergic neurotransmission, which may provide insights to guide both rational clinical interventions as well as system-specific research models...
- Variations in brain gray matter associated with chronic pain
Patrick B Wood
Pacific Rheumatology Associates, 4300 Talbot Road South, Suite 101, Renton, WA 98055, USA
Curr Rheumatol Rep 12:462-9. 2010
..Interpretation of findings from morphometric studies also must take into account genetic and experiential factors that recently have been demonstrated to influence brain morphometry and the risk of developing chronic pain...
- Hippocampal metabolite abnormalities in fibromyalgia: correlation with clinical features
Patrick B Wood
Department of Family Medicine, LSU Health Sciences Center, Shreveport, Louisiana, USA
J Pain 10:47-52. 2009
..A significant negative correlation between patient subjective experience of symptoms and a reduced NAA/Cr ratio suggests a role for hippocampal pathology in fibromyalgia...
- Role of central dopamine in pain and analgesia
Patrick B Wood
Angler Biomedical Technologies, LLC, 18401 Reed Parks Road, Jonestown, TX 78645, USA
Expert Rev Neurother 8:781-97. 2008
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- Changes in hippocampal metabolites after effective treatment for fibromyalgia: a case study
Patrick B Wood
Department of Family Medicine, Anesthesiology and Psychiatry, LSU Health Sciences Center, Biomedical Research Institute of NW Louisiana, Shreveport, USA
Clin J Pain 25:810-4. 2009
..Basic science has demonstrated the hippocampus to be exquisitely sensitive to the effects of stressful experience, which results in changes including alterations in metabolite content and frank atrophy...
- Changes in gray matter density in fibromyalgia: correlation with dopamine metabolism
Patrick B Wood
Department of Family Medicine, Louisiana State University Health Sciences Center Shreveport, USA
J Pain 10:609-18. 2009
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- Enhanced pain perception in rheumatoid arthritis: novel considerations
Patrick B Wood
Pacific Rheumatology Associates, 4300 Talbot Road South, Suite 101, Renton, WA 98055, USA
Curr Pain Headache Rep 13:434-9. 2009
..Identification of factors that contribute to enhanced pain perception in RA may aid in the development of novel analgesic strategies that, in turn, may decrease disease activity and improve general clinical outcomes...
- Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study
Patrick B Wood
Department of Family Medicine and Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA 71103, USA
J Pain 8:51-8. 2007
..PERSPECTIVE: An association between FMS and reduced dopamine metabolism within the pain neuromatrix provides important insights into the pathophysiology of this mysterious disorder...
- Insular hypometabolism in a patient with fibromyalgia: a case study
Patrick B Wood
Department of Family Medicine, Louisiana State University Health Sciences Center Shreveport, Louisiana 71103, USA
Pain Med 9:365-70. 2008
..Neuroimaging studies have demonstrated differential involvement of a variety of brain centers in fibromyalgia both at baseline and in response to stimulation. The insular cortex is one such structure...
- Mesolimbic dopaminergic mechanisms and pain control
Patrick B Wood
Departments of Family Medicine, Anesthesiology and Psychiatry, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Pain 120:230-4. 2006
- Open trial of pindolol in the treatment of fibromyalgia
Patrick B Wood
Department of Family Medicine, Louisiana State University Health Science Center Shreveport, LA 71103 3932, USA
Ann Pharmacother 39:1812-6. 2005
..Evidence suggests that fibromyalgia is related to both chronic sympathetic hyperactivity and decreased levels of serotonin...
- Neuroimaging in functional somatic syndromes
Patrick B Wood
Department of Family Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
Int Rev Neurobiol 67:119-63. 2005
- Novel pharmacotherapy for fibromyalgia
Patrick B Wood
Louisiana State University Health Sciences Center Shreveport, Department of Family Medicine, Shreveport, LA 71130, USA
Expert Opin Investig Drugs 16:829-41. 2007
..Key insights from basic research are the basis for increased optimism for effective relief among patients and clinicians...
- Stress and dopamine: implications for the pathophysiology of chronic widespread pain
Patrick B Wood
Department of Family Medicine, LSU Health Science Center Shreveport, 1501 Kings Highway Shreveport, LA 71103, USA
Med Hypotheses 62:420-4. 2004
..A stress-related dysfunction of mesolimbic dopaminergic activity might serve as the basis for other fibromyalgia-associated phenomena as well...
- Fibromyalgia patients show an abnormal dopamine response to pain
Patrick B Wood
McGill University Centre for Research on Pain, Faculty of Dentistry, 3640 University Street, Strathcona Building, Montreal, QC, Canada, H3A 2B2
Eur J Neurosci 25:3576-82. 2007
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