Hester A Doyle

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Posttranslational modifications of self-antigens
    Hester A Doyle
    Section of Rheumatology, Yale University School of Medicine, P O Box 208031, New Haven, CT 06520 8031, USA
    Ann N Y Acad Sci 1050:1-9. 2005
  2. ncbi Intracellular protein modification associated with altered T cell functions in autoimmunity
    Mei Ling Yang
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 177:4541-9. 2006
  3. ncbi Altered immunogenicity of isoaspartate containing proteins
    Hester A Doyle
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Autoimmunity 40:131-7. 2007
  4. ncbi Isoaspartyl post-translational modification triggers anti-tumor T and B lymphocyte immunity
    Hester A Doyle
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Biol Chem 281:32676-83. 2006
  5. ncbi Posttranslational protein modifications: new flavors in the menu of autoantigens
    Hester A Doyle
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Rheumatol 14:244-9. 2002
  6. ncbi A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production
    Hester A Doyle
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:2840-7. 2003
  7. ncbi Autoantigenesis: the evolution of protein modifications in autoimmune disease
    Hester A Doyle
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT, United States
    Curr Opin Immunol 24:112-8. 2012

Collaborators

  • Mark Mamula
  • Mei Ling Yang
  • Jonathan D Lowenson
  • Steven Clarke
  • Renelle J Gee
  • Dana W Aswad
  • Mei-Ling Yang
  • Brian R Lawson

Detail Information

Publications7

  1. ncbi Posttranslational modifications of self-antigens
    Hester A Doyle
    Section of Rheumatology, Yale University School of Medicine, P O Box 208031, New Haven, CT 06520 8031, USA
    Ann N Y Acad Sci 1050:1-9. 2005
    ..We review some of the posttranslationally modified self-antigens associated with autoimmune diseases, how they arise, and how they break immune tolerance...
  2. ncbi Intracellular protein modification associated with altered T cell functions in autoimmunity
    Mei Ling Yang
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 177:4541-9. 2006
    ..These studies demonstrate a role for the accumulation of intracellular isoAsp proteins associated with T cell proliferative defects of MRL autoimmune mice...
  3. ncbi Altered immunogenicity of isoaspartate containing proteins
    Hester A Doyle
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Autoimmunity 40:131-7. 2007
    ..These finding demonstrate the importance of post-translational modifications in shaping autoimmune responses in and the development of tolerance to self-proteins...
  4. ncbi Isoaspartyl post-translational modification triggers anti-tumor T and B lymphocyte immunity
    Hester A Doyle
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Biol Chem 281:32676-83. 2006
    ..Potentially, post-translational protein modification can be utilized to trigger strong immune responses to either tumor proteins or potentially weakly immunogenic pathogens...
  5. ncbi Posttranslational protein modifications: new flavors in the menu of autoantigens
    Hester A Doyle
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Rheumatol 14:244-9. 2002
    ..Lastly, we will address how posttranslational modifications in self-antigens affect current diagnostic techniques and the development of immunotherapies for autoimmune diseases...
  6. ncbi A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production
    Hester A Doyle
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:2840-7. 2003
    ..These observations, coupled with the fact that humans have polymorphisms in the pcmt gene, suggest that isoaspartyl self-proteins may alter the maintenance of peripheral immune tolerance...
  7. ncbi Autoantigenesis: the evolution of protein modifications in autoimmune disease
    Hester A Doyle
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT, United States
    Curr Opin Immunol 24:112-8. 2012
    ..Finally, we will address how post-translational modifications in self-antigens may affect the analyses of B and T cell specificity, current diagnostic techniques, and/or the development of immunotherapies for autoimmune diseases...