Alexander R Vaccaro

..No assessment of regional differences has been described. We report regional variability in use of the TLISS system between United States and non-US surgeons...

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..abstract:..

..A prospective, randomized, controlled, multicenter clinical study was conducted...

..Image guidance may afford a safety benefit to patients when anterior thoracic screws are required in the setting of spinal stabilization after trauma...

..A prospective, randomized, controlled, multicenter clinical study...

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..There were no adverse events related to the OP-1 putty implant in this study, which supports findings in other studies suggesting the safety of bone morphogenetic proteins in spinal surgery...

..A new proposed classification system for thoracolumbar (TL) spine injuries, including injury severity assessment, designed to assist in clinical management...

..With familiarity of the constraints and benefits of the available instrumentation systems, the individual fixation needs of a clinical situation can be fulfilled and successful patient outcomes can be achieved...

..Randomized controlled trial comparing OP-1 (rhBMP-7) with iliac crest autograft in patients with symptomatic degenerative spondylolisthesis and spinal stenosis treated with decompression and uninstrumented posterolateral arthrodesis...

..Prospective diagnostic imaging study...

..The classification system was derived through a literature review and expert opinion of experienced spine surgeons. In addition, a multicenter reliability and validity study of the system was conducted on a collection of trauma cases...

..The goal of this work is to present a proposal of a detailed treatment algorithm to assist in the nonoperative or operative management of thoracolumbar injuries...

..In the absence of good scientific data, expert consensus opinions may provide surgeons with a practical framework to guide therapy and to conduct future research...

..The lack of adverse events related to the OP-1 putty implant in this study is in agreement with other studies supporting the safety of bone morphogenetic proteins in spinal surgery...

..Prospective study of 5 spine surgeons rating 71 clinical cases of thoracolumbar spinal injuries using the Thoracolumbar Injury Severity Score (TLISS) and then re-rating the cases in a different order 1 month later...

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..Posterolateral lumbar fusions were performed in nicotine-exposed, New Zealand white rabbits. Animals that developed a pseudarthrosis were then regrafted with no graft, autograft, or osteogenic protein-1 (OP-1)...

..Survey of neurosurgical and orthopedic spine surgeons...

..Previous clinical studies involving patients with degenerative spondylolisthesis have reported that the efficacy and safety of OP-1 Putty is comparable to that of autograft at both 1- and 2-year follow-up...

..CONCLUSIONS: The usefulness of this new system will have to be proven in future studies investigating inter- and intraobserver reliability, as well as long-term outcome studies for operative and nonoperative treatment methods...

..To investigate effects of FGF-2 on nucleus pulposus cell growth and differentiation...

..Physical examination findings and history of the mechanism of injury were ranked lower than imaging studies. Future analysis should focus on indicators of PLC injury when plain radiographic findings are either subtle or not present...

..Until the results of more studies in human spinal applications become available, the precise indications for the use of bioabsorbable interbody spacers will continue to evolve...

..Retrospective...

..To study radiographic and clinical outcomes after transforaminal lumbar interbody fusion (TLIF) in order to determine the impact of TLIF on lumbar lordosis, intervertebral height and improvement in clinical outcome measures...

..In this study, the authors analyzed radiographic parameters of patients with LDS at the L4-5 level to better characterize this entity...

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..A retrospective review of neurophysiologic alerts during anterior cervical surgery...

..A retrospective review...

..CONCLUSIONS: The results of this preliminary study indicate that bioresorbable ACP systems for single-level ACDF are both safe and effective...

..To identify and characterize endogenous progenitor cell population from intervertebral disc...

..The Thoracolumbar Injury Severity Score (TLISS) and the Thoracolumbar Injury Classification and Severity Score (TLICS) were prospectively evaluated...

..Retrospective review of radiographic parameters...

..The nonspecified disease group had the lowest rate of surgical adverse events and the highest rate of neurological improvement...

..The increased rigidity afforded by segmental fixation may significantly decrease the likelihood of plate dislodgement in the setting of anterior instrumentation alone following anterior alone, long segment reconstruction procedures...

..The C1 lateral mass and C2 pedicle/isthmus screw technique has increased significantly since its description. Pneumonia, vocal cord, and swallowing problems occurred more often with anterior approaches...

..Systematic review of published incidence of radiographic adjacent segment degeneration (ASDeg) and symptomatic adjacent segment disease (ASDis) after arthrodesis or total disc replacement...

..Retrospective cohort study...

..Concerns remain, however, regarding the clinical efficacy and safety of its use...

..An anatomic study that describes the relationship of the pedicle center to the mid-lateral pars (MLP) in the lower lumbar spine as a guide to pedicle screw placement...

..To validate this assessment, the authors revised their survey to make it appropriate for a lay audience and repeated the assessment with a cohort of patients who underwent spine surgery...

..The purpose of this study was to determine the interrater reliability of indicators surgeons use when assessing PLC disruption on imaging studies, including computed tomography (CT) and magnetic resonance imaging (MRI)...

..The correlation between obesity and incidence of complications in spine surgery is unclear, with some reports suggesting linear relationships between body mass index (BMI) and complication incidence and others noting no relationship...

..j.a.)...

..This study is a retrospective review of fusion rates for cervical plates, analyzed by means of computerized analysis...

..Retrospective case series, literature review...

..Although its use eliminates the risk of harvesting autograft, rhBMP-2 is associated with other complications that raise concern, including a high rate of postoperative radiculitis...

..Prospective clinical assessment of the interobserver reliability of the Thoracolumbar Injury Classification and Severity Score (TLISS) in a series of consecutive patients...

..Polyetheretherketone (PEEK) has been increasingly used as a biomaterial for spinal implants. PEEK lumbar fusion rods have recently become available for use in posterior lumbar fusion procedures...

..An illustrative technique display and discussions...

..Rat lumbar discs comprising nucleus pulposus, annulus fibrosus, and cartilaginous endplates were cultured for 1 week in a specialized media containing either TGF-beta1 or TGF-beta3. Role of TGF-beta isoforms on cell function was evaluated...

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..The results of this preliminary study indicate that bioresorbable anterior cervical plating for single-level anterior cervical diskectomy and fusion is both safe and effective...

..Progenitor cells were isolated using standard culture conditions and their osteogenic potential evaluated...

..Further study regarding surgical navigation systems for intervertebral disk replacement is warranted...

..Outcomes following aggressive treatment of this complication can be excellent, with no long-term loss of function and complete eradication of the infection...

..g., ankylosing spondylitis in which spontaneous fusions obscure surgical landmarks for pedicle access), or when used postsurgically in the setting of a posterolateral fusion...

..A patient presenting with an acute neurologic deficit with no apparent etiology presents a diagnostic dilemma. A broad differential diagnosis must be entertained, considering both organic and psychiatric causes...

..Multinational survey of spine trauma surgeons...

..Two clinical syndromes sometimes associated with these injuries are conus medullaris syndrome (CMS) and cauda equina syndrome (CES)...

..Prospective cohort study...

..SafePath (Mekanika, Boca Raton, FL) is an alternative pedicle probe designed for pedicle cannulation. This is a blunt-tipped, nonaggressive drill that seeks the cancellous portion of the pedicle...

..Human trials ultimately will provide data to clarify the optimal role of osteogenic protein-1 in human spinal surgery...

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..Although posterior surgical approaches to the cervicothoracic junction are relatively straightforward, anterior approaches require mastery in traversing the various bony and soft-tissue structures...

..The objective of this study was to compare C-arm fluoroscopy and computer-assisted image guidance in terms of radiation exposure to the operative surgeon when placing pedicle screw-rod constructs in cadaver specimens...

..Initial application of the TLICS has shown good to excellent reliability and validity. Additional evaluation of the TLICS is needed to prospectively define its clinical utility and identify potential limitations...

..In addition, postoperative management is covered, including deep venous thrombosis prophylaxis...

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..Coronal magnetic resonance imaging offers the best means of visualizing a conjoined nerve root. The chance for a successful operation can be significantly enhanced if the surgeon is prepared to encounter this pathology...

..Unilateral pedicle screws frews further increased stiffness at the L4-L5 segment. However, TLIF with bilateral pedicle screws most closely approximated the L4-L5 segmental flexibility of the intact spine...

..Among hook-rod configurations, the distraction hook-rod strategy provided the least stability...

..Systematic review...

..With the aging of the population, painful osteoporotic compression fractures are becoming more common...

..A retrospective study evaluating early halo immobilization of Types II and IIA hangman's fractures...

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..This article examines the underemphasized but crucial role of the osteoconductive scaffold in the composite synthetic bone graft...

..However, errors may occur with all techniques. Further refinement in registration procedures may highly improve the accuracy of percutaneous screw placement in a variety of spinopelvic procedures...

..Complications were primarily related to infection, wound healing, and asymptomatic rod breakage, and were without long-term sequelae...

..CT scanning provides excellent osseous detail for the measurement of such parameters, and with its widespread use in the evaluation of cervical disorders, large numbers of patients can be reviewed...

..75 to 0.98. CONCLUSION: A new cervical spine classification system of injury is paramount to treatment and outcomes. A new system may increase reliability and therefore allow more accurate determination of stability and dictate treatment...

..To the best of the authors' knowledge, this article represents the first reported case series of these unique spinal lesions...

..The authors review indications for surgery, bone grafting, and instrumentation as they pertain to children...

..Perhaps identifying objective findings on imaging studies and clinical examination in place of guessing injury mechanisms may allow for a more reliable and valid thoracolumbar injury classification system...

..As such, a fusion should be considered whenever a laminectomy is performed in the immature cervical spine. Risk factors for kyphosis include a high cervical level, multiple laminectomy levels, and postoperative irradiation...

..CONCLUSIONS: In the rabbit pseudarthrosis model, gene expression data supported the hypothesis that successful pseudarthrosis repair is related to the induction of osteogenic and angiogenic cytokines by osteogenic protein-1...

..The greater than 2-year clinical and radiographic results of this series are presented along with as a review of relevant preclinical and preliminary clinical studies of bioresorbables...

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..However, confusion exists when plain radiography shows injury to the anterior spinal column without significant kyphosis or widening of the posterior interspinous space...

..Present single-tube approaches may entail significant facet injury. We explore the feasibility of a dual-tube minimally invasive laminectomy approach in a cadaver model...

..Systematic review of literature and expert clinical opinions of the members of the Spine Trauma Study Group were combined to develop and refine this algorithm...

..Questionnaires administered to practicing orthopedic and neurosurgical spine surgeons from various regions of the United States and abroad...

..The study is a prospective observational study of 48 continuous patients with symptomatic lumbar degenerative disk disease. Each patient underwent discography, MRI, and a biochemical analysis of disk lavage fluid...