Muhammad Wasif Saif

..The authors review the literature on the role of PET/CT in management of various tumors and discuss the medicoeconomic usefulness...

..Further confirmatory prospective studies are needed to evaluate the role of K-Ras mutation detections in tumor metastases, early stage CRC, and method of sampling specimens...

..The authors review the current literature and provide their expert opinion on the incorporation of S-1 in the treatment of solid malignancies [corrected]...

..This case also suggests that severe toxicity to infusional 5-FU might not be indicative of severe toxicity to oral fluoropyrimidine drugs...

..Safety of panitumumab in patients with a previous severe HSR with cetuximab is not fully known. We present three patients with GI cancers who tolerated panitumumab without HSR after experiencing severe HSR to cetuximab...

..Pancreatic cancer remains a dismal disease and early diagnostic markers and therapeutic targets are urgently needed...

..CONKO-003 study: final results of a randomized trial in patients with gemcitabine-refractory pancreatic cancer...

..The EGFR is known to be overexpressed in pancreatic cancer and data suggest that the presence of EGFR is associated with a poor prognosis...

..To our knowledge, this case report is the second report of possible correlation between rash and a positive drug response associated with bevacizumab and warrants further investigation of similar observation...

..Adequate and timely management of rash depending on the grade of rash is important for therapy continuation...

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..We, as oncologist, have to change our attitudes towards clinical trials and need to think beyond a trial design such as gemcitabine vs. drug of our choice...

..The syndrome of 5-fluorouracil (5-FU)-associated cardiotoxicity remains poorly defined...

..There is no randomized trial comparing infusional 5-FU to capecitabine. We retrospectively compared the safety and efficacy of CAP-based regimens with well-established CIV-5-FU-based regimens in LARC...

..In this review, we will evaluate the chemotherapy regimens investigated in older adult patients with CRC, and how the safety profiles and efficacy of chemotherapy in the older adult compare with those observed in younger patients...

..in Cancer Chemother Pharmacol 63(6):1017-1022, 2009). However, safety of cetuximab after IR with panitumumab is not known. We report two patients successfully desensitized with cetuximab after IR with panitumumab...

..Monitor patients closely after starting EGFR blocking agents and initiate immediate skin care based on general guideline are highly recommended...

..The administration of edotecarin in combination with infusional 5-FU/LV once every 14 days, even without the 5-FU bolus, did not permit adequate time for recovery from neutropenia...

..These targeted therapies can then be used alone or in combination with standard cytotoxic chemotherapy regimens...

..We suggest that electronic communication is of crucial importance to detect early, diagnose and treat anti-EGFR related skin rash in order to continue the benefit of anti-EGFR...

..Future studies will hopefully provide insight into the many unanswered questions...

..Herein, the authors report some updated information from the 2010 ASCO Gastrointestinal Cancers Symposium in detecting early stage pancreatic cancer...

..An increased understanding of the EGFR pathway in CRC has paved the way for the development of other targeted agents to augment therapeutic efficacy as well as for efforts to circumvent tumor resistance to therapy...

..We conducted a Phase I study using PHY906 in combination with capecitabine in patients with advanced pancreatic and gastrointestinal malignancies to determine the maximum tolerated dose (MTD) of capecitabine in combination with PHY906...

..To determine in patients, with locally advanced or metastatic pancreatic cancer (APC), efficacy and safety of treatment with intravenous paclitaxel loaded polymeric micelle (GPM)...

..Previous reported cases all involved female lung cancer patients. We emphasize the importance of recognizing the side effects of EGFR inhibitor therapy and its implications on the prognosis of the cancer treated...

..We review the data on pharmacokinetically guided dose adjustment of 5-FU and discuss the potential of this approach to advance therapeutic outcomes...

..To assess the use of capecitabine-based therapy and associated complication rates in patients with gastroesophageal cancer (GEC) in a real-world treatment setting...

..Secondary resection is a valid treatment goal for certain patients with initially unresectable liver metastases and an important end point for future clinical trials...

..Median survival after diagnosis of malignant ascites is in the range of 1 to 4 months; survival is apt to be longer for ovarian and breast cancers if systemic anti-cancer treatments are available...

..A phase I study proved that the combination (gemcitabine plus LY) is safe and well tolerated...

..This is the first human study that analyzes the association of TP/DPD ratio with overall survival and disease-free survival in cases of locally advanced pancreatic cancer (LAPC)...

..Future studies will be needed to confirm this as well as to determine the long-term adverse effects associated with pregabalin...

..The most effective treatment is discontinuation of gemcitabine, the provision of antihypertensive medications as needed, and consideration of plasmapheresis or use of immunoadsorption column in severe cases...

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..We present a case of hyperexcitability syndrome that developed during the treatment of pancreatic cancer with oxaliplatin and gemcitabine (GEMOX) that was successfully treated with pregabalin...

..To determine the maximal tolerated doses (MTD) and dose-limiting toxicities (DLT) of combination of 24-h infusions of gemcitabine and irinotecan in patients with advanced solid tumors...

..This review addresses the toxicities noted in trials using bevacizumab for the treatment of CRC and provides recommendations for toxicity management...

..This article reviews the adjuvant therapy for colon cancer and discusses the potential role and current trials involving the targeted agents...

..drug of our choice. Environment within which research is being conducted also has to be changed and last but not the least, access to trials for patients with pancreatic cancer is the key step in the fight against pancreatic cancer...

..In this article, the author discusses the incidence, clinical presentation, pathogenesis, risk factors and current strategies of management of HSR associated with oxaliplatin...

..In addition to severe to life-threatening toxicities akin to 5-fluorouracil, capecitabine can lead to unusual variants of common toxicities, including HFS, in DPD-deficient patients...

..Capecitabine offers physicians a more convenient treatment for advanced colorectal cancer, with manageable toxicity and antitumor activity comparable to that of CI therapies...

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..Recent progress in development of panitumumab in the management of CRC is reviewed, and management of associated rash is discussed herein...

..Treatment usually consists of a combination of chemotherapy and radiation therapy, or stem cell transplantation. Primary pancreatic lymphomas has a much better prognosis than adenocarcinoma of the pancreas...

..This article reviews the incidence, presentation, pathogenesis, risk factors, and management of GI perforation in patients with colorectal cancer who are treated with bevacizumab...

..Herein, the author reviews the literature concerning the diagnosis and treatment of CRC in pregnancy and discusses the role of newer agents approved for the treatment of CRC...

..Our case appears to be the second report of such a manifestation. Both cases responded well to chemotherapy...

..Screening should be considered in view of the widespread use of capecitabine and 5-FU, the severe toxicity that can develop in patients with low DPD activity, and the prevalence of the mutation...

..This review focuses on medical research on pancreatic cancer models and the underlying genetic alterations...

..Role of markers of angiogenesis in predicting response to therapy is also discussed...

..We suggest discontinuing gemcitabine if radiation recall is observed. Further studies are warranted into the pathogenesis of this unique phenomenon...

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..The authors review the autoantibodies associated with gastrointestinal malignancies and their clinical implications...

..Awareness of this rare tumor of pancreas is essential for early detection and proper management. The author review the clinical presentation, etiology, diagnosis, treatment and prognosis of PB in this presentation...

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..Capecitabine is currently being evaluated for the treatment of a variety of gastrointestinal malignancies...

..PN401 may therefore be useful for permitting dose escalation of 5-fluorouracil (5-FU) with consequent improvements in antitumor efficacy...

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..Among single agents, erlotinib and Src inhibitor failed to show seemingly benefit, while abraxane and pemetrexed deserve further investigation...

..Thinking beyond the gemcitabine box and exploring novel agents are very crucial now...

..Genetic variations such as polymorphic abnormality of TYMS are potential causative factors for a significant portion of serious adverse reactions to 5-FU-based therapy...

..The most common side effect is myelosuppression. Dyspnea is reported in 23% and bronchospasm occurs in less than 2% of subjects. Acute respiratory distress syndrome is rare with single agent use or in combination...

..2 months, p=0.03). Patients' quality of life did not deteriorate significantly during treatment. This finding supported further investigation of PHY906 as an adjuvant therapy of capecitabine in a larger hepatocellular cancer population...

..In conclusion, Bolus 5-FU can be used in patients developing cardio-toxicity due to 5-FU infusion...

..The authors summarize these findings presented at the 2010 ASCO Gastrointestinal Cancers Symposium, January 22-24, 2010, Orlando, FL, USA...

..Validated clinical tools that can assist in managing patients through the narrow therapeutic window are needed...

..These abstracts provide exciting new directions for the treatment of gemcitabine-refractory advanced pancreatic cancer...

..The early phase II study demonstrated a response rate approaching 20% while the combination is reaching more than 35%...

..The authors summarize and discuss the data from the meeting...

..Ethnicity is an important factor known to impact the biology and outcome of many cancers. In pancreatic cancer, African Americans are thought to have a higher incidence and poorer prognosis than Whites...

..Oxaliplatin use in gastrointestinal malignancies is limited by neurotoxicity. This study aimed to assess the efficacy of pregabalin (LYRICA(R)) in the treatment of oxaliplatin-induced neurotoxicity...

..Abstract e14625 combined S-1 to gemcitabine and abstract #4113 demonstrated a positive correlation between symptoms and CA 19-9 levels with the length of survival...

..Docetaxel activity against pancreatic cancer is reported both in the preclinical and clinical setting. This study retrospectively evaluated the role of docetaxel as second-line therapy in patients with gemcitabine-refractory disease...

..In this article, we review and summarize the findings from these studies...

..This article provides a summary of herbal medicine, presented at the Annual Meeting of ASCO, 2008. The clinical applications of these active compounds warrant further investigation in randomized, controlled clinical trials...

..Often, there are liver lesions seen on diagnostic CT suspicious for secondary deposits. Positron emission tomography (PET)-CT may have a great potential in confirming or ruling out actual malignancy in those areas...

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..In this article we review various treatment options, including cytotoxic and targeted agents, currently available for patients with mCRC...

..We report here another pancreatic cancer patient with a radiation recall receiving capecitabine following capecitabine-XRT...

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..The objective of this review is to evaluate the literature for evidence of efficacy and safety of fluoropyrimidine plus gemcitabine (FG) in patients with advanced CRC...

..The nature and extent of this interaction requires further investigation...

..With regard to oxaliplatin, knowledge of its rare but eminent toxicity is paramount, because this drug is widely used in treating colorectal cancer, the second-highest cause of cancer mortality in the United States...

..We believe this to be the first case in the literature with cough as a sole manifestation of HSR to oxaliplatin...

..Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity...

..The patient's bone marrow revealed a B-cell lymphoma of CLL/SLL phenotype, which to our knowledge has not been linked to MLP in previously reported cases...

..The addition of triphendiol to gemcitabine is synergistic in in vitro and in vivo models of pancreatic cancer and represents a novel combination of drugs for pancreatic cancer patients...

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..Many of these behaviors are potentially modifiable with appropriate education, communication, and intervention...

..Dose-limiting diarrhea was observed only with a twice-weekly administration schedule. Recent progress in preclinical and clinical studies of edotecarin is reviewed...