Mefloquine--its 20 years in the Thai Malaria Control ProgramChansuda Wongsrichanalai
US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 35:300-8. 2004
..Thailand is the country with the most experience in the use of this drug in a malaria control program. We present here a review of mefloquine's pharmacology and usage in Thailand...
- Hematologic and clinical indices of malaria in a semi-immune population of western Thailand
Laura M Erhart
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 70:8-14. 2004
..This study supplements previous literature on the hematologic effects of malaria and helps define those alterations for a semi-immune population. Thrombocytopenia is identified as a key indicator of malaria in these febrile patients...
- A study of'febrile illnesses on the Thai-Myanmar border: predictive factors of rickettsioses
Amy L PicKard
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 35:657-63. 2004
..Timely administration of empiric treatment in highly suspicious cases can deter potential morbidity from these arthropod-borne infections...
- Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study
R Scott Miller
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 74:401-6. 2006
..Three- and five-day azithromycin-quinine combination therapy appears safe, well tolerated, and effective in curing drug-resistant P. falciparum malaria. Further evaluation, especially in pediatric and obstetric populations, is warranted...
- Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II
Harald Noedl
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences USAMC AFRIMS, Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Exp Parasitol 102:157-63. 2002
..HRP2 therefore allows for a very accurate estimation of parasite development and its inhibition and may therefore be ideally suited for use in drug sensitivity or bioassays...
- Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand
D Gray Heppner
Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 73:842-9. 2005
..falciparum (PE =71%, 95% C =-14-94%). We conclude that daily azithromycin was safe, well-tolerated, and had a high efficacy for the prevention of P. vivax malaria...
- Rapid diagnostic devices for malaria: field evaluation of a new prototype immunochromatographic assay for the detection of Plasmodium falciparum and non-falciparum Plasmodium
Chansuda Wongsrichanalai
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 69:26-30. 2003
..malariae; thus, specificity for non-falciparum Plasmodium was 100%. These results suggest improved performance over NOW ICT predecessors...
- Co-infection with malaria and leptospirosis
Chansuda Wongsrichanalai
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 68:583-5. 2003
..Treatment focusing on malaria mono-infections instead of dual infections could result in a delay of specific therapy for leptospirosis and possible consequences of serious complications...
- Histidine-rich protein II: a novel approach to malaria drug sensitivity testing
Harald Noedl
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences USAMC AFRIMS, Bangkok, Thailand
Antimicrob Agents Chemother 46:1658-64. 2002
..Standard operating procedures, updated information, and analytical software are available from http://malaria.farch.net...
- Measuring allelic heterogeneity in Plasmodium falciparum by a heteroduplex tracking assay
Warunee Ngrenngarmlert
Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 72:694-701. 2005
..This study is a proof of concept that HTA is a sensitive allelic discrimination method able to determine genetic diversity in P. falciparum and warrants its use in studies of antimalarial drug efficacy...
- Epidemiology of drug-resistant malaria
Chansuda Wongsrichanalai
Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
Lancet Infect Dis 2:209-18. 2002
..This review describes the various features of drug resistance in Plasmodium falciparum, including its determinants, current status in diverse geographical areas, molecular markers, and their implications...
- Emerging rickettsioses of the Thai-Myanmar border
Philippe Parola
Armed Forces Research Institute of Medical Sciences (AFRIMS, Bangkok, Thailand
Emerg Infect Dis 9:592-5. 2003
..Four patients had murine typhus, three patients had scrub typhus, and eight patients had spotted fever group rickettsioses, including the first case of Rickettsia felis infection reported in Asia...
- Detection of Ehrlichia spp., Anaplasma spp., Rickettsia spp., and other eubacteria in ticks from the Thai-Myanmar border and Vietnam
Philippe Parola
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok
J Clin Microbiol 41:1600-8. 2003
..Finally, two bacteria named Eubacterium sp. strain Hw124 and Eubacterium sp. strain Hw191 were identified in Haemaphysalis wellingtoni ticks collected from chicken in Thailand; these strains could belong to a new group of bacteria...
- In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003
Saowanit Vijaykadga
Disease Control Department, Ministry of Public Health, Nonthaburi, Thailand
Trop Med Int Health 11:211-9. 2006
..To monitor the efficacy of anti-malarial treatments in Thailand...
- Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
Alisa P Alker
Department of Epidemiology, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
Am J Trop Med Hyg 76:641-7. 2007
..040). pfmdr1 copy number should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia...
- pfmdr1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border
Amy L Nelson
University of North Carolina School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina 27599 7435, USA
Am J Trop Med Hyg 72:586-92. 2005
..Increased pfmdr1 gene copy number was significantly associated with recrudescence (relative risk 2.30, 95% CI 1.27-4.15). pfmdr1 gene copy number may be a useful surveillance tool for mefloquine-resistant falciparum malaria in Thailand...
- Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border
Chansuda Wongsrichanalai
US Naval Medical Research Unit No 2, Jakarta, Indonesia
Emerg Infect Dis 14:716-9. 2008
..g., in Africa? Enforcement of rational drug use and improved diagnostic capacity are among the measures needed to avoid and contain ACT resistance...
- Importance of protection of antimalarial combination therapies
Socheat Duong
Lancet 364:1754-5. 2004
- Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia
Naman K Shah
University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
Emerg Infect Dis 14:1637-40. 2008
....
- Lack of prediction of mefloquine and mefloquine-artesunate treatment outcome by mutations in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene for P. falciparum malaria in Peru
Dylan R Pillai
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
Am J Trop Med Hyg 68:107-10. 2003
..5%) contained the D1246 mutation reported to confer MQ resistance in vitro. However, neither this mutation nor a double mutation (S1034, D1246; n = 16) was predictive of MQ treatment outcome...
- Malaria drug-sensitivity testing: new assays, new perspectives
Harald Noedl
Dept of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Kinderspitalgasse 15, A 1095, Vienna, Austria
Trends Parasitol 19:175-81. 2003
..This review examines the various new approaches to the in vitro assessment of malaria drug sensitivity and their limitations...
- Devices for rapid diagnosis of Malaria: evaluation of prototype assays that detect Plasmodium falciparum histidine-rich protein 2 and a Plasmodium vivax-specific antigen
J Russ Forney
United States Military Academy, West Point, New York, USA
J Clin Microbiol 41:2358-66. 2003
..vivax were 0.8907 and 0.8522, respectively. These findings indicate that assays for rapid diagnosis have the potential to enhance diagnostic capabilities in those instances in which skilled microscopy is not readily available...
- Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1
Amy L PicKard
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
Antimicrob Agents Chemother 47:2418-23. 2003
..001). Thus, measurement of pfmdr1 mutations and gene copy number may be useful for surveillance of mefloquine-resistant malaria in Southeast Asia...
- A new method for detection of pfmdr1 mutations in Plasmodium falciparum DNA using real-time PCR
Anne Purfield
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Malar J 3:9. 2004
..Real-time PCR methods for the detection of parasite single-nucleotide polymorphisms (SNPs) and gene amplification could be useful survellance tools...
- Sources of variability in determining malaria parasite density by microscopy
Wendy Prudhomme O'Meara
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
Am J Trop Med Hyg 73:593-8. 2005
..We discuss the implications of this analysis for field studies and clinical trials...
- Malaria rapid tests: a public health perspective
Chansuda Wongsrichanalai
Lancet 359:1781. 2002
- World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility
David J Bacon
Parasitology Program, Naval Medical Research Center Detachment, Lima, Peru
Malar J 6:120. 2007
..Such a network would facilitate the rapid detection of strains with novel antimalarial resistance profiles and investigate suitable alternative treatments with retained efficacy...
- Gametocytemia in Plasmodium vivax and Plasmodium falciparum infections
F Ellis McKenzie
Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
J Parasitol 92:1281-5. 2006
..falciparum patients with gametocytemia had similar platelet counts but lower red blood cell counts, hemoglobin levels, hematocrit levels, and higher lymphocyte counts than patients without gametocytemia...
- Ensuring quality and access for malaria diagnosis: how can it be achieved?
David Bell
Malaria, other Vector borne and Parasitic Diseases, World Health Organization Regional Office for the Western Pacific, P O Box 2932, Manila, Philippines
Nat Rev Microbiol 4:682-95. 2006
....
- Fever in patients with mixed-species malaria
F Ellis McKenzie
Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
Clin Infect Dis 42:1713-8. 2006
..Clinical symptoms of mixed-species malaria infections have been variously reported as both less severe and more severe than those of single-species infections...
- Dependence of malaria detection and species diagnosis by microscopy on parasite density
F Ellis McKenzie
Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Trop Med Hyg 69:372-6. 2003
..7% of the samples. The likelihood of parasite detection and correct diagnosis at the clinic varied in accordance with the reference-standard estimates of parasite density...
- White blood cell counts and malaria
F Ellis McKenzie
Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 192:323-30. 2005
..For instance, in the present study, use of this conventional approach would have overestimated average asexual parasite densities in the P. falciparum-infected patients in Thailand by nearly one-third...
- Rapid diagnostic testing for malaria
Clinton K Murray
Infectious Diseases Service, Brooke Army Medical Center, San Antonio, TX 78234 6200, USA
Trop Med Int Health 8:876-83. 2003
....
- Malaria drug-susceptibility testing. HRP2-based assays: current data, future perspectives
Harald Noedl
Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Vienna, Austria
Wien Klin Wochenschr 115:23-7. 2003
..It has proved to be a valuable tool for a wide range of applications, from epidemiological field studies to the screening of new drugs, and may therefore have the potential to replace traditional in-vitro drug-sensitivity techniques...
