Research Topics
Genomes and Genes | Hong Wei WangSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Structural insights into RNA processing by the human RISC-loading complexHong Wei Wang
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Nat Struct Mol Biol 16:1148-53. 2009..A model generated by docking the available atomic structures of Dicer and Argonaute homologs into the RLC reconstruction suggests a mechanism for siRNA transfer from Dicer to AGO2...- Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complexStefan Westermann
Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Mol Cell 17:277-90. 2005..These observations suggest a mechanism by which the kinetochore can recognize and stay attached to the plus ends of microtubules... - The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule endsStefan Westermann
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3202, USA
Nature 440:565-9. 2006..The Dam1 ring complex is a molecular device that can translate the force generated by microtubule depolymerization into movement along the lattice to facilitate chromosome segregation... - Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanismsHong Wei Wang
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
Nat Struct Mol Biol 14:721-6. 2007..One of Ipl1's roles might be to fine-tune the coupling of the microtubule interaction with the conformational change required for oligomerization, with phosphorylation resulting in ring breakdown... - The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubuleVincent H Ramey
Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA
Mol Biol Cell 22:457-66. 2011..The present studies constitute a significant step forward by linking structural and biochemical observations toward a comprehensive understanding of the Dam1 complex... - Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicineHong Wei Wang
Life Science Division, Lawrence Berkeley National Lab, Berkeley, California, USA
Cell Cycle 4:1157-60. 2005..Finally, we add our thoughts on the possible biological meaning of tubulin polymerization versatility... - Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processingHong Wei Wang
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 104:16844-9. 2007..The Rrp44-exosome (RE) architecture suggests an active site sequestration mechanism for strict control of 3' exoribonuclease activity in the RE complex... - Nucleotide-dependent bending flexibility of tubulin regulates microtubule assemblyHong Wei Wang
Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720 3200, USA
Nature 435:911-5. 2005..Closure into a microtubule does not require GTP hydrolysis... - Cryo-EM studies of microtubule structural intermediates and kinetochore-microtubule interactionsEva Nogales
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3220, USA
Methods Cell Biol 95:129-56. 2010..We describe the experimental in vitro protocols to produce biologically relevant self-assembled structures of Dam 1 around microtubules and their structural characterization by cryo-EM... - Architecture and flexibility of the yeast Ndc80 kinetochore complexHong Wei Wang
Life Science Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
J Mol Biol 383:894-903. 2008..We hypothesize that the kink in Ndc80 is essential for correct kinetochore geometry and could be part of a tension-sensing mechanism at the kinetochore... - Structural intermediates in microtubule assembly and disassembly: how and why?Eva Nogales
Howard Hughes Medical Institute, Molecular and Cell Biology Department, UC Berkeley and Lawrence Berkeley National Lab, 355 LSA UC Berkeley, Berkeley, CA 94720 3200, USA
Curr Opin Cell Biol 18:179-84. 2006..The discovery of these intermediates a decade ago has been followed recently by quantitative descriptions of their structure and their relationship to nucleotide state... - Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relativesEva Nogales
Howard Hughes Medical Institute, Molecular and Cell Biology Department, University of California Berkeley and Lawrence Berkeley National Laboratory, 355 LSA, University of California Berkeley, Berkeley, CA 94720 3200, USA
Curr Opin Struct Biol 16:221-9. 2006..In particular, a two-state mechanism has been proposed for the recycling of alphabeta-tubulin during the microtubule disassembly-assembly cycle; this mechanism may be unique to eukaryotic dimeric tubulin and the microtubule structure... - Ab initio reconstruction of helical samples with heterogeneity, disorder and coexisting symmetriesVincent H Ramey
Biophysics Graduate Program, UC Berkeley, Berkeley, CA, USA
J Struct Biol 167:97-105. 2009.... - Tubulin rings: which way do they curve?Eva Nogales
Howard Hughes Medical Institute, Molecular and Cell Biology Department and Life Science Division, Lawrence Berkeley National Laboratory, 355 Life Sciences Addition, University of California, 94720-3200, USA
Curr Opin Struct Biol 13:256-61. 2003..How these kinks relate to what happens when the stored energy of GTP hydrolysis is released, freeing GDP*tubulin into an unconstrained state, remains an open question...