Research Topics
Species | KELLY COSGROVESummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Evolving knowledge of sex differences in brain structure, function, and chemistryKelly P Cosgrove
Division of Psychiatry SPECT Imaging, Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut 06516, USA
Biol Psychiatry 62:847-55. 2007....- Sex and estrogen influence drug abuseMarilyn E Carroll
Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
Trends Pharmacol Sci 25:273-9. 2004..In all phases of drug abuse, females seem to be more sensitive to the rewarding effects of drugs than males, and estrogen is a major factor that underlies these sex differences... - Sex differences in the vulnerability to drug abuse: a review of preclinical studiesMegan E Roth
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Biobehav Rev 28:533-46. 2004..The animal literature on sex differences in drug abuse treatment effectiveness is also discussed... - 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phaseKelly P Cosgrove
Yale University School of Medicine, New Haven, Connecticut, USA
J Nucl Med 48:1633-40. 2007..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women... - Sex Differences in Availability of ?2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco SmokersKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave 116A6, West Haven, CT 06516
Arch Gen Psychiatry 69:418-27. 2012..Sex differences in availability of nicotinic acetylcholine receptors containing the ?(2) subunit (?(2)*-nAChRs) may underlie differential nicotine and tobacco smoking effects and related behaviors in women vs men... - Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smokingKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Neuropsychopharmacology 34:2218-26. 2009..Smoking appears to suppress neuroadaptive changes in DA and 5-HT transporters during acute withdrawal from alcohol... - Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primatesKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine and the VACHS, New Haven, CT 06516, USA
Synapse 64:729-32. 2010..The decrease in beta(2)*-nAChR availability is influenced by alcohol consumption, suggesting the chronicity and severity of alcohol consumption may underlie persistent changes in beta(2)*-nAChR availability... - Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokersKelly P Cosgrove
Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
Nicotine Tob Res 12:535-9. 2010.... - SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brainKelly P Cosgrove
Yale University School of Medicine, VA Connecticut HCS 116A6, West Haven, CT 06516, USA
Nucl Med Biol 37:587-91. 2010..The purpose of this study was to characterize and determine the in vivo selectivity of iodine-123-labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane, [(123)I]p ZIENT, in nonhuman primate brain... - Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]?-CIT SPECT imaging studyKelly P Cosgrove
Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States
Psychiatry Res 184:192-5. 2010..Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found... - Imaging receptor changes in human drug abusersKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Curr Top Behav Neurosci 3:199-217. 2010..The development of novel radiotracers that target additional receptor systems will further our understanding of the neurochemical basis of addiction... - Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependenceKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine and the VACHS, West Haven, CT 06516, USA
Neuropharmacology 60:1318-25. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Assessing the sensitivity of [¹¹C]p943, a novel 5-HT(1B) radioligand, to endogenous serotonin releaseKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Synapse 65:1113-7. 2011..Receptor occupancy by P943 (0.2 mg/kg) was 68 and 86% in the baboons. PET imaging of 5-HT(1B) receptors with [¹¹C]P943 may be a useful approach for measuring changes in endogenous 5-HT in the living human brain... - beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smokingKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
Arch Gen Psychiatry 66:666-76. 2009..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence... - Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECTEffie M Mitsis
Yale University School of Medicine, New Haven, CT 06510, USA
Neurobiol Aging 30:1490-7. 2009..These results in living human subjects corroborate postmortem reports of decline in high affinity nicotine binding with age and may aid in elucidating the role of beta(2)-nAChRs in cognitive aging... - Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: a behavioral economic analysisKelly P Cosgrove
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
J Pharmacol Exp Ther 301:993-1002. 2002..These results extend the findings that kappa-agonists reduce the self-administration of drug and nondrug reinforcers to smoked cocaine base and oral ethanol, PCP, and saccharin in rhesus monkeys... - SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individualsIrina Esterlis
Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
Drug Alcohol Depend 108:146-50. 2010..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers... - GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depressionIrina Esterlis
Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
Synapse 63:1089-99. 2009..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression... - Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable bindingIrina Esterlis
Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
J Nucl Med 51:1226-33. 2010..In this study, we measured nicotine occupancy and nondisplaceable binding in healthy smokers after they had smoked to satiety... - Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokersJulie K Staley
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
J Neurosci 26:8707-14. 2006..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence... - [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brainEffie M Mitsis
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Ann N Y Acad Sci 1097:168-70. 2007..Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging... - Brain ?2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhalerIrina Esterlis
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Int J Neuropsychopharmacol 14:389-98. 2011..13, p=0.04). These results demonstrate significant differences in occupancy of ?2*-nAChRs by nicotine after use of the inhaler vs. a cigarette and confirm the ability of the nicotine inhaler to relieve withdrawal symptoms... - Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophreniaDEEPAK CYRIL D'SOUZA
Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
Am J Psychiatry 169:326-34. 2012..The purpose of this study was to measure ?(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia... - Differential effects of bremazocine on oral phencyclidine (PCP) self-administration in male and female rhesus monkeysKelly P Cosgrove
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
Exp Clin Psychopharmacol 12:111-7. 2004.... - Wheel-running attenuates intravenous cocaine self-administration in rats: sex differencesKelly P Cosgrove
Department of Psychiatry, University of Minnesota, Mayo Box 392, Minneapolis 55455, USA
Pharmacol Biochem Behav 73:663-71. 2002..These results indicate that wheel-running activity had a greater suppressant effect on cocaine self-administration in females than in males, and in females, wheel-running and cocaine self-administration are substitutable as reinforcers... - Effects of a non-drug reinforcer, saccharin, on oral self-administration of phencyclidine in male and female rhesus monkeysKelly P Cosgrove
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 170:9-16. 2003..Males show elevated drug-maintained responding compared with females, but when differential body weights are considered (mg/kg) females consume more than males only under limited schedule parameters...
Research Grants
- TREATMENT FOR ALCHOLISM: A PRIMATE MODELKELLY COSGROVE; Fiscal Year: 2002..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
- Brain Imaging of Sex Differences in Tobacco SmokersKELLY COSGROVE; Fiscal Year: 2007..This will aid in the development of medications that are specifically designed to help both women and men quit smoking. ..
- GABAergic Mechanisms of Comorbid Alcohol and Nicotine DependenceKELLY COSGROVE; Fiscal Year: 2009..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
- GABAergic Mechanisms of Comorbid Alcohol and Nicotine DependenceKelly P Cosgrove; Fiscal Year: 2010..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..