D F Stern

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
    D F Stern
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Breast Cancer Res 2:176-83. 2000
  2. ncbi Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
    Z Sun
    Department of Pathology, Yale University of Medicine, New Haven Connecticut 06520 8023, USA
    Genes Dev 10:395-406. 1996
  3. ncbi Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2
    D J Riese
    Department of Pathology, Yale University, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 273:11288-94. 1998
  4. ncbi Functional assay for HER-2/neu demonstrates active signalling in a minority of HER-2/neu-overexpressing invasive human breast tumours
    M P DiGiovanna
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Br J Cancer 74:802-6. 1996
  5. ncbi Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer
    A D Thor
    Department of Pathology, Evanston Hospital Northwestern University, Evanston, IL 60201, USA
    J Clin Oncol 18:3230-9. 2000
  6. ncbi Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells
    S Agarwal
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Br J Cancer 100:941-9. 2009
  7. ncbi Specificity within the EGF family/ErbB receptor family signaling network
    D J Riese
    Department of Pathology, Yale University, New Haven, CT, USA
    Bioessays 20:41-8. 1998
  8. ncbi Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4
    A J Jackson-Fisher
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Oncogene 25:5664-72. 2006
  9. ncbi Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation
    F E Jones
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Oncogene 18:3481-90. 1999
  10. ncbi Pathobiologic findings in DCIS of the breast: morphologic features, angiogenesis, HER-2/neu and hormone receptors
    E B Claus
    Department of Pathology, Yale Comprehensive Cancer Center, New Haven, Connecticut 06520, USA
    Exp Mol Pathol 70:303-16. 2001

Collaborators

Detail Information

Publications18

  1. ncbi Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
    D F Stern
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Breast Cancer Res 2:176-83. 2000
    ..Optimal use of therapeutics targeting these receptors will require consideration of the several modes of regulation of these receptors and their interactions with steroid receptors...
  2. ncbi Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
    Z Sun
    Department of Pathology, Yale University of Medicine, New Haven Connecticut 06520 8023, USA
    Genes Dev 10:395-406. 1996
    ..This regulation is mediated through a protein kinase cascade that potentially includes Mec1p and Tel1p as the upstream kinases...
  3. ncbi Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2
    D J Riese
    Department of Pathology, Yale University, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 273:11288-94. 1998
    ..Therefore, these results establish that EPR exhibits novel activities and modes of regulation, which may have significant implications for EPR function in vivo...
  4. ncbi Functional assay for HER-2/neu demonstrates active signalling in a minority of HER-2/neu-overexpressing invasive human breast tumours
    M P DiGiovanna
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Br J Cancer 74:802-6. 1996
    ..The clinicopathological characteristics of these cases are described. This functional assay is predicted to improve the utility of HER-2/ neu as a prognostic indicator...
  5. ncbi Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer
    A D Thor
    Department of Pathology, Evanston Hospital Northwestern University, Evanston, IL 60201, USA
    J Clin Oncol 18:3230-9. 2000
    ..This study was designed to compare the incidence and prognostic value of ErbB-2 (HER-2/neu) and P-ErbB-2 immunoexpression in archival breast cancer samples...
  6. ncbi Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells
    S Agarwal
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Br J Cancer 100:941-9. 2009
    ..Phosphoproteomic analysis by RTK capture arrays may be a valuable tool for identifying the subset of tumours with functional receptor activation, regardless of mechanism...
  7. ncbi Specificity within the EGF family/ErbB receptor family signaling network
    D J Riese
    Department of Pathology, Yale University, New Haven, CT, USA
    Bioessays 20:41-8. 1998
    ....
  8. ncbi Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4
    A J Jackson-Fisher
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Oncogene 25:5664-72. 2006
    ..Taken together these results suggest that ErbB4 is not a potent, highly penetrant tumor suppressor, nor is it a factor in Neu-mediated tumorigenesis in this model...
  9. ncbi Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation
    F E Jones
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Oncogene 18:3481-90. 1999
    ..These results demonstrate that ErbB2 signaling is required for proper mammary development and lactation at parturition...
  10. ncbi Pathobiologic findings in DCIS of the breast: morphologic features, angiogenesis, HER-2/neu and hormone receptors
    E B Claus
    Department of Pathology, Yale Comprehensive Cancer Center, New Haven, Connecticut 06520, USA
    Exp Mol Pathol 70:303-16. 2001
    ..The role of these molecular/pathologic markers in the biology of DCIS and their potential clinical implications are discussed...
  11. ncbi Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
    G Garcia-Cardena
    Department of Pharmacology and the Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 271:27237-40. 1996
    ....
  12. ncbi Production of antibodies that recognize specific tyrosine-phosphorylated peptides
    M P DiGiovanna
    Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Protoc Mol Biol . 2001
    ..Support protocols are provided for the coupling of peptides and phosphotyrosine to the affinity matrix (Affi-Gel 10); BSA-agarose affinity matrix is commercially available...
  13. ncbi The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4
    D J Riese
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 271:20047-52. 1996
    ..Therefore, EGF, TGF-alpha, AR, and HB-EGF are functionally identical in this model system and behave differently from the EGF family hormones betacellulin and neuregulins...
  14. ncbi Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
    Z Sun
    Department of Biology, Yale University, New Haven, CT 06511, USA
    Science 281:272-4. 1998
    ..Thus, Rad53 integrates DNA damage signals by coupling with phosphorylated Rad9. The hitherto uncharacterized FHA domain appears to be a modular protein-binding domain...
  15. ncbi A role for DNA primase in coupling DNA replication to DNA damage response
    F Marini
    Dipartimento di Genetica e di Biologia dei Microrganismi, Universita degli Studi di Milano, Italy
    EMBO J 16:639-50. 1997
    ..Altogether, our results suggest that DNA primase plays an essential role in a subset of the Rad53p-dependent checkpoint pathways controlling cell cycle progression in response to DNA damage...
  16. ncbi Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells
    S Kannan
    Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, NIC, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:3330-5. 1997
    ..These data demonstrate that CR-1 can function through a receptor which activates intracellular components in the ras/raf/MEK/MAPK pathway...
  17. ncbi Ligands for ErbB-family receptors encoded by a neuregulin-like gene
    H Chang
    Department of Neurobiology, Stanford University School of Medicine, California 94305 5401, USA
    Nature 387:509-12. 1997
    ..However, in cell lines with defined combinations of ErbBs, neuregulin-2beta only activates those with ErbB3 and/or ErbB4, suggesting that signalling by neuregulin-2 is mediated by ErbB3 and/or ErbB4 receptors...
  18. ncbi Spk1, a new kinase from Saccharomyces cerevisiae, phosphorylates proteins on serine, threonine, and tyrosine
    D F Stern
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510
    Mol Cell Biol 11:987-1001. 1991
    ....