A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHDTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Behav Brain Funct 4:24. 2008
..abstract:..
- Cognitive function testing: the case for standardization and automation
Keith A Wesnes
Cognitive Drug Research, Goring on Thames, UK
J Br Menopause Soc 12:158-63. 2006
....
- Assessing change in cognitive function in dementia: the relative utilities of the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Cognitive Drug Research system
Keith A Wesnes
Cognitive Drug Research Ltd, Goring on Thames, UK
Neurodegener Dis 5:261-3. 2008
..Finally, the CDR system has a large normative database which allows treatment effects in dementia to be put into an unambiguous clinical perspective...
- Rivastigmine tartrate with a focus on dementia associated with Parkinson's disease
Keith Wesnes
Cognitive Drug Research, Ltd, Goring on Thames, and Human Cognitive Neuroscience Unit, Northumbria University, Newcastle on Tyne, UK
Drugs Today (Barc) 43:349-59. 2007
..A treatment is now available for a previously unmet medical need...
- Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg
Keith A Wesnes
Cognitive Drug Research Ltd, Goring on Thames, UK
Expert Opin Drug Saf 8:615-26. 2009
..To assess the cognitive effects of single doses of solifenacin 10 mg compared with placebo (primary objective) and oxybutynin immediate release (IR) 10 mg (secondary objective) in elderly subjects...
- Cognition assessment in paediatric clinical trials
Chris J Edgar
Cognitive Drug Research Ltd, CDR House, Goring on Thames, UK
Drug Discov Today 13:79-85. 2008
..This requirement to evaluate cognition in children and adolescents, and new legislation for paediatric clinical trials, has created an increased demand for suitable assessment methods...
- The effects of L-theanine, caffeine and their combination on cognition and mood
Crystal F Haskell
Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
Biol Psychol 77:113-22. 2008
..These results suggest that beverages containing L-theanine and caffeine may have a different pharmacological profile to those containing caffeine alone...
- Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine
Crystal F Haskell
Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
Psychopharmacology (Berl) 179:813-25. 2005
..Differences in the patterns of responses to caffeine by habitual consumers and habitual non-consumers may go some way to explaining why some individuals become caffeine consumers...
- A low glycaemic index breakfast cereal preferentially prevents children's cognitive performance from declining throughout the morning
Jeanet Ingwersen
Cognition and Communication Research Centre, Division of Psychology, University of Northumbria, Newcastle upon Tyne NE1 8ST, UK
Appetite 49:240-4. 2007
..742 and -13.510, respectively, p<0.05) and secondary memory (M=-30.675 and -47.183, respectively, p<0.05)...
- Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: a prospective study
Romola S Bucks
University of Southampton, UK
Brain Behav Immun 22:399-407. 2008
..URTIs also affect mood. Future studies need to examine the role of inflammatory molecules and the brain regions implicated in mediating these findings...
- The cognitive effects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls
Colin Palmer
Behavioural Neuroscience Laboratory, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Victoria, Australia
Hum Psychopharmacol 23:151-9. 2008
....
- An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
Andrew B Scholey
Brain Sciences Institute, Swinburne University, Melbourne, Vic, 3122, Australia
Psychopharmacology (Berl) 198:127-39. 2008
..In recent controlled trials, administration of sage extracts with established cholinergic properties improved cognitive function in young adults...
- Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers
Jaymin Shah
Elan Pharmaceuticals, Inc, San Diego, California, USA
Clin Ther 28:1308-17. 2006
..The large interpatient variability in plasma profiles most likely dampened the ability to fully elucidate the differences between the 2 formulations...
- Orthostatic hypotension in Parkinson's disease: association with cognitive decline?
Liesl M Allcock
Parkinson's Disease Research Unit, Department of Neurology, Sunderland Royal Hospital, Sunderland, UK
Int J Geriatr Psychiatry 21:778-83. 2006
..CONCLUSION: We conclude that there are differences in the neuropsychological performance of patients with PD and OH, supporting the hypothesis that OH might be a marker for disease progression and cognitive decline in PD...
- Reboxetine versus paroxetine versus placebo: effects on cognitive functioning in depressed patients
James M Ferguson
University of Utah, Salt Lake City, Utah, USA
Int Clin Psychopharmacol 18:9-14. 2003
..The results of the present study provide objective data to support the possibility that reboxetine favourably affects cognitive processes in depressed patients...
- Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers
Harumi Kitagawa
Quintiles, Inc, Tokyo, Japan
Neuropsychopharmacology 28:542-51. 2003
..These data indicate that GTS-21 may represent a novel treatment for dementia...
- Basal activity of the HPA axis and cognitive function in anorexia nervosa
Julie A Seed
Division of Psychology, University of Northumbria, New Castle upon Tyne, UK
Int J Neuropsychopharmacol 5:17-25. 2002
..The limitations of cortisol as an indicator of HPA axis activity are discussed...
- Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies
Ian G McKeith
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 18:94-100. 2004
..This may reflect the greater cholinergic deficits in areas of the brain responsible for visual hallucinations, offering greater potential for attentional improvement...
- Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory
Cathy Matrenza
Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
J Psychopharmacol 18:21-31. 2004
..These findings suggest that simultaneously depleting the availability of brain serotonin and catecholamines in healthy female subjects selectively impairs sustained attention, without affecting other cognitive domains...
- Selective effects of acute serotonin and catecholamine depletion on memory in healthy women
Ben J Harrison
Neuropsychopharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Melbourne Australia
J Psychopharmacol 18:32-40. 2004
..This may shed light on the role of these neurotransmitters in disorders that are characterized by significant memory impairment...
- Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial
C V Russell Blacker
Department of Health and Social Sciences, University of Exeter, Exeter, England
JAMA 292:1195-204. 2004
..There is no established pharmacological treatment for the core symptoms of chronic fatigue syndrome (CFS). Galantamine hydrobromide, an acetyl cholesterone inhibitor, has pharmacological properties that might benefit patients with CFS...
- Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly
Nunzio Pomara
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neurochem Res 29:2311-5. 2004
..Plasma GABA concentration does not appear to be a useful marker of susceptibility to benzodiazepine-induced cognitive toxicity in the elderly. Other approaches to estimating central GABA activity should be pursued...
- Short-term transdermal estradiol therapy, cognition and depressive symptoms in healthy older women. A randomised placebo controlled pilot cross-over study
Rebekah Schiff
Department of Medicine for the Elderly, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Psychoneuroendocrinology 30:309-15. 2005
..However, the results do support the concept that depressive symptoms may be reduced by estradiol, and not simply due to the relief of climacteric symptoms...
- Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers
Gary G Kay
Washington Neuropsychological Institute, Washington, DC 20008, USA
BJU Int 96:1055-62. 2005
..To evaluate the pharmacodynamic effects of darifenacin (a muscarinic M(3) selective receptor antagonist) and dicyclomine (an M(1) selective receptor antagonist) in healthy male volunteers...
- Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease
Daniel M Forton
Hepatology Section, Division of Medicine A, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
Hepatology 35:433-9. 2002
..The findings on MRS suggest that a biological cause underlies this abnormality...
