Research Topics
| Michael R SeringhausSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Publishing perishing? Towards tomorrow's information architectureMichael R Seringhaus
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
BMC Bioinformatics 8:17. 2007..We present our vision of the optimal information architecture for the biosciences, and close with tangible steps to improve our handling of scientific information today while paving the way for an expansive central index in the future...
Mismatch oligonucleotides in human and yeast: guidelines for probe design on tiling microarraysMichael Seringhaus
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
BMC Genomics 9:635. 2008..Here, we present the results of two large-scale microarray experiments on S. cerevisiae and H. sapiens genomic DNA, to explore MM oligonucleotide behavior with real sample mixtures under tiling-array conditions...
Divergence of transcription factor binding sites across related yeast speciesAnthony R Borneman
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
Science 317:815-9. 2007..Transcription factor binding sites have therefore diverged substantially faster than ortholog content. Thus, gene regulation resulting from transcription factor binding is likely to be a major cause of divergence between related species...
Transcription factor binding site identification in yeast: a comparison of high-density oligonucleotide and PCR-based microarray platformsAnthony R Borneman
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
Funct Integr Genomics 7:335-45. 2007..The HDO array platform provides a far more robust array system by all measures than PCR-based arrays, all of which is directly attributable to the large number of probes available...
Uncovering trends in gene namingMichael R Seringhaus
Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
Genome Biol 9:401. 2008..We categorize, for instance, those that involve a naming system transferred from another context (for example, Pavlov's dogs). We hope this analysis provides clues to better steer gene naming in the future...
Personalized genomic medicine with a patchwork, partially owned genomeChristopher E Mason
Program on Neurogenetics, Yale University Medical School, New Haven, Connecticut 06511, USA
Yale J Biol Med 80:145-51. 2007..In this brief review, we shall focus on these developments and examine how they are changing our understanding of our genome...
