O Castejon

Summary

Affiliation: Universidad Central de Venezuela
Country: Venezuela

Publications

  1. ncbi Confocal laser scanning microscopy of hamster cerebellum using FM4-64 as intracellular staining
    O Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Scanning 21:15-21. 1999
  2. ncbi Morphological changes of dendrites in the human edematous cerebral cortex. A transmission electron microscopic study
    O J Castejon
    Institute of Biological Investigations, Drs Orlando J Castejón y Haydée Viloria de Castejón, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 35:395-413. 2003
  3. ncbi Co-existence of anemia, vitamin A deficiency and growth retardation among children 24-84 months old in Maracaibo, Venezuela
    H V Castejon
    Biological Research Institute, Maracaibo, Venezuela
    Nutr Neurosci 7:113-9. 2004
  4. ncbi Correlative microscopy of Purkinje dendritic spines: a field emission scanning and transmission electron microscopic study
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:29-36. 2004
  5. ncbi Structural patterns of injured mitochondria in human oedematous cerebral cortex
    Orlando J Castejon
    Instituto de Investigaciones Biologicas, Universidad del Zulia, Maracaibo, Venezuela
    Brain Inj 18:1107-26. 2004
  6. ncbi Ultrastructural pathology of neuronal membranes in the oedematous human cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Orlando Castejón y Haydee V Castejón, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:167-79. 2004
  7. ncbi Transmission electron microscopy of cortical dendritic spines in the human oedematous cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:181-91. 2004
  8. ncbi Lysosome abnormalities and lipofucsin content of nerve cells of oedematous human cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:263-71. 2004
  9. ncbi Nerve cell nuclear and nucleolar abnormalities in the human oedematous cerebral cortex. An electron microscopic study using cortical biopsies
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:273-83. 2004
  10. ncbi Traumatic axolemmal and cytoskeletal derangement in myelinated axons of human oedematous cerebral cortex and loss of consciousness. An electron microscopic study using cortical biopsies
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:285-93. 2004

Collaborators

  • G Gomez
  • H V Castejon
  • D Amaya
  • P Ortega
  • J Leal

Detail Information

Publications33

  1. ncbi Confocal laser scanning microscopy of hamster cerebellum using FM4-64 as intracellular staining
    O Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Scanning 21:15-21. 1999
    ..The z-series of stacks of optodigital sections allowed us to explore in depth the cytoarchitectonic arrangement, nerve and glial cell morphology, and the topographic relationship with the afferent fibers...
  2. ncbi Morphological changes of dendrites in the human edematous cerebral cortex. A transmission electron microscopic study
    O J Castejon
    Institute of Biological Investigations, Drs Orlando J Castejón y Haydée Viloria de Castejón, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 35:395-413. 2003
    ..Dendrotoxicity due to brain edema and brain ischemia seems to be the fundamental pathogenetic mechanism...
  3. ncbi Co-existence of anemia, vitamin A deficiency and growth retardation among children 24-84 months old in Maracaibo, Venezuela
    H V Castejon
    Biological Research Institute, Maracaibo, Venezuela
    Nutr Neurosci 7:113-9. 2004
    ..99% of the sample. The prevalence of micronutrient deficiencies remain as significant public health problems which should be simultaneously treated as virtually independent, giving priority to infant, toddler and preschool age groups...
  4. ncbi Correlative microscopy of Purkinje dendritic spines: a field emission scanning and transmission electron microscopic study
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:29-36. 2004
    ..Simultaneous contacts with the necks and heads were also found. The variety of Pds shapes were interpreted as spine conformational changes related with spine dynamic, and spine plasticity...
  5. ncbi Structural patterns of injured mitochondria in human oedematous cerebral cortex
    Orlando J Castejon
    Instituto de Investigaciones Biologicas, Universidad del Zulia, Maracaibo, Venezuela
    Brain Inj 18:1107-26. 2004
    ..Cerebral cortical biopsies of 37 patients with clinical diagnosis of congenital malformations, brain trauma and tumours were studied to establish mitochondrial morphological alterations...
  6. ncbi Ultrastructural pathology of neuronal membranes in the oedematous human cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Orlando Castejón y Haydee V Castejón, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:167-79. 2004
    ....
  7. ncbi Transmission electron microscopy of cortical dendritic spines in the human oedematous cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:181-91. 2004
    ..The presence of axonless spines is symptomatic of a loss of nerve connectivity, and are expected to have a significant input on neurological and mental functions...
  8. ncbi Lysosome abnormalities and lipofucsin content of nerve cells of oedematous human cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:263-71. 2004
    ..The role of released and activated lysosomal enzymes is discussed in relation with the cytoplasmatic focal necrosis of nerve cells and the genesis of moderate and severe oedema...
  9. ncbi Nerve cell nuclear and nucleolar abnormalities in the human oedematous cerebral cortex. An electron microscopic study using cortical biopsies
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:273-83. 2004
    ..The nuclear and nucleolar morphological alterations are discussed in relation with oxidative stress, peroxidative damage, hemoglobin-induced cytotoxicity, calcium overload, glutamate excitotoxicity, and caspase activation...
  10. ncbi Traumatic axolemmal and cytoskeletal derangement in myelinated axons of human oedematous cerebral cortex and loss of consciousness. An electron microscopic study using cortical biopsies
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 36:285-93. 2004
    ....
  11. ncbi The inflammatory reaction in human traumatic oedematous cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 37:43-52. 2005
    ..The inflammatory process developed according to the intensity of traumatic insult, patient age, associated hematoma or hygroma, severity of vasogenic and cytotoxic oedema, and anoxic-ischemic conditions of brain parenchyma...
  12. ncbi Nerve cell death types in the edematous human cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 38:21-36. 2006
    ....
  13. ncbi Blood-brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation
    Orlando J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Apartado 526, Maracaibo, Venezuela
    Folia Neuropathol 47:11-9. 2009
    ..The electron microscopic findings demonstrated breakdown of the blood-brain barrier in all cases examined...
  14. ncbi The extracellular space in the edematous human cerebral cortex: an electron microscopic study using cortical biopsies
    Orlando J Castejon
    Biological Research Institute Drs Orlando Castejon and Haydee V Castejon, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    Ultrastruct Pathol 33:102-11. 2009
    ..The enlarged extracellular space found in congenital hydrocephalus, vascular anomalies, brain trauma, and tumors is closely related to the clinical symptoms exhibited by the patients under study...
  15. ncbi Immunohistochemistry of GluR1 subunits of AMPA receptors of rat cerebellar nerve cells
    Orlando J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, PO Box 526, Maracaibo, Venezuela
    Biocell 33:71-80. 2009
    ....
  16. ncbi Intranuclear filamentous inclusion in human oedematous cerebellar Golgi cells
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 35:389-93. 2003
    ..2 nm thick separated by clear spaces, 5.4 nm in width. These structures are considered abnormal protein aggregates apparently induced by excitotoxicity, oxidative stress and impaired energy metabolism...
  17. ncbi Synaptic plasticity in the oedematous human cerebral cortex
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 35:177-97. 2003
    ..Coexisting synaptic plasticity and synaptic degeneration were observed in the patients under study. Dendritic and astrocyte synapse-like junctions were also characterized...
  18. ncbi Oligodendroglial cell behaviour in traumatic oedematous human cerebral cortex: a light and electron microscopic study
    O J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Brain Inj 14:303-17. 2000
    ..The vasogenic and cytotoxic components of traumatic brain oedema are discussed in relation with the oligodendroglial cell changes and reactivity...
  19. ncbi Correlative microscopy of cerebellar Golgi cells
    O J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Biocell 24:13-30. 2000
    ..Shaft asymmetric axodendritic and axospinodendritic contacts between Golgi cell dendrites and climbing fibers were also found in the molecular layer...
  20. ncbi Cytoarchitectonic arrangement and intracortical circuits of hamster cerebellum. A study by means of confocal scanning laser microscopy
    O Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Biocell 23:187-96. 1999
    ....
  21. ncbi Three-dimensional morphology of cerebellar climbing fibers. A study by means of confocal laser scanning microscopy and scanning electron microscopy
    O J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Scanning 22:211-7. 2000
    ..By field emission high-resolution SEM of primate cerebellar cortex, the climbing fiber terminal collaterals were appreciated ending by means of round synaptic knobs upon the spines of secondary and tertiary Purkinje cell dendrites...
  22. ncbi Confocal, scanning and transmission electron microscopic study of cerebellar mossy fiber glomeruli
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 32:247-60. 2000
    ..The integrated microscopy approach offers a new and more comprehensive view of three-dimensional morphology, organization and quantitative aspects of mossy fiber glomeruli...
  23. ncbi Further observations on cerebellar climbing fibers. A study by means of light microscopy, confocal laser scanning microscopy and scanning and transmission electron microscopy
    O J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad de Zulia, Apartado 526, Maracaibo, Venezuela
    Biocell 24:197-212. 2000
    ..The correlative microscopy approach provides new views in the cerebellar cortex information processing...
  24. ncbi Consecutive light microscopy, scanning-transmission electron microscopy and transmission electron microscopy of traumatic human brain oedema and ischaemic brain damage
    O J Castejon
    Institute of Biological Researchs, School of Medicine, University of the Zulia, Maracaibo, Venezuela
    Histol Histopathol 16:1117-34. 2001
    ..The (S)TEM is recommended as a suitable technique for studying pathological processes in the central nervous system and as an informative adjunct to LM and TEM...
  25. ncbi Light microscopy, confocal laser scanning microscopy, scanning and transmission electron microscopy of cerebellar basket cells
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 33:23-32. 2001
    ..The correlative microscopy approach demonstrates the potential value of these methodologies for studying the three-dimensional aspect of short intracortical circuits in the central nervous system...
  26. ncbi Oligodendroglial cell damage and demyelination in infant hydrocephalus. An electron microscopic study
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 33:33-40. 2001
    ..They did not show any association with neighbouring axons, and myelinated axons were not observed in the neuropil. These observations suggest demyelination in infant hydrocephalus...
  27. ncbi Confocal laser scanning, conventional scanning and transmission electron microscopy of vertebrate cerebellar granule cells
    O J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Apartado Postal No 526, Maracaibo, Venezuela
    Biocell 25:235-55. 2001
    ..The above findings provide new vistas for future studies dealing with intracortical circuits and information processing in the cerebellar cortex...
  28. ncbi Glycogen-rich and glycogen-depleted astrocytes in the oedematous human cerebral cortex associated with brain trauma, tumours and congenital malformations: an electron microscopy study
    Orlando J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Brain Inj 16:109-32. 2002
    ..The anaerobic mobilization of astrocyte glycogen in anoxic-ischemic regions of the oedematous human cerebral cortex is analysed. METHODS and..
  29. ncbi Field emission scanning electron microscopy and freeze-fracture transmission electron microscopy of mouse cerebellar synaptic contacts
    O J Castejon
    Institute of Biological Investigations Dres Orlando J Castejon y Haydee Viloria de Castejón, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 33:289-300. 2001
    ....
  30. ncbi A light and electron microscopic study of oedematous human cerebral cortex in two patients with post-traumatic seizures
    O J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela
    Brain Inj 16:331-46. 2002
    ..Brain cortical biopsies of two patients with clinical diagnosis of complicated brain trauma who had seizures, were studied by means of light and electron microscopes in order to correlate structural alterations with seizure activity...
  31. ncbi Correlative microscopy of cerebellar Bergmann glial cells
    O J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela
    J Submicrosc Cytol Pathol 34:131-42. 2002
    ..The study reveals three-dimensional Bergmann glial cells heterogeneity and the complex network formed by Bergmann glial cells in the molecular layer...
  32. ncbi Submicroscopic pathology of human and experimental hydrocephalic cerebral cortex
    Orlando J Castejon
    Instituto de Investigaciones Biologicas, Facultad de Medicina, Universidad del Zulia, Apartado 526, Maracaibo, Venezuela
    Folia Neuropathol 48:159-74. 2010
    ....
  33. ncbi Localization of synapsin-I and PSD-95 in developing postnatal rat cerebellar cortex
    Orlando J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, PO Box 526, Maracaibo, Venezuela
    Brain Res Dev Brain Res 151:25-32. 2004
    ....